These mice carry two linked, spontaneous mutations, waved 2 (Egfrwa2) and vestigial tail (Wnt3avt); they display curly whiskers and short tails.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Egfr | epidermal growth factor receptor |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | a | nonagouti |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Hypomorph) | Wnt3a | wingless-type MMTV integration site family, member 3A |
Mice homozygous for the spontaneous waved 2 mutation (Egfrwa2) are recognizable at 2 to 3 days by curly whiskers. The first coat is waved but later coats are not; vibrissae usually remain curled and the guard hairs curved. Some homozygotes have eyelids open at birth. Fertile mutant females have impaired lactation. Mice homozygous for the vestigial tail spontaneous mutation (Wnt3avt) have very short tails, few presacral vertebrae, and abnormal formation of the lumbar vertebrae.
The vt mutation in Wnt3a arose spontaneously in the C57BR background.
Allele Name | waved 2 |
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Allele Type | Spontaneous |
Allele Synonym(s) | wa2; wa-2; waved2 |
Gene Symbol and Name | Egfr, epidermal growth factor receptor |
Gene Synonym(s) | |
Strain of Origin | STOCK ac |
Chromosome | 11 |
General Note | Found by Keeler in an ``abnormal corpus callosum'' stock at the Bussey Institution. |
Molecular Note | A T-to-G transversion mutation in the sequences encoding the tyrosine kinase domain results in a substitution of a highly conserved valine with glycine at position 767 (P.V767G) in the third kinase subdomain. |
Allele Name | wild-type agouti |
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Allele Type | Spontaneous |
Allele Synonym(s) | dark-bellied agouti |
Gene Symbol and Name | a, nonagouti |
Gene Synonym(s) | |
Strain of Origin | various |
Chromosome | 2 |
General Note | The A allele is usually regarded as a wild-type allele. For example,the C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back. |
Molecular Note | This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. |
Allele Name | vestigial tail |
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Allele Type | Spontaneous (Hypomorph) |
Allele Synonym(s) | vt |
Gene Symbol and Name | Wnt3a, wingless-type MMTV integration site family, member 3A |
Gene Synonym(s) | |
Strain of Origin | C57BR |
Chromosome | 11 |
Molecular Note | Examination of the Wnt3a gene by Southern blot, Northern blot on adult lung tissue and cDNA sequence analysis revealed no sign of an obvious mutation that could account for a mutant phenotype. However, this mutation and a targeted mutation, Wnt3atm1Amc, were demonstrated to be noncomplemeting alleles. Further evidence from whole mount in situ hybridization studies on embryos demonstrated that expression of the encoded protein is reduced in homozygous embryos, suggesting that this hypomorphic allele results from a mutation in a regulatory element. |
When using the B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000553 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for <wa2>, Heterozygous for Wnt3a<vt> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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