AKR/J

Stock No:: 000648 |; AKR

Also Known As: AKR, AK

AKR mice are useful in cancer, immunology, and metabolism research.

Genetic overview

Genetic Background	Generation
	Contact Technical Support (2018-07-27 00:00:00)

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Research Applications

Metabolism Research
Research Tools
Neurobiology Research
Sensorineural Research
Immunology, Inflammation and Autoimmunity Research
Cancer Research
Internal/Organ Research
Cardiovascular Research

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Base Price

Starting at:

$53.19 Domestic price for female 3-week

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Details

Detailed Description

Originally inbred at the Rockefeller Institute, AKR mice are widely used in cancer research for their high leukemia incidence (60-90%) and in immunology as a source of the Thy1.1 (theta AKR) antigen. AKR/J mice are viremic from birth, and express the ecotropic retrovirus AKV in all tissues. The hair interior defect (hid) mutation, a strain characteristic of AKR mice, causes alterations in hair development that is only evident microscopically. Adrenocortical lipid depletion (ald) in AKR mice is caused by a mutation in sterol O-acyltransferase 1 (Soat1), and leads to a truncated SOAT1 protein. AKR/J mice are relatively resistant to aortic lesion formation on a semi-synthetic high fat diet and are hyporesponsive to diets containing high levels of fat and cholesterol.

Selected References

Molne K; Brabrand G. 1968. Spontaneous adrenocortical lipid depletion in mice. Relationship to general growth, degeneration of adrenal X zone, and maturation of seminiferous epithelium. (4): 478-90. PubMed: 5693089 MGI: 5078
Doering CH; Shire JG; Kessler S; Clayton RB. 1973. Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice. (1): 101-11. PubMed: 4348256 MGI: 5322
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. (3): 467-77. PubMed: 1971301 MGI: 15389
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. (1): 65-73. PubMed: 3841001 MGI: 111030
Uelmen PJ; Oka K; Sullivan M; Chang CC; Chang TY; Chan L. 1995. Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. (44): 26192-201. PubMed: 7592824 MGI: 29766
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. (6 Pt 2): R1025-32. PubMed: 1621856 MGI: 1348
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. (7): 599-605. PubMed: 8355588 MGI: 13219
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. (2): 316-23. PubMed: 2317166 MGI: 22723
Meiner VL; Welch CL; Cases S; Myers HM; Sande E; Lusis AJ; Farese RV Jr. 1998. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. (2): 1064-9. PubMed: 9422770 MGI: 42296
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. (2): 458S-462S. PubMed: 7625360 MGI: 28346
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. (7): 1522-32. PubMed: 7595076 MGI: 28655
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. (5): 902-11. PubMed: 15081119 MGI: 90283
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. (34): 9158-9163. PubMed: 28784771 MGI: 245385

View All References

Genetics

Soat1^ald

Allele Symbol: Soat1^ald

Allele Name	adrenocortical lipid depletion
Allele Type	Spontaneous
Allele Synonym(s)	Acact-; Soat1^hid; ald; hid
Gene Symbol and Name	Soat1, sterol O-acyltransferase 1
Gene Synonym(s)	hid; adrenocortical lipid depletion; 8430426K15Rik; ACAT1; ACACT; ACAT; ACAT-1; RIKEN cDNA 8430426K15 gene; Acact; 8430426K15Rik; hair interior defect; hid; SOAT; expressed sequence AW550831; acetyl coenzyme A cholesterol acyltransferase; STAT; ald; AW550831; Acat-1; Acact
Strain of Origin	AKR/O
Chromosome	1
General Note	All AKR sublines are homozygous for Soat1.
Molecular Note	Deletion of 118 bp in the a Soat1 mRNA. This region corresondes to the 5'UTR and the initial coding sequences. In addition, two missense mutations were observed: A1248G resulting in Ile to Val at amino acid 147 and C1422T resulting in His to Tyr at amino acid 205. Other nucleotide differences were observed that did not result in amino acid changes. A truncated protein is expressed from this allele, presumably due to internal initiation.

Obq3^AKR/J

Allele Symbol: Obq3^AKR/J

Allele Name	AKR/J
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Obq3, obesity QTL 3
Gene Synonym(s)
Strain of Origin	AKR/J
Chromosome	2
General Note	Obq3 exhibits an additive mode of inheritance.
Molecular Note	This allele confers increased adiposity in male animals compared to C57L/J.

Obq4^AKR/J

Allele Symbol: Obq4^AKR/J

Allele Name	AKR/J
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Obq4, obesity QTL 4
Gene Synonym(s)
Strain of Origin	AKR/J
Chromosome	17
General Note	Obq4 may also be consistent with an additive mode of inheritance.

Ahr^d

Allele Symbol: Ahr^d

Allele Name	d variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^d; Ah^k; AhRd; Ahhⁿ; ah; in
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	bHLHe76; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; Ahh; dioxin receptor; In; Ah; Ahre; inflammatory reactivity
Strain of Origin	Not Applicable
Chromosome	12
General Note	Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note	This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Hc⁰

Allele Symbol: Hc⁰

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	C5-; C5-d; C5-def; C5-deficient; Hc^Hfib2; hc^o
Gene Symbol and Name	Hc, hemolytic complement
Gene Synonym(s)	He; CPAMD4; ECLZB; C5b; He; C5; C5a; C5D; C5; Hfib2; hepatic fibrogenesis 2; Hfib2
Strain of Origin	multiple strains
Chromosome	2
General Note	This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note	A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, A/J, AKR/J, DBA/2J, I/LnJ, KK/HlJ, MOLF/EiJ, NZB/B1NJ, RF/J, ST/bJ SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5.

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	Cdh23^753A; mdfw
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	bob; bustling; bobby; nmf112; nmf252; nmf252; 4930542A03Rik; ahl; 4930542A03Rik; W; sals; mdfw; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; modifier of deaf waddler; age related hearing loss 1; v; USH1D; nmf181; RIKEN cDNA 4930542A03 gene; CDHR23; sals; waltzer; nmf112; nmf181; mdfw; neuroscience mutagenesis facility, 112; bus; ahl; bob; salsa; PITA5
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Il3ra^m1

Allele Symbol: Il3ra^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	Il3ra^A/J; Il3raⁿ
Gene Symbol and Name	Il3ra, interleukin 3 receptor, alpha chain
Gene Synonym(s)	Cyrl; SUT-1; hIL-3Ra; IL-3 receptor alpha chain; IL3R; IL3RAY; IL3RX; IL3RY; CD123
Strain of Origin	A/J
Chromosome	14
Molecular Note	Sequence analysis revealed A/J mice lack the sequence corresponding to exon 8, which encodes 10 amino acid residues in the extracellular domain. Aberrant splicing was due to a 5 base pair deletion at the branch point in intron 7.

Rmcf^s

Allele Symbol: Rmcf^s

Allele Name	MCF sensitive
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Rmcf, resistance to MCF virus
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcf^r determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcf^s determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1, a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcf^r protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxv^s/Sxv^r mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcf^r increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcf^r allele contains an endogenous MCF gp70 env gene and that the Rmcf^s allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note	This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The recessive s (susceptible) allele is found in AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB and 129/J.

Ogg1^m1

Allele Symbol: Ogg1^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	OGG1-R336H
Gene Symbol and Name	Ogg1, 8-oxoguanine DNA-glycosylase 1
Gene Synonym(s)	MUTM; Mmh; HMMH; HOGG1; OGH1
Strain of Origin	various
Chromosome	6
Molecular Note	A guanine to adenine change at the fifty-ninth nucleotide in exon 7 resulted in a substitution of the 336th amino acid, arginine, by histidine (R336H) in a putative nuclear localization signal. The mutation led to disruption of the nuclear localization of the enzyme, although the activity remained normal.

Cd5^b

Allele Symbol: Cd5^b

Allele Name	b variant
Allele Type	Spontaneous
Allele Synonym(s)	CD5.2; Ly-1.2
Gene Symbol and Name	Cd5, CD5 antigen
Gene Synonym(s)	Ly-12; lymphocyte antigen 1; T1; T-lymphocyte antigen 1; LEU1; Ly-1; Lyt-1; lymphocyte antigen 12; Ly-12; Lyt-1; Ly-A; Ly-1
Strain of Origin	multiple strains
Chromosome	19
Molecular Note	This variant is found in many inbred strains including C57BL/6J, C58/J, AKR/J, SJL/J, SWR. Sequence analysis shows that relative to the a variant of C3H/HeJ the b variant has point mutations that result in isoleucine instead of valine at amino acid 9, glutamine instead of leucine at amino acid 52, and phenylalanine instead of isoleucine at amino acid 71, all within the amino terminal scavenger receptor cysteine-rich D1 domain, in addition to 7 silent point mutations.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahr^d related

Metabolism Research
Research Tools
- Toxicology Research

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Genotype: Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - specific complement deficiency
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement

Genotype: Il3ra^m1 related

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
  - genes regulating susceptibility to infectious disease and endotoxin

Metabolism Research
- Enzyme Deficiency
Cancer Research
- Increased Tumor Incidence
  - Leukemia: lymphatic
  - Leukemia
Internal/Organ Research
- Adrenal Cortex Defects
Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Relatively Resistant
- Atherosclerosis
  - Soat1^ald
Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Diabetes and Obesity Research
- Obesity With Diabetes
  - diet-induced
- Hyperglycemia
  - diet-induced, moderate
- Type 2 Diabetes (NIDDM)
  - diet-induced
Developmental Biology Research
- Lymphoid Tissue Defects
  - hematopoietic defects
Endocrine Deficiency Research
- Hypothalamus/Pituitary Defects
  - Soat1^ald
- Adrenal Cortex Defects

Mammalian Phenotype Terms by Genotype

Genotype: Ahr^d/Ahr^d
AKR

mortality/aging

decreased sensitivity to xenobiotic induced morbidity/mortality
- mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

homeostasis/metabolism phenotype

decreased physiological sensitivity to xenobiotic
- mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

decreased sensitivity to xenobiotic induced morbidity/mortality
- mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

Genotype: Il3ra^m1/Il3ra^m1
AKR/J

hematopoietic system phenotype

abnormal common myeloid progenitor cell morphology
- CFU-GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3

Genotype: Soat1^ald/Soat1^ald
AKR

integument phenotype

abnormal hair growth
- all AKR strains are homozygous for this mutation
- distal regions of all hair types are especially affected
- homozygotes can be ascertained only by microscopic examination of the hair
- morphology and arrangement of medullary cells are abnormal

abnormal hair medulla
- medulla morphology and arrangement are abnormal
- random and tightly packed medullary cells produce irregularities of hair shaft calibre

abnormal hair shaft morphology
- medullary cell abnormality effects calibre of hair shaft

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Soat1^ald/Soat1^ald
AKR/O

endocrine/exocrine gland phenotype

abnormal adrenal cortex morphology
- adrenal cortex of females is not totally depleted and lipid pattern is variable
- adrenal cortex of males is totally depleted of lipid
- in males adrenocortical lipid depletion coincides roughly with adrenal X-zone degeneration and maturation of seminiferous epithelium
- large doses of ACTH restores lipid concentration and distribution
- onset of adrenocortical lipid depletion takes place in mice between 30 and 40 days of age

abnormal adrenocortical cell morphology
- cells are enriched with mitochondria
- lipid vacuoles are sparse

thymus hyperplasia
- evident from birth

hematopoietic system phenotype

thymus hyperplasia
- evident from birth

immune system phenotype

thymus hyperplasia
- evident from birth

neoplasm

increased leukemia incidence
- high incidence of lymphatic leukemia

Phenotype Information

References

Molne K; Brabrand G. 1968. Spontaneous adrenocortical lipid depletion in mice. Relationship to general growth, degeneration of adrenal X zone, and maturation of seminiferous epithelium. (4): 478-90. PubMed: 5693089 MGI: 5078
Doering CH; Shire JG; Kessler S; Clayton RB. 1973. Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice. (1): 101-11. PubMed: 4348256 MGI: 5322
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. (3): 467-77. PubMed: 1971301 MGI: 15389
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. (1): 65-73. PubMed: 3841001 MGI: 111030
Uelmen PJ; Oka K; Sullivan M; Chang CC; Chang TY; Chan L. 1995. Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. (44): 26192-201. PubMed: 7592824 MGI: 29766
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. (6 Pt 2): R1025-32. PubMed: 1621856 MGI: 1348
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. (7): 599-605. PubMed: 8355588 MGI: 13219
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. (2): 316-23. PubMed: 2317166 MGI: 22723
Meiner VL; Welch CL; Cases S; Myers HM; Sande E; Lusis AJ; Farese RV Jr. 1998. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. (2): 1064-9. PubMed: 9422770 MGI: 42296
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. (2): 458S-462S. PubMed: 7625360 MGI: 28346
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. (7): 1522-32. PubMed: 7595076 MGI: 28655
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. (5): 902-11. PubMed: 15081119 MGI: 90283
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. (34): 9158-9163. PubMed: 28784771 MGI: 245385

Additional References

Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. (1): 1-16. PubMed: 4959665 MGI: 5005
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. (5735): 207-8. PubMed: 492335 MGI: 6203
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. (5): 1442-7. PubMed: 3572304 MGI: 8678
Trigg MJ. 1972. Hair growth in mouse mutants affecting coat texture. 165-198. MGI: 15157
West DB; Waguespack J; York B; Goudey-Lefevre J; Price RA. 1994. Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. (9): 546-52. PubMed: 8000138 MGI: 20301
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. (5): 2435-40. PubMed: 2303408 MGI: 24109
West DB; Goudey-Lefevre J; York B; Truett GE. 1994. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. (4): 1410-6. PubMed: 7929816 MGI: 20873
West DB; Waguespack J; McCollister S. 1995. Dietary obesity in the mouse: interaction of strain with diet composition. (3 Pt 2): R658-65. PubMed: 7900908 MGI: 24572
Eberhart GP; West DB; Boozer CN; Atkinson RL. 1994. Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to diet-induced obesity. (5 Pt 2): R1423-8. PubMed: 8203615 MGI: 18667
Festing MF; Blackmore DK. 1971. Life span of specified-pathogen-free (MRC category 4) mice and rats. (2): 179-92. PubMed: 5166568 MGI: 22715
Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. (4): 537-45. PubMed: 11017920 MGI: 67588
Rossmeisl M; Rim JS; Koza RA; Kozak LP. 2003. Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity. (8): 1958-66. PubMed: 12882911 MGI: 87006
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. (1): 4-20. PubMed: 16971002 MGI: 139775
Hara T; Ichihara M; Takagi M; Miyajima A. 1995. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. (9): 2331-6. PubMed: 7727767 MGI: 25008
Smith BK; West DB; York DA. 1997. Carbohydrate versus fat intake: differing patterns of macronutrient selection in two inbred mouse strains. (1 Pt 2): R357-62. PubMed: 9039029 MGI: 39224
Taylor BA; Phillips SJ. 1997. Obesity QTLs on mouse chromosomes 2 and 17. (3): 249-57. PubMed: 9268627 MGI: 40125
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. (4): R797-805. PubMed: 10749765 MGI: 62545
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. (8): 5047-55. PubMed: 15067087 MGI: 124080
Roberts JE; Watters JW; Ballard JD; Dietrich WF. 1998. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. (2): 581-91. PubMed: 9720874 MGI: 50110
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice (8): 602-13. PubMed: 14945054 MGI: 167384
Hoag WG. 1963. Spontaneous cancer in mice 805-831. PubMed: 14081516 MGI: 2434
Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. (7364): 289-94. PubMed: 21921910 MGI: 178133
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. e05607. PubMed: 26067236 MGI: 224852
Menghini P; Di Martino L; Lopetuso LR; Corridoni D; Webster JC; Xin W; Arseneau KO; Lam M; Pizarro TT; Cominelli F. 2017. A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. (3): e0174121. PubMed: 28301579 MGI: 251042
Furth J; Seibold HR; Rathbone RR. 1933. Experimental studies on lymphomatosis of mice (3): 521-604. MGI: 25469

Additional - Ahr^d

Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. (5): 818-26. PubMed: 1658612 MGI: 2134
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. (4): 1315-25. PubMed: 4114109 MGI: 5271
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. (4): 655-9. PubMed: 4750810 MGI: 5376
Taylor BA. 1971. Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice. (19): 1127-34. PubMed: 5132702 MGI: 5233
Thorgeirsson SS; Nebert DW. 1977. The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. 149-93. PubMed: 405846 MGI: 5811
Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. (17): 6769-78. PubMed: 808546 MGI: 5553
Nebert DW; Jensen NM. 1979. Benzo[a]pyrene-initiated leukemia in mice. Association with allelic differences at the Ah locus. (1): 149-51. PubMed: 758905 MGI: 6063
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. (1): 79-87. PubMed: 7095422 MGI: 6797
Poland A; Bradfield C. 1992. A brief review of the Ah locus. (2): 83-7. PubMed: 1339107 MGI: 12511
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. (4): 471-8. PubMed: 2823093 MGI: 8883
Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. 339-62. PubMed: 1030186 MGI: 12127
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. (29): 22203-9. PubMed: 8408082 MGI: 15064
Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. (6): 312-21. PubMed: 8148872 MGI: 17318
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. (5): 915-21. PubMed: 7969080 MGI: 22251
Oesch F; Morris N; Daly JW. 1973. Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene. (5): 629-6. PubMed: 4788156 MGI: 25975
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. (3): 558-62. PubMed: 6021513 MGI: 27884
Okey AB; Vella LM; Harper PA. 1989. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. (6): 823-30. PubMed: 2543914 MGI: 27995
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. (3): 306-12. PubMed: 2169579 MGI: 34923
Schmid FA; Elmer I; Tarnowski GS. 1969. Genetic determination of differential inflammatory reactivity and subcutaneous tumor susceptibility of AKR-J and C57BL-6J mice to 7,12-dimethylbenz- [a]anthracene. (8): 1585-9. PubMed: 5807232 MGI: 34379
Thomas PE; Kouri RE; Hutton JJ. 1972. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. (2): 157-68. PubMed: 4666754 MGI: 34380
Moriguchi T; Motohashi H; Hosoya T; Nakajima O; Takahashi S; Ohsako S; Aoki Y; Nishimura N; Tohyama C; Fujii-Kuriyama Y; Yamamoto M. 2003. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. (10): 5652-7. PubMed: 12730383 MGI: 133473
Poel WE; Stanton D; Peters E; Wade HO. 1958. Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene 335. MGI: 85219
Schmid FA; Demetriades MS; Schabel FM 3rd; Tarnowski GS. 1967. Toxicity of several cancerigenic polycyclic hydrocarbons and other agents in AKR and C57BL-6 mice. (3): 563-7. PubMed: 6021514 MGI: 85220
Poland A; Glover E; Kende AS. 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. (16): 4936-46. PubMed: 956169 MGI: 85221
Nebert DW; Gelboin HV. 1969. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. (1): 76-89. PubMed: 4981257 MGI: 85222
Nebert DW; Goujon FM; Gielen JE. 1972. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. (65): 107-10. PubMed: 4502804 MGI: 85223
Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. (4): 1125-37. PubMed: 4110756 MGI: 85224
Nebert DW; Gielen JE; Goujon FM. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450. (6): 651-66. PubMed: 4118364 MGI: 85225
Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. (6): 667-80. PubMed: 4118365 MGI: 85226
Nebert DW; Kon H. 1973. Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals. (1): 169-78. PubMed: 4348203 MGI: 85288
Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. (2): 266-77. PubMed: 4123113 MGI: 85289
Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. (1): 148-59. PubMed: 4716952 MGI: 85290
Poland AP; Glover E; Robinson JR; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically 'nonresponsive' to other aromatic hydrocarbons. (17): 5599-606. PubMed: 4370044 MGI: 85291
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. (18): 5851-9. PubMed: 4413562 MGI: 85292
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. (2): 559-64. PubMed: 1119809 MGI: 85293
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. (2 Pt 2 Suppl 1): 393-414. PubMed: 1091656 MGI: 85294
Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. (9): 2777-83. PubMed: 679184 MGI: 85295
Walisser JA; Bunger MK; Glover E; Bradfield CA. 2004. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. (47): 16677-82. PubMed: 15545609 MGI: 95456
Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. (2): 454-64. PubMed: 16291824 MGI: 114371
Yu Z; Mahadevan B; Lohr CV; Fischer KA; Louderback MA; Krueger SK; Pereira CB; Albershardt DJ; Baird WM; Bailey GS; Williams DE. 2006. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. (10): 2116-23. PubMed: 16704990 MGI: 114442
Poland A; Teitelbaum P; Glover E; Kende A. 1989. Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor. (1): 121-7. PubMed: 2546046 MGI: 127469
Quintana FJ; Basso AS; Iglesias AH; Korn T; Farez MF; Bettelli E; Caccamo M; Oukka M; Weiner HL. 2008. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. (7191): 65-71. PubMed: 18362915 MGI: 137145
Shi Z; Chen Y; Dong H; Amos-Kroohs RM; Nebert DW. 2008. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. (4): 775-80. PubMed: 18814841 MGI: 142616
Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. (3): 454-8. PubMed: 18848954 MGI: 144697
Yeager RL; Reisman SA; Aleksunes LM; Klaassen CD. 2009. Introducing the 'TCDD-inducible AhR-Nrf2 gene battery'. (2): 238-46. PubMed: 19474220 MGI: 155176
Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. (1): 52-61. PubMed: 9443932 MGI: 46138
Simonian PL; Wehrmann F; Roark CL; Born WK; O'Brien RL; Fontenot AP. 2010. gammadelta T cells protect against lung fibrosis via IL-22. (10): 2239-53. PubMed: 20855496 MGI: 166899
Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues. (6): 1094-102. PubMed: 21270426 MGI: 174802
Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. (2): 391-404. PubMed: 22228805 MGI: 184811
Stiborova M; Levova K; Barta F; Shi Z; Frei E; Schmeiser HH; Nebert DW; Phillips DH; Arlt VM. 2012. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. (2): 345-58. PubMed: 22086975 MGI: 184758
Tanos R; Murray IA; Smith PB; Patterson A; Perdew GH. 2012. Role of the ah receptor in homeostatic control of Fatty Acid synthesis in the liver. (2): 372-9. PubMed: 22696238 MGI: 189260
Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. (3): 360-7. PubMed: 22982977 MGI: 193961
Shivanna B; Zhang W; Jiang W; Welty SE; Couroucli XI; Wang L; Moorthy B. 2013. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. (3): 209-17. PubMed: 23337360 MGI: 194589
Zhou Y; Tung HY; Tsai YM; Hsu SC; Chang HW; Kawasaki H; Tseng HC; Plunkett B; Gao P; Hung CH; Vonakis BM; Huang SK. 2013. Aryl hydrocarbon receptor controls murine mast cell homeostasis. (16): 3195-204. PubMed: 23462117 MGI: 198649
Kennedy GD; Nukaya M; Moran SM; Glover E; Weinberg S; Balbo S; Hecht SS; Pitot HC; Drinkwater NR; Bradfield CA. 2014. Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. (1): 135-43. PubMed: 24718703 MGI: 216446
Curran CP; Altenhofen E; Ashworth A; Brown A; Kamau-Cheggeh C; Curran M; Evans A; Floyd R; Fowler J; Garber H; Hays B; Kraemer S; Lang A; Mynhier A; Samuels A; Strohmaier C. 2012. Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity. (6): 1436-42. PubMed: 22935098 MGI: 226184
Williams EG; Mouchiroud L; Frochaux M; Pandey A; Andreux PA; Deplancke B; Auwerx J. 2014. An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement. (9): e1004673. PubMed: 25255223 MGI: 233545
Curran CP; Nebert DW; Genter MB; Patel KV; Schaefer TL; Skelton MR; Williams MT; Vorhees CV. 2011. In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. (9): 1286-93. PubMed: 21571617 MGI: 284097
Curran CP; Vorhees CV; Williams MT; Genter MB; Miller ML; Nebert DW. 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. (1): 189-208. PubMed: 20961953 MGI: 284126
Klinefelter K; Hooven MK; Bates C; Colter BT; Dailey A; Infante SK; Kania-Korwel I; Lehmler HJ; Lopez-Juarez A; Ludwig CP; Curran CP. 2018. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. (1-2): 112-127. PubMed: 29197979 MGI: 278232
Wong TH; Lee CL; Su HH; Lee CL; Wu CC; Wang CC; Sheu CC; Lai RS; Leung SY; Lin CC; Wei YF; Wang CJ; Lin YC; Chen HL; Huang MS; Yen JH; Huang SK; Suen JL. 2018. A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. (1): 5198. PubMed: 29581487 MGI: 288977
Nebert DW; Atlas SA; Guenthner TM; Kouri RE. 1978. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk of cancer. In: Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment. Academic Press, New York. MGI: 30991

Additional - Cd5^b

Morse HC 3rd. 1992. Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563] (10): 3129-34. PubMed: 1431091 MGI: 3170
Boyse EA; Cantor H; Shen F-W; McKenzie JFC. 1977. Nomenclature for antigens demonstrable on lymphocytes. 189. MGI: 4414
Boyse EA; Miyazawa M; Aoki T; Old LJ. 1968. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. (19): 175-93. PubMed: 4385242 MGI: 5062
Ledbetter JA; Rouse RV; Micklem HS; Herzenberg LA. 1980. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. (2): 280-95. PubMed: 6156984 MGI: 6348
Hayakawa K; Hardy RR; Parks DR; Herzenberg LA. 1983. The Ly-1 B cell subpopulation in normal immunodefective, and autoimmune mice. (1): 202-18. PubMed: 6600267 MGI: 6911
Huang HJ; Jones NH; Strominger JL; Herzenberg LA. 1987. Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5). (1): 204-8. PubMed: 3025855 MGI: 8534
Starling GC; Llewellyn MB; Whitney GS; Aruffo A. 1997. The Ly-1.1 and Ly-1.2 epitopes of murine CD5 map to the membrane distal scavenger receptor cysteine-rich domain. (1): 1-6. PubMed: 9027958 MGI: 40597
Shiku H; Kisielow P; Boyse EA; Oettgen HF. 1976. Immunogenetic identification of functional T-cell subsets. (3): 381-5. PubMed: 1086540 MGI: 5706
Snell GD; Cherry M. 1972. Loci determining cell surface antigens. In: RNA Viruses and Host Genome in Oncogenesis. North Holland, Amsterdam. MGI: 31049

Additional - Cdh23^ahl

Noben-Trauth K; Zheng QY; Johnson KR; Nishina PM. 1997. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). (3): 266-72. PubMed: 9325047 MGI: 39072
Johnson KR; Erway LC; Cook SA; Willott JF; Zheng QY. 1997. A major gene affecting age-related hearing loss in C57BL/6J mice (1-2): 83-92. PubMed: 9447922 MGI: 45247
Johnson KR; Zheng QY; Bykhovskaya Y; Spirina O; Fischel-Ghodsian N. 2001. A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. (2): 191-4. PubMed: 11175788 MGI: 68262
Zheng QY; Johnson KR. 2001. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. (1-2): 45-53. PubMed: 11423214 MGI: 71915
Davis RR; Newlander JK; Ling X; Cortopassi GA; Krieg EF; Erway LC. 2001. Genetic basis for susceptibility to noise-induced hearing loss in mice. (1-2): 82-90. PubMed: 11335078 MGI: 70630
Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). (1-2): 31-41. PubMed: 11750125 MGI: 74895
Noben-Trauth K; Zheng QY; Johnson KR. 2003. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. (1): 21-3. PubMed: 12910270 MGI: 87887
Keithley EM; Canto C; Zheng QY; Fischel-Ghodsian N; Johnson KR. 2004. Age-related hearing loss and the ahl locus in mice. (1-2): 21-8. PubMed: 14759567 MGI: 88766
Johnson KR; Zheng QY; Weston MD; Ptacek LJ; Noben-Trauth K. 2005. The Mass1(frings) mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. (5): 582-90. PubMed: 15820310 MGI: 98559
Mathews CE; Leiter EH. 1999. Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. (11): 2189-96. PubMed: 10535453 MGI: 110973
Johnson KR; Zheng QY; Noben-Trauth K. 2006. Strain background effects and genetic modifiers of hearing in mice. (1): 79-88. PubMed: 16579977 MGI: 111541
Vazquez AE; Jimenez AM; Martin GK; Luebke AE; Lonsbury-Martin BL. 2004. Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions. (1-2): 87-96. PubMed: 15276680 MGI: 118835
Liu X; Bulgakov OV; Darrow KN; Pawlyk B; Adamian M; Liberman MC; Li T. 2007. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. (11): 4413-8. PubMed: 17360538 MGI: 120016
Johnson KR; Longo-Guess C; Gagnon LH; Yu H; Zheng QY. 2008. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. (4): 219-25. PubMed: 18662770 MGI: 140316
Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. (3): 290-5. PubMed: 12787792 MGI: 88995
Watson CJ; Tempel BL. 2013. A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers. 41-8. PubMed: 23792079 MGI: 221757
Noben-Trauth K; Latoche JR; Neely HR; Bennett B. 2010. Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. (7): e11459. PubMed: 20628639 MGI: 164213
Johnson KR; Yu H; Ding D; Jiang H; Gagnon LH; Salvi RJ. 2010. Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice. (1-2): 85-92. PubMed: 20470874 MGI: 164131
Perrin BJ; Sonnemann KJ; Ervasti JM. 2010. beta-actin and gamma-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. (10): e1001158. PubMed: 20976199 MGI: 168639
Manji SS; Williams LH; Miller KA; Ooms LM; Bahlo M; Mitchell CA; Dahl HH. 2011. A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. (3): e17607. PubMed: 21423608 MGI: 172797
Han F; Yu H; Tian C; Chen HE; Benedict-Alderfer C; Zheng Y; Wang Q; Han X; Zheng QY. 2012. A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. (1): 30-44. PubMed: 20644563 MGI: 175854
Zilberstein Y; Liberman MC; Corfas G. 2012. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. (2): 405-10. PubMed: 22238076 MGI: 181007
Zheng QY; Scarborough JD; Zheng Y; Yu H; Choi D; Gillespie PG. 2012. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. (11): 2588-98. PubMed: 22381527 MGI: 184994
Kane KL; Longo-Guess CM; Gagnon LH; Ding D; Salvi RJ; Johnson KR. 2012. Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice. (1-2): 80-8. PubMed: 22138310 MGI: 184853
Fetoni AR; Picciotti PM; Paludetti G; Troiani D. 2011. Pathogenesis of presbycusis in animal models: a review. (6): 413-25. PubMed: 21211561 MGI: 188060
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. (8): e43602. PubMed: 22952717 MGI: 192759
Perrin BJ; Strandjord DM; Narayanan P; Henderson DM; Johnson KR; Ervasti JM. 2013. beta-Actin and Fascin-2 Cooperate to Maintain Stereocilia Length. (19): 8114-21. PubMed: 23658152 MGI: 198234
Hurd EA; Adams ME; Layman WS; Swiderski DL; Beyer LA; Halsey KE; Benson JM; Gong TW; Dolan DF; Raphael Y; Martin DM. 2011. Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. (1-2): 184-95. PubMed: 21875659 MGI: 221527
Nagtegaal AP; Rainey RN; van der Pluijm I; Brandt RM; van der Horst GT; Borst JG; Segil N. 2015. Cockayne syndrome group B (csb) and group a (csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. (10): 4280-6. PubMed: 25762674 MGI: 221090
Murillo-Cuesta S; Rodriguez-de la Rosa L; Contreras J; Celaya AM; Camarero G; Rivera T; Varela-Nieto I. 2015. Transforming growth factor beta1 inhibition protects from noise-induced hearing loss. 32. PubMed: 25852546 MGI: 243628
Johnson KR; Tian C; Gagnon LH; Jiang H; Ding D; Salvi R. 2017. Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains. 44450. PubMed: 28287619 MGI: 242229
Miyasaka Y; Suzuki S; Ohshiba Y; Watanabe K; Sagara Y; Yasuda SP; Matsuoka K; Shitara H; Yonekawa H; Kominami R; Kikkawa Y. 2013. Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice. (4): 333-46. PubMed: 24172198 MGI: 266552
Zhang C; Sun W; Li J; Xiong B; Frye MD; Ding D; Salvi R; Kim MJ; Someya S; Hu BH. 2017. Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. 179-191. PubMed: 28818524 MGI: 260243

Additional - Hc⁰

Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. (1): 1-16. PubMed: 4959665 MGI: 5005
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. (5735): 207-8. PubMed: 492335 MGI: 6203
CINADER B; DUBISKI S; WARDLAW AC. 1964. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT. 897-924. PubMed: 14247728 MGI: 12956
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. (5): 1442-7. PubMed: 3572304 MGI: 8678
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. (5): 2435-40. PubMed: 2303408 MGI: 24109
Miller CG; Justus DE; Jayaraman S; Kotwal GJ. 1995. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis. (2): 326-32. PubMed: 7743560 MGI: 25397
Miller CG; Cook DN; Kotwal GJ. 1996. Two chemotactic factors, C5a and MIP-1alpha, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1alpha has a protective role. (14): 1135-7. PubMed: 9047380 MGI: 38781
Prodeus AP; Zhou X; Maurer M; Galli SJ; Carroll MC. 1997. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. (6656): 172-5. PubMed: 9367154 MGI: 44499
Wang Y; Kristan J; Hao L; Lenkoski CS; Shen Y; Matis LA. 2000. A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis. (8): 4340-7. PubMed: 10754334 MGI: 62530
Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. (3): 425-35. PubMed: 18328742 MGI: 134035
Ji H; Gauguier D; Ohmura K; Gonzalez A; Duchatelle V; Danoy P; Garchon HJ; Degott C; Lathrop M; Benoist C; Mathis D. 2001. Genetic influences on the end-stage effector phase of arthritis. (3): 321-30. PubMed: 11489951 MGI: 71833
Garcia S; DiSanto J; Stockinger B. 1999. Following the development of a CD4 T cell response in vivo: from activation to memory formation. (2): 163-71. PubMed: 10485651 MGI: 152843
Zal T; Weiss S; Mellor A; Stockinger B. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. (17): 9102-7. PubMed: 8799161 MGI: 152846
Girardi G; Berman J; Redecha P; Spruce L; Thurman JM; Kraus D; Hollmann TJ; Casali P; Caroll MC; Wetsel RA; Lambris JD; Holers VM; Salmon JE. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. (11): 1644-54. PubMed: 14660741 MGI: 87827
Niculescu T; Weerth S; Niculescu F; Cudrici C; Rus V; Raine CS; Shin ML; Rus H. 2004. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis. (9): 5702-6. PubMed: 15100315 MGI: 90671
Mullick A; Elias M; Picard S; Bourget L; Jovcevski O; Gauthier S; Tuite A; Harakidas P; Bihun C; Massie B; Gros P. 2004. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. (10): 5868-76. PubMed: 15385488 MGI: 94122
Bauer K; Yu X; Wernhoff P; Koczan D; Thiesen HJ; Ibrahim SM. 2004. Identification of new quantitative trait loci in mice with collagen-induced arthritis. (11): 3721-8. PubMed: 15529344 MGI: 95338
Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. (7): 835-46. PubMed: 15466618 MGI: 94939
Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. (2): 234-45. PubMed: 15379984 MGI: 93922
Younger JG; Shankar-Sinha S; Mickiewicz M; Brinkman AS; Valencia GA; Sarma JV; Younkin EM; Standiford TJ; Zetoune FS; Ward PA. 2003. Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia. (4): 432-8. PubMed: 14500254 MGI: 95604
Sood R; Sholl L; Isermann B; Zogg M; Coughlin SR; Weiler H. 2008. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. (3): 585-91. PubMed: 18490515 MGI: 139533
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. (8): 835-43. PubMed: 15995705 MGI: 101186
Cunnion KM; Benjamin DK Jr; Hester CG; Frank MM. 2004. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. (6): 358-65. PubMed: 15192652 MGI: 103015
Kyriakides C; Austen W Jr; Wang Y; Favuzza J; Kobzik L; Moore FD Jr; Hechtman HB. 1999. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration. (6): 2357-61. PubMed: 10601189 MGI: 104410
Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. (10): 775-83. PubMed: 16261419 MGI: 103708
Kim DD; Miwa T; Kimura Y; Schwendener RA; van Lookeren Campagne M; Song WC. 2008. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. (4): 1109-19. PubMed: 18524992 MGI: 139503
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. (2): 1196-203. PubMed: 16428769 MGI: 106059
Actor JK; Breij E; Wetsel RA; Hoffmann H; Hunter RL Jr; Jagannath C. 2001. A role for complement C5 in organism containment and granulomatous response during murine tuberculosis. (5): 464-74. PubMed: 11309154 MGI: 105051
Wolfe DN; Kirimanjeswara GS; Harvill ET. 2005. Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity. (10): 6508-13. PubMed: 16177324 MGI: 105283
Mahesh J; Daly J; Cheadle WG; Kotwal GJ. 1999. Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice. (5): 340-9. PubMed: 10565608 MGI: 60596
Addis-Lieser E; Kohl J; Chiaramonte MG. 2005. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. (3): 1894-902. PubMed: 16034133 MGI: 108343
Deguchi Y; Andoh A; Inatomi O; Araki Y; Hata K; Tsujikawa T; Kitoh K; Fujiyama Y. 2005. Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5. (4): 605-8. PubMed: 16142393 MGI: 108655
Karp CL; Grupe A; Schadt E; Ewart SL; Keane-Moore M; Cuomo PJ; Kohl J; Wahl L; Kuperman D; Germer S; Aud D; Peltz G; Wills-Karp M. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. (3): 221-6. PubMed: 10973279 MGI: 109285
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. (4): 577-83. PubMed: 10449528 MGI: 109802
Strey CW; Markiewski M; Mastellos D; Tudoran R; Spruce LA; Greenbaum LE; Lambris JD. 2003. The proinflammatory mediators C3a and C5a are essential for liver regeneration. (6): 913-23. PubMed: 12975457 MGI: 110459
Mastellos D; Papadimitriou JC; Franchini S; Tsonis PA; Lambris JD. 2001. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. (4): 2479-86. PubMed: 11160308 MGI: 112083
Pickering MC; Warren J; Rose KL; Carlucci F; Wang Y; Walport MJ; Cook HT; Botto M. 2006. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. (25): 9649-54. PubMed: 16769899 MGI: 112114
Zal T; Volkmann A; Stockinger B. 1994. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. (6): 2089-99. PubMed: 7964486 MGI: 112733
Mullick A; Leon Z; Min-Oo G; Berghout J; Lo R; Daniels E; Gros P. 2006. Cardiac failure in C5-deficient A/J mice after Candida albicans infection. (8): 4439-51. PubMed: 16861630 MGI: 113491
Borders CW; Courtney A; Ronen K; Pilar Laborde-Lahoz M; Guidry TV; Hwang SA; Olsen M; Hunter RL Jr; Hollmann TJ; Wetsel RA; Actor JK. 2005. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. (2): 123-30. PubMed: 16101818 MGI: 115403
Refici ML; Metzger DW; Arulanandam BP; Lennartz MR; Loegering DJ. 2001. Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels. (4): R1037-44. PubMed: 11247825 MGI: 115382
Xiao H; Schreiber A; Heeringa P; Falk RJ; Jennette JC. 2007. Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. (1): 52-64. PubMed: 17200182 MGI: 118137
Tanaka D; Kagari T; Doi H; Shimozato T. 2006. Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis. (2): 195-202. PubMed: 16836650 MGI: 119640
Trendelenburg M; Fossati-Jimack L; Cortes-Hernandez J; Turnberg D; Lewis M; Izui S; Cook HT; Botto M. 2005. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. (10): 6909-14. PubMed: 16272350 MGI: 120782
Daniel DS; Dai G; Singh CR; Lindsey DR; Smith AK; Dhandayuthapani S; Hunter RL Jr; Jagannath C. 2006. The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes. (7): 4688-98. PubMed: 16982908 MGI: 140406
Zhou W; Farrar CA; Abe K; Pratt JR; Marsh JE; Wang Y; Stahl GL; Sacks SH. 2000. Predominant role for C5b-9 in renal ischemia/reperfusion injury. (10): 1363-71. PubMed: 10811844 MGI: 121658
Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. (11): 7504-11. PubMed: 16301658 MGI: 123248
Mocco J; Mack WJ; Ducruet AF; Sosunov SA; Sughrue ME; Hassid BG; Nair MN; Laufer I; Komotar RJ; Claire M; Holland H; Pinsky DJ; Connolly ES Jr. 2006. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. (2): 209-17. PubMed: 16778128 MGI: 124750
Moulton RA; Mashruwala MA; Smith AK; Lindsey DR; Wetsel RA; Haviland DL; Hunter RL; Jagannath C. 2007. Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. (4): 956-67. PubMed: 17675563 MGI: 126282
Pritchard MT; McMullen MR; Stavitsky AB; Cohen JI; Lin F; Medof ME; Nagy LE. 2007. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. (3): 1117-26. PubMed: 17383432 MGI: 129310
Kerepesi LA; Hess JA; Nolan TJ; Schad GA; Abraham D. 2006. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. (7): 4315-22. PubMed: 16547268 MGI: 130964
Carter WO; Bull C; Bortolon E; Yang L; Jesmok GJ; Gundel RH. 1998. A murine skeletal muscle ischemia-reperfusion injury model: differential pathology in BALB/c and DBA/2N mice. (5): 1676-83. PubMed: 9804569 MGI: 51631
Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. (1): 97-102. PubMed: 17967861 MGI: 131389
Pilione MR; Agosto LM; Kennett MJ; Harvill ET. 2006. CD11b is required for the resolution of inflammation induced by Bordetella bronchiseptica respiratory infection. (5): 758-68. PubMed: 16611225 MGI: 136833
Mori L; de Libero G. 1998. Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice. (2): 256-62. PubMed: 9485083 MGI: 135204
Rittirsch D; Flierl MA; Nadeau BA; Day DE; Huber-Lang M; Mackay CR; Zetoune FS; Gerard NP; Cianflone K; Kohl J; Gerard C; Sarma JV; Ward PA. 2008. Functional roles for C5a receptors in sepsis. (5): 551-7. PubMed: 18454156 MGI: 137796
Patel SN; Berghout J; Lovegrove FE; Ayi K; Conroy A; Serghides L; Min-oo G; Gowda DC; Sarma JV; Rittirsch D; Ward PA; Liles WC; Gros P; Kain KC. 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. (5): 1133-43. PubMed: 18426986 MGI: 137391
Rittirsch D; Flierl MA; Day DE; Nadeau BA; McGuire SR; Hoesel LM; Ipaktchi K; Zetoune FS; Sarma JV; Leng L; Huber-Lang MS; Neff TA; Bucala R; Ward PA. 2008. Acute lung injury induced by lipopolysaccharide is independent of complement activation. (11): 7664-72. PubMed: 18490769 MGI: 137472
Fairweather D; Frisancho-Kiss S; Njoku DB; Nyland JF; Kaya Z; Yusung SA; Davis SE; Frisancho JA; Barrett MA; Rose NR. 2006. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart. (6): 3516-24. PubMed: 16517720 MGI: 130601
Bora NS; Kaliappan S; Jha P; Xu Q; Sohn JH; Dhaulakhandi DB; Kaplan HJ; Bora PS. 2006. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. (3): 1872-8. PubMed: 16849499 MGI: 139119
Flierl MA; Rittirsch D; Nadeau BA; Day DE; Zetoune FS; Sarma JV; Huber-Lang MS; Ward PA. 2008. Functions of the complement components C3 and C5 during sepsis. (10): 3483-90. PubMed: 18587006 MGI: 141343
Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. (12): 2684-94. PubMed: 19136662 MGI: 147631
Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. (7): 2423-31. PubMed: 17536017 MGI: 148115
Wright RJ; Bikoff EK; Stockinger B. 1998. The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice. (3): 309-13. PubMed: 9824491 MGI: 51167
Kassiotis G; Zamoyska R; Stockinger B. 2003. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. (8): 1007-16. PubMed: 12707300 MGI: 152836
Flynn S; Stockinger B. 2003. Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. (11): 4472-8. PubMed: 12543861 MGI: 152837
Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. (3): 244-50. PubMed: 11836529 MGI: 152840
Barthlott T; Stockinger B. 2001. Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties. (12): 3595-601. PubMed: 11745379 MGI: 152841
Ferreira C; Barthlott T; Garcia S; Zamoyska R; Stockinger B. 2000. Differential survival of naive CD4 and CD8 T cells. (7): 3689-94. PubMed: 11034373 MGI: 152842
Chen HC; Hofman FM; Kung JT; Lin YD; Wu-Hsieh BA. 2007. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. (11): 5518-26. PubMed: 17360740 MGI: 154415
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. (39): 16758-63. PubMed: 19805369 MGI: 154310
Lee HM; Wu W; Wysoczynski M; Liu R; Zuba-Surma EK; Kucia M; Ratajczak J; Ratajczak MZ. 2009. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes. (11): 2052-62. PubMed: 19657368 MGI: 155575
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. (3): 573-82. PubMed: 20033053 MGI: 159119
Ratajczak MZ; Lee H; Wysoczynski M; Wan W; Marlicz W; Laughlin MJ; Kucia M; Janowska-Wieczorek A; Ratajczak J. 2010. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due toactivation of complement cascade/membrane attack complex. (5): 976-85. PubMed: 20357827 MGI: 161279
Schultz G; Tedesco MM; Sho E; Nishimura T; Sharif S; Du X; Myles T; Morser J; Dalman RL; Leung LL. 2010. Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice. (7): 1363-70. PubMed: 20431069 MGI: 181957
Schmitt J; Roderfeld M; Sabrane K; Zhang P; Tian Y; Mertens JC; Frei P; Stieger B; Weber A; Mullhaupt B; Roeb E; Geier A. 2012. Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice. (3): 445-50. PubMed: 22277671 MGI: 182364
Kim CH; Wu W; Wysoczynski M; Abdel-Latif A; Sunkara M; Morris A; Kucia M; Ratajczak J; Ratajczak MZ. 2012. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. (1): 106-16. PubMed: 21769103 MGI: 182159
de Jorge EG; Macor P; Paixao-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. 2011. The development of atypical hemolytic uremic syndrome depends on complement C5. (1): 137-45. PubMed: 21148255 MGI: 186979
Kwan WH; Hashimoto D; Paz-Artal E; Ostrow K; Greter M; Raedler H; Medof ME; Merad M; Heeger PS. 2012. Antigen-presenting cell-derived complement modulates graft-versus-host disease. (6): 2234-8. PubMed: 22585573 MGI: 191588
Strainic MG; Shevach EM; An F; Lin F; Medof ME. 2012. Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells. (2): 162-71. PubMed: 23263555 MGI: 193709
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. (8): e43602. PubMed: 22952717 MGI: 192759
Bode J; Dutow P; Sommer K; Janik K; Glage S; Tummler B; Munder A; Laudeley R; Sachse KW; Klos A. 2012. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. (11): e50327. PubMed: 23189195 MGI: 195880
Baudino L; Sardini A; Ruseva MM; Fossati-Jimack L; Cook HT; Scott D; Simpson E; Botto M. 2014. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. (4): 1503-8. PubMed: 24474777 MGI: 207745
Liu Q; He S; Groysman L; Shaked D; Russin J; Cen S; Mack WJ. 2013. White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition. (12): e84802. PubMed: 24386419 MGI: 210937
Ehrnthaller C; Huber-Lang M; Nilsson P; Bindl R; Redeker S; Recknagel S; Rapp A; Mollnes T; Amling M; Gebhard F; Ignatius A. 2013. Complement C3 and C5 deficiency affects fracture healing. (11): e81341. PubMed: 24260573 MGI: 210766
Fossati-Jimack L; Ling GS; Baudino L; Szajna M; Manivannan K; Zhao JC; Midgley R; Chai JG; Simpson E; Botto M; Scott D. 2015. Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. (1): 149-57. PubMed: 25039245 MGI: 221228
Bulla R; Tripodo C; Rami D; Ling GS; Agostinis C; Guarnotta C; Zorzet S; Durigutto P; Botto M; Tedesco F. 2016. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. 10346. PubMed: 26831747 MGI: 237383
Freeley SJ; Popat RJ; Parmar K; Kolev M; Hunt BJ; Stover CM; Schwaeble W; Kemper C; Robson MG. 2016. Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5. (1): 61-71. PubMed: 27235854 MGI: 242639
Kalbitz M; Karbach M; Braumueller S; Kellermann P; Gebhard F; Huber-Lang M; Perl M. 2016. Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI). (7): e0159417. PubMed: 27437704 MGI: 261473
Syed SN; Rau E; Ziegelmann M; Sogkas G; Brune B; Schmidt RE. 2018. C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice. (4): 696-704. PubMed: 29277896 MGI: 283060
Doran AG; Wong K; Flint J; Adams DJ; Hunter KW; Keane TM. 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. (1): 167. PubMed: 27480531 MGI: 289628

Additional - Il3ra^m1

Gainsford T; Roberts AW; Kimura S; Metcalf D; Dranoff G; Mulligan RC; Begley CG; Robb L; Alexander WS. 1998. Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production. (8): 2745-52. PubMed: 9531584 MGI: 47778
Ichihara M; Hara T; Takagi M; Cho LC; Gorman DM; Miyajima A. 1995. Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. (5): 939-50. PubMed: 7889941 MGI: 24096
Hara T; Ichihara M; Takagi M; Miyajima A. 1995. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. (9): 2331-6. PubMed: 7727767 MGI: 25008

Additional - Obq3^AKR/J

Taylor BA; Phillips SJ. 1997. Obesity QTLs on mouse chromosomes 2 and 17. (3): 249-57. PubMed: 9268627 MGI: 40125

Additional - Obq4^AKR/J

Taylor BA; Phillips SJ. 1997. Obesity QTLs on mouse chromosomes 2 and 17. (3): 249-57. PubMed: 9268627 MGI: 40125

Additional - Ogg1^m1

Choi JY; Kim HS; Kang HK; Lee DW; Choi EM; Chung MH. 1999. Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. (7-8): 848-54. PubMed: 10515589 MGI: 60665
Mori M; Toyokuni S; Kondo S; Kasai H; Naiki H; Toichi E; Hosokawa M; Higuchi K. 2001. Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. (10): 1130-6. PubMed: 11369503 MGI: 120556

Additional - Rmcf^s

Hartley JW; Yetter RA; Morse HC 3rd. 1983. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. (1): 16-24. PubMed: 6306133 MGI: 7096
Buller RS; Sitbon M; Portis JL. 1988. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. (5): 1535-46. PubMed: 2835418 MGI: 27558
Jung YT; Lyu MS; Buckler-White A; Kozak CA. 2002. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. (16): 8218-24. PubMed: 12134027 MGI: 79044

Additional - Soat1^ald

Molne K. 1969. Autoradiographic studies on the incorporation of H-uridine into the adrenal glands of mice with spontaneous adrenocortical lipid depletion. A comparison with C57B1 mice. (3): 369-78. PubMed: 4192329 MGI: 5147
Arnesen K. 1963. The cytology of the adrenal cortex in mice with spontaneous adrenocortical lipid depletion. 212-218. MGI: 12128
Taylor BA; Meier H; Whitten WK. 1974. Chromosomal location and site of action of the adrenal lipid depletion gene of the mouse. s65. MGI: 12920
Trigg MJ. 1972. Hair growth in mouse mutants affecting coat texture. 165-198. MGI: 15157
Arnesen K. 1974. Adrenocortical lipid depletion and leukemia in mice. 15-9. PubMed: 4451118 MGI: 30824
Rice RH; Rocke DM; Tsai HS; Silva KA; Lee YJ; Sundberg JP. 2009. Distinguishing mouse strains by proteomic analysis of pelage hair. (9): 2120-5. PubMed: 19295613 MGI: 154585
Giehl KA; Potter CS; Wu B; Silva KA; Rowe LB; Awgulewitsch A; Sundberg JP. 2009. Hair interior defect in AKR/J mice. (4): 509-17. PubMed: 19522984 MGI: 166049
ARNESEN K. 1955. Constitutional difference in lipid content of adrenals in two strains of mice and their hybrids. (4): 396-401. PubMed: 14375655 MGI: 167604
Masterson JC; McNamee EN; Jedlicka P; Fillon S; Ruybal J; Hosford L; Rivera-Nieves J; Lee JJ; Furuta GT. 2011. CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. (5): 2302-14. PubMed: 21945903 MGI: 178436
Wu B; Potter CS; Silva KA; Liang Y; Reinholdt LG; Alley LM; Rowe LB; Roopenian DC; Awgulewitsch A; Sundberg JP. 2010. Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. (11): 2666-8. PubMed: 20574437 MGI: 181953
Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. (12): e51956. PubMed: 23251662 MGI: 196760
Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. MGI: 30414

Technical Support

Contact Technical Support

Genotyping Protocols
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is a good breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- albino
  Related Genotype: a/a Tyr^c/Tyr^c Soat1^ald/Soat1^ald hid/hid

Animal Health Reports

Facility Barrier Level Descriptions

MP16 (Standard)

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Cryorecovery - Pricing

Service	Genotype	Price
	Please inquire

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: AKR, AK

Genetic overview

Research Applications

Base Price

Detailed Description

Selected References

Soat1ald

Allele Symbol: Soat1ald

Obq3AKR/J

Allele Symbol: Obq3AKR/J

Obq4AKR/J

Allele Symbol: Obq4AKR/J

Ahrd

Allele Symbol: Ahrd

Hc0

Allele Symbol: Hc0

Cdh23ahl

Allele Symbol: Cdh23ahl

Il3ram1

Allele Symbol: Il3ram1

Rmcfs

Allele Symbol: Rmcfs

Ogg1m1

Allele Symbol: Ogg1m1

Cd5b

Allele Symbol: Cd5b

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahrd related

Genotype: Cdh23ahl related

Genotype: Hc0 related

Genotype: Il3ram1 related

Mammalian Phenotype Terms by Genotype

Genotype: Ahrd/AhrdAKR

mortality/aging

homeostasis/metabolism phenotype

Genotype: Il3ram1/Il3ram1AKR/J

hematopoietic system phenotype

Genotype: Soat1ald/Soat1aldAKR

integument phenotype

Genotype: Soat1ald/Soat1aldAKR/O

endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype

neoplasm

Phenotype Information

References

Additional References

Additional - Ahrd

Additional - Cd5b

Additional - Cdh23ahl

Additional - Hc0

Additional - Il3ram1

Additional - Obq3AKR/J

Additional - Obq4AKR/J

Additional - Ogg1m1

Additional - Rmcfs

Additional - Soat1ald

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Soat1^ald

Allele Symbol: Soat1^ald

Obq3^AKR/J

Allele Symbol: Obq3^AKR/J

Obq4^AKR/J

Allele Symbol: Obq4^AKR/J

Ahr^d

Allele Symbol: Ahr^d

Hc⁰

Allele Symbol: Hc⁰

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Il3ra^m1

Allele Symbol: Il3ra^m1

Rmcf^s

Allele Symbol: Rmcf^s

Ogg1^m1

Allele Symbol: Ogg1^m1

Cd5^b

Allele Symbol: Cd5^b

Genotype: Ahr^d related

Genotype: Cdh23^ahl related

Genotype: Hc⁰ related

Genotype: Il3ra^m1 related

Genotype: Ahr^d/Ahr^d
AKR

Genotype: Il3ra^m1/Il3ra^m1
AKR/J

Genotype: Soat1^ald/Soat1^ald
AKR

Genotype: Soat1^ald/Soat1^ald
AKR/O

Additional - Ahr^d

Additional - Cd5^b

Additional - Cdh23^ahl

Additional - Hc⁰

Additional - Il3ra^m1

Additional - Obq3^AKR/J

Additional - Obq4^AKR/J

Additional - Ogg1^m1

Additional - Rmcf^s

Additional - Soat1^ald