JAX Mouse Strain Datasheet - 000661

C3H/HeSnJ

Stock No:: 000661

Inbred Strain

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Overview

Also Known As: C3H Snell, C3H/HeDiSnJ, C3Sn

C3H mice are used as a general purpose strain in a wide variety of research areas including cancer, infectious disease, sensorineural, and cardiovascular biology research. This C3H substrain was rederived in the 1960's and again in 1999, as a result, this line does not carry the exogenous mouse mammary tumor virus (MMTV). These mice are homozygous for the retinal degeneration allele Pde6b^rd1.

Genetic overview

Genetic Background	Generation
	F191+F29 (25-MAY-16)

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Research Applications

Neurobiology Research
Research Tools
Sensorineural Research

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Base Price

Starting at:

$224.00 Domestic price for female

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Details

Important Note

This strain does not carry mouse mammary tumor virus (MMTV). See JAX^® NOTES, May 2000, No. 480. This strain is also homozygous for the retinal degeneration allele Pde6b^rd1. A sighted alternative is Stock No. 003648, C3Sn.BLiA-Pde6b⁺/DnJ.

Detailed Description

C3H mice are used as a general purpose strain in a wide variety of research areas including cancer, infectious disease, sensorineural, and cardiovascular biology research. The C3H/HeSnJ substrain served as the parental strain for the Snell (Sn) congenic strains. This substrain does not carry the exogenous mouse mammary tumor virus (MMTV) and, like the other C3H strains, is homozygous for the retinal degeneration allele (rd1), but lacks the nob5 allele of Gpr179 (Chang, 2015). Unlike other C3H inbred strains, this strain is homozygous for the Clcc1^m1J allele, which has a more mild phenotype on this background than on the C57BL/6J congenic background (see Stock# 007723). C3H/HeSnJ have pyknotic granule cells in the cerebellum by 2 months of age, and hypoplastic cerebellum with numerous vacuoles by 22 months of age (Jia et al, 2015).

Development

The C3H parent strain was developed by LC Strong in 1920 from a cross of a Bagg albino female with a DBA male followed by selection for high incidence of mammary tumors. This high incidence resulted from exogenous mouse mammary tumor virus (MMTV) transmitted through the mother's milk. The Jackson Laboratory maintains four C3H substrains, C3H/HeJ (Stock No. 000659), C3H/HeOuJ (Stock No. 000635), C3HeB/FeJ (Stock No. 000658) and C3H/HeSnJ (Stock No. 000661) that are now free of exogenous MMTV. C3H/HeSnJ, C3H/HeJ and C3H/HeOuJ mice previously carried MMTV but were rederived in 1999 during planned efforts to increase the overall health status of the mice and the virus was not reintroduced. A spontaneous mutation occurred in C3H/HeJ sometime between 1960 and 1968 at lipopolysaccharide response locus (mutation in toll-like receptor 4 gene, Tlr4^lps) making C3H/HeJ mice endotoxin resistant while the other three C3H strains are endotoxin sensitive.

Selected References

Chang B. 2015. Survey of the mutation in C3H substrains. Mol Vis 21:1101-1105. PubMed: 26396487 MGI: J:224435
Jia Y; Jucius TJ; Cook SA; Ackerman SL. 2015. Loss of Clcc1 Results in ER Stress, Misfolded Protein Accumulation, and Neurodegeneration. J Neurosci 35(7):3001-9. PubMed: 25698737 MGI: J:218443
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298

View All References

Genetics

Clcc1^m1J

Allele Symbol: Clcc1^m1J

Allele Name	mutation 1, Jackson
Allele Type	Spontaneous
Allele Synonym(s)	nm2453; sprawler
Gene Symbol and Name	Clcc1, chloride channel CLIC-like 1
Gene Synonym(s)	MCLC; Mclc; Mclc; Mid-1-related chloride channel 1
Strain of Origin	C3H/HeSnJ
Chromosome	3
Molecular Note	The mutation is an intracisternal A-particle (IAP) retrotransposon insertion into a C3H/HeSnJ genomic region. The IAP is inserted into intron 2 of the gene and disrupts the normal splicing of the mRNA transcribed from this gene. Resulting in-frame stop codons from the insertion of IAP sequences resulted in severely reduced protein levels in mutant tissues. The retrotransposition of this IAP is a recent event occurring during, or after, the establishment of the C3H/HeSnJ substrain.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	Pdeb^rd1; rd; rd-1; rd1; rodless retina
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; Pdeb; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; r; rd; rd; rd-1; rd1; rd1; rd10; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Hearing Defects
  - Age related hearing loss, control
Research Tools
- General Purpose
Sensorineural Research
- Hearing Defects
  - Age related hearing loss, control
- Retinal Degeneration
  - Homozygous for Pde6b^rd1

Genotype: Clcc1^m1J related

Neurobiology Research
- Ataxia (Movement) Defects
- Cerebellar Defects
- Neurodegeneration

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration

Mammalian Phenotype Terms by Genotype

Genotype: Pde6b^rd1/Pde6b^rd1
C3H/HeJ

vision/eye phenotype

abnormal retinal outer nuclear layer morphology
- nearly complete absence of outer nuclear layer

absent photoreceptor outer segment

retinal degeneration
- entire outer retina is destroyed, however the inner retina remains intact

vision/eye phenotype
- despite the absence of rods, mice exhibit normal photopotentiation (defined as a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure)

nervous system phenotype

absent photoreceptor outer segment

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Clcc1^m1J/Clcc1^m1J
C3H/HeSnJ

nervous system phenotype

abnormal cerebellar granule cell morphology
- Background Sensitivity - pyknotic granule cells are found in the cerebellum as early as 2 months of age, although cell death progresses more slowly than in homozygotes on the C57BL/6J congenic background

brain vacuoles
- Background Sensitivity - found by 22 months of age, later onset and decreased severity than that found on the C57BL/6J background

cerebellum hypoplasia
- Background Sensitivity - cerebellum is hypoplastic by 22 months of age compared with that of C3H/HeOuJ, C3HeB/FeJ and C3H/HeJ inbred mice, which lack this IAP

nervous system phenotype
- Background Sensitivity - The peripheral neuropathy, neurogenic muscular atrophy and mild truncal ataxia that is found on the C57BL/6J background is not found on the C3H/HeSnJ background

Phenotype Information

Festing Inbred Strain Characteristics: C3H

References

Chang B. 2015. Survey of the mutation in C3H substrains. Mol Vis 21:1101-1105. PubMed: 26396487 MGI: J:224435
Jia Y; Jucius TJ; Cook SA; Ackerman SL. 2015. Loss of Clcc1 Results in ER Stress, Misfolded Protein Accumulation, and Neurodegeneration. J Neurosci 35(7):3001-9. PubMed: 25698737 MGI: J:218443
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298

Additional References

International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. PubMed: 14945054 MGI: J:166288
Zheng QY; Johnson KR; Erway LC. 1999. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130(1-2):94-107. PubMed: 10320101 MGI: J:54812

Additional - Pde6b^rd1 related

Acosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. PubMed: 16163270 MGI: J:103970
Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. PubMed: 19524569 MGI: J:151412
Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. PubMed: 18326735 MGI: J:133024
Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 18(8):797-801. PubMed: 17471069 MGI: J:122802
Alavi MV; Bette S; Schimpf S; Schuettauf F; Schraermeyer U; Wehrl HF; Ruttiger L; Beck SC; Tonagel F; Pichler BJ; Knipper M; Peters T; Laufs J; Wissinger B. 2007. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain 130(Pt 4):1029-42. PubMed: 17314202 MGI: J:154966
Allen AE; Brown TM; Lucas RJ. 2011. A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus. J Neurosci 31(46):16833-43. PubMed: 22090509 MGI: J:177906
Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. PubMed: 21124780 MGI: J:167121
Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration. Brain Res 1024(1-2):137-45. PubMed: 15451375 MGI: J:92980
Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res 1087(1):134-41. PubMed: 16626665 MGI: J:109668
Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina. Neurosci Lett 357(3):223-6. PubMed: 15003290 MGI: J:121036
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Ash J; McLeod DS; Lutty GA. 2005. Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye. Mol Vis 11:298-308. PubMed: 15889014 MGI: J:98579
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Yee CW; Toychiev AH; Ivanova E; Sagdullaev BT. 2014. Aberrant synaptic input to retinal ganglion cells varies with morphology in a mouse model of retinal degeneration. J Comp Neurol 522(18):4085-99. PubMed: 25099614 MGI: J:238192
Yi H; Nakamura RE; Mohamed O; Dufort D; Hackam AS. 2007. Characterization of Wnt signaling during photoreceptor degeneration. Invest Ophthalmol Vis Sci 48(12):5733-41. PubMed: 18055826 MGI: J:132500
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Also Known As: C3H Snell, C3H/HeDiSnJ, C3Sn

Genetic overview

Research Applications

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Detailed Description

Development

Selected References

Clcc1m1J

Allele Symbol: Clcc1m1J

Pde6brd1

Allele Symbol: Pde6brd1

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Clcc1m1J related

Genotype: Pde6brd1 related

Mammalian Phenotype Terms by Genotype

Genotype: Pde6brd1/Pde6brd1C3H/HeJ

vision/eye phenotype

nervous system phenotype

Genotype: Clcc1m1J/Clcc1m1JC3H/HeSnJ

nervous system phenotype

Phenotype Information

References

Additional References

Additional - Pde6brd1 related

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Live Mouse

Cryorecovery - Pricing

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Clcc1^m1J

Allele Symbol: Clcc1^m1J

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Genotype: Clcc1^m1J related

Genotype: Pde6b^rd1 related

Genotype: Pde6b^rd1/Pde6b^rd1
C3H/HeJ

Genotype: Clcc1^m1J/Clcc1^m1J
C3H/HeSnJ

Additional - Pde6b^rd1 related