This B6/By congenic strain carries the ‘minor’ histocompatibility allele, H38c, from BALB/cBy.
Don Bailey, The Jackson Laboratory
Genetic Background | Generation |
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000663 C57BL/6By |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Ahr | aryl-hydrocarbon receptor |
Marker Symbol | Marker Name | |
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H38 | histocompatibility 38 |
This B6/By congenic strain carries the ‘minor’ histocompatibility allele, H38c, from BALB/cBy.
Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility by crossing BALB/cBy females with C57BL/6By males, and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with histocompatibility loci. This backcrossing, with testing, was continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey, 1975). Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967. The strain was cryopreserved in 1981.
Allele Name | b-2 variant |
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Allele Type | Not Applicable |
Allele Synonym(s) | Ahb-2; Ahh |
Gene Symbol and Name | Ahr, aryl-hydrocarbon receptor |
Gene Synonym(s) | |
Strain of Origin | BALB/cBy |
Chromosome | 12 |
General Note | C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460). Strain of origin - this allele was found in BALB/cByJ, A/J, C3H/HeJ, CBA strains |
Molecular Note | This allele encodes a high affinity, heat labile, 104 kDa receptor containing 848 amino acids. Sequencing studies of cDNA from C57BL/6J congenic mice homozygous for this allele identified nucleotide substitutions in the ORF that would cause 5 amino acid differences between the C57BL/6J and BALB/cBy peptides, and 2 amino acid differences between the BALB/cBy and DBA/2J peptides. A T to C transition in exon 11 replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the BALB/cBy allele. This change would extend translation of the BALB/cBy mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa, vs 95 kDa for the C57BL/6J allele). |
Marker Synonym(s) | |
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Chromosome(s) | 12 |
When using the HW119 mouse strain in a publication, please cite the originating article(s) and include JAX stock #000370 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for H38<c>, 1 pair minimum |
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