B6D2-Sox18^Ra-Op/J

Stock number: 000508
Product name: opossum
Research areas: Dermatology Research

Description

These mice carry a spontaneous mutation at the Sox18 locus characterized by a delayed coat development, failure of skin darkening, and paucity of fur.

Detailed description

The Sox18^Ra-Op allele causes a more severe phenotype than either the Sox18^Ra or Sox18^Ra-J allele. Green and Mann determined that only approximately 17% of the Sox18^Ra-Op/+ heterozygotes are born and survive to wean age. Heterozygotes have a deficiency of vibrissae, a distinguishing feature in utero and usually evident at birth, and can be distinguished at three days of age by their pink skin which, with its delayed coat development, fails to darken like that of wildtype siblings. A paucity of fur is apparent by 9 days of age and persists throughout life. Heterozygotes are smaller in overall size and many of those that die shortly after birth are cyanotic and edematous. Dead pups have glossy skin with red patches that may result from superficial hemorrhages. Homozygotes die by embryonic day 11.5. (Green and Mann, 1961; Mann, 1963.)

Allele

Symbol: Sox18^Ra-Op
Name: opossum
MGI accession ID: MGI:1856136
Generation method: Spontaneous
Marker symbol: Sox18
Marker name: SRY (sex determining region Y)-box 18
Chromosome: 2
Strain of origin: (C57BL/6J x DBA/2J)F1
Molecular note: The mutation was identified as a deletion of a single cytosine at nucleotide 1048.