These mice carry a spontaneous mutation at the Sox18 locus characterized by a delayed coat development, failure of skin darkening, and paucity of fur.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Sox18 | SRY (sex determining region Y)-box 18 |
The Sox18Ra-Op allele causes a more severe phenotype than either the Sox18Ra or Sox18Ra-J allele. Green and Mann determined that only approximately 17% of the Sox18Ra-Op/+ heterozygotes are born and survive to wean age. Heterozygotes have a deficiency of vibrissae, a distinguishing feature in utero and usually evident at birth, and can be distinguished at three days of age by their pink skin which, with its delayed coat development, fails to darken like that of wildtype siblings. A paucity of fur is apparent by 9 days of age and persists throughout life. Heterozygotes are smaller in overall size and many of those that die shortly after birth are cyanotic and edematous. Dead pups have glossy skin with red patches that may result from superficial hemorrhages. Homozygotes die by embryonic day 11.5. (Green and Mann, 1961; Mann, 1963.)
Allele Name | opossum |
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Allele Type | Spontaneous |
Allele Synonym(s) | Op; RaOp |
Gene Symbol and Name | Sox18, SRY (sex determining region Y)-box 18 |
Gene Synonym(s) | |
Strain of Origin | (C57BL/6J x DBA/2J)F1 |
Chromosome | 2 |
Molecular Note | The mutation was identified as a deletion of a single cytosine at nucleotide 1048. |
Homozygotes are embryonic lethal. Heterozygous females are poor breeders, and some heterozygotes may die at birth. When maintaining a live colony, wildtype females from the colony may be bred to heterozygous males.
When using the opossum mouse strain in a publication, please cite the originating article(s) and include JAX stock #000508 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Ra-Op> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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