This B10 congenic strain carries the H2pa haplotype from a non-inbred stock. It also carries the H2-T18c allele.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | H2-T18 | histocompatibility 2, T region locus 18 |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | H2 | histocompatibility-2, MHC |
Marker Symbol | Marker Name | |
---|---|---|
H2 | histocompatibility-2, MHC |
This B10 congenic strain carries the H2pa haplotype from a non-inbred stock. It also carries the H2-T18c allele.
This is one of the “Congenic Resistant” strains of mice developed by George D. Snell in his studies of histocompatibility. [Snell, G.D. 1978. In Origins of Inbred Mice (H.C. Morse III, ed.). Academic Press, New York.]
The H2pa haplotype, presumably including H2-T18c, from a non-inbred stock designated “Y” was transferred onto C57BL/10Sn by the equivalent of 9 generations of backcrossing before being maintained by sib matings. It was cryopreserved in 1998 at generation N9F118.
Allele Name | c variant |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | Tlac |
Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
Molecular Note | The allele H2-T18c determines presence of specificities TL.2, 7 and occurs in strains BALB/c, DBA/2, 129/J, and others. |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 17 |
When using the B10.Y/Sn mouse strain in a publication, please cite the originating article(s) and include JAX stock #000444 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for H2<pa>, Homozygous for H2-T18<c>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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