This B6/By congenic strain carries a histocompatibility mutation.
Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility including lines carrying histocompatibility mutations. To reveal histocompatibility mutations, orthotopic tailskin grafts were made between F1 mice of a cross between C57BL/6By and BALB/cBy. The pattern of rejected grafts between F1 recipients showed whether the histocompatibility mutation determined a gain or loss of antigenicity, and subsequent grafts from the two parental strains onto a mutant carrier indicated in which genome the mutation occurred. Backcrossing, with testing, was carried out until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey 1975 Immunogenetics 2:249-56). Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967. The strain was cryopreserved in 1981 at generation N11F37.
Currently there are no related genes or alleles for this strain.