Jackson Laboratory SEARCH FOR MICE
129S1/Sv-Vsx2or-J/J
Stock No: 000395
  • Spontaneous Mutation
Contact Customer Service
Contact Customer Service
  • Email
  • Download PDF
  • Print
  • Help
  • Overview
  • Details
    • Detailed Description
    • Development
    • Control Suggestions
  • Genetics
  • Disease/Phenotype
    • Disease Terms
    • Research Areas By Phenotype
    • Mammalian Phenotype Terms by Genotype
    • References
  • Technical Support
    • Genotyping Protocols
    • Mating System
    • Breeder Pairs
    • Appearance
    • Citation
    • Animal Health Reports
    • Contact Technical Support
  • Pricing & Availability
    • Price
    • Payment Terms
  • Terms Of Use
  • Related Strains

Overview

Ocular retardation Jackson (or-J) is a spontanous mutation in Vsx2 (visual system homeobox 2), homozygotes exhibit small eyes with closed lids, reduced lens size, abnormal retinal layers and the absence of the optic nerve. This mutant mouse strain may be useful in studies of eye development.

Read More +

Genetic overview

Genetic Background Generation
F?+26
(2020-04-23 00:00:00)

Vsx2or-J

Allele Type Gene Symbol Gene Name
Spontaneous Vsx2 visual system homeobox 2
View Genetics

Research Applications

  • Sensorineural Research
  • Mouse/Human Gene Homologs
View All Research Applications

Base Price

Starting at:

$188.87 Domestic price for female
View Price List

Details

Detailed Description

Vsx2 (visual system homeobox 2) or CHX10 encodes a homeodomain protein expressed (in human) in the progenitor cells of the neuroretina and in the inner nuclear layer of the mature retina.
Mutations in VSX2 are associated with microphthalmia, cataracts and iris abnormalities.
Similar to the original ocular retardation (or) allele, mice homozygous for ocular retardation Jackson (or-J) exhibit small eyes with closed lids, reduced lens size, abnormal retinal layers and the absence of the optic nerve. Mutants can be identified at E12 by small eyes and a thickening of the inner wall of the optic fissure. This mutant mouse strain may be useful in studies of eye development.

Development

The ocular retardation Jackson or-J mutation arose spontaneously on the 129S1/Sv-Oca2+ Tyr+ KitlSl-J background at The Jackson Laboratory in 1975. The mutation was later identified as a premature stop codon (C to A transversion that alters codon 176 from tyrosine to a stop) in exon 3 of the homeobox domain of visual system homeobox 2 (Vsx2) gene.

Control Suggestions

Approximate Controls

  • 002448 129S1/SvImJ

Additional Information

  • Considerations for Choosing Controls

Genetics

Vsx2or-J

Allele Symbol: Vsx2or-J

Allele Name ocular retardation Jackson
Allele Type Spontaneous
Allele Synonym(s) Chx10-; orJ
Gene Symbol and Name Vsx2, visual system homeobox 2
Gene Synonym(s)
Strain of Origin 129S1/Sv-Oca2+ Tyr+ KitlSl
Chromosome 12
Molecular Note The molecular mutation is a premature stop codon in exon 3, corresponding to the homeobox domain of the encoded protein.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Vsx2or-J related

  • Sensorineural Research
    • Eye Defects
  • Mouse/Human Gene Homologs
    • non-syndromic microphthalmia, cataracts and iris abnormalities

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Vsx2or-J/Vsx2or-J
involves: 129S1/Sv

pigmentation phenotype

  • abnormal retinal pigmentation
    • ectopic pigmentation of the retina
    • (MGI Ref ID J:190452)
  • abnormal retinal pigment epithelium morphology
    • thickened
    • (MGI Ref ID J:190452)

vision/eye phenotype

  • abnormal retinal pigmentation
    • ectopic pigmentation of the retina
    • (MGI Ref ID J:190452)
  • abnormal retinal development
    • onset of neurogenesis is delayed by 1-2 days in the retina
    • (MGI Ref ID J:190452)
  • decreased total retina thickness
      (MGI Ref ID J:190452)
  • microphthalmia
    • by E11.5
    • (MGI Ref ID J:190452)
    • becomes progressively more severe with age
    • (MGI Ref ID J:190452)
  • abnormal retinal pigment epithelium morphology
    • thickened
    • (MGI Ref ID J:190452)
  • small lens
      (MGI Ref ID J:190452)
  • abnormal retina morphology
      (MGI Ref ID J:190452)

Genotype: Vsx2or-J/Vsx2or-J
129S1/Sv

cellular phenotype

  • abnormal cell death
    • at E10.5 the retinas of mutant mice show no evidence of cell death compared with retinas of normal mice where zones of cell necrosis are obvious
    • (MGI Ref ID J:5966)
    • at E12.5 necrotic foci in mutant retinas far exceed the number found in wild-type mice
    • (MGI Ref ID J:5966)

vision/eye phenotype

  • abnormal optic fissure morphology
    • by E12 the optic fissure has a thickened inner wall and appears as a plug of retinal layer material
    • (MGI Ref ID J:5767)
  • abnormal optic stalk morphology
    • stalk is reduced in size or absent by E13
    • (MGI Ref ID J:5767)
    • formation of the optic stalk fissure is delayed and remained abnormal
    • (MGI Ref ID J:5966)
  • absent optic nerve
    • at weaning, mice have a layer of connective tissue in place of the optic nerve
    • (MGI Ref ID J:5767)
  • abnormal lens development
    • homozygotes exhibit delayed lens formation
    • (MGI Ref ID J:5767)
  • abnormal retinal ganglion cell morphology
    • at E12.5 there is no evidence of expected ganglion cell differentiation
    • (MGI Ref ID J:5966)
  • abnormal hyaloid artery morphology
    • hyaloid artery is reduced in homozygotes at E11.5
    • (MGI Ref ID J:5767)
  • abnormal retinal progenitor cell morphology
      (MGI Ref ID J:5767)
  • disorganized retinal layers
    • retinal layers are uneven and normal cell layers are missing
    • (MGI Ref ID J:5767)
  • small lens
    • lens is reduced in size and fills most of eyecup
    • (MGI Ref ID J:5767)
  • eyelids fail to open
      (MGI Ref ID J:5767)
  • decreased eye pigmentation
      (MGI Ref ID J:5767)
  • abnormal eye development
    • in comparison to wild-type only a few necrotic sites are observed in retinal anlage at E12 and existing necrotic sites are restricted to optic stalk
    • (MGI Ref ID J:5767)
  • abnormal optic cup morphology
      (MGI Ref ID J:5767)
  • microphthalmia
    • small eyes are observed by E12
    • (MGI Ref ID J:5767)

nervous system phenotype

  • absent optic nerve
    • at weaning, mice have a layer of connective tissue in place of the optic nerve
    • (MGI Ref ID J:5767)
  • abnormal retinal ganglion cell morphology
    • at E12.5 there is no evidence of expected ganglion cell differentiation
    • (MGI Ref ID J:5966)

pigmentation phenotype

  • decreased eye pigmentation
      (MGI Ref ID J:5767)

References

Additional References

  • Bone-Larson C; Basu S; Radel JD; Liang M; Perozek T; Kapousta-Bruneau N; Green DG; Burmeister M; Hankin MH. 2000. Partial rescue of the ocular retardation phenotype by genetic modifiers J Neurobiol 42(2):232-47PubMed: 10640330MGI: J:60051
  • Burmeister M; Novak J; Liang MY; Basu S; Ploder L; Hawes NL; Vidgen D; Hoover F; Goldman D; Kalnins VI; Roderick TH; Taylor BA; Hankin MH; McInnes RR. 1996. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 12(4):376-84PubMed: 8630490MGI: J:32083

Additional - Vsx2or-J related

Technical Support

CONTACT TECHNICAL SUPPORT
  • Genotyping Protocols

    • Genotyping resources and troubleshooting
  • Mating System

    • Homozygote x Homozygote
  • Appearance

    • white-bellied agouti
      Related Genotype: Aw/Aw
  • Citation

    When using the 129S1/Sv-Vsx2or-J/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000395 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

Availability Varies
  • Domestic
  • International

Live Mouse

Age Genotype Price
weeks

Cryorecovery - Pricing

Service/Product Description Price
Please inquire

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470
Email: TechTran@jax.org

Related Strains

  • All
  • By Allele
  • By Gene
  • By Collection
View All Strains
There are no related strains using this filter.
▲
  • Stock No: |
    Related By:
▼
FEEDBACK
Did you find what you were looking for?

What information were you hoping to find through your search?

How easy was it to find what you were looking for?

We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.

Please Enter a Valid Email Address

Skip

Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.