RHJ/Le

Stock number: 000266
Product name: rhino Jackson
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

This inbred mutant strain is homozygous for nonagouti (a), brown (Tyrp^b), and albino (Tyr^c), and carries the segregating mutant allele, rhino Jackson (Hr^rh-J).

Detailed description

Rhino mice have spleen cells with a defective response to T-dependent antigens and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which occur in young mice and increase with age. These mice have increased numbers of Thy1 positive epidermal dendritic cells. Like homozygous hairless mice, rhino mice are hairless by 5 weeks and their skin becomes wrinkled and thickened.

Development

The rhino Jackson mutation (Hr^rh-J) was found at Carworth Farms (a New York commercial breeder) in a stock of undetermined genetic background and sent to The Jackson Laboratory in 1951. It was outcrossed to BALB/cHu for 6 generations and then sibling mated. At F15 in 1963 it was outcrossed to the albino hook (Hk) stock, which had C57BL/6J, AKR and A/Sn in its background, and was again sibling mated selecting away from hook. The stock was nonagouti (a/a), brown (Tyrp1^b), albino (Tyr^c) and carrying rhino Jackson (Hr^rh-J). It was maintained by mating heterozygous (haired) females to rhino Jackson homozygous males and reached F96 in 1990. This same stock is also in the production facility as RHJ/LeJ (Stock No. 001591) and is also maintained by mating haired females by affected males. It was cryopreserved by mating heterozygous females to homozygous males at F76.

Allele

Symbol: Hr^rh-J
Name: rhino Jackson
MGI accession ID: MGI:1856061
Generation method: Spontaneous
Marker symbol: Hr
Marker name: lysine demethylase and nuclear receptor corepressor
Chromosome: 14
Strain of origin: Carworth Farms stock