Originally inbred at the Rockefeller Institute, AKR mice are widely used in cancer research for their high leukemia incidence (60-90%) and in immunology as a source of the Thy1.1 (theta AKR) antigen. AKR/J mice are viremic from birth, and express the ecotropic retrovirus AKV in all tissues. The hair interior defect (hid) mutation, a strain characteristic of AKR mice, causes alterations in hair development that is only evident microscopically. Adrenocortical lipid depletion (ald) in AKR mice is caused by a mutation in sterol O-acyltransferase 1 (Soat1), and leads to a truncated SOAT1 protein. AKR/J mice are relatively resistant to aortic lesion formation on a semi-synthetic high fat diet and are hyporesponsive to diets containing high levels of fat and cholesterol.

Selected References

Doering CH; Shire JG; Kessler S; Clayton RB. 1973. Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice. Biochem Genet 8(1):101-11. PubMed: 4348256 MGI: J:5333
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77. PubMed: 1971301 MGI: J:15484
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. PubMed: 7595076 MGI: J:28648
Meiner VL; Welch CL; Cases S; Myers HM; Sande E; Lusis AJ; Farese RV Jr. 1998. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. J Biol Chem 273(2):1064-9. PubMed: 9422770 MGI: J:42073
Molne K; Brabrand G. 1968. Spontaneous adrenocortical lipid depletion in mice. Relationship to general growth, degeneration of adrenal X zone, and maturation of seminiferous epithelium. Acta Pathol Microbiol Scand 72(4):478-90. PubMed: 5693089 MGI: J:5089
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. PubMed: 8355588 MGI: J:13267
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. PubMed: 7625360 MGI: J:28248
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. PubMed: 2317166 MGI: J:22615
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Uelmen PJ; Oka K; Sullivan M; Chang CC; Chang TY; Chan L. 1995. Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem 270(44):26192-201. PubMed: 7592824 MGI: J:29712
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. PubMed: 1621856 MGI: J:1348

View All References

Genetics

Ahr^d

Allele Symbol: Ahr^d

Allele Name	d variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^d; Ah^k; AhRd; Ahhⁿ; ah; in
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity
Strain of Origin	Not Applicable
Chromosome	12
General Note	Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note	This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Cd5^b

Allele Symbol: Cd5^b

Allele Name	b variant
Allele Type	Spontaneous (Not Applicable)
Allele Synonym(s)	CD5.2; Ly-1.2
Gene Symbol and Name	Cd5, CD5 antigen
Gene Synonym(s)	LEU1; Ly-1; Ly-1; Ly-12; Ly-12; Ly-A; Lyt-1; Lyt-1; T-lymphocyte antigen 1; T1; lymphocyte antigen 1; lymphocyte antigen 12
Strain of Origin	multiple strains
Chromosome	19
Molecular Note	This variant is found in many inbred strains including C57BL/6J, C58/J, AKR/J, SJL/J, SWR. Sequence analysis shows that relative to the a variant of C3H/HeJ the b variant has point mutations that result in isoleucine instead of valine at amino acid 9, glutamine instead of leucine at amino acid 52, and phenylalanine instead of isoleucine at amino acid 71, all within the amino terminal scavenger receptor cysteine-rich D1 domain, in addition to 7 silent point mutations.

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	Cdh23^753A; mdfw
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	4930542A03Rik; 4930542A03Rik; CDHR23; PITA5; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; ahl; bob; bob; bobby; bus; bustling; mdfw; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf112; nmf181; nmf181; nmf252; nmf252; sals; sals; salsa; v; waltzer
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Hc⁰

Allele Symbol: Hc⁰

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	C5-; C5-d; C5-def; C5-deficient; Hc^Hfib2; hc^o
Gene Symbol and Name	Hc, hemolytic complement
Gene Synonym(s)	C5; C5; C5D; C5a; C5b; CPAMD4; ECLZB; He; He; Hfib2; Hfib2; hepatic fibrogenesis 2
Strain of Origin	multiple strains
Chromosome	2
General Note	This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note	A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5.

Il3ra^m1

Allele Symbol: Il3ra^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	Il3ra^A/J; Il3raⁿ
Gene Symbol and Name	Il3ra, interleukin 3 receptor, alpha chain
Gene Synonym(s)	CD123; Cyrl; IL-3 receptor alpha chain; IL3R; IL3RAY; IL3RX; IL3RY; SUT-1; hIL-3Ra
Strain of Origin	A/J
Chromosome	14
Molecular Note	Sequence analysis revealed A/J mice lack the sequence corresponding to exon 8, which encodes 10 amino acid residues in the extracellular domain. Aberrant splicing was due to a 5 base pair deletion at the branch point in intron 7.

Obq3^AKR/J

Allele Symbol: Obq3^AKR/J

Allele Name	AKR/J
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Obq3, obesity QTL 3
Gene Synonym(s)
Strain of Origin	AKR/J
Chromosome	2
General Note	Obq3 exhibits an additive mode of inheritance.
Molecular Note	This allele confers increased adiposity in male animals compared to C57L/J.

Obq4^AKR/J

Allele Symbol: Obq4^AKR/J

Allele Name	AKR/J
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Obq4, obesity QTL 4
Gene Synonym(s)
Strain of Origin	AKR/J
Chromosome	17
General Note	Obq4 may also be consistent with an additive mode of inheritance.

Ogg1^m1

Allele Symbol: Ogg1^m1

Allele Name	mutation 1
Allele Type	Spontaneous (Not Applicable)
Allele Synonym(s)	OGG1-R336H
Gene Symbol and Name	Ogg1, 8-oxoguanine DNA-glycosylase 1
Gene Synonym(s)	HMMH; HOGG1; MUTM; Mmh; OGH1
Strain of Origin	various
Chromosome	6
Molecular Note	A guanine to adenine change at the fifty-ninth nucleotide in exon 7 resulted in a substitution of the 336th amino acid, arginine, by histidine (R336H) in a putative nuclear localization signal. The mutation led to disruption of the nuclear localization of the enzyme, although the activity remained normal.

Rmcf^s

Allele Symbol: Rmcf^s

Allele Name	MCF sensitive
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Rmcf, resistance to MCF virus
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcf^r determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcf^s determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1, a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcf^r protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxv^s/Sxv^r mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcf^r increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcf^r allele contains an endogenous MCF gp70 env gene and that the Rmcf^s allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note	This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The recessive s (susceptible) allele is found in AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB and 129/J.

Soat1^ald

Allele Symbol: Soat1^ald

Allele Name	adrenocortical lipid depletion
Allele Type	Spontaneous
Allele Synonym(s)	Acact-; Soat1^hid; ald; hid
Gene Symbol and Name	Soat1, sterol O-acyltransferase 1
Gene Synonym(s)	8430426K15Rik; 8430426K15Rik; ACACT; ACAT; ACAT-1; ACAT1; AW550831; Acact; Acact; Acat-1; RIKEN cDNA 8430426K15 gene; SOAT; STAT; acetyl coenzyme A cholesterol acyltransferase; adrenocortical lipid depletion; ald; expressed sequence AW550831; hair interior defect; hid; hid
Strain of Origin	AKR/O
Chromosome	1
General Note	All AKR sublines are homozygous for Soat1.
Molecular Note	Deletion of 118 bp in the a Soat1 mRNA. This region corresondes to the 5'UTR and the initial coding sequences. In addition, two missense mutations were observed: A1248G resulting in Ile to Val at amino acid 147 and C1422T resulting in His to Tyr at amino acid 205. Other nucleotide differences were observed that did not result in amino acid changes. A truncated protein is expressed from this allele, presumably due to internal initiation.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cancer Research
- Increased Tumor Incidence
  - Leukemia
  - Leukemia: lymphatic
Cardiovascular Research
- Atherosclerosis
  - Soat1^ald
- Diet-Induced Atherosclerosis
  - Relatively Resistant
Developmental Biology Research
- Lymphoid Tissue Defects
  - hematopoietic defects
Diabetes and Obesity Research
- Hyperglycemia
  - diet-induced, moderate
- Obesity With Diabetes
  - diet-induced
- Type 2 Diabetes (NIDDM)
  - diet-induced
Endocrine Deficiency Research
- Adrenal Cortex Defects
- Hypothalamus/Pituitary Defects
  - Soat1^ald
Internal/Organ Research
- Adrenal Cortex Defects
Metabolism Research
- Enzyme Deficiency
Neurobiology Research
- Hearing Defects
  - Age related hearing loss

Genotype: Ahr^d related

Metabolism Research
Research Tools
- Toxicology Research

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Genotype: Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - specific complement deficiency
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement

Genotype: Il3ra^m1 related

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
  - genes regulating susceptibility to infectious disease and endotoxin

Mammalian Phenotype Terms by Genotype

Genotype: Ahr^d/Ahr^d
AKR

mortality/aging

decreased sensitivity to xenobiotic induced morbidity/mortality
- mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

homeostasis/metabolism phenotype

decreased physiological sensitivity to xenobiotic
- mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

decreased sensitivity to xenobiotic induced morbidity/mortality
- mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

Genotype: Il3ra^m1/Il3ra^m1
AKR/J

hematopoietic system phenotype

abnormal common myeloid progenitor cell morphology
- CFU-GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3

Genotype: Soat1^ald/Soat1^ald
AKR

integument phenotype

abnormal hair growth
- all AKR strains are homozygous for this mutation
- distal regions of all hair types are especially affected
- homozygotes can be ascertained only by microscopic examination of the hair
- morphology and arrangement of medullary cells are abnormal

abnormal hair medulla
- medulla morphology and arrangement are abnormal
- random and tightly packed medullary cells produce irregularities of hair shaft calibre

abnormal hair shaft morphology
- medullary cell abnormality effects calibre of hair shaft

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Soat1^ald/Soat1^ald
AKR/O

endocrine/exocrine gland phenotype

abnormal adrenal cortex morphology
- adrenal cortex of females is not totally depleted and lipid pattern is variable
- adrenal cortex of males is totally depleted of lipid
- in males adrenocortical lipid depletion coincides roughly with adrenal X-zone degeneration and maturation of seminiferous epithelium
- large doses of ACTH restores lipid concentration and distribution
- onset of adrenocortical lipid depletion takes place in mice between 30 and 40 days of age

abnormal adrenocortical cell morphology
- cells are enriched with mitochondria
- lipid vacuoles are sparse

thymus hyperplasia
- evident from birth

hematopoietic system phenotype

thymus hyperplasia
- evident from birth

immune system phenotype

thymus hyperplasia
- evident from birth

neoplasm

increased leukemia incidence
- high incidence of lymphatic leukemia

Phenotype Information

References

Doering CH; Shire JG; Kessler S; Clayton RB. 1973. Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice. Biochem Genet 8(1):101-11. PubMed: 4348256 MGI: J:5333
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77. PubMed: 1971301 MGI: J:15484
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. PubMed: 7595076 MGI: J:28648
Meiner VL; Welch CL; Cases S; Myers HM; Sande E; Lusis AJ; Farese RV Jr. 1998. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. J Biol Chem 273(2):1064-9. PubMed: 9422770 MGI: J:42073
Molne K; Brabrand G. 1968. Spontaneous adrenocortical lipid depletion in mice. Relationship to general growth, degeneration of adrenal X zone, and maturation of seminiferous epithelium. Acta Pathol Microbiol Scand 72(4):478-90. PubMed: 5693089 MGI: J:5089
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. PubMed: 8355588 MGI: J:13267
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. PubMed: 7625360 MGI: J:28248
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. PubMed: 2317166 MGI: J:22615
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Uelmen PJ; Oka K; Sullivan M; Chang CC; Chang TY; Chan L. 1995. Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem 270(44):26192-201. PubMed: 7592824 MGI: J:29712
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. PubMed: 1621856 MGI: J:1348

Additional References

Eberhart GP; West DB; Boozer CN; Atkinson RL. 1994. Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to diet-induced obesity. Am J Physiol 266(5 Pt 2):R1423-8. PubMed: 8203615 MGI: J:18464
Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. Am J Respir Cell Mol Biol 23(4):537-45. PubMed: 11017920 MGI: J:66641
Festing MF; Blackmore DK. 1971. Life span of specified-pathogen-free (MRC category 4) mice and rats. Lab Anim 5(2):179-92. PubMed: 5166568 MGI: J:22607
Hara T; Ichihara M; Takagi M; Miyajima A. 1995. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Blood 85(9):2331-6. PubMed: 7727767 MGI: J:24918
Hoag WG. 1963. Spontaneous cancer in mice Ann N Y Acad Sci 108:805-831. PubMed: 14081516 MGI: J:2434
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. Elife 4:e05607. PubMed: 26067236 MGI: J:223755
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. PubMed: 14945054 MGI: J:166288
Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94. PubMed: 21921910 MGI: J:177037
Menghini P; Di Martino L; Lopetuso LR; Corridoni D; Webster JC; Xin W; Arseneau KO; Lam M; Pizarro TT; Cominelli F. 2017. A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. PLoS One 12(3):e0174121. PubMed: 28301579 MGI: J:247066
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20. PubMed: 16971002 MGI: J:138682
Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. J Exp Med 125(1):1-16. PubMed: 4959665 MGI: J:5016
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. Nature 282(5735):207-8. PubMed: 492335 MGI: J:6214
Roberts JE; Watters JW; Ballard JD; Dietrich WF. 1998. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol 29(2):581-91. PubMed: 9720874 MGI: J:49726
Rossmeisl M; Rim JS; Koza RA; Kozak LP. 2003. Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity. Diabetes 52(8):1958-66. PubMed: 12882911 MGI: J:86027
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. PubMed: 10749765 MGI: J:61602
Smith BK; West DB; York DA. 1997. Carbohydrate versus fat intake: differing patterns of macronutrient selection in two inbred mouse strains. Am J Physiol 272(1 Pt 2):R357-62. PubMed: 9039029 MGI: J:39025
Taylor BA; Phillips SJ. 1997. Obesity QTLs on mouse chromosomes 2 and 17. Genomics 43(3):249-57. PubMed: 9268627 MGI: J:39947
Trigg MJ. 1972. Hair growth in mouse mutants affecting coat texture. J Zool 168:165-198. MGI: J:15247
West DB; Goudey-Lefevre J; York B; Truett GE. 1994. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 94(4):1410-6. PubMed: 7929816 MGI: J:20700
West DB; Waguespack J; McCollister S. 1995. Dietary obesity in the mouse: interaction of strain with diet composition. Am J Physiol 268(3 Pt 2):R658-65. PubMed: 7900908 MGI: J:24480
West DB; Waguespack J; York B; Goudey-Lefevre J; Price RA. 1994. Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome 5(9):546-52. PubMed: 8000138 MGI: J:20129
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. J Biol Chem 265(5):2435-40. PubMed: 2303408 MGI: J:23983
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. J Exp Med 165(5):1442-7. PubMed: 3572304 MGI: J:8690
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. PubMed: 15067087 MGI: J:122988

Additional - Ahr^d related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. PubMed: 4123113 MGI: J:84312
Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. PubMed: 1030186 MGI: J:12156
Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. PubMed: 18848954 MGI: J:143604
Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. PubMed: 8148872 MGI: J:17460
Curran CP; Altenhofen E; Ashworth A; Brown A; Kamau-Cheggeh C; Curran M; Evans A; Floyd R; Fowler J; Garber H; Hays B; Kraemer S; Lang A; Mynhier A; Samuels A; Strohmaier C. 2012. Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity. Neurotoxicology 33(6):1436-42. PubMed: 22935098 MGI: J:225088
Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. PubMed: 16291824 MGI: J:113285
Curran CP; Nebert DW; Genter MB; Patel KV; Schaefer TL; Skelton MR; Williams MT; Vorhees CV. 2011. In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environ Health Perspect 119(9):1286-93. PubMed: 21571617 MGI: J:260665
Curran CP; Vorhees CV; Williams MT; Genter MB; Miller ML; Nebert DW. 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicol Sci 119(1):189-208. PubMed: 20961953 MGI: J:260693
Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. J Biol Chem 250(17):6769-78. PubMed: 808546 MGI: J:5564
Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. PubMed: 4110756 MGI: J:84250
Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. PubMed: 4118365 MGI: J:84252
Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. PubMed: 1658612 MGI: J:2134
Kennedy GD; Nukaya M; Moran SM; Glover E; Weinberg S; Balbo S; Hecht SS; Pitot HC; Drinkwater NR; Bradfield CA. 2014. Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. Toxicol Sci 140(1):135-43. PubMed: 24718703 MGI: J:215349
Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 126(2):391-404. PubMed: 22228805 MGI: J:183715
Klinefelter K; Hooven MK; Bates C; Colter BT; Dailey A; Infante SK; Kania-Korwel I; Lehmler HJ; Lopez-Juarez A; Ludwig CP; Curran CP. 2018. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 29(1-2):112-127. PubMed: 29197979 MGI: J:259801
Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. Cancer Res 38(9):2777-83. PubMed: 679184 MGI: J:84318
Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol 265(3):360-7. PubMed: 22982977 MGI: J:192865
Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues. Biol Reprod 84(6):1094-102. PubMed: 21270426 MGI: J:173706
Moriguchi T; Motohashi H; Hosoya T; Nakajima O; Takahashi S; Ohsako S; Aoki Y; Nishimura N; Tohyama C; Fujii-Kuriyama Y; Yamamoto M. 2003. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc Natl Acad Sci U S A 100(10):5652-7. PubMed: 12730383 MGI: J:132380
Nebert DW; Atlas SA; Guenthner TM; Kouri RE. 1978. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk of cancer. In: Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment. Academic Press, New York. MGI: J:30693
Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. PubMed: 4716952 MGI: J:84313
Nebert DW; Gelboin HV. 1969. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys 134(1):76-89. PubMed: 4981257 MGI: J:84248
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. PubMed: 4114109 MGI: J:5282
Nebert DW; Gielen JE; Goujon FM. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450. Mol Pharmacol 8(6):651-66. PubMed: 4118364 MGI: J:84251
Nebert DW; Goujon FM; Gielen JE. 1972. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol 236(65):107-10. PubMed: 4502804 MGI: J:84249
Nebert DW; Jensen NM. 1979. Benzo[a]pyrene-initiated leukemia in mice. Association with allelic differences at the Ah locus. Biochem Pharmacol 28(1):149-51. PubMed: 758905 MGI: J:6074
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. Genetics 100(1):79-87. PubMed: 7095422 MGI: J:6809
Nebert DW; Kon H. 1973. Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals. J Biol Chem 248(1):169-78. PubMed: 4348203 MGI: J:84311
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. PubMed: 1091656 MGI: J:84317
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. PubMed: 1119809 MGI: J:84316
Oesch F; Morris N; Daly JW. 1973. Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene. Mol Pharmacol 9(5):629-6. PubMed: 4788156 MGI: J:25852
Okey AB; Vella LM; Harper PA. 1989. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. Mol Pharmacol 35(6):823-30. PubMed: 2543914 MGI: J:27899
Poel WE; Stanton D; Peters E; Wade HO. 1958. Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene Proc Am Assoc Cancer Res 2:335. MGI: J:84245
Poland A; Bradfield C. 1992. A brief review of the Ah locus. Tohoku J Exp Med 168(2):83-7. PubMed: 1339107 MGI: J:12546
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579 MGI: J:34840
Poland A; Glover E; Kende AS. 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251(16):4936-46. PubMed: 956169 MGI: J:84247
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. PubMed: 2823093 MGI: J:8895
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. PubMed: 7969080 MGI: J:22144
Poland A; Teitelbaum P; Glover E; Kende A. 1989. Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor. Mol Pharmacol 36(1):121-7. PubMed: 2546046 MGI: J:126377
Poland AP; Glover E; Robinson JR; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically 'nonresponsive' to other aromatic hydrocarbons. J Biol Chem 249(17):5599-606. PubMed: 4370044 MGI: J:84314
Quintana FJ; Basso AS; Iglesias AH; Korn T; Farez MF; Bettelli E; Caccamo M; Oukka M; Weiner HL. 2008. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453(7191):65-71. PubMed: 18362915 MGI: J:136052
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. PubMed: 4413562 MGI: J:84315
Schmid FA; Demetriades MS; Schabel FM 3rd; Tarnowski GS. 1967. Toxicity of several cancerigenic polycyclic hydrocarbons and other agents in AKR and C57BL-6 mice. Cancer Res 27(3):563-7. PubMed: 6021514 MGI: J:84246
Schmid FA; Elmer I; Tarnowski GS. 1969. Genetic determination of differential inflammatory reactivity and subcutaneous tumor susceptibility of AKR-J and C57BL-6J mice to 7,12-dimethylbenz- [a]anthracene. Cancer Res 29(8):1585-9. PubMed: 5807232 MGI: J:34134
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. PubMed: 6021513 MGI: J:26440
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. PubMed: 8408082 MGI: J:15153
Shi Z; Chen Y; Dong H; Amos-Kroohs RM; Nebert DW. 2008. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. Biochem Biophys Res Commun 376(4):775-80. PubMed: 18814841 MGI: J:141523
Shivanna B; Zhang W; Jiang W; Welty SE; Couroucli XI; Wang L; Moorthy B. 2013. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol 267(3):209-17. PubMed: 23337360 MGI: J:193493
Simonian PL; Wehrmann F; Roark CL; Born WK; O'Brien RL; Fontenot AP. 2010. gammadelta T cells protect against lung fibrosis via IL-22. J Exp Med 207(10):2239-53. PubMed: 20855496 MGI: J:165803
Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 53(1):52-61. PubMed: 9443932 MGI: J:45850
Stiborova M; Levova K; Barta F; Shi Z; Frei E; Schmeiser HH; Nebert DW; Phillips DH; Arlt VM. 2012. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. Toxicol Sci 125(2):345-58. PubMed: 22086975 MGI: J:183662
Tanos R; Murray IA; Smith PB; Patterson A; Perdew GH. 2012. Role of the ah receptor in homeostatic control of Fatty Acid synthesis in the liver. Toxicol Sci 129(2):372-9. PubMed: 22696238 MGI: J:188164
Taylor BA. 1971. Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice. Life Sci I 10(19):1127-34. PubMed: 5132702 MGI: J:5244
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. PubMed: 4750810 MGI: J:5387
Thomas PE; Kouri RE; Hutton JJ. 1972. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet 6(2):157-68. PubMed: 4666754 MGI: J:31977
Thorgeirsson SS; Nebert DW. 1977. The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Adv Cancer Res 25:149-93. PubMed: 405846 MGI: J:5822
Walisser JA; Bunger MK; Glover E; Bradfield CA. 2004. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A 101(47):16677-82. PubMed: 15545609 MGI: J:94465
Williams EG; Mouchiroud L; Frochaux M; Pandey A; Andreux PA; Deplancke B; Auwerx J. 2014. An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement. PLoS Genet 10(9):e1004673. PubMed: 25255223 MGI: J:232452
Yeager RL; Reisman SA; Aleksunes LM; Klaassen CD. 2009. Introducing the 'TCDD-inducible AhR-Nrf2 gene battery'. Toxicol Sci 111(2):238-46. PubMed: 19474220 MGI: J:154083
Yu Z; Mahadevan B; Lohr CV; Fischer KA; Louderback MA; Krueger SK; Pereira CB; Albershardt DJ; Baird WM; Bailey GS; Williams DE. 2006. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis 27(10):2116-23. PubMed: 16704990 MGI: J:113356
Zhou Y; Tung HY; Tsai YM; Hsu SC; Chang HW; Kawasaki H; Tseng HC; Plunkett B; Gao P; Hung CH; Vonakis BM; Huang SK. 2013. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood 121(16):3195-204. PubMed: 23462117 MGI: J:197552

Additional - Cd5^b related

Boyse EA; Cantor H; Shen F-W; McKenzie JFC. 1977. Nomenclature for antigens demonstrable on lymphocytes. Immunogenetics 5:189. MGI: J:4419
Boyse EA; Miyazawa M; Aoki T; Old LJ. 1968. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci 170(19):175-93. PubMed: 4385242 MGI: J:5073
Hayakawa K; Hardy RR; Parks DR; Herzenberg LA. 1983. The Ly-1 B cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med 157(1):202-18. PubMed: 6600267 MGI: J:6923
Huang HJ; Jones NH; Strominger JL; Herzenberg LA. 1987. Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5). Proc Natl Acad Sci U S A 84(1):204-8. PubMed: 3025855 MGI: J:8546
Ledbetter JA; Rouse RV; Micklem HS; Herzenberg LA. 1980. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med 152(2):280-95. PubMed: 6156984 MGI: J:6359
Morse HC 3rd. 1992. Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563] J Immunol 149(10):3129-34. PubMed: 1431091 MGI: J:3170
Shiku H; Kisielow P; Boyse EA; Oettgen HF. 1976. Immunogenetic identification of functional T-cell subsets. Transplant Proc 8(3):381-5. PubMed: 1086540 MGI: J:5717
Snell GD; Cherry M. 1972. Loci determining cell surface antigens. In: RNA Viruses and Host Genome in Oncogenesis. North Holland, Amsterdam. MGI: J:30732
Starling GC; Llewellyn MB; Whitney GS; Aruffo A. 1997. The Ly-1.1 and Ly-1.2 epitopes of murine CD5 map to the membrane distal scavenger receptor cysteine-rich domain. Tissue Antigens 49(1):1-6. PubMed: 9027958 MGI: J:40410

Additional - Cdh23^ahl related

Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. PubMed: 22952717 MGI: J:191663
Davis RR; Newlander JK; Ling X; Cortopassi GA; Krieg EF; Erway LC. 2001. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hear Res 155(1-2):82-90. PubMed: 11335078 MGI: J:69679
Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). Gene 281(1-2):31-41. PubMed: 11750125 MGI: J:73941
Fetoni AR; Picciotti PM; Paludetti G; Troiani D. 2011. Pathogenesis of presbycusis in animal models: a review. Exp Gerontol 46(6):413-25. PubMed: 21211561 MGI: J:186964
Han F; Yu H; Tian C; Chen HE; Benedict-Alderfer C; Zheng Y; Wang Q; Han X; Zheng QY. 2012. A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. Pharmacogenomics J 12(1):30-44. PubMed: 20644563 MGI: J:174758
Hurd EA; Adams ME; Layman WS; Swiderski DL; Beyer LA; Halsey KE; Benson JM; Gong TW; Dolan DF; Raphael Y; Martin DM. 2011. Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. Hear Res 282(1-2):184-95. PubMed: 21875659 MGI: J:220430
Johnson KR; Erway LC; Cook SA; Willott JF; Zheng QY. 1997. A major gene affecting age-related hearing loss in C57BL/6J mice Hear Res 114(1-2):83-92. PubMed: 9447922 MGI: J:44966
Johnson KR; Longo-Guess C; Gagnon LH; Yu H; Zheng QY. 2008. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics 92(4):219-25. PubMed: 18662770 MGI: J:139223
Johnson KR; Tian C; Gagnon LH; Jiang H; Ding D; Salvi R. 2017. Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains. Sci Rep 7:44450. PubMed: 28287619 MGI: J:241137
Johnson KR; Yu H; Ding D; Jiang H; Gagnon LH; Salvi RJ. 2010. Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice. Hear Res 268(1-2):85-92. PubMed: 20470874 MGI: J:163035
Johnson KR; Zheng QY; Bykhovskaya Y; Spirina O; Fischel-Ghodsian N. 2001. A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. Nat Genet 27(2):191-4. PubMed: 11175788 MGI: J:67312
Johnson KR; Zheng QY; Noben-Trauth K. 2006. Strain background effects and genetic modifiers of hearing in mice. Brain Res 1091(1):79-88. PubMed: 16579977 MGI: J:110459
Johnson KR; Zheng QY; Weston MD; Ptacek LJ; Noben-Trauth K. 2005. The Mass1(frings) mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85(5):582-90. PubMed: 15820310 MGI: J:97534
Kane KL; Longo-Guess CM; Gagnon LH; Ding D; Salvi RJ; Johnson KR. 2012. Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice. Hear Res 283(1-2):80-8. PubMed: 22138310 MGI: J:183757
Keithley EM; Canto C; Zheng QY; Fischel-Ghodsian N; Johnson KR. 2004. Age-related hearing loss and the ahl locus in mice. Hear Res 188(1-2):21-8. PubMed: 14759567 MGI: J:87783
Liu X; Bulgakov OV; Darrow KN; Pawlyk B; Adamian M; Liberman MC; Li T. 2007. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A 104(11):4413-8. PubMed: 17360538 MGI: J:118927
Manji SS; Williams LH; Miller KA; Ooms LM; Bahlo M; Mitchell CA; Dahl HH. 2011. A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. PLoS One 6(3):e17607. PubMed: 21423608 MGI: J:171701
Mathews CE; Leiter EH. 1999. Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. Diabetes 48(11):2189-96. PubMed: 10535453 MGI: J:109893
Miyasaka Y; Suzuki S; Ohshiba Y; Watanabe K; Sagara Y; Yasuda SP; Matsuoka K; Shitara H; Yonekawa H; Kominami R; Kikkawa Y. 2013. Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice. Exp Anim 62(4):333-46. PubMed: 24172198 MGI: J:250509
Murillo-Cuesta S; Rodriguez-de la Rosa L; Contreras J; Celaya AM; Camarero G; Rivera T; Varela-Nieto I. 2015. Transforming growth factor beta1 inhibition protects from noise-induced hearing loss. Front Aging Neurosci 7:32. PubMed: 25852546 MGI: J:242536
Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev 13(3):290-5. PubMed: 12787792 MGI: J:88012
Nagtegaal AP; Rainey RN; van der Pluijm I; Brandt RM; van der Horst GT; Borst JG; Segil N. 2015. Cockayne syndrome group B (csb) and group a (csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. J Neurosci 35(10):4280-6. PubMed: 25762674 MGI: J:219993
Noben-Trauth K; Latoche JR; Neely HR; Bennett B. 2010. Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. PLoS One 5(7):e11459. PubMed: 20628639 MGI: J:163117
Noben-Trauth K; Zheng QY; Johnson KR. 2003. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet 35(1):21-3. PubMed: 12910270 MGI: J:86905
Noben-Trauth K; Zheng QY; Johnson KR; Nishina PM. 1997. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44(3):266-72. PubMed: 9325047 MGI: J:38429
Perrin BJ; Sonnemann KJ; Ervasti JM. 2010. beta-actin and gamma-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. PLoS Genet 6(10):e1001158. PubMed: 20976199 MGI: J:167543
Perrin BJ; Strandjord DM; Narayanan P; Henderson DM; Johnson KR; Ervasti JM. 2013. beta-Actin and Fascin-2 Cooperate to Maintain Stereocilia Length. J Neurosci 33(19):8114-21. PubMed: 23658152 MGI: J:197137
Vazquez AE; Jimenez AM; Martin GK; Luebke AE; Lonsbury-Martin BL. 2004. Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions. Hear Res 194(1-2):87-96. PubMed: 15276680 MGI: J:117746
Watson CJ; Tempel BL. 2013. A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers. Hear Res 304:41-8. PubMed: 23792079 MGI: J:220660
Zhang C; Sun W; Li J; Xiong B; Frye MD; Ding D; Salvi R; Kim MJ; Someya S; Hu BH. 2017. Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. Neuroscience 361:179-191. PubMed: 28818524 MGI: J:249779
Zheng QY; Johnson KR. 2001. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res 154(1-2):45-53. PubMed: 11423214 MGI: J:70964
Zheng QY; Scarborough JD; Zheng Y; Yu H; Choi D; Gillespie PG. 2012. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. Hum Mol Genet 21(11):2588-98. PubMed: 22381527 MGI: J:183898
Zilberstein Y; Liberman MC; Corfas G. 2012. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J Neurosci 32(2):405-10. PubMed: 22238076 MGI: J:179911

Additional - Hc⁰ related

Actor JK; Breij E; Wetsel RA; Hoffmann H; Hunter RL Jr; Jagannath C. 2001. A role for complement C5 in organism containment and granulomatous response during murine tuberculosis. Scand J Immunol 53(5):464-74. PubMed: 11309154 MGI: J:103981
Addis-Lieser E; Kohl J; Chiaramonte MG. 2005. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. J Immunol 175(3):1894-902. PubMed: 16034133 MGI: J:107269
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infect Immun 74(2):1196-203. PubMed: 16428769 MGI: J:104987
Barthlott T; Stockinger B. 2001. Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties. Eur J Immunol 31(12):3595-601. PubMed: 11745379 MGI: J:151748
Baudino L; Sardini A; Ruseva MM; Fossati-Jimack L; Cook HT; Scott D; Simpson E; Botto M. 2014. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A 111(4):1503-8. PubMed: 24474777 MGI: J:206648
Bauer K; Yu X; Wernhoff P; Koczan D; Thiesen HJ; Ibrahim SM. 2004. Identification of new quantitative trait loci in mice with collagen-induced arthritis. Arthritis Rheum 50(11):3721-8. PubMed: 15529344 MGI: J:94347
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. PubMed: 19805369 MGI: J:153217
Bode J; Dutow P; Sommer K; Janik K; Glage S; Tummler B; Munder A; Laudeley R; Sachse KW; Klos A. 2012. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One 7(11):e50327. PubMed: 23189195 MGI: J:194784
Bora NS; Kaliappan S; Jha P; Xu Q; Sohn JH; Dhaulakhandi DB; Kaplan HJ; Bora PS. 2006. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J Immunol 177(3):1872-8. PubMed: 16849499 MGI: J:138026
Borders CW; Courtney A; Ronen K; Pilar Laborde-Lahoz M; Guidry TV; Hwang SA; Olsen M; Hunter RL Jr; Hollmann TJ; Wetsel RA; Actor JK. 2005. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. Scand J Immunol 62(2):123-30. PubMed: 16101818 MGI: J:114316
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. PubMed: 22952717 MGI: J:191663
Bulla R; Tripodo C; Rami D; Ling GS; Agostinis C; Guarnotta C; Zorzet S; Durigutto P; Botto M; Tedesco F. 2016. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. Nat Commun 7:10346. PubMed: 26831747 MGI: J:236291
CINADER B; DUBISKI S; WARDLAW AC. 1964. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT. J Exp Med 120:897-924. PubMed: 14247728 MGI: J:13003
Carter WO; Bull C; Bortolon E; Yang L; Jesmok GJ; Gundel RH. 1998. A murine skeletal muscle ischemia-reperfusion injury model: differential pathology in BALB/c and DBA/2N mice. J Appl Physiol 85(5):1676-83. PubMed: 9804569 MGI: J:51187
Chen HC; Hofman FM; Kung JT; Lin YD; Wu-Hsieh BA. 2007. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol 81(11):5518-26. PubMed: 17360740 MGI: J:153322
Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. PubMed: 16261419 MGI: J:102639
Cunnion KM; Benjamin DK Jr; Hester CG; Frank MM. 2004. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. J Lab Clin Med 143(6):358-65. PubMed: 15192652 MGI: J:101948
Daniel DS; Dai G; Singh CR; Lindsey DR; Smith AK; Dhandayuthapani S; Hunter RL Jr; Jagannath C. 2006. The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes. J Immunol 177(7):4688-98. PubMed: 16982908 MGI: J:139313
Deguchi Y; Andoh A; Inatomi O; Araki Y; Hata K; Tsujikawa T; Kitoh K; Fujiyama Y. 2005. Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5. Int J Mol Med 16(4):605-8. PubMed: 16142393 MGI: J:107581
Ehrnthaller C; Huber-Lang M; Nilsson P; Bindl R; Redeker S; Recknagel S; Rapp A; Mollnes T; Amling M; Gebhard F; Ignatius A. 2013. Complement C3 and C5 deficiency affects fracture healing. PLoS One 8(11):e81341. PubMed: 24260573 MGI: J:209669
Fairweather D; Frisancho-Kiss S; Njoku DB; Nyland JF; Kaya Z; Yusung SA; Davis SE; Frisancho JA; Barrett MA; Rose NR. 2006. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart. J Immunol 176(6):3516-24. PubMed: 16517720 MGI: J:129509
Ferreira C; Barthlott T; Garcia S; Zamoyska R; Stockinger B. 2000. Differential survival of naive CD4 and CD8 T cells. J Immunol 165(7):3689-94. PubMed: 11034373 MGI: J:151749
Flierl MA; Rittirsch D; Nadeau BA; Day DE; Zetoune FS; Sarma JV; Huber-Lang MS; Ward PA. 2008. Functions of the complement components C3 and C5 during sepsis. FASEB J 22(10):3483-90. PubMed: 18587006 MGI: J:140250
Flynn S; Stockinger B. 2003. Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. Blood 101(11):4472-8. PubMed: 12543861 MGI: J:151744
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. PubMed: 10449528 MGI: J:108724
Fossati-Jimack L; Ling GS; Baudino L; Szajna M; Manivannan K; Zhao JC; Midgley R; Chai JG; Simpson E; Botto M; Scott D. 2015. Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. Immunology 144(1):149-57. PubMed: 25039245 MGI: J:220131
Freeley SJ; Popat RJ; Parmar K; Kolev M; Hunt BJ; Stover CM; Schwaeble W; Kemper C; Robson MG. 2016. Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5. J Pathol 240(1):61-71. PubMed: 27235854 MGI: J:241547
Garcia S; DiSanto J; Stockinger B. 1999. Following the development of a CD4 T cell response in vivo: from activation to memory formation. Immunity 11(2):163-71. PubMed: 10485651 MGI: J:151750
Girardi G; Berman J; Redecha P; Spruce L; Thurman JM; Kraus D; Hollmann TJ; Casali P; Caroll MC; Wetsel RA; Lambris JD; Holers VM; Salmon JE. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112(11):1644-54. PubMed: 14660741 MGI: J:86845
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37(8):835-43. PubMed: 15995705 MGI: J:100159
Ji H; Gauguier D; Ohmura K; Gonzalez A; Duchatelle V; Danoy P; Garchon HJ; Degott C; Lathrop M; Benoist C; Mathis D. 2001. Genetic influences on the end-stage effector phase of arthritis. J Exp Med 194(3):321-30. PubMed: 11489951 MGI: J:70882
Kalbitz M; Karbach M; Braumueller S; Kellermann P; Gebhard F; Huber-Lang M; Perl M. 2016. Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI). PLoS One 11(7):e0159417. PubMed: 27437704 MGI: J:248820
Karp CL; Grupe A; Schadt E; Ewart SL; Keane-Moore M; Cuomo PJ; Kohl J; Wahl L; Kuperman D; Germer S; Aud D; Peltz G; Wills-Karp M. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol 1(3):221-6. PubMed: 10973279 MGI: J:108211
Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol 3(3):244-50. PubMed: 11836529 MGI: J:151747
Kassiotis G; Zamoyska R; Stockinger B. 2003. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med 197(8):1007-16. PubMed: 12707300 MGI: J:151743
Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 113(2):234-45. PubMed: 15379984 MGI: J:92933
Kerepesi LA; Hess JA; Nolan TJ; Schad GA; Abraham D. 2006. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol 176(7):4315-22. PubMed: 16547268 MGI: J:129872
Kim CH; Wu W; Wysoczynski M; Abdel-Latif A; Sunkara M; Morris A; Kucia M; Ratajczak J; Ratajczak MZ. 2012. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. Leukemia 26(1):106-16. PubMed: 21769103 MGI: J:181063
Kim DD; Miwa T; Kimura Y; Schwendener RA; van Lookeren Campagne M; Song WC. 2008. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood 112(4):1109-19. PubMed: 18524992 MGI: J:138410
Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. PubMed: 16301658 MGI: J:122156
Kwan WH; Hashimoto D; Paz-Artal E; Ostrow K; Greter M; Raedler H; Medof ME; Merad M; Heeger PS. 2012. Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest 122(6):2234-8. PubMed: 22585573 MGI: J:190492
Kyriakides C; Austen W Jr; Wang Y; Favuzza J; Kobzik L; Moore FD Jr; Hechtman HB. 1999. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration. J Appl Physiol 87(6):2357-61. PubMed: 10601189 MGI: J:103341
Lee HM; Wu W; Wysoczynski M; Liu R; Zuba-Surma EK; Kucia M; Ratajczak J; Ratajczak MZ. 2009. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes. Leukemia 23(11):2052-62. PubMed: 19657368 MGI: J:154482
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. Leukemia 24(3):573-82. PubMed: 20033053 MGI: J:158026
Liu Q; He S; Groysman L; Shaked D; Russin J; Cen S; Mack WJ. 2013. White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition. PLoS One 8(12):e84802. PubMed: 24386419 MGI: J:209840
Mahesh J; Daly J; Cheadle WG; Kotwal GJ. 1999. Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice. Shock 12(5):340-9. PubMed: 10565608 MGI: J:59655
Mastellos D; Papadimitriou JC; Franchini S; Tsonis PA; Lambris JD. 2001. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J Immunol 166(4):2479-86. PubMed: 11160308 MGI: J:111000
Miller CG; Cook DN; Kotwal GJ. 1996. Two chemotactic factors, C5a and MIP-1alpha, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1alpha has a protective role. Mol Immunol 33(14):1135-7. PubMed: 9047380 MGI: J:38592
Miller CG; Justus DE; Jayaraman S; Kotwal GJ. 1995. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis. Cell Immunol 162(2):326-32. PubMed: 7743560 MGI: J:25289
Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood 113(12):2684-94. PubMed: 19136662 MGI: J:146538
Mocco J; Mack WJ; Ducruet AF; Sosunov SA; Sughrue ME; Hassid BG; Nair MN; Laufer I; Komotar RJ; Claire M; Holland H; Pinsky DJ; Connolly ES Jr. 2006. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res 99(2):209-17. PubMed: 16778128 MGI: J:123658
Mori L; de Libero G. 1998. Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice. Arthritis Rheum 41(2):256-62. PubMed: 9485083 MGI: J:134111
Moulton RA; Mashruwala MA; Smith AK; Lindsey DR; Wetsel RA; Haviland DL; Hunter RL; Jagannath C. 2007. Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. J Leukoc Biol 82(4):956-67. PubMed: 17675563 MGI: J:125190
Mullick A; Elias M; Picard S; Bourget L; Jovcevski O; Gauthier S; Tuite A; Harakidas P; Bihun C; Massie B; Gros P. 2004. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. Infect Immun 72(10):5868-76. PubMed: 15385488 MGI: J:93132
Mullick A; Leon Z; Min-Oo G; Berghout J; Lo R; Daniels E; Gros P. 2006. Cardiac failure in C5-deficient A/J mice after Candida albicans infection. Infect Immun 74(8):4439-51. PubMed: 16861630 MGI: J:112405
Niculescu T; Weerth S; Niculescu F; Cudrici C; Rus V; Raine CS; Shin ML; Rus H. 2004. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis. J Immunol 172(9):5702-6. PubMed: 15100315 MGI: J:89686
Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. J Exp Med 125(1):1-16. PubMed: 4959665 MGI: J:5016
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. Nature 282(5735):207-8. PubMed: 492335 MGI: J:6214
Patel SN; Berghout J; Lovegrove FE; Ayi K; Conroy A; Serghides L; Min-oo G; Gowda DC; Sarma JV; Rittirsch D; Ward PA; Liles WC; Gros P; Kain KC. 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 205(5):1133-43. PubMed: 18426986 MGI: J:136298
Pickering MC; Warren J; Rose KL; Carlucci F; Wang Y; Walport MJ; Cook HT; Botto M. 2006. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci U S A 103(25):9649-54. PubMed: 16769899 MGI: J:111031
Pilione MR; Agosto LM; Kennett MJ; Harvill ET. 2006. CD11b is required for the resolution of inflammation induced by Bordetella bronchiseptica respiratory infection. Cell Microbiol 8(5):758-68. PubMed: 16611225 MGI: J:135740
Pritchard MT; McMullen MR; Stavitsky AB; Cohen JI; Lin F; Medof ME; Nagy LE. 2007. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132(3):1117-26. PubMed: 17383432 MGI: J:128218
Prodeus AP; Zhou X; Maurer M; Galli SJ; Carroll MC. 1997. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Nature 390(6656):172-5. PubMed: 9367154 MGI: J:44240
Ratajczak MZ; Lee H; Wysoczynski M; Wan W; Marlicz W; Laughlin MJ; Kucia M; Janowska-Wieczorek A; Ratajczak J. 2010. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due toactivation of complement cascade/membrane attack complex. Leukemia 24(5):976-85. PubMed: 20357827 MGI: J:160183
Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. PubMed: 17536017 MGI: J:147022
Refici ML; Metzger DW; Arulanandam BP; Lennartz MR; Loegering DJ. 2001. Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels. Am J Physiol Regul Integr Comp Physiol 280(4):R1037-44. PubMed: 11247825 MGI: J:114295
Rittirsch D; Flierl MA; Day DE; Nadeau BA; McGuire SR; Hoesel LM; Ipaktchi K; Zetoune FS; Sarma JV; Leng L; Huber-Lang MS; Neff TA; Bucala R; Ward PA. 2008. Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol 180(11):7664-72. PubMed: 18490769 MGI: J:136379
Rittirsch D; Flierl MA; Nadeau BA; Day DE; Huber-Lang M; Mackay CR; Zetoune FS; Gerard NP; Cianflone K; Kohl J; Gerard C; Sarma JV; Ward PA. 2008. Functional roles for C5a receptors in sepsis. Nat Med 14(5):551-7. PubMed: 18454156 MGI: J:136703
Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. Infect Immun 76(1):97-102. PubMed: 17967861 MGI: J:130296
Schmitt J; Roderfeld M; Sabrane K; Zhang P; Tian Y; Mertens JC; Frei P; Stieger B; Weber A; Mullhaupt B; Roeb E; Geier A. 2012. Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice. Biochem Biophys Res Commun 418(3):445-50. PubMed: 22277671 MGI: J:181268
Schultz G; Tedesco MM; Sho E; Nishimura T; Sharif S; Du X; Myles T; Morser J; Dalman RL; Leung LL. 2010. Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice. Arterioscler Thromb Vasc Biol 30(7):1363-70. PubMed: 20431069 MGI: J:180861
Sood R; Sholl L; Isermann B; Zogg M; Coughlin SR; Weiler H. 2008. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood 112(3):585-91. PubMed: 18490515 MGI: J:138440
Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med 200(7):835-46. PubMed: 15466618 MGI: J:93949
Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. PubMed: 18328742 MGI: J:132942
Strainic MG; Shevach EM; An F; Lin F; Medof ME. 2012. Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells. Nat Immunol 14(2):162-71. PubMed: 23263555 MGI: J:192613
Strey CW; Markiewski M; Mastellos D; Tudoran R; Spruce LA; Greenbaum LE; Lambris JD. 2003. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 198(6):913-23. PubMed: 12975457 MGI: J:109380
Syed SN; Rau E; Ziegelmann M; Sogkas G; Brune B; Schmidt RE. 2018. C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice. Eur J Immunol 48(4):696-704. PubMed: 29277896 MGI: J:261609
Tanaka D; Kagari T; Doi H; Shimozato T. 2006. Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis. Immunology 119(2):195-202. PubMed: 16836650 MGI: J:118551
Trendelenburg M; Fossati-Jimack L; Cortes-Hernandez J; Turnberg D; Lewis M; Izui S; Cook HT; Botto M. 2005. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol 175(10):6909-14. PubMed: 16272350 MGI: J:119691
Wang Y; Kristan J; Hao L; Lenkoski CS; Shen Y; Matis LA. 2000. A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis. J Immunol 164(8):4340-7. PubMed: 10754334 MGI: J:61587
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. J Biol Chem 265(5):2435-40. PubMed: 2303408 MGI: J:23983
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. J Exp Med 165(5):1442-7. PubMed: 3572304 MGI: J:8690
Wolfe DN; Kirimanjeswara GS; Harvill ET. 2005. Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity. Infect Immun 73(10):6508-13. PubMed: 16177324 MGI: J:104212
Wright RJ; Bikoff EK; Stockinger B. 1998. The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice. Immunology 95(3):309-13. PubMed: 9824491 MGI: J:50737
Xiao H; Schreiber A; Heeringa P; Falk RJ; Jennette JC. 2007. Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. Am J Pathol 170(1):52-64. PubMed: 17200182 MGI: J:117048
Younger JG; Shankar-Sinha S; Mickiewicz M; Brinkman AS; Valencia GA; Sarma JV; Younkin EM; Standiford TJ; Zetoune FS; Ward PA. 2003. Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia. Am J Respir Cell Mol Biol 29(4):432-8. PubMed: 14500254 MGI: J:94613
Zal T; Volkmann A; Stockinger B. 1994. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J Exp Med 180(6):2089-99. PubMed: 7964486 MGI: J:111649
Zal T; Weiss S; Mellor A; Stockinger B. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc Natl Acad Sci U S A 93(17):9102-7. PubMed: 8799161 MGI: J:151753
Zhou W; Farrar CA; Abe K; Pratt JR; Marsh JE; Wang Y; Stahl GL; Sacks SH. 2000. Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 105(10):1363-71. PubMed: 10811844 MGI: J:120567
de Jorge EG; Macor P; Paixao-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. 2011. The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol 22(1):137-45. PubMed: 21148255 MGI: J:185883

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Gainsford T; Roberts AW; Kimura S; Metcalf D; Dranoff G; Mulligan RC; Begley CG; Robb L; Alexander WS. 1998. Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production. Blood 91(8):2745-52. PubMed: 9531584 MGI: J:47462
Hara T; Ichihara M; Takagi M; Miyajima A. 1995. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Blood 85(9):2331-6. PubMed: 7727767 MGI: J:24918
Ichihara M; Hara T; Takagi M; Cho LC; Gorman DM; Miyajima A. 1995. Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J 14(5):939-50. PubMed: 7889941 MGI: J:23971

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Mori M; Toyokuni S; Kondo S; Kasai H; Naiki H; Toichi E; Hosokawa M; Higuchi K. 2001. Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. Free Radic Biol Med 30(10):1130-6. PubMed: 11369503 MGI: J:119467

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Hartley JW; Yetter RA; Morse HC 3rd. 1983. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. J Exp Med 158(1):16-24. PubMed: 6306133 MGI: J:7108
Jung YT; Lyu MS; Buckler-White A; Kozak CA. 2002. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. J Virol 76(16):8218-24. PubMed: 12134027 MGI: J:78083

Additional - Soat1^ald related

ARNESEN K. 1955. Constitutional difference in lipid content of adrenals in two strains of mice and their hybrids. Acta Endocrinol (Copenh) 18(4):396-401. PubMed: 14375655 MGI: J:166508
Arnesen K. 1974. Adrenocortical lipid depletion and leukemia in mice. Acta Pathol Microbiol Scand [A] Suppl 248:15-9. PubMed: 4451118 MGI: J:30991
Arnesen K. 1963. The cytology of the adrenal cortex in mice with spontaneous adrenocortical lipid depletion. Acta Pathol Microbiol Scand 58:212-218. MGI: J:12157
Giehl KA; Potter CS; Wu B; Silva KA; Rowe LB; Awgulewitsch A; Sundberg JP. 2009. Hair interior defect in AKR/J mice. Clin Exp Dermatol 34(4):509-17. PubMed: 19522984 MGI: J:164953
Masterson JC; McNamee EN; Jedlicka P; Fillon S; Ruybal J; Hosford L; Rivera-Nieves J; Lee JJ; Furuta GT. 2011. CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. Am J Pathol 179(5):2302-14. PubMed: 21945903 MGI: J:177340
Molne K. 1969. Autoradiographic studies on the incorporation of H-uridine into the adrenal glands of mice with spontaneous adrenocortical lipid depletion. A comparison with C57B1 mice. Acta Pathol Microbiol Scand 77(3):369-78. PubMed: 4192329 MGI: J:5158
Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. PubMed: 23251662 MGI: J:195664
Rice RH; Rocke DM; Tsai HS; Silva KA; Lee YJ; Sundberg JP. 2009. Distinguishing mouse strains by proteomic analysis of pelage hair. J Invest Dermatol 129(9):2120-5. PubMed: 19295613 MGI: J:153492
Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. MGI: J:30359
Taylor BA; Meier H; Whitten WK. 1974. Chromosomal location and site of action of the adrenal lipid depletion gene of the mouse. Genetics 77:s65. MGI: J:12966
Trigg MJ. 1972. Hair growth in mouse mutants affecting coat texture. J Zool 168:165-198. MGI: J:15247
Wu B; Potter CS; Silva KA; Liang Y; Reinholdt LG; Alley LM; Rowe LB; Roopenian DC; Awgulewitsch A; Sundberg JP. 2010. Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. J Invest Dermatol 130(11):2666-8. PubMed: 20574437 MGI: J:180857

Also Known As: AKR, AK

Genetic overview

Research Applications

Base Price

Detailed Description

Selected References

Ahrd

Allele Symbol: Ahrd

Cd5b

Allele Symbol: Cd5b

Cdh23ahl

Allele Symbol: Cdh23ahl

Hc0

Allele Symbol: Hc0

Il3ram1

Allele Symbol: Il3ram1

Obq3AKR/J

Allele Symbol: Obq3AKR/J

Obq4AKR/J

Allele Symbol: Obq4AKR/J

Ogg1m1

Allele Symbol: Ogg1m1

Rmcfs

Allele Symbol: Rmcfs

Soat1ald

Allele Symbol: Soat1ald

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahrd related

Genotype: Cdh23ahl related

Genotype: Hc0 related

Genotype: Il3ram1 related

Mammalian Phenotype Terms by Genotype

Genotype: Ahrd/AhrdAKR

mortality/aging

homeostasis/metabolism phenotype

Genotype: Il3ram1/Il3ram1AKR/J

hematopoietic system phenotype

Genotype: Soat1ald/Soat1aldAKR

integument phenotype

Genotype: Soat1ald/Soat1aldAKR/O

endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype

neoplasm

Phenotype Information

References

Additional References

Additional - Ahrd related

Additional - Cd5b related

Additional - Cdh23ahl related

Additional - Hc0 related

Additional - Il3ram1 related

Additional - Obq3AKR/J related

Additional - Obq4AKR/J related

Additional - Ogg1m1 related

Additional - Rmcfs related

Additional - Soat1ald related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Ahr^d

Allele Symbol: Ahr^d

Cd5^b

Allele Symbol: Cd5^b

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Hc⁰

Allele Symbol: Hc⁰

Il3ra^m1

Allele Symbol: Il3ra^m1

Obq3^AKR/J

Allele Symbol: Obq3^AKR/J

Obq4^AKR/J

Allele Symbol: Obq4^AKR/J

Ogg1^m1

Allele Symbol: Ogg1^m1

Rmcf^s

Allele Symbol: Rmcf^s

Soat1^ald

Allele Symbol: Soat1^ald

Genotype: Ahr^d related

Genotype: Cdh23^ahl related

Genotype: Hc⁰ related

Genotype: Il3ra^m1 related

Genotype: Ahr^d/Ahr^d
AKR

Genotype: Il3ra^m1/Il3ra^m1
AKR/J

Genotype: Soat1^ald/Soat1^ald
AKR

Genotype: Soat1^ald/Soat1^ald
AKR/O

Additional - Ahr^d related

Additional - Cd5^b related

Additional - Cdh23^ahl related

Additional - Hc⁰ related

Additional - Il3ra^m1 related

Additional - Obq3^AKR/J related

Additional - Obq4^AKR/J related

Additional - Ogg1^m1 related

Additional - Rmcf^s related

Additional - Soat1^ald related