Overview

Also Known As:weaver

Mice homozygous for the weaver spontaneous mutation (Kcnj6^wv) are recognizable in the second postnatal week by their small size, instability of gait, weakness, and hypotonia. Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in homozygous mutants is very small, simple, and almost devoid of granule cells, which degenerate during the second week. Heterozygotes behave normally, but they have a smaller than normal cerebellum with a deficiency of granule cells, some of which fail to migrate into the internal granule layer and remain scattered in the molecular layer. Evidence from cultures of mutant and normal cerebellum show that granule cells of Kcnj6^wv/Kcnj6^wv and Kcnj6^wv/+ mice have gene-dosage dependent abnormalities in morphology and cell behavior. Studies using homozygous weaver/wildtype chimeras indicate that the migration defect of granule cells ...

Genetic overview

Genetic Background	Generation

Kcnj6^wv

Allele Type	Gene Symbol	Gene Name
Spontaneous	Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6

A^w-J

Allele Type	Gene Symbol	Gene Name
Spontaneous	a	nonagouti

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Research Applications

Neurobiology Research
Cell Biology Research

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Details

Detailed Description

Mice homozygous for the weaver spontaneous mutation (Kcnj6^wv) are recognizable in the second postnatal week by their small size, instability of gait, weakness, and hypotonia. Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in homozygous mutants is very small, simple, and almost devoid of granule cells, which degenerate during the second week. Heterozygotes behave normally, but they have a smaller than normal cerebellum with a deficiency of granule cells, some of which fail to migrate into the internal granule layer and remain scattered in the molecular layer. Evidence from cultures of mutant and normal cerebellum show that granule cells of Kcnj6^wv/Kcnj6^wv and Kcnj6^wv/+ mice have gene-dosage dependent abnormalities in morphology and cell behavior. Studies using homozygous weaver/wildtype chimeras indicate that the migration defect of granule cells is intrinsic to the granule cells themselves. The disarrangement of Purkinje cells, however, is not caused by intrinsic action of weaver in these cells. Cell mixing experiments also suggest Kcnj6^wv acts non-autonomously and encodes a membrane-associated ligand that induces external germinal layer neuron differentiation.

Development

Weaver (Kcnj6^wv) arose spontaneously in the pedigreed expansion stocks of C57BL/6J at The Jackson Laboratory in 1961. It was maintained by mating tested pairs until F21. Ovarian transplantation to C57BL/6J was used to F21N3 and then because of poor breeding performance a weaver (wv/wv) male was outcrossed to a CBA/Ca female and the tested offspring (wv/+) were mated to the B6CBACa hybrids. Backcrossing to the hybrid B6CBACa was then made each generation by mating a homozygous female weaver to a hybrid and mating the known heterozygotes. The stock was at N46 in 1992. It was cryopreserved in 1986 by mating heterozygous females to heterozygous males at N30-N32 or by mating homozygous females to B6CBACa F1 males.

Control Suggestions

Untyped from the colony

Additional Information

Considerations for Choosing Controls

Selected References

Hirano A; Dembitzer HM. 1973. Cerebellar alterations in the weaver mouse. J Cell Biol 56(2):478-86PubMed: 4118891 MGI: J:5315
Yao W; Zhong J; Rosen CJ; Hock JM; Lee WH. 2005. Igf-I and postnatal growth of weaver mutant mice. Endocrine 26(2):117-25PubMed: 15888923 MGI: J:109832

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Genetics

Kcnj6^wv

Allele Symbol: Kcnj6^wv

Allele Name	weaver
Allele Type	Spontaneous
Allele Synonym(s)	wv
Gene Symbol and Name	Kcnj6, potassium inwardly-rectifying channel, subfamily J, member 6
Gene Synonym(s)
Strain of Origin	C57BL/6J
Chromosome	16
Molecular Note	A G-to-A transition at coding nucleotide 466 replaces a glycine with serine at amino acid residue 156 (p.G156S), affecting the highly conserved H5 domain of the channel.

A^w-J

Allele Symbol: A^w-J

Allele Name	white bellied agouti Jackson
Allele Type	Spontaneous
Allele Synonym(s)	A^WJ
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)
Strain of Origin	C57BL/6J
Chromosome	2

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Parkinson's Disease

Genotype: Kcnj6^wv related

Neurobiology Research
- Ataxia (Movement) Defects
- Cerebellar Defects
- Epilepsy
- Channel and Transporter Defects
  - potassium
Cell Biology Research
- Channel and Transporter Defects
  - potassium

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Kcnj6^wv/Kcnj6^wv
C57BL/6J-Kcnj6

behavior/neurological phenotype

abnormal gait

abnormal maternal nurturing

abnormal motor capabilities/coordination/movement
- author states that behavior resembles that of Reln^rl and Rora^sg; no data is given

abnormal motor coordination/balance
- adult mice are unable to stand or step forward without falling over
- coordination is better in the second week of life than in the third week

decreased food intake
- mutants nurse poorly

impaired righting response

induced hyperactivity
- unique to cerebellar mutants: mice may leap when excited or agitated despite being neurologically compromised

tonic-clonic seizures

tremors
- a fine, rapid tremor is seen in the trunk and extremities
- the mouse moving accentuates the tremor

weaving

growth/size/body region phenotype

decreased body size
- obvious 8 to 10 days after birth

decreased body weight
- mutants weigh about 50 percent of control sibling weight until the second month when they reach control sibling weight

mortality/aging

lethality at weaning, incomplete penetrance
- Background Sensitivity - majority die at about 3 weeks of age

premature death
- almost all mutants die within a year, whereas normal littermates live considerably longer
- most homozygous mutants do not live to maturity

nervous system phenotype

abnormal cerebellar granule cell morphology
- cytoskeletal organization of mutant granule cell neurons in mutants shows a denser cytoplasmic matrix, indistinct skeletal structure of the cytoplasm, and microtubules delineating the boundary of microspike-like projections and entering them
- granule cell neurons in the cerebellum have an unusually large number of coated vesicles throughout the length of the neurite in mutants
- microtubules in mutant granule cell neurites are less densely packed, curving and crossing along the neurite length and delimiting the neurite perimeter while in wild-type microtubules fill the internal dimensions of the neurite

abnormal cerebellar granule layer morphology
- almost complete absence of granule cells
- cells are restricted to the most lateral portions of the cerebellar hemisphere and paraflocculus

abnormal cerebellar molecular layer
- during greatest mitotic activity, the majority of granule cells are degenerating

abnormal cerebellar Purkinje cell layer
- during greatest mitotic activity, some granule cells are degenerating

abnormal cerebellum development

abnormal cerebellum external granule cell layer morphology
- extensive degeneration of external granule cells prior to migration to form granule layer

absent cerebellar lobules

absent cerebellum fissure

increased Purkinje cell number
- relative to the volume of cerebellar cortical tissue

small cerebellum
- abnormally small at 5 to 7 days and thereafter
- about one-fourth the size of normal in mature mice

tonic-clonic seizures

reproductive system phenotype

reduced female fertility

reduced male fertility

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6J

cellular phenotype

abnormal cell migration
- prior to P4, granule cell migration is delayed

increased apoptosis
- percentage of pyknotic nuclei in the granule layer in cerebella of homozygotes is dramatically increased compared to wild-type and heterozygotes; this is increased in the vermis relative to that of the cerebellar hemisphere

nervous system phenotype

abnormal cerebellar cortex morphology
- small caliber parallel fibers are virtually absent

abnormal cerebellar granule layer morphology
- by P2 there is a decrease in the number of cells in the vermal external granule layer in homozygotes; the difference is mor striking at P4 and unlike wild-type or heterozygous mice, no spindle-shaped cells are observed
- there is a severe paucity of granule cells in homozygotes

abnormal cerebellar molecular layer
- the molecular layer is thin and relatively acellular from P0 to P6 compared to wild-type

abnormal cerebellar Purkinje cell layer
- Purkinje cells display disordered arrangement

abnormal cerebellum morphology
- at P8 the width of the cerebellum is reduced by 10 and 13% compared to heterozygotes and wild-type respectively
- at P8, the area of the cerebellar hemispheres is reduced by 23% compared to wild-type
- cytoarchitecture of cerebellum is completely disorganized
- there is no clear distinction between cortical layers

abnormal cerebellum vermis morphology
- area of the vermis in homozygotes at P2 is 46% that of wild-type and 69% that of heterozygous mice; at P4, the vermis is 48% the size of wild-type

abnormal Purkinje cell morphology
- Purkinje cells display disordered arrangement

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6

homeostasis/metabolism phenotype

decreased taurine level
- taurine levels are 64% of control levels at 7 days of age

nervous system phenotype

abnormal cerebellar granule cell morphology
- in cultured cerebellar granule cells, very little inwardly rectifying K+ current can be evoked with somatostatin or by direct activation of G proteins, compared to wild-type cells

abnormal CNS synaptic transmission

abnormal cochlear VIII nucleus morphology
- less granule cell loss
- loss of cartwheel cells in the dorsal cochlear nucleus is modest

abnormal neurotransmitter level
- aspartate, glutamine, and serine levels low at 10 days
- taurine levels are 64% of control levels at 7 days of age

abnormal synaptic glutamate release
- levels low at 7 and 21 days

decreased Purkinje cell number
- scattered Purkinje cells beneath a thin molecular layer

small cerebellum
- weight is 56% of control weight at 7 days (80% of controls for heterozygotes)
- weight of cerebellum is normal at 3 days of age

Genotype: Kcnj6^wv/Kcnj6⁺
involves: C57BL/6J

behavior/neurological phenotype

abnormal locomotor behavior

reproductive system phenotype

male infertility

cellular phenotype

abnormal cell migration
- prior to P4, granule cell migration is delayed

increased apoptosis
- more pyknotic nuclei are observed in the external granule layer of heterozygotes at all times compared to wild-type

nervous system phenotype

abnormal cerebellar molecular layer
- in heterozygotes the molecular layer is thin and relative acellular at P4; at P6 the molecular layer appears to be hypercellular compared to wild-type
- in the cerebellar hemispheres, 40% fewer pyknotic nuclei are observed than in the vermis

abnormal cerebellum morphology
- at P8, total width of the cerebellum is decreased by 13%
- cerebellar hemispheres in heterozygotes are 37% smaller than wild-type

abnormal cerebellum vermis morphology
- from P2 to P4, area of the vermis is 33% smaller in heterozygotes than in wild-type; by P8, the vermal area of mutants is 57% of the area of wild-type

abnormal substantia nigra pars compacta morphology
- substantial cell loss in the substantia nigra pars compacta of the midbrain

The following phenotype relates to a compound genotype created using this strain

Genotype: Kcnj6^wv/Kcnj6^wv
B6CBACa A/A-Kcnj6/J

behavior/neurological phenotype

abnormal locomotor activation
- when mutants are treated with direct dopamine agonists, they display a greater increase in locomotor activity than wild-type; amphetamine, which potentiates release of endogenous dopamine stores has less effect in mutants than in wild-type

ataxia
- homozygotes are characterized by an ataxic gait

growth/size/body region phenotype

decreased body weight
- homozygotes have decreased body weight compared to wild-type

homeostasis/metabolism phenotype

decreased dopamine level
- dopamine levels are decreased by 27% in the olfactory tubercle, 77% lower in the frontal cortex and 75% lower in the striatum in 6 month-old mutants compared to wild-type

mammalian phenotype

homeostasis/metabolism phenotype
- Normal - no aberrant bleeding time after tail vein nick

nervous system phenotype

abnormal cerebellar cortex morphology
- in homozygotes, Purkinje cell ectopia in the nodular zone is less pronounced but the Purkinje cell layer is several layers thick

abnormal cerebellar lobule formation
- in homozygotes, normal lobation is disrupted

abnormal cerebellar Purkinje cell layer

abnormal nervous system morphology
- in mutants the dopamine system fails to form

abnormal Purkinje cell dendrite morphology
- in central zone, Purkinje cells have stunted and disorganized dendrites

abnormal substantia nigra pars compacta morphology
- in mutants the pars compacta of substantia nigra appears hypocellular compared to wild-type

decreased dopaminergic neuron number
- in mutants fewer large neurons are seen in the midbrain

ectopic Purkinje cell
- in the central zone of the cerebellar cortex, almost all Purkinje cells are clustered ectopically

Genotype: Kcnj6^wv/Kcnj6⁺
B6CBACa A/A-Kcnj6/J

nervous system phenotype

abnormal cerebellar Purkinje cell layer
- disruptions of Purkinje cell alignment are observed
- in more rostral regions of the central zone, Purkinje cells are ecctopic and have stunted and disorganized dendrites

abnormal Purkinje cell dendrite morphology
- in more rostral regions of the central zone, cells have stunted and have randomly organized dendrites

abnormal Purkinje cell morphology
- in the central zone, Purkinje cells located farther from the pial surface are clumped together in clusters

delaminated Purkinje cell layer
- Purkinje cell layer is irregular and several cell layers thick, especially in the anterior zone of the cerebellar cortex

Genotype: Kcnj6^wv/Kcnj6^wv
B6CBA A/A-Kcnj6

cellular phenotype

abnormal male germ cell morphology
- in numerous cases, fragments of a few flagella are seen within the same cytoplasmic matrix

abnormal sperm motility
- in mutants, percentage of mobile sperm is 23.8% compared to 73% in wild-type

abnormal spermatid morphology
- numerous multinucleated spermatids are present at P21
- spermatid nuclei often show irregular chromosomal condensation

globozoospermia
- at P56, numerous round spermatids are swollen, multinucleated, show defects in acrosomal structures and are undergoing degeneration

oligozoospermia
- sperm count in mutants is 7.1 x 10⁵ compared to 202.5 x 10⁵ in wild-type

homeostasis/metabolism phenotype

abnormal ion homeostasis
- resting Ca²⁺ levels are elevated in mutant cerebellar granule neurons compared to wild-type; high potassium stimulation evokes less [Ca²⁺] change in mutant cerebellar granule neurons than in wild-type

reproductive system phenotype

abnormal male germ cell morphology
- in numerous cases, fragments of a few flagella are seen within the same cytoplasmic matrix

abnormal seminiferous tubule epithelium morphology
- at P56 in mutants seminiferous epithelium displays progressive atrophic changes and many cellular aberrations

abnormal seminiferous tubule morphology
- in P21 mutants, there is a lack of patent lumina

abnormal Sertoli cell morphology
- at P21, mutants show Sertoli cells with slightly vacuolated cytoplasm
- at P56, defects in seminiferous tubule epithelium are often associated with shrinkage of the apical processes of Sertoli cells, their disconnection from the surface of germ cells and paucity of mature spermatids
- at P56, degenerating Sertoli cells of mutants are electron-dense, conspicuously shrunken, and have a foamy cytoplasmic appearance; many are round with small nuclei that have deeply folded surface configurations

abnormal sperm motility
- in mutants, percentage of mobile sperm is 23.8% compared to 73% in wild-type

abnormal spermatid morphology
- numerous multinucleated spermatids are present at P21
- spermatid nuclei often show irregular chromosomal condensation

abnormal spermatogenesis
- cytoplasmic processes are observed which incorporate parallel membranous structures that show connections to the cisternae and vesicles of the smooth endoplasmic reticulum
- in seminiferous tubules at P21, mutants have less advanced spermatid maturation and there are numerous multinucleated spermatids

globozoospermia
- at P56, numerous round spermatids are swollen, multinucleated, show defects in acrosomal structures and are undergoing degeneration

oligozoospermia
- sperm count in mutants is 7.1 x 10⁵ compared to 202.5 x 10⁵ in wild-type

endocrine/exocrine gland phenotype

abnormal seminiferous tubule epithelium morphology
- at P56 in mutants seminiferous epithelium displays progressive atrophic changes and many cellular aberrations

abnormal seminiferous tubule morphology
- in P21 mutants, there is a lack of patent lumina

abnormal Sertoli cell morphology
- at P21, mutants show Sertoli cells with slightly vacuolated cytoplasm
- at P56, defects in seminiferous tubule epithelium are often associated with shrinkage of the apical processes of Sertoli cells, their disconnection from the surface of germ cells and paucity of mature spermatids
- at P56, degenerating Sertoli cells of mutants are electron-dense, conspicuously shrunken, and have a foamy cytoplasmic appearance; many are round with small nuclei that have deeply folded surface configurations

Genotype: Kcnj6^wv/Kcnj6⁺
B6CBA A/A-Kcnj6

cellular phenotype

abnormal male germ cell morphology
- in numerous cases, fragments of a few flagella are seen within the same cytoplasmic matrix

abnormal sperm motility

abnormal spermatid morphology
- many step 2-3 spermatids often have 2 to 3 acrosomal vesicles associated with one nucleus
- mature spermatids are deformed, maloriented and display irregular chromosomal condensation
- mature spermatids are often absent in affected areas of the seminiferous tubules; multinucleated spermatids are common

oligozoospermia
- sperm count in mutants is 7.1 x 10⁵ compared to 127.7 x 10⁵ in wild-type

endocrine/exocrine gland phenotype

abnormal seminiferous tubule epithelium morphology
- cellular abnormalities of the germinal epithelium are more apparent at P140 and P211; seminiferous epithelium has prominent extracellular spaces and local depletion of the epithelium

reproductive system phenotype

abnormal male germ cell morphology
- in numerous cases, fragments of a few flagella are seen within the same cytoplasmic matrix

abnormal seminiferous tubule epithelium morphology
- cellular abnormalities of the germinal epithelium are more apparent at P140 and P211; seminiferous epithelium has prominent extracellular spaces and local depletion of the epithelium

abnormal sperm motility

abnormal spermatid morphology
- many step 2-3 spermatids often have 2 to 3 acrosomal vesicles associated with one nucleus
- mature spermatids are deformed, maloriented and display irregular chromosomal condensation
- mature spermatids are often absent in affected areas of the seminiferous tubules; multinucleated spermatids are common

abnormal spermatogenesis

oligozoospermia
- sperm count in mutants is 7.1 x 10⁵ compared to 127.7 x 10⁵ in wild-type

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6 * CBA/CaGnLe

behavior/neurological phenotype

ataxia
- at P10, homozygotes display ataxia, tremor and hindlimb weakness
- homozygous mutants are distinguished by ataxia at 3 weeks of age

impaired righting response
- at 7 days of age, homozygotes are distinguished by difficulty in righting themselves

retropulsion
- A 7 days of age, homozygotes display tendency to move backward

tremors
- homozygous mutants are distinguished by tremors at 3 weeks of age

homeostasis/metabolism phenotype

increased noradrenaline level
- elevated noradrenaline in the cerebellum, cerebral cortex, and spinal cord

muscle phenotype

hypotonia
- homozygous mutants are distinguished by hypotonia at 3 weeks of age

nervous system phenotype

abnormal cerebellar granule layer morphology
- there is a marked depletion of granule cells in the internal granule cell layer

abnormal cerebellar molecular layer
- there are ectopic granule cells found in the molecular layer

abnormal cerebellum external granule cell layer morphology
- apoptotic cells lay mainly along the inner margin of the layer at P7 and 14; at P21 and 28, most apoptotic cells are confined to the thin external granule layer
- at P7, the normal organization of granule cells into a proliferative and a nonprolifeative zone is not maintained in homozygotes
- numerous dying cells are seen compared to wild-type

increased noradrenaline level
- elevated noradrenaline in the cerebellum, cerebral cortex, and spinal cord

small cerebellum
- at P7, the cerebellum of homozygotes is one-fifth the size of wild-type with a pronounced midline sulcus
- cerebellum wet weight is 40% of controls
- homozygotes have and abnormally small and malformed cerebellum

reproductive system phenotype

abnormal epididymis morphology
- lumens of epididymes of mutants are either empty or packed with degenerating germ cells with pyknotic nuclei and cellular debris; there are no long sickle-shaped nuclei indicative of mature sperm

abnormal seminiferous tubule morphology
- in homozygotes, the testes have few seminiferous tubules containing elongated spermatids

abnormal testis morphology
- at P28, germ cells are underdeveloped or delayed; degeneration of germ cells in the semiferous epithelium is apparent and no tubules have late-step elongated spermatids and 6% of the tubules show degenerating seminiferous epithelia
- at P35, mutant males show only a small number of germ cells that have finished the first round of spermatogenesis

azoospermia
- no sperm are found in seminiferous tubules of male homozygotes

male infertility

seminiferous tubule degeneration
- at P35, degeneration is much more severe than that observed at P28; degenerating germ cells are present in all mutants examined
- homozygotes display variable germinal epithelial degeneration
- testes of homozygotes show degenerating tubules with degenerating germ cells

cellular phenotype

azoospermia
- no sperm are found in seminiferous tubules of male homozygotes

increased apoptosis
- at P7 and 14, there is much greater cell death in the cerebellum of homozygotes
- in homozygotes there are many more apoptotic germ cells than in wild-type

endocrine/exocrine gland phenotype

abnormal seminiferous tubule morphology
- in homozygotes, the testes have few seminiferous tubules containing elongated spermatids

abnormal testis morphology
- at P28, germ cells are underdeveloped or delayed; degeneration of germ cells in the semiferous epithelium is apparent and no tubules have late-step elongated spermatids and 6% of the tubules show degenerating seminiferous epithelia
- at P35, mutant males show only a small number of germ cells that have finished the first round of spermatogenesis

seminiferous tubule degeneration
- at P35, degeneration is much more severe than that observed at P28; degenerating germ cells are present in all mutants examined
- homozygotes display variable germinal epithelial degeneration
- testes of homozygotes show degenerating tubules with degenerating germ cells

Genotype: Kcnj6^wv/Kcnj6⁺
involves: C57BL/6 * CBA/CaGnLe

nervous system phenotype

abnormal cerebellar granule layer morphology
- there is moderated loss of granule cells

abnormal cerebellar Purkinje cell layer
- heterozygotes display a disordered Purkinje cell layer

abnormal cerebellum morphology
- in heterozygotes the cerebellum is slightly shrunken, and some folia is less well-developed than in wild-type

small cerebellum
- cerebellum is slightly smaller in heterozygotes; it is misshapen and deflated

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6J * CBA

nervous system phenotype

abnormal hippocampal mossy fiber morphology
- mossy fibers emanating from the hilus of the dentate gyrus are not confined to the layers flanking the pyramidal cell layer

abnormal hippocampus pyramidal cell layer
- in homozygous mutants the pyramidal cell layer of area CA3 appears to be thicker than normal
- subdivision of the pyramidal layer into 2 and 3 layers is seen in area CA3

ectopic hippocampus pyramidal cells
- ectopic pyramidal cells are seen in the stratum radiatum and/or in the stratum oriens: these appear as small clusters or single cells surrounded by neuropil

References

Hirano A; Dembitzer HM. 1973. Cerebellar alterations in the weaver mouse. J Cell Biol 56(2):478-86PubMed: 4118891 MGI: J:5315
Yao W; Zhong J; Rosen CJ; Hock JM; Lee WH. 2005. Igf-I and postnatal growth of weaver mutant mice. Endocrine 26(2):117-25PubMed: 15888923 MGI: J:109832

Additional References

Douhou A; Debeir T; Michel PP; Stankovski L; Oueghlani-Bouslama L; Verney C; Raisman-Vozari R. 2003. Differential activation of astrocytes and microglia during post-natal development of dopaminergic neuronal death in the weaver mouse. Brain Res Dev Brain Res 145(1):9-17PubMed: 14519489 MGI: J:86201
Gao WQ; Liu XL; Hatten ME. 1992. The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell 68(5):841-54PubMed: 1547486 MGI: J:2009
Guatteo E; Fusco FR; Giacomini P; Bernardi G; Mercuri NB. 2000. The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons. J Neurosci 20(16):6013-20PubMed: 10934250 MGI: J:63835
Patil N; Cox DR; Bhat D; Faham M; Myers RM; Peterson AS. 1995. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation [see comments] Nat Genet 11(2):126-9PubMed: 7550338 MGI: J:29230
Perandones C; Costanzo RV; Kowaljow V; Pivetta OH; Carminatti H; Radrizzani M. 2004. Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development. Brain Res Mol Brain Res 128(1):8-19PubMed: 15337313 MGI: J:92848
Rotter A; Rath S; Evans JE; Frostholm A. 2000. Modulation of GABA(A) receptor subunit mRNA levels in olivocerebellar neurons of purkinje cell degeneration and weaver mutant mice. J Neurochem 74(5):2190-200PubMed: 10800965 MGI: J:61537

Additional - A^w-J related

Additional - Kcnj6^wv related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Separated PCR:A A A Alternate2
- Genotyping resources and troubleshooting
Appearance
- white-bellied agouti, ataxic
  Related Genotype: A^w-J/? Kcnj6^wv/Kncj6^wv
  
  agouti, ataxic
  Related Genotype: A/A Kcnj6^wv/Kncj6^wv
  
  white-bellied agouti, unaffected
  Related Genotype: A^w-J/? +/? or A^w-J/A Kncj6^wv/+
  
  agouti, unaffected
  Related Genotype: A/A +/? or A/A Kncj6^wv/+
Citation
When using the weaver mouse strain in a publication, please cite the originating article(s) and include JAX stock #000247 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

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Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous or Homozygous for Kcnj6<wv>

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As:weaver

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Kcnj6wv

Allele Symbol: Kcnj6wv

Aw-J

Allele Symbol: Aw-J

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Kcnj6wv related

Mammalian Phenotype Terms by Genotype

Genotype: Kcnj6wv/Kcnj6wvC57BL/6J-Kcnj6

behavior/neurological phenotype

growth/size/body region phenotype

mortality/aging

nervous system phenotype

reproductive system phenotype

Genotype: Kcnj6wv/Kcnj6wvinvolves: C57BL/6J

cellular phenotype

nervous system phenotype

Genotype: Kcnj6wv/Kcnj6wvinvolves: C57BL/6

homeostasis/metabolism phenotype

nervous system phenotype

Genotype: Kcnj6wv/Kcnj6+involves: C57BL/6J

behavior/neurological phenotype

reproductive system phenotype

cellular phenotype

nervous system phenotype

Genotype: Kcnj6wv/Kcnj6wvB6CBACa A/A-Kcnj6/J

behavior/neurological phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

mammalian phenotype

nervous system phenotype

Genotype: Kcnj6wv/Kcnj6+B6CBACa A/A-Kcnj6/J

nervous system phenotype

Genotype: Kcnj6wv/Kcnj6wvB6CBA A/A-Kcnj6

cellular phenotype

homeostasis/metabolism phenotype

reproductive system phenotype

endocrine/exocrine gland phenotype

Genotype: Kcnj6wv/Kcnj6+B6CBA A/A-Kcnj6

cellular phenotype

endocrine/exocrine gland phenotype

reproductive system phenotype

Genotype: Kcnj6wv/Kcnj6wvinvolves: C57BL/6 * CBA/CaGnLe

behavior/neurological phenotype

homeostasis/metabolism phenotype

muscle phenotype

nervous system phenotype

reproductive system phenotype

cellular phenotype

endocrine/exocrine gland phenotype

Genotype: Kcnj6wv/Kcnj6+involves: C57BL/6 * CBA/CaGnLe

nervous system phenotype

Genotype: Kcnj6wv/Kcnj6wvinvolves: C57BL/6J * CBA

nervous system phenotype

References

Additional References

Additional - Aw-J related

Additional - Kcnj6wv related

Genotyping Protocols

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

Kcnj6^wv

Allele Symbol: Kcnj6^wv

A^w-J

Allele Symbol: A^w-J

Genotype: Kcnj6^wv related

Genotype: Kcnj6^wv/Kcnj6^wv
C57BL/6J-Kcnj6

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6J

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6

Genotype: Kcnj6^wv/Kcnj6⁺
involves: C57BL/6J

Genotype: Kcnj6^wv/Kcnj6^wv
B6CBACa A/A-Kcnj6/J

Genotype: Kcnj6^wv/Kcnj6⁺
B6CBACa A/A-Kcnj6/J

Genotype: Kcnj6^wv/Kcnj6^wv
B6CBA A/A-Kcnj6

Genotype: Kcnj6^wv/Kcnj6⁺
B6CBA A/A-Kcnj6

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6 * CBA/CaGnLe

Genotype: Kcnj6^wv/Kcnj6⁺
involves: C57BL/6 * CBA/CaGnLe

Genotype: Kcnj6^wv/Kcnj6^wv
involves: C57BL/6J * CBA

Additional - A^w-J related

Additional - Kcnj6^wv related