The Yaa gene, present on the Y chromosome in BXSB mice, is responsible for accelerated autoimmune disease. However, C57BL/6J mice carrying the Yaa gene do not demonstrate this autoimmune disease, and are indistinguishable from wildtype controls. A lupus-like syndrome can be seen in male F1 hybrids obtained by crossing male C57BL/6J mice carrying the Yaa gene with NZW females. Thus, the Yaa gene may not be sufficient to induce accelerated autoimmunity unless present on a susceptible genetic background.
The Y chromosome from SB/Le was backcrossed onto C57BL/6J until reaching N9. From that point on, it has been maintained by sibling mating.
|Allele Name||accelerated autoimmunity and lymphoproliferation|
|Allele Synonym(s)||Is(XOfd1-Mid1;Y)1Mp; Tp(X;Y)1Ekw|
|Gene Symbol and Name||Yaa, accelerated autoimmunity and lymphoproliferation transposition|
|Strain of Origin||SB/Le|
|Molecular Note||An approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells.|
When using the B6.SB-Yaa/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000483 in your Materials and Methods section.