A 7 base pair deletion was reported in the Cd4 5' untranslated region of Stock No. 000550, MOLF/EiJ (Wade et al., 1993, Capparelli et al., 2004). Subsequent testing at The Jackson Laboratory indicated that MOLC/EiJ, MOLD/EiJ and MOLG/EiJ also carry the variant sequence. The deletion is not believed to affect expression.
In 2019-2020, researchers at The Jackson Laboratory discovered this inbred strain contains the Trem2S148E allele - a naturally occurring variant at position 48351151-48351152 on Chr 17 (rs108080490 and rs107649577; Ensembl GRCm38.p6). This TC to GA transition results in a serine to glutamic acid substitution at amino acid 148 (S148E).
In 1969 Dr. Michael Potter at NCI sent 10 M. m. molossinus from a population that was within 1 to 3 generations of the wild population captured in Fukuoka, Kyushu, Japan to Dr. Eva Eicher and Dr Thomas Roderick at The Jackson Laboratory. Dr. Roderick generated three inbred lines from single pairings of these mice and named them MOLC/Rk, MOLD/Rk, and MOLE/Rk. MOLC/Rk derived from the line he designated MOL 3-I, and MOLD/Rk and MOLE/Rk derived from the line designated MOL 3-III. MOLG/DnJ was split off as a substrain from MOLC/Rk at F14. (Roderick, 1982.)
Currently there are no related genes or alleles for this strain.
These mice are small and may need to delay weaning until 4+ weeks.
When using the MOLG/DnJ mouse strain in a publication, please include JAX stock #000555 in your Materials and Methods section.