These congenic mice carry the Y Chromosome responsible for accelerated autoimmune disease from the SB/Le strain on a C57BL/6J genetic background.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Yaa | accelerated autoimmunity and lymphoproliferation transposition |
The Yaa gene, present on the Y chromosome in BXSB mice, is responsible for accelerated autoimmune disease. However, C57BL/6J mice carrying the Yaa gene do not demonstrate this autoimmune disease, and are indistinguishable from wildtype controls. A lupus-like syndrome can be seen in male F1 hybrids obtained by crossing male C57BL/6J mice carrying the Yaa gene with NZW females. Thus, the Yaa gene may not be sufficient to induce accelerated autoimmunity unless present on a susceptible genetic background.
The Y chromosome from SB/Le was backcrossed onto C57BL/6J until reaching N9. From that point on, it has been maintained by sibling mating.
Allele Name | accelerated autoimmunity and lymphoproliferation |
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Allele Type | Spontaneous |
Allele Synonym(s) | Is(XOfd1-Mid1;Y)1Mp; Tp(X;Y)1Ekw |
Gene Symbol and Name | Yaa, accelerated autoimmunity and lymphoproliferation transposition |
Gene Synonym(s) | |
Strain of Origin | SB/Le |
Chromosome | Y |
Molecular Note | An approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells. |
When using the B6.SB-Yaa/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000483 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for a, Y linked Hemizygous males or Wildtype females |
Frozen Mouse Embryo | B6.SB-Yaa/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.SB-Yaa/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.SB-Yaa/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.SB-Yaa/J Frozen Embryos | $3373.50 |
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