Overview

Also Known As:whirler

These mice carry the spontaneous mutation, whirler (Whrn^wi) which is maintained in coupling with the brown coat color allele, Tyrp1^b.

Genetic overview

Genetic Background	Generation
000664 C57BL/6J

Whrn^wi

Allele Type	Gene Symbol	Gene Name
Spontaneous	Whrn	whirlin

Allele Type	Gene Symbol	Gene Name
Spontaneous	Tyrp1	tyrosinase-related protein 1

Research Applications

Dermatology Research
Mouse/Human Gene Homologs
Metabolism Research
Neurobiology Research
Sensorineural Research

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Detailed Description

At 9 to 10 days of age Whrn^wi homozygotes display increased activity, decreased ability to right their selves, and are generally smaller than unaffected siblings. By 14 to 16 days of age homozygotes display head bobbing, circling, and an unsteady gate. Adults display head tossing and circling behavior and deafness is indicated by 20 days of age. Sackler and Weltman reported the average number of circles by a prodded 12-week old female homozygote to be 407 in 10 minutes. They found female homozygotes to have an increased metabolic rate and adrenocorticosteroid activity and decreased body weights. Homozygous males were reported to have decreased blood glucose and liver glycogen levels, decreased white blood cell and eosinophil counts, increased plasma albumin levels, and decreased globulin levels, in addition to decreased weight and increased food intake. (Lane 1963; Sackler and Weltman 1967, 1970, 1971.)

While the organ of Corti in whirler homozygotes shows normal gross cellular architecture at postnatal day (P) 35, stereocilia are shorter and stubbier. The inner hair cells have shorter stereocila as early as embryonic day (E) 18.5, are less than half the length of wild type by P5, and the normal graded variation in length and width along stereocilia ranks is diminished. While normal outer hair cell stereocillia develop a W-shaped array of ranks with a basal to apical increase in length, the outer hair cell stereocilia in whirler homozygotes develop a U-shaped or V-shaped array and the variation in length is diminished. The outer hair cells begin to degenerate by P60 while inner hair cells take longer to show degeneration, but both are undergoing degeneration by P80. (Kiernan et al., 1998; Holme et al., 2002.)

Development

The wi mutation arose spontaneously in approximately 1955 in a multiple recessive stock homozygous for a, Tyrp1^b, Myo5a^d, Oca2^p, and Ednrb^s in the laboratory of Dr. Meredith N. Runner. This was the HO stock received from Dr. Holman. The phenotype was initially identified in a single male that was then outcrossed to C57BL/6J and the offspring were intercrossed once, non-sibling intercrossed once, then sibling mated to F5 before being maintained by backcross-intercross to C57BL/6J until N7. They were then maintained primarily by sibling intercross with occasional backcross to a parent until they were transferred to Dr. Eva Eicher in 1971. This strain has been maintained with Whrn^wi in coupling with Tyrp1^b from the original stock background on which the Whrn^wi mutation arose. In 1981 N15F8 Whrn^wi Tyrp1^b/Whrn^wi Tyrp1^b males were bred with C57BL/6J females to generate embryos for cryopreservation.

Selected References

Lane PW. 1963. Whirler mice, a recessive behavior mutation in linkage group VIII J Hered 54:263-6PubMed: 14098314 MGI: J:269

View All References

Genetics

Whrn^wi

Allele Symbol: Whrn^wi

Allele Name	whirler
Allele Type	Spontaneous
Allele Synonym(s)	wi
Gene Symbol and Name	Whrn, whirlin
Gene Synonym(s)
Strain of Origin	STOCK a Tyrp1^b Myo5a^d Oca2^p Ednrb^s
Chromosome	4
General Note	They have defects of the membranous labyrinth similar to those of Myo15 (M.S. Deol, personal communication).
Molecular Note	The mutation was identified as a 526 bp deletion encompassing the first putative methionine of the short C-terminal isoform and part of the long isoform. This creates a frameshift resulting in premature termination of the long isoform before the third PDZ domain. This deletion encompasses the majority of exons 6-10 of the gene, thus resulting in the ablation of both the long (WHRN-L) and the short (WHRN-S) isoforms.

Tyrp1^b

Allele Symbol: Tyrp1^b

Allele Name	brown
Allele Type	Spontaneous
Allele Synonym(s)	b
Gene Symbol and Name	Tyrp1, tyrosinase-related protein 1
Gene Synonym(s)
Strain of Origin	old mutant of the mouse fancy
Chromosome	4
Molecular Note	A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation changes cysteine to tyrosine at position 110 (p.C110Y) in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype.

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

autosomal recessive nonsyndromic deafness 31

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Tyrp1^b related

Dermatology Research
- Color and White Spotting Defects
Mouse/Human Gene Homologs
- oculocutaneous albinism type III

Genotype: Whrn^wi related

Metabolism Research
- Exertion Related
Neurobiology Research
- Hearing Defects
- Vestibular Defects
Sensorineural Research
- Hearing Defects
- Vestibular Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Whrn^wi/Whrn^wi
involves: C57BL/6J * STOCK a Tyrp1 Myo5a Oca2
Ednrb

adipose tissue phenotype

decreased total body fat amount
there is a noticeable deficiency of adipose tissue in the abdominal cavity
(MGI Ref ID J:5538)

renal/urinary system phenotype

increased kidney weight
the kidney weight at 3.5 and 10 months in female mutants is significantly higher
(MGI Ref ID J:5037)
this difference is no longer significant at 18 months
(MGI Ref ID J:5037)

reproductive system phenotype

decreased seminal vesicle weight
the seminal vesicle weight at 16 weeks in male mutants is significantly smaller
(MGI Ref ID J:5538)

decreased uterus weight
the uterine weight at 3.5 months in female mutants is significantly smaller
(MGI Ref ID J:5037)
there is no significant difference at 10 and 18 months
(MGI Ref ID J:5037)

cardiovascular system phenotype

increased heart weight
the heart weight at 16 weeks in male mutants is significantly larger
(MGI Ref ID J:5538)

endocrine/exocrine gland phenotype

decreased seminal vesicle weight
the seminal vesicle weight at 16 weeks in male mutants is significantly smaller
(MGI Ref ID J:5538)

decreased thymus weight
the thymus weight at 3.5 and 18 months in female mutants is significantly lower
(MGI Ref ID J:5037)

enlarged adrenal glands
the adrenal weight at 16 weeks in male mutants is significantly higher
(MGI Ref ID J:5538)
the adrenal weight at 3.5, 10, and 18 months in female mutants is significantly higher
(MGI Ref ID J:5037)

behavior/neurological phenotype

abnormal gait
at P14 to P16 the gait is unsteady and mutants constantly topple over
(MGI Ref ID J:269)

abnormal maternal nurturing
females tend to trample their young
(MGI Ref ID J:269)

circling
(MGI Ref ID J:269)

head bobbing
(MGI Ref ID J:48657)
this behavior is noticeable at P14 to P16
(MGI Ref ID J:269)

head tossing
(MGI Ref ID J:5037)
this behavior is seen in adults
(MGI Ref ID J:269)

hyperactivity
mutants are restless and excitable
(MGI Ref ID J:5037)

impaired righting response
at P9 to P10 when placed on their backs mutants take longer to return to an upright position
(MGI Ref ID J:269)

impaired swimming
adults can not swim
(MGI Ref ID J:269)
some mutants at weaning age can swim if the head is not submerged
(MGI Ref ID J:269)

growth/size/body region phenotype

decreased body weight
at P9 to P10 and P14 to P16 mutants are smaller
(MGI Ref ID J:269)
the body weight at 13 to 16 weeks in male mutants is significantly lower
(MGI Ref ID J:5538)
the body weight at 3.5 and 18 months in female mutants is significantly lower
(MGI Ref ID J:5037)

increased heart weight
the heart weight at 16 weeks in male mutants is significantly larger
(MGI Ref ID J:5538)

increased kidney weight
the kidney weight at 3.5 and 10 months in female mutants is significantly higher
(MGI Ref ID J:5037)
this difference is no longer significant at 18 months
(MGI Ref ID J:5037)

increased liver weight
the liver weight at 3.5 and 10 months in female mutants is significantly higher
(MGI Ref ID J:5037)
this difference is no longer significant at 18 months
(MGI Ref ID J:5037)

hearing/vestibular/ear phenotype

abnormal cochlear hair cell stereociliary bundle morphology
the specialized microvilli (stereocilia) that project from the apical surface of the inner and outer hair cells are abnormal
(MGI Ref ID J:77939)

abnormal cochlear inner hair cell morphology
from P5 up to P40, all IHCs along the entire length of the cochlea are similarly affected, with many abnormal stereocilia
(MGI Ref ID J:48657)

abnormal cochlear outer hair cell morphology
most outer hair cells exhibit a non-convex region on their apical circumference unlike wild-type cells
(MGI Ref ID J:158897)
outer hair cells exhibit a slight flattening of their neural sides compared to in wild-type mice
(MGI Ref ID J:158897)

abnormal outer hair cell stereociliary bundle morphology
an increase in diameter and variable heights within bundles
(MGI Ref ID J:122600)
at P10, the extra OHC microvilli in the center of the W-shape have not yet cleared totally in the apical turn but have disappeared in the basal turn, while kinocilia are still present but regress by P15
(MGI Ref ID J:48657)
at P5 (but not at P3), the center of the developing W-shape of OHC stereocilia still contains excess microvilli which have not yet been absorbed, indicating delayed development of OHC stereociliary bundles
(MGI Ref ID J:48657)
in mutants on P15 and P35 stereocilia height within a rank of outer hair cells is irregular instead of uniform
(MGI Ref ID J:77939)
on P4 the stereocilia are arranged in a U-shaped pattern rather than the normal W-shaped pattern
(MGI Ref ID J:77939)
outer hair bundles exhibit a linear rather than V-shaped configuration unlike in wild-type mice
(MGI Ref ID J:158897)
outer hair cells appear normal until P4
(MGI Ref ID J:77939)

cochlear hair cell degeneration
at P80, both IHCs and OHCs are degenerating
(MGI Ref ID J:48657)

cochlear inner hair cell degeneration
at P60, IHCs have still not degenerated or developed further; however, IHCs are degenerating at P80
(MGI Ref ID J:48657)
by P80 both outer hair cells and inner hair cells in the base of the cochlear duct are degenerating
(MGI Ref ID J:77939)

cochlear outer hair cell degeneration
although apparently normal at P15, OHCs start showing signs of degeneration from P60 onwards
(MGI Ref ID J:48657)
by P60 outer hair cells are showing signs of degeneration
(MGI Ref ID J:77939)
by P80 both outer hair cells and inner hair cells in the base of the cochlear duct are degenerating
(MGI Ref ID J:77939)
by P80 only outer hair cells are degenerating in the apex of the cochlear duct
(MGI Ref ID J:77939)

deafness
(MGI Ref ID J:48657)
adults are deaf
(MGI Ref ID J:269)

decreased outer hair cell stereocilia number
the center-to-center spacing between the stereocilia was greater
(MGI Ref ID J:122600)
the number of outer hair cell stereocilia was sgnificantly reduced
(MGI Ref ID J:122600)

short inner hair cell stereocilia
from P5 onwards, IHCs are abnormal with many short, stubby stereocilia, although the kinocilium is correctly positioned and of normal length
(MGI Ref ID J:48657)
however in mutants the stereocilia at the center of a rank are still significantly taller than those on the edge as is seen in controls
(MGI Ref ID J:77939)
overall the stereocilia of inner hair cells in mutants are significantly shorter at E18.5, P1, and P35
(MGI Ref ID J:77939)
stereocilia of inner hair cells are short with larger diameters without a corresponding increase in the number of actin filaments at P20
(MGI Ref ID J:122600)
the length of stereocilia on inner hair cells in mutants decreases between P1 and P4 and between P4 and P35 rather than increasing
(MGI Ref ID J:77939)
the morphological differences between stereocilia in different ranks of inner hair cells are not as prominent in mutants at P35
(MGI Ref ID J:77939)

short outer hair cell stereocilia
(MGI Ref ID J:158897)

hematopoietic system phenotype

decreased leukocyte cell number
the white blood cell counts are significantly smaller at 15 weeks in male mutants
(MGI Ref ID J:5538)

decreased thymus weight
the thymus weight at 3.5 and 18 months in female mutants is significantly lower
(MGI Ref ID J:5037)

homeostasis/metabolism phenotype

decreased circulating glucose level
the blood glucose levels are significantly lower at 16 weeks in male mutants
(MGI Ref ID J:5538)

decreased liver glycogen level
liver glycogen and liver phosphorylase levels are significantly lower at 16 weeks in male mutants
(MGI Ref ID J:5538)

increased circulating corticosterone level
consistent and significantly higher corticosterone levels in the plasma and adrenals
(MGI Ref ID J:5538)
corticosterone levels are higher in the adrenals when comparing per pair of adrenals or per 100 mg adrenals
(MGI Ref ID J:5538)

increased oxygen consumption
free and semi-restrained O₂ consumption is increased at 12 and 14 weeks and 14 months
(MGI Ref ID J:5037)
free and semi-restrained O₂ consumption is increased at 13 and 14 weeks respectively
(MGI Ref ID J:5538)

immune system phenotype

decreased leukocyte cell number
the white blood cell counts are significantly smaller at 15 weeks in male mutants
(MGI Ref ID J:5538)

decreased thymus weight
the thymus weight at 3.5 and 18 months in female mutants is significantly lower
(MGI Ref ID J:5037)

liver/biliary system phenotype

decreased liver glycogen level
liver glycogen and liver phosphorylase levels are significantly lower at 16 weeks in male mutants
(MGI Ref ID J:5538)

increased liver weight
the liver weight at 3.5 and 10 months in female mutants is significantly higher
(MGI Ref ID J:5037)
this difference is no longer significant at 18 months
(MGI Ref ID J:5037)

nervous system phenotype

abnormal cochlear hair cell stereociliary bundle morphology
the specialized microvilli (stereocilia) that project from the apical surface of the inner and outer hair cells are abnormal
(MGI Ref ID J:77939)

abnormal cochlear inner hair cell morphology
from P5 up to P40, all IHCs along the entire length of the cochlea are similarly affected, with many abnormal stereocilia
(MGI Ref ID J:48657)

abnormal cochlear outer hair cell morphology
most outer hair cells exhibit a non-convex region on their apical circumference unlike wild-type cells
(MGI Ref ID J:158897)
outer hair cells exhibit a slight flattening of their neural sides compared to in wild-type mice
(MGI Ref ID J:158897)

abnormal outer hair cell stereociliary bundle morphology
an increase in diameter and variable heights within bundles
(MGI Ref ID J:122600)
at P10, the extra OHC microvilli in the center of the W-shape have not yet cleared totally in the apical turn but have disappeared in the basal turn, while kinocilia are still present but regress by P15
(MGI Ref ID J:48657)
at P5 (but not at P3), the center of the developing W-shape of OHC stereocilia still contains excess microvilli which have not yet been absorbed, indicating delayed development of OHC stereociliary bundles
(MGI Ref ID J:48657)
in mutants on P15 and P35 stereocilia height within a rank of outer hair cells is irregular instead of uniform
(MGI Ref ID J:77939)
on P4 the stereocilia are arranged in a U-shaped pattern rather than the normal W-shaped pattern
(MGI Ref ID J:77939)
outer hair bundles exhibit a linear rather than V-shaped configuration unlike in wild-type mice
(MGI Ref ID J:158897)
outer hair cells appear normal until P4
(MGI Ref ID J:77939)

cochlear hair cell degeneration
at P80, both IHCs and OHCs are degenerating
(MGI Ref ID J:48657)

cochlear inner hair cell degeneration
at P60, IHCs have still not degenerated or developed further; however, IHCs are degenerating at P80
(MGI Ref ID J:48657)
by P80 both outer hair cells and inner hair cells in the base of the cochlear duct are degenerating
(MGI Ref ID J:77939)

cochlear outer hair cell degeneration
although apparently normal at P15, OHCs start showing signs of degeneration from P60 onwards
(MGI Ref ID J:48657)
by P60 outer hair cells are showing signs of degeneration
(MGI Ref ID J:77939)
by P80 both outer hair cells and inner hair cells in the base of the cochlear duct are degenerating
(MGI Ref ID J:77939)
by P80 only outer hair cells are degenerating in the apex of the cochlear duct
(MGI Ref ID J:77939)

decreased outer hair cell stereocilia number
the center-to-center spacing between the stereocilia was greater
(MGI Ref ID J:122600)
the number of outer hair cell stereocilia was sgnificantly reduced
(MGI Ref ID J:122600)

short inner hair cell stereocilia
from P5 onwards, IHCs are abnormal with many short, stubby stereocilia, although the kinocilium is correctly positioned and of normal length
(MGI Ref ID J:48657)
however in mutants the stereocilia at the center of a rank are still significantly taller than those on the edge as is seen in controls
(MGI Ref ID J:77939)
overall the stereocilia of inner hair cells in mutants are significantly shorter at E18.5, P1, and P35
(MGI Ref ID J:77939)
stereocilia of inner hair cells are short with larger diameters without a corresponding increase in the number of actin filaments at P20
(MGI Ref ID J:122600)
the length of stereocilia on inner hair cells in mutants decreases between P1 and P4 and between P4 and P35 rather than increasing
(MGI Ref ID J:77939)
the morphological differences between stereocilia in different ranks of inner hair cells are not as prominent in mutants at P35
(MGI Ref ID J:77939)

short outer hair cell stereocilia
(MGI Ref ID J:158897)

Genotype: Whrn^wi/Whrn⁺
involves: C57BL/6J * STOCK a Tyrp1 Myo5a Oca2
Ednrb

hearing/vestibular/ear phenotype

abnormal cochlear inner hair cell morphology
(MGI Ref ID J:77939)

short inner hair cell stereocilia
by P80 no hair cells are degenerating in the cochlear duct of heterozygotes unlike in homozygotes
(MGI Ref ID J:77939)
the stereocilia of inner hair cells in heterozygotes are slightly shorter at P35
(MGI Ref ID J:77939)

nervous system phenotype

abnormal cochlear inner hair cell morphology
(MGI Ref ID J:77939)

short inner hair cell stereocilia
by P80 no hair cells are degenerating in the cochlear duct of heterozygotes unlike in homozygotes
(MGI Ref ID J:77939)
the stereocilia of inner hair cells in heterozygotes are slightly shorter at P35
(MGI Ref ID J:77939)

Genotype: Whrn^wi/Whrn^wi
involves: STOCK a Tyrp1 Myo5a Oca2
Ednrb

behavior/neurological phenotype

circling
(MGI Ref ID J:235390)

head bobbing
(MGI Ref ID J:235390)

impaired righting response
when placed on their backs, adult mice take several seconds to right themselves
(MGI Ref ID J:235390)

nervous system phenotype

abnormal outer hair cell stereociliary bundle morphology
at P21, OHC stereocilia bundles appear rounded (U- rather than W-shaped) and show irregular spacing between stereocilia rows relative to controls
(MGI Ref ID J:235390)

absent cochlear microphonics
at P13-P20, cochlear microphonics responses are below detection limits, within the noise floor
(MGI Ref ID J:235390)

absent cochlear nerve compound action potential
at P20, mice exhibit no compound action potentials (CAPs) even at the highest stimulus intensities used
(MGI Ref ID J:235390)

short cochlear hair cell stereocilia
hair cell stereocilia are shorter than in wild-type mice
(MGI Ref ID J:132633)

short inner hair cell stereocilia
at P21, IHC stereocilia are abnormally short
(MGI Ref ID J:235390)

short vestibular hair cell stereocilia
at P21, vestibular stereocilia are consistently shorter than in controls across all hair cells
(MGI Ref ID J:235390)
the length of tallest stereocilia in both the extrastriolar and striolar regions is reduced by ~80% relative to controls
(MGI Ref ID J:235390)

hearing/vestibular/ear phenotype

abnormal auditory summating potential
at P13-P20, summating potentials are detected in 27 of 28 mice studied, albeit at high stimulus intensities, suggesting that some hair cells can depolarize in response to sound
(MGI Ref ID J:235390)

abnormal outer hair cell stereociliary bundle morphology
at P21, OHC stereocilia bundles appear rounded (U- rather than W-shaped) and show irregular spacing between stereocilia rows relative to controls
(MGI Ref ID J:235390)

absent cochlear microphonics
at P13-P20, cochlear microphonics responses are below detection limits, within the noise floor
(MGI Ref ID J:235390)

absent cochlear nerve compound action potential
at P20, mice exhibit no compound action potentials (CAPs) even at the highest stimulus intensities used
(MGI Ref ID J:235390)

deafness
adult mice are profoundly deaf
(MGI Ref ID J:235390)

increased or absent threshold for auditory brainstem response
at P20 and P98, mice fail to show any auditory brainstem response (ABR) to the highest sound stimulus used
(MGI Ref ID J:235390)

short cochlear hair cell stereocilia
hair cell stereocilia are shorter than in wild-type mice
(MGI Ref ID J:132633)

short inner hair cell stereocilia
at P21, IHC stereocilia are abnormally short
(MGI Ref ID J:235390)

short vestibular hair cell stereocilia
at P21, vestibular stereocilia are consistently shorter than in controls across all hair cells
(MGI Ref ID J:235390)
the length of tallest stereocilia in both the extrastriolar and striolar regions is reduced by ~80% relative to controls
(MGI Ref ID J:235390)

References

Lane PW. 1963. Whirler mice, a recessive behavior mutation in linkage group VIII J Hered 54:263-6PubMed: 14098314 MGI: J:269

Additional References
Fleming J; Rogers MJ; Brown SD; Steel KP. 1994. Linkage analysis of the whirler deafness gene on mouse chromosome 4. Genomics 21(1):42-8PubMed: 8088814 MGI: J:18269
Mburu P; Mustapha M; Varela A; Weil D; El-Amraoui A; Holme RH; Rump A; Hardisty RE; Blanchard S; Coimbra RS; Perfettini I; Parkinson N; Mallon AM; Glenister P; Rogers MJ; Paige AJ; Moir L; Clay J; Rosenthal A; Liu XZ; Blanco G; Steel KP; Petit C; Brown SD. 2003. Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Nat Genet 34(4):421-8PubMed: 12833159 MGI: J:86904
Sackler AM; Weltman AS. 1967. Metabolic and endocrine differences between the mutation whirler and normal female mice. J Exp Zool 164(2):133-40PubMed: 6034501 MGI: J:5037

Additional - Tyrp1^b related
Additional - Whrn^wi related

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Citation
When using the whirler mouse strain in a publication, please cite the originating article(s) and include JAX stock #000571 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

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Live Mouse

Age Genotype Price

weeks

Cryorecovery - Pricing

Service/Product Description Price

Heterozygous for Whrn<wi>, Heterozygous for Tyrp1<b>

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Also Known As:whirler

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Selected References

Whrnwi

Allele Symbol: Whrnwi

Tyrp1b

Allele Symbol: Tyrp1b

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Tyrp1b related

Genotype: Whrnwi related

Mammalian Phenotype Terms by Genotype

Genotype: Whrnwi/Whrnwiinvolves: C57BL/6J * STOCK a Tyrp1 Myo5a Oca2 Ednrb

adipose tissue phenotype

renal/urinary system phenotype

reproductive system phenotype

cardiovascular system phenotype

endocrine/exocrine gland phenotype

behavior/neurological phenotype

growth/size/body region phenotype

hearing/vestibular/ear phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

liver/biliary system phenotype

nervous system phenotype

Genotype: Whrnwi/Whrn+involves: C57BL/6J * STOCK a Tyrp1 Myo5a Oca2 Ednrb

hearing/vestibular/ear phenotype

nervous system phenotype

Genotype: Whrnwi/Whrnwiinvolves: STOCK a Tyrp1 Myo5a Oca2 Ednrb

behavior/neurological phenotype

nervous system phenotype

hearing/vestibular/ear phenotype

References

Additional References

Additional - Tyrp1b related

Additional - Whrnwi related

Genotyping Protocols

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Whrn^wi

Allele Symbol: Whrn^wi

Tyrp1^b

Allele Symbol: Tyrp1^b

Genotype: Tyrp1^b related

Genotype: Whrn^wi related

Genotype: Whrn^wi/Whrn^wi
involves: C57BL/6J * STOCK a Tyrp1 Myo5a Oca2
Ednrb

Genotype: Whrn^wi/Whrn⁺
involves: C57BL/6J * STOCK a Tyrp1 Myo5a Oca2
Ednrb

Genotype: Whrn^wi/Whrn^wi
involves: STOCK a Tyrp1 Myo5a Oca2
Ednrb

Additional - Tyrp1^b related

Additional - Whrn^wi related