These mice carry a spontaneous mutation at the Mpzl3 locus characterized by gradual hair loss.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Mpzl3 | myelin protein zero-like 3 |
The rough coat (Mpzl3rc) mutation is recessive and fully penetrant. Homozygotes have an unkempt coat appearance and gradual hair loss that becomes extensive. As early as two weeks of age, thinning fur can be seen, and the hair becomes brittle, clumpy and oily in appearance. Homozygotes are fertile. (Lane 1966; Ruvinsky et al., 2002.)
The Mpzl3rc mutation arose spontaneously in 1964 in the C57BL/6J background at The Jackson Laboratory. In 1981 C57BL/6J females were bred with homozygous males at F41 and F42 to generate embryos for cryopreservation.
Allele Name | rough coat |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Mpzl3, myelin protein zero-like 3 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 9 |
Molecular Note | A G-to-A transition was identified in exon 3. This results in an arginine to glutamine substitution at amino acid residue 100 (p.R100Q). |
When using the rough coat mouse strain in a publication, please cite the originating article(s) and include JAX stock #000540 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Mpzl3<rc> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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