Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Radiation induced | a | nonagouti |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Gdf5 | growth differentiation factor 5 |
The ae mutation was discovered by W.F. Hollander and J.W. Gowen among descendants of an irradiated male albino mouse of the S strain then maintained at Iowa State College and a female of the multiple-recessive P testing stock. A single black, typical non-agouti male produced by these matings was bred to three AY/A+ females (of unidentified background), yielding five male offspring that survived to maturity, three of which proved fertile. Each of these was bred to a female homozygous for the black-and-tan (a t) allele, which is recessive to both AY and A+. Black-and-tan offspring of this cross were bred among themselves, as were progeny of the latter crosses. In one of the resultant lines, the black mice had an extreme non-agouti phenotype, having no yellow hairs. This line contributed to the background of the inbred strain AEJ, which carries ae. Gdf5bp-H occurred spontaneously in the PCT multiple recessive stock at Harwell, U.K. It was backcrossed onto AEJ/GnLe-ae for 5 generations, and the stock has since been maintained by brother-sister inbreeding.
Allele Name | extreme nonagouti |
---|---|
Allele Type | Radiation induced |
Allele Synonym(s) | |
Gene Symbol and Name | a, nonagouti |
Gene Synonym(s) | |
Strain of Origin | (P x S)F1 |
Chromosome | 2 |
General Note | The ae mutation was found among descendants of an irradiated mouse. ae is recessive to all other alleles except al. |
Allele Name | brachypodism Harwell |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | bp-H |
Gene Symbol and Name | Gdf5, growth differentiation factor 5 |
Gene Synonym(s) | |
Strain of Origin | PCT |
Chromosome | 2 |
General Note | This remutation arose spontaneously at Harwell in the PCT multiple recessive stock (J:13391). |
Molecular Note | This allele was identified by a noncomplementation test with Gdf5bp. |
When using the AEJ.Cg-ae +/a Gdf5bp-H/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000251 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Double heterozygous in repulsion, or Gdf5<bp-H> homozygous or a<e> homozygous |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.