JAX Mouse Strain Datasheet - 000287

B6CBACa A^w-J/A-Plp1^jp Eda^Ta/J

Stock No:: 000287

Cryo Recovery

Overview

Hemizygous males carrying the X-linked jimpy spontaneous mutation (Plp1^jp) appear normal when sitting quietly, but beginning at about 3 weeks of age they show a marked tremor of the hindquarters when attempting movement. After 3 weeks of age convulsions may occur. These males die between 20 and 40 days of age. In males, the CNS is very deficient in myelin, but the PNS is normally myelinated. Heterozygous jimpy females have normal lifespans with no overt phenotype. However, jimpy heterozygous females are reported to have reduced numbers of oligodendrocytes compared to wildtype females. While the mutation is recessive, only partial phenotypic rescue was attained by the transgenic expression of the two major isoforms, PLP and DM20, suggesting a dominant negative action from this allele (Nandon et al., 1994). This stock is also carrying the X-linked tabby mutation (Eda^Ta).

Genetic overview

Genetic Background	Generation

A^w-J

Allele Type	Gene Symbol	Gene Name
Spontaneous	a	nonagouti

Eda^Ta

Allele Type	Gene Symbol	Gene Name
Spontaneous	Eda	ectodysplasin-A

Plp1^jp

Allele Type	Gene Symbol	Gene Name
Spontaneous	Plp1	proteolipid protein (myelin) 1

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Research Applications

Dermatology Research
Developmental Biology Research
Sensorineural Research
Neurobiology Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Important Note

This strain is heterozygous for Plp1^jp and Eda^Ta maintained on the same X chromosome.

Detailed Description

Development

The tabby (Eda^Ta) and jimpy (Plp1^jp) mutations were imported to The Jackson Laboratory together from Dr. Mary Lyon at Harwell in 1961. Tabby had arisen spontaneously in a strain selected for large size (Falconer DS 1953. Z Indukt Abstammungs-Vererbungsl 85:210-19) and jimpy arose in an inbred line (Philips RJS. 1954. Z Indukt Abstammungs Vererbungsl 86:322-6) in 1954. The imported stock was segregating for other loci but tabby and jimpy, linked and located on the X Chromosome, were maintained by sibling matings generally of the Eda^Ta Plp1^jp/+ + genotype crossed to a Ta/Y or +/Y male. In 1965 at approximately generation F6 a Eda^Ta Plp1^jp/+ + female was outcrossed to a C57BL/6J-A^w-J male and pairs were mated. At F3 a Eda^Ta Plp1^jp/+ + female was again crossed to a C57BL/6J-A^w-J male. The stock was then continually backcrossed into the C57BL/6J-A^w-J strain to N10. At N11 a cross of a Eda^Ta Plp1^jp/+ + female was made to a CBA/Ca male and in the next generation a Eda^Ta Plp1^jp/+ + female was crossed to the B6CBACa F1 hybrid male and the stock was then bred by crossing to the hybrid male each generation. It was cryopreserved in 1981 by mating Eda^Ta Plp1^jp-?/+ + females at N71 to B6CBACa-A^w-J/A F1 males.

Control Suggestions

Untyped from the colony

Additional Information

Considerations for Choosing Controls

Genetics

A^w-J

Allele Symbol: A^w-J

Allele Name	white bellied agouti Jackson
Allele Type	Spontaneous
Allele Synonym(s)	A^WJ
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)	AGSW; AGTI; AGTIL; ASP; As; As; SHEP9; agouti; agouti signal protein; agouti suppressor
Strain of Origin	C57BL/6J
Chromosome	2

Eda^Ta

Allele Symbol: Eda^Ta

Allele Name	tabby
Allele Type	Spontaneous
Allele Synonym(s)	Ta; Ta3; Ta^Fa; Ta^f
Gene Symbol and Name	Eda, ectodysplasin-A
Gene Synonym(s)	ECTD1; ED1; ED1-A1; ED1-A2; EDA-A1; EDA-A2; EDA1; EDA2; Ed1; Eda-A1; Eda-A2; HED; HED1; ODT1; RGD1563178; STHAGX1; TNLG7C; Ta; Tnlg7c; XHED; XLHED; tabby
Strain of Origin	stock including A, C57BL, CBA, and RIII
Chromosome	X
General Note	This mutation arose in a strain selected for large size. Hemizygous mutant males breed satisfactorily, but homozygous mutant females are often sterile. Hemizygous mutant females are fully fertile (J:249).Hemizygous males and homozygous females are identical in phenotype with homozygous crinkled (Edaradd^cr) and downless (Edar^dl) mice and with homozygous or heterozygous sleek (Dl^slk) mice. They are characterized by absence of guard hairs and zigzags in the coat, a bald patch behind the ear, bald tail with a few kinks near the tip, reduced aperture of the eyelids, a respiratory disorder, and a modified agouti pattern (J:249). The number of vibrissae is reduced (J:14912). The incisors may be reduced or absent, and the molars are usually smaller than normal with the third molar often absent (J:5018, J:5138). There are defects of many endocrine glands. The structures affected by the mutation all arise embryologically as downgrowths of solid epithelial cords, not by invagination with a lumen or by outgrowths from deep grooves (J:5246).Hemizygous mutant females are most easily recognized if they are agouti, in which case they show transverse stripes of light-colored normal and dark tabby hair. They have normal incisors but may have mutant or intermediate-type molars (J:5138). A small proportion of heterozygous females may show some slight defects of some of the exocrine glands (J:5193).In the development of the coat of homozygous and hemizygous mutant mice, hair follicle initiation begins at 17 days of gestation, 3 days later than normal, and ends 1 or 2 days after birth, several days earlier than normal. The hairs are of only one type and resemble abnormal awls (J:12100, J:5137). By use of dermal--epidermal recombination grafts of embryonic flank skin, it was shown that Eda^Ta acts in the epidermis in its effects on structure of the hairs (J:6041). The effect of the mutation in preventing growth of hair on the tail may be either dermal or epidermal. The mutation may act directly on hair cells or via a diffusible product (J:7450). The phenotype of Eda^Ta/+ females has been extensively studied because of its relevance to the X-inactivation theory of dosage compensation (J:5018, J:5238).Eda^Ta and the related mutations Edaradd^cr and Edar^dl disrupt normal development of certain epidermal derivatives, including sweat glands. Although the sensory innervation of footpad skin and the sympathetic innervation of blood vessels in the foot pad is normal in these mutants, the sympathetic fibers that normally innervate the sweat glands fail to develop (J:19910).A candidate gene for the human familial X-linked disorder hypohidrotic ectodermal dysplasia (EDA)(OMIM 305100) has been partially cloned. Eda, a candidate for which has also been cloned, is the homologous gene in the mouse, on the basis of phenotype - hypoplasia of sweat glands, teeth, and hair - and of homologous mapping. There is high sequence identity between the cloned portions of the two genes. Known Eda mutations have been identified in the candidate mouse gene. An extracellular collagenous domain of the mouse gene, not yet identified in the EDA gene, may represent the location of mutations in 85-90% of human families (J:42614). A mouse gene Eda (ectodysplasin-A) has been proposed as the site of the tabby mutations (J:44605).Exogenous epidermal growth factor can reverse phenotypic features of Eda^Ta mice, advancing the delayed opening of eyelids and eruption of incisors (J:42661) and inducing development of dermal ridges and functional sweat glands (J:42660). Expression of epidermal growth factor receptor is reduced in EDA and in Eda^Ta mice (J:33361).
Molecular Note	This allele is characterized by an ~ 2 kb deletion: Genomic DNA was hybridized with an exon 1 probe showing a deletion including the coding region and primers for DNA flanking exon 1 failed to amplify in a PCR assay.

Plp1^jp

Allele Symbol: Plp1^jp

Allele Name	jimpy
Allele Type	Spontaneous
Allele Synonym(s)	jp
Gene Symbol and Name	Plp1, proteolipid protein (myelin) 1
Gene Synonym(s)	DM20; GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; Plp; Plp; SPG2; jimpy; jp; msd; myelin synthesis deficiency; proteolipid protein (myelin); rsh; rump shaker
Strain of Origin	(KLM STOCK x XY STOCK)F1
Chromosome	X
Molecular Note	Sequence analysis showed that this allele carries an A to G base change at the 3' splice acceptor site of intron 4.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Eda^Ta related

Dermatology Research
- Color and White Spotting Defects
- Skin and Hair Texture Defects
Developmental Biology Research
- Eye Defects
Sensorineural Research
- Eye Defects

Genotype: Plp1^jp related

Neurobiology Research
- Myelination Defects
- Tremor Defects

Mammalian Phenotype Terms by Genotype

Genotype: Plp1^jp/Y
B6CB-A^w-J/A Eda^Ta Plp1^jp

behavior/neurological phenotype

abnormal startle reflex
- onset is developmentally delayed

decreased vocalization
- up to P8, mice exhibit less ultrasonic vocalizations compared with wild-type mice

hypoactivity
- by P12

nervous system phenotype

abnormal astrocyte physiology
- cell cycle length of astrocytes is increased by 5 to 6 hours compared with wild-type cells

abnormal myelination
- microsomes prepared from brains of 18 day old homozygotes show a reduction in fatty acid chain elongation activity with arachidoyl CoA, behenoyl CoA, and palmitoyl CoA substrates

abnormal oligodendrocyte morphology
- as myelination advances oligodendrocytes become abnormal with lipid inclusions and multimembrane tubes unlike in wild-type mice

decreased oligodendrocyte number
- during the early period of myelination (1 to 6 days of age)

growth/size/body region phenotype

decreased body weight

vision/eye phenotype

delayed eyelid opening

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Plp1^jp/Plp1⁺
B6CB-A^w-J/A Eda^Ta Plp1^jp

nervous system phenotype

astrocytosis

Genotype: Plp1^jp/Y
Not Specified

mortality/aging

premature death
- death usually occurs by 30 days commonly after a seizure
- mice die at around 28 days with some living as long as 40 days

nervous system phenotype

abnormal astrocyte morphology
- freeze-etching of optic nerves shows that plasmalemma of astrocytes have twice normal numbers of assemblies of 7nm particles, which are similar to type III gap junctions, and these appear to unite abnormally with type I junctions

abnormal brain morphology
- brain contains traces of cholesterol ester

abnormal brain white matter morphology
- cytoplasmic nonpolar lipids are observed in the basis pedunculi, optic tract and white matter of the cerebellum and spinal cord; these cells appear to be fatty macrophages and are first observed in the 12 day old brain

abnormal myelin sheath morphology
- freeze-etching of optic nerves shows abnormally smooth protoplasmic fracture faces and exoplasmic fracture faces and there are fewer than normal intramyelinic tight junctions

abnormal myelination
- general architecture of gray and white matter is normal
- little myelin is found in any region of the central nervous system
- myelination is observed in the peripheral nervous system

abnormal oligodendrocyte morphology
- freeze-etching of optic nerves shows that the oligodendroglia plasma membrane is highly convoluted with numerous irregular invaginations and elevations

environmentally induced seizures
- when disturbed or handled mice exhibit convulsions characterized by body tension with head thrown back, fore limbs scrabbling and hind limbs stretched sideways for about 5 seconds sometimes followed by rigid extensor tetanus lasting 20 seconds unlike wild-type mice-type mice

tonic-clonic seizures
- generalized seizures without focal onset occur by 4 weeks of age

behavior/neurological phenotype

environmentally induced seizures
- when disturbed or handled mice exhibit convulsions characterized by body tension with head thrown back, fore limbs scrabbling and hind limbs stretched sideways for about 5 seconds sometimes followed by rigid extensor tetanus lasting 20 seconds unlike wild-type mice-type mice

hindlimb paralysis
- observed in some mice

paraparesis
- some animals exhibit hindlimb weakness by weaning age

tonic-clonic seizures
- generalized seizures without focal onset occur by 4 weeks of age

tremors
- mice exhibit intention tremors
- tremors are first observed at about10-12 days of age

References

Additional References

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Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. PubMed: 9285798 MGI: J:42614
Nave KA; Lai C; Bloom FE; Milner RJ. 1986. Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. Proc Natl Acad Sci U S A 83(23):9264-8. PubMed: 3466187 MGI: J:8514
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Tvrdik P; Westerberg R; Silve S; Asadi A; Jakobsson A; Cannon B; Loison G; Jacobsson A. 2000. Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol 149(3):707-18. PubMed: 10791983 MGI: J:61900

Additional - A^w-J related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. PubMed: 15136142 MGI: J:92174
Banerjee H; Das A; Srivastava S; Mattoo HR; Thyagarajan K; Khalsa JK; Tanwar S; Das DS; Majumdar SS; George A; Bal V; Durdik JM; Rath S. 2012. A role for apoptosis-inducing factor in T cell development. J Exp Med 209(9):1641-53. PubMed: 22869892 MGI: J:191446
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Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. PubMed: 9831049 MGI: J:118430
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. PubMed: 15723861 MGI: J:112546
Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. PubMed: 19280713 MGI: J:145908
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. PubMed: 16738056 MGI: J:111051
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. PubMed: 17673451 MGI: J:129949
Cui CY; Yin M; Sima J; Childress V; Michel M; Piao Y; Schlessinger D. 2014. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development 141(19):3752-60. PubMed: 25249463 MGI: J:217500
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Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. PubMed: 10749990 MGI: J:61324
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Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. PubMed: 15813941 MGI: J:101081
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Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. PubMed: 15312246 MGI: J:111491
Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. PubMed: 10729341 MGI: J:109469
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. PubMed: 11758785 MGI: J:116953
Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. PubMed: 15014119 MGI: J:97010
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Additional - Eda^Ta related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. PubMed: 15136142 MGI: J:92174
Ahtiainen L; Uski I; Thesleff I; Mikkola ML. 2016. Early epithelial signaling center governs tooth budding morphogenesis. J Cell Biol 214(6):753-67. PubMed: 27621364 MGI: J:242661
Azar A; Piccinelli C; Brown H; Headon D; Cheeseman M. 2016. Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology. Hum Mol Genet 25(16):3564-3577. PubMed: 27378689 MGI: J:237866
Blecher SR; Kapalanga J; Lalonde D. 1990. Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Nature 345(6275):542-4. PubMed: 2348861 MGI: J:42660
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. PubMed: 15723861 MGI: J:112546
Cerghet M; Bessert DA; Nave KA; Skoff RP. 2001. Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways. J Neurocytol 30(9-10):841-55. PubMed: 12165674 MGI: J:121313
Charles C; Pantalacci S; Peterkova R; Peterka M; Laudet V; Viriot L. 2007. Disruption of the palatal rugae pattern in Tabby (eda) mutant mice. Eur J Oral Sci 115(6):441-8. PubMed: 18028050 MGI: J:147677
Charles C; Pantalacci S; Tafforeau P; Headon D; Laudet V; Viriot L. 2009. Distinct impacts of Eda and Edar loss of function on the mouse dentition. PLoS One 4(4):e4985. PubMed: 19340299 MGI: J:148176
Claxton JH. 1967. The initiation and development of the hair follicle population in tabby mice. Genet Res 10:161-171. MGI: J:12100
Dulos GJ; Bagchus WM. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int Immunopharmacol 1(2):321-8. PubMed: 11360932 MGI: J:109877
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Falconer DS; Latyszewski M. 1952. The environment in relation to selection for size in mice J Genet 51:67-80. MGI: J:78116
Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. PubMed: 9285798 MGI: J:42614
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Additional - Plp1^jp related

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Knapp PE; Bartlett WP; Williams LA; Yamada M; Ikenaka K; Skoff RP. 1999. Programmed cell death without DNA fragmentation in the jimpy mouse: secreted factors can enhance survival. Cell Death Differ 6(2):136-45. PubMed: 10200560 MGI: J:53665
Knapp PE; Benjamins JA; Skoff RP. 1996. Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse. J Neurobiol 29(2):138-50. PubMed: 8821173 MGI: J:31558
Knapp PE; Dutta S; Skoff RP. 1990. Differences in levels of neuroglial cell death in jimpy male mice and carrier females. Dev Neurosci 12(3):145-52. PubMed: 2364893 MGI: J:116371
Knapp PE; Ismaili S; Hauser KF; Ghandour MS. 1999. Abnormal Ca(2+) regulation in oligodendrocytes from the dysmyelinating jimpy mouse. Brain Res 847(2):332-7. PubMed: 10575104 MGI: J:58599
Knapp PE; Skoff RP. 1993. Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro. Dev Neurosci 15(1):31-6. PubMed: 8269866 MGI: J:116364
Kopmels B; Wollman EE; Guastavino JM; Delhaye-Bouchaud N; Fradelizi D; Mariani J. 1990. Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. J Neurochem 55(6):1980-5. PubMed: 2230805 MGI: J:28095
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Lachapelle F; Gumpel M; Baumann N. 1994. Contribution of transplantations to the understanding of the role of the PLP gene. Neurochem Res 19(8):1083-90. PubMed: 7528353 MGI: J:19842
Lachapelle F; Lapie P; Campagnoni AT; Gumpel M. 1991. Oligodendrocytes of the jimpy phenotype can be partially restored by environmental factors in vivo. J Neurosci Res 29(2):235-43. PubMed: 1890702 MGI: J:27477
Lachapelle F; Lapie P; Gumpel M. 1992. Oligodendrocytes from jimpy and normal mature tissue can be 'activated' when transplanted in a newborn environment. Dev Neurosci 14(2):105-13. PubMed: 1396170 MGI: J:3029
Le Goascogne C; Eychenne B; Tonon MC; Lachapelle F; Baumann N; Robel P. 2000. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Glia 29(1):14-24. PubMed: 10594919 MGI: J:78788
Li WX; Kuchler S; Zaepfel M; Badache A; Thomas D; Vincendon G; Baumann N; Zanetta JP. 1993. Cerebellar soluble lectin and its glycoprotein ligands in the developing brain of control and dysmyelinating mutant mice. Neurochem Int 22(2):125-33. PubMed: 8439766 MGI: J:4577
Macklin WB; Gardinier MV; King KD; Kampf K. 1987. An AG----GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon. FEBS Lett 223(2):417-21. PubMed: 2444462 MGI: J:42979
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Matthieu JM; Widmer S; Herschkowitz. 1973. Jimpy, an anomaly of, myelin maturation. Biochemical study of myelination phases. Brain Res 55(2):403-12. PubMed: 4123465 MGI: J:5352
Meier C; Bischoff A. 1975. Oligodendroglial cell development in jimpy mice and controls. An electron-microscopic study in the optic nerve. J Neurol Sci 26(4):517-28. PubMed: 1206429 MGI: J:5611
Meier C; Bischoff A. 1974. Dysmyelination in jimpy mouse. Electron microscopic study. J Neuropathol Exp Neurol 33(3):343-53. PubMed: 4835113 MGI: J:5461
Meier C; Herschkowitz N; Bischoff A. 1974. Morphological and biochemical observations in the Jimpy spinal cord. Acta Neuropathol (Berl) 27(4):349-62. PubMed: 4366515 MGI: J:5465
Mikoshiba K; Kohsaka S; Hayakawa T; Takamatsu K; Tsukada Y. 1985. Immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin basic protein in the central nervous system of the jimpy and the normal mouse. J Neurochem 44(3):686-91. PubMed: 2579194 MGI: J:7747
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Moriguchi A; Ikenaka K; Furuichi T; Okano H; Iwasaki Y; Mikoshiba K. 1987. The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice. Gene 55(2-3):333-7. PubMed: 2444499 MGI: J:20094
Murad S; Kishimoto Y. 1975. Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. J Biol Chem 250(15):5841-6. PubMed: 1150661 MGI: J:106960
Nadon NL; Arnheiter H; Hudson LD. 1994. A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse. J Neurochem 63(3):822-33. PubMed: 7519661 MGI: J:19774
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Aw-J

Allele Symbol: Aw-J

EdaTa

Allele Symbol: EdaTa

Plp1jp

Allele Symbol: Plp1jp

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Genotype: EdaTa related

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Genotype: Plp1jp/YB6CB-Aw-J/A EdaTa Plp1jp

behavior/neurological phenotype

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Genotype: Plp1jp/Plp1+B6CB-Aw-J/A EdaTa Plp1jp

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A^w-J

Allele Symbol: A^w-J

Eda^Ta

Allele Symbol: Eda^Ta

Plp1^jp

Allele Symbol: Plp1^jp

Genotype: Eda^Ta related

Genotype: Plp1^jp related

Genotype: Plp1^jp/Y
B6CB-A^w-J/A Eda^Ta Plp1^jp

Genotype: Plp1^jp/Plp1⁺
B6CB-A^w-J/A Eda^Ta Plp1^jp

Genotype: Plp1^jp/Y
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