B10.Y-H2^pa H2-T18^c/SnJ

Stock number: 000444
Product name: B10.Y/Sn
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This B10 congenic strain carries the H2^pa haplotype from a non-inbred stock. It also carries the H2-T18^c allele.

Development

This is one of the “Congenic Resistant” strains of mice developed by George D. Snell in his studies of histocompatibility. [Snell, G.D. 1978. In Origins of Inbred Mice (H.C. Morse III, ed.). Academic Press, New York.]

The H2^pa haplotype, presumably including H2-T18^c, from a non-inbred stock designated “Y” was transferred onto C57BL/10Sn by the equivalent of 9 generations of backcrossing before being maintained by sib matings. It was cryopreserved in 1998 at generation N9F118.

Allele

Symbol: H2-T18^c
Name: c variant
MGI accession ID: MGI:4820509
Generation method: Not Applicable
Synonyms: Tla^c
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Marker synonyms: H-2T18; TL Ag; Tla
Chromosome: 17
Strain of origin: Not Applicable
Molecular note: The allele H2-T18^c determines presence of specificities TL.2, 7 and occurs in strains BALB/c, DBA/2, 129/J, and others.

Allele

Symbol: H2^pa
Name: histocompatibility-2, MHC; pa variant
MGI accession ID: MGI:6323600
Generation method: Spontaneous
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Marker synonyms: H-2; MHC-II
Chromosome: 17
Strain of origin: Not Applicable

Allele

MGI accession ID: MGI:95894
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Marker synonyms: H-2; MHC-II
Chromosome: 17