Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (MitfMi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes show slight microphthalmia but a normal skeleton. Heterozygotes (MitfMi-wh/+) have a dilut...Read More +
|Allele Type||Gene Symbol||Gene Name|
|Spontaneous||Kit||KIT proto-oncogene receptor tyrosine kinase|
|Allele Type||Gene Symbol||Gene Name|
|Spontaneous||Mitf||melanogenesis associated transcription factor|
|Allele Type||Gene Symbol||Gene Name|
|Spontaneous||T||brachyury, T-box transcription factor T|
Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (MitfMi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes show slight microphthalmia but a normal skeleton. Heterozygotes (MitfMi-wh/+) have a diluted coat color, light ears, a white belly spot, and in rare cases a dorsal spot. In addition, they display abnormalities of both the cochlear and vestibular portions of the inner ear. Mice heterozygous for the brachyury spontaneous mutation (T) have tail defects and associated skeletal abnormalities.
The KitW-v mutation arose spontaneously at The Jackson Laboratory in strain C57BL/6J before 1937. The mutation MitfMi-wh arose spontaneously in offspring of a cross between strains DBA and C57BL at the University of Rochester about 1947. T was found by Dobrovolskaia-Zavadskaia in a laboratory stock about 1927. Both MitfMi-wh and T were imported into The Jackson Laboratory from Dr. D. Falconer of Edinburgh in 1950. Both mutations were together in a dominant testing stock that had been outcrossed to CBA and C57. At The Jackson Laboratory they were maintained together by sibling matings. In 1958 a KitW-v MitfMi-wh T linkage testing stock was constructed. The stock was sibling bred and subsequently backcrossed to C57BL/6By. In 1981 KitW-v/+ MitfMi-wh/+ T/+ males at N29F2 were bred with C57BL/6By females to generate embryos for cryopreservation.
|Allele Name||viable dominant spotting|
|Allele Synonym(s)||KitWv; W'; W2; Wv; Wv|
|Gene Symbol and Name||Kit, KIT proto-oncogene receptor tyrosine kinase|
|Gene Synonym(s)||Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco1; Gsfsco5; Gsfsco5; Gsfsow3; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; belly-spot; c-KIT; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male|
|Strain of Origin||silvered black strain|
|Molecular Note||A C to T point mutation at nucleotide 2007 results in a threonine to methionine substitution at amino acid 660.|
|Allele Synonym(s)||Miwh; mitfwh|
|Gene Symbol and Name||Mitf, melanogenesis associated transcription factor|
|Gene Synonym(s)||BCC2; CMM8; COMMAD; Gsfbcc2; Gsfbcc2; MI; WS2; WS2A; bHLHe32; black eyed white; bw; gsf bright coat colour 2; mi; mi; microphthalmia; vit; vitiligo; wh|
|Strain of Origin||(C57BL x DBA)F1|
|General Note||Combination heterozygotes of MitfMi-wh/MitfMi, MitfMi-wh/MitfMi-b, and MitfMi-wh/MitfMi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). MitfMi-b/MitfMi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).|
|Molecular Note||T to A transversion at bp 764, which leads to an isoleucine to asparagine substitution at the corresponding amino acid (212) in the encoded protein. This mutation is in the basic region of the protein.|
|Gene Symbol and Name||T, brachyury, T-box transcription factor T|
|Gene Synonym(s)||Bra; Low; Lr; SAVA; T1; TFT; Tbxt; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio|
|Strain of Origin||Laboratory stock|
|Molecular Note||Pulsed-field gel electrophoresis revealed an altered restriction fragment size consistent with a deletion of 160-200kb.|
|Heterozygous or Wild-type for Mi<wh>,Heterozygous or Wild-type for W<v>,Heterozygous or Wild-type for T|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
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