The semidominant oligosyndactlism (Os) mutation is maintained in repulsion with the spontaneous mutation myodystrophy(Largemyd). Myodystrophy (myd) is a spontaneous mutation in Large (like-glycosyltransferase), a glycosyltransferase involved in the glycosylation of alpha-dystroglycan. Mice homozygous for the mutation exhibit diffuse and progressive myopathy, as well as hearing loss and retinal abnormalities. This allele may be useful for studying congenital muscular dystrophy with brain and eye abnormalities (MDDGA6). Mice heterozygous for oligosyndactlism (Os) exhibit fused digits in all four feet and small kidney size.
|Allele Type||Gene Symbol||Gene Name|
|Allele Type||Gene Symbol||Gene Name|
Large (like-glycosyltransferase) encodes a glycosyltransferase involved in the glycosylation of alpha-dystroglycan. Mutations in LARGE are associated with congenital muscular dystrophy with brain and eye abnormalities (MDDGA6). Mice homozygous for the myodystrophy (myd) allele exhibit a short, shuffling gait, kyphosis, diffuse and progressive myopathy, myositis, cardiomyopathy and a reduced lifespan (average 17.25 weeks). Skeletal muscle pathologies include variation in fiber size, loss of striation, centralized nuclei, calcification and nuclear rowing. Other characteristics include hearing loss, disorganized retinal layers, and axon demyelination in the peripheral nervous system.
Mice heterozygous for oligosyndactlism (Os) exhibit fused digits in all four feet, progressive diabetes, small kidney size and reduced numbers of kidney glomeruli. Homozygotes are embryonic lethal.The semidominant oligosyndactlism (Os) mutation is maintained in repulsion with the spontaneous mutation myodystrophy(Largemyd).
Myodystrophy (Largemyd) arose spontaneously in 1963 at The Jackson Laboratory in the lethal spotting stock (LS/LeJ) which had been imported from University College, London in 1961. The first affected male was outcrossed to a C57BL/6J female. Matings of a homoygote times a heterozygote were carried out as often as possible or as heterozygous pairs. Close linkage was found on Chromosome 8 and oligosyndactylism (Os) was used as a marker. A Largemyd/+ male at F38 was crossed to a pintail (Pt), oligosyndactyly (Os) female of the ROP strain and after 3 sib matings an Os/+ was selected and this genotype was crossed 7 times to the +/+ members of the strain. At N7 an Os/+ was again crossed to a Largemyd/+ and the strain was maintained by sibling matings selecting the Os phenotype which was generally Os +/+ Largemyd. It was cryopreserved in 1981 by mating Os +/+ Largemyd males at N7F22 -F27 to non Os (+ +/+ ?) females.
|Allele Synonym(s)||Largemyd; fg; froggy; myd|
|Gene Symbol and Name||Large, like-glycosyltransferase|
|Gene Synonym(s)||BPFD#36; MDC1D; MDDGA6; MDDGB6; Mbp-1; Mbp1; enervated; enr; enr; fg; fg; froggy; froggy; mKIAA0609; myd; myelin basic protein transgene; myodystrophy|
|Strain of Origin||STOCK Edn3 |
|Allele Type||Radiation induced|
|Gene Symbol and Name||Os, oligosyndactylism|
|Gene Synonym(s)||94-A; 94-K; PlmTgN(Pgk1)1Ddp; PlmTgN(Pgk1)1Ddp; PlmTgN(Pgk1)2Ddp; PlmTgN(Pgk1)2Ddp; postimplantation lethal mutation induced by Pgk1 transgene insertion-Dimitrina D. Pravtcheva 1; postimplantation lethal mutation induced by Pgk1 transgene insertion-Dimitrina D. Pravtcheva 2|
|Strain of Origin||(101 x C3H)F1|
At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical).
The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to
ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery
will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the
genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the
recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of
interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny
testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified.
If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female
(one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains
requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some
strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the
time taken to produce the mice identified as carrying the mutation. Please Customer Service for more information
on the cost of progeny testing for a strain.
Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.
MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.
Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.