B6CBACa A^w-J/A-Eda^Ta/J-XO

Stock number: 000314
Research areas: Reproductive Biology Research

Description

In December, 2021, once reliable genotyping was developed to identify XO mice and the tabby marker became unnecessary, Stock No. 000314 was replaced with Stock# 036414, which has had the tabby allele bred out.

Females of this strain have only one X chromosome, and may be useful in studies of Turner Syndrome in humans.

Detailed description

XO or monsomy X mice lack a second sex chromosome. The condition is inherited as an X-linked dominant trait with male lethality. XO mice exhibit some degree of growth retardation, high frequency hearing loss, reduced thyroid activity, reduced body temperature and some behavioral abnormalities. Unlike Turner Syndrome in humans, XO females are fertile. The two-step mating system for this strain (described under Mating System) incorporates the X-linked coat color marker tabby so that mice can be identified by a combination of coat color and sex. This strain may be useful for studies of Turner Syndrome or X-linked recessive alleles.

Development

The female progenitor of the X/O line now maintained at the Jackson Laboratory was a Ta+/+Bn, Ta+/O mosaic. She was the offspring of a Mo+/+Ta x Bn/Y cross and looked like a Ta/O non-Bn female except for faint transverse striping across the rump. Seven of her apparently wild type daughters after mating her to a wild type male were mated with Ta/Y males. One produced Ta/O daughters and was apparently +/O. (from M.C. Green, Mouse News Letter 1967 33:37)