These mice carry the spontaneous, autosomal recessive mutation, plucked (pk) characterized by loss of truncal hair. Adult mutant mice lose truncal hair because of the scarring of follicles due to an apparent obstruction of the outward movement of the hair shaft within the follicular canal.Read More +
Plucked mice have short or absent whiskers at birth. The skin becomes thickened, folded, and darkly pigmented, and the first coat is delayed until about 11 days, when a thick coat of short irregular hairs appears. The same sequence is repeated in later cycles. The distal ends of all hair types are missing, and the proximal parts are variably irregular in structure. Sebaceous glands enlarge abnormally, and the internal root sheath regresses prematurely.
Plucked (pk) arose spontaneously in strain DBA/2J at F76 at The Jackson Laboratory in 1963. It was outcrossed to C57BL/6J and continually backcrossed onto the C57BL/6J background to N12 in 1971. It was then sibling mated by forced heterozygosity until 1975 when it was backcrossed continually onto strain C57BL/6JEi. Embryos were generated for cryopreservation in 1982 by mating C57BL/6J females with males either homozygous or heterozgyous for the plucked mutation, which were at generation N12F24.