The balding (Dsg3bal) mutation of the mouse is an autosomal recessive mutation that causes alopecia and immunologic anomalies.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Dsg3 | desmoglein 3 |
The balding (Dsg3bal) mutation of the mouse is an autosomal recessive mutation that causes alopecia and immunologic anomalies.
The mutation arose spontaneously in the C57BL/6J inbred strain. Embryos produced by mating heterozygous C57BL/6J-Dsg3bal/J males to C57BL/6J females were cryopreserved in 1983.
Allele Name | balding |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | Dsg3bal-J |
Gene Symbol and Name | Dsg3, desmoglein 3 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 18 |
Molecular Note | This mutation was identified as an insertion of a thymidine residue in exon 14. The insertion causes a frameshift that results in a premature stop codon 78 bp downstream of the insertion. Antibodies to both extracellular and intracellular epitopes failed to stain epithelium of homozygous mutant mice, suggesting that any protein that may be synthesized is not inserted into the plasma membrane and/or is rapidly degraded. |
While maintaining a live colony, these mice are bred as a heterozygote x heterozygote or heterozygote x homozygote mating. Female homozygotes are usually poor breeders. Homozygotes are smaller and may have extreme loss of fur; recommendation is to wean at 4 weeks of age and provide powdered food if necessary.
When using the balding mouse strain in a publication, please cite the originating article(s) and include JAX stock #000519 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Dsg3<bal> |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.