The rough coat (Mpzl3rc) mutation is recessive and fully penetrant. Homozygotes have an unkempt coat appearance and gradual hair loss that becomes extensive. As early as two weeks of age, thinning fur can be seen, and the hair becomes brittle, clumpy and oily in appearance. Homozygotes are fertile. (Lane 1966; Ruvinsky et al., 2002.)
The Mpzl3rc mutation arose spontaneously in 1964 in the C57BL/6J background at The Jackson Laboratory. In 1981 C57BL/6J females were bred with homozygous males at F41 and F42 to generate embryos for cryopreservation.
|Allele Name||rough coat|
|Gene Symbol and Name||Mpzl3, myelin protein zero-like 3|
|Strain of Origin||C57BL/6J|
|Molecular Note||A G-to-A transition was identified in exon 3. This results in an arginine to glutamine substitution at amino acid residue 100 (p.R100Q).|