B6.SB-Yaa/J

Stock number: 000483
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

These congenic mice carry the Y Chromosome responsible for accelerated autoimmune disease from the SB/Le strain on a C57BL/6J genetic background.

Detailed description

The Yaa gene, present on the Y chromosome in BXSB mice, is responsible for accelerated autoimmune disease. However, C57BL/6J mice carrying the Yaa gene do not demonstrate this autoimmune disease, and are indistinguishable from wildtype controls. A lupus-like syndrome can be seen in male F1 hybrids obtained by crossing male C57BL/6J mice carrying the Yaa gene with NZW females. Thus, the Yaa gene may not be sufficient to induce accelerated autoimmunity unless present on a susceptible genetic background.

Development

The Y chromosome from SB/Le was backcrossed onto C57BL/6J until reaching N9. From that point on, it has been maintained by sibling mating.

Allele

Symbol: Yaa
Name: accelerated autoimmunity and lymphoproliferation
MGI accession ID: MGI:1856277
Generation method: Spontaneous
Synonyms: Is(XOfd1-Mid1;Y)1Mp; Tp(X;Y)1Ekw
Marker symbol: Yaa
Marker name: accelerated autoimmunity and lymphoproliferation transposition
Marker synonyms: Tp(X;Y)1Ekw
Chromosome: Y
Strain of origin: SB/Le
Molecular note: An approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells.