JAX Mouse Strain Datasheet - 000231

B6;C3Fe a/a-Csf1^op/J

Stock No:: 000231 |; osteopetrosis

Spontaneous Mutation

Repository Live

Overview

Also Known As: osteopetrosis

Mice homozygous for the osteopetrosis spontaneous mutation (Csf1^op) may be useful to study the role of glia in neurological disease.

Genetic overview

Genetic Background	Generation
	N74 (20-JUL-17)

Csf1^op

Allele Type	Gene Symbol	Gene Name
Spontaneous	Csf1	colony stimulating factor 1 (macrophage)

Allele Type	Gene Symbol	Gene Name
Spontaneous	a	nonagouti

Research Applications

Internal/Organ Research
Neurobiology Research
Cancer Research
Developmental Biology Research
Endocrine Deficiency Research
Immunology, Inflammation and Autoimmunity Research
Research Tools

View All Research Applications

Base Price

Starting at:

$255.00 Domestic price for female

$424.90 Domestic price for breeder pair

$2,595.00 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

Mice homozygous for the osteopetrosis spontaneous mutation (Csf1^op) are viable and exhibit osteopetrosis. The osteoclasts are the primary cell type affected in homozygous mutant mice. This results in a generalized macrophage deficiency, monocytopenia, and defective bone remodeling. Homozygous mutant mice also have abnormal calcium regulation, impaired dental growth and female mice fail to lactate. Total leukocyte counts are reduced and marrow cells are decreased to one-tenth of normal control mice.Homozygous mutant mice have a deficient microglia and macrophage response, and therefore may be useful tools to study the role of glia in neurological disease if mated to transgenic models of neurodegenerative disease.

Development

The osteopetrotic mutation arose spontaneously in 1970 at The Jackson Laboratory in the beginning congenic stock that became B6.DW-Pou1f1^dw/J, which was then at generation N3. Osteopetrotic heterozygotes were backcrossed to C57BL/6J for 7 generations. The line was then bred once to C3FeLe.B6-a/a/J and the strain was subsequently maintained via homozygous ovarian transplant host bred to (C57BL/6J x C3FeLe.B6-a/a/J)F1 then intercross of the obligate heterozygous offspring.

Control Suggestions

Untyped from the colony

Additional Information

Considerations for Choosing Controls

Genetics

Csf1^op

Allele Symbol: Csf1^op

Allele Name	osteopetrosis
Allele Type	Spontaneous
Allele Synonym(s)	Csf-1^op; Csf1^- op; Csfm^op; M-; csfmop; op
Gene Symbol and Name	Csf1, colony stimulating factor 1 (macrophage)
Gene Synonym(s)	C87615; CSF-1; Csfm; Csfm; M-CSF; MCSF; colony stimulating factor, macrophage; colony-stimulating factor-1; expressed sequence C87615; op; osteopetrosis
Strain of Origin	B6;DW-Pou1f1
Chromosome	3
Molecular Note	A single nucleotide (T) insertion 262 bp downstream from the initiation codon resulted in a frameshift and the creation of a stop codon 21 bp downstream of the insertion.

a

Allele Symbol: a

Allele Name	nonagouti
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)	AGSW; AGTI; AGTIL; ASP; As; As; SHEP9; agouti; agouti signal protein; agouti suppressor
Strain of Origin	old mutant of the mouse fancy
Chromosome	2
Molecular Note	Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for a^t-2Gso and A^w-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Internal/Organ Research
- Skeleton
  - Bone
Neurobiology Research
- Alzheimer's Disease
- Parkinson's Disease

Genotype: Csf1^op related

Cancer Research
- Growth Factors/Receptors/Cytokines
Developmental Biology Research
- Skeletal Defects
  - osteopetrosis
Endocrine Deficiency Research
- Bone/Bone Marrow Defects
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
- Immunodeficiency
- Immunodeficiency Associated with Other Defects
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - Macrophage Deficiency

Mammalian Phenotype Terms by Genotype

Genotype: Csf1^op/Csf1^op
involves: C3HeB/FeJ * C57BL/6J

homeostasis/metabolism phenotype

abnormal circulating calcium level
- unable to raise serum calcium concentration in response to parathyroid extract (PTE)

decreased circulating phosphate level
- phosphate serum levels are low but calcium levels are normal

decreased circulating testosterone level
- mutant male mice have a seven-fold lower concentration of circulating testosterone than wild-type mice

reproductive system phenotype

abnormal ovary morphology
- very few macrophages present in ovaries at all stages of cycle and follicular development

abnormal ovulation
- significantly lower ovulation rate and frequency

abnormal proestrus
- mice do not display the characteristic surge in circulating estradiol-17 beta expected during proestrus

abnormal sperm number
- a lower then normal number of viable sperm are detected
- normal numbers of viable sperm are restored after testosterone or CSF-1 treatment throughout the postnatal period

abnormal testis physiology
- testosterone level in the tesis is lower than normal

decreased corpora lutea number

decreased fertilization frequency
- only 50% of the mated superovulated mutant females produced fertilized ooctyes compared with 83.3% of the mated superovulated heterozygous females

decreased litter size

decreased ovulation rate
- 20% of ovaries fail to undergo ovulation
- the ovulation rate is low for mice that do ovulate

impaired embryo implantation
- a lower than normal number of implantations are seen

prolonged estrous cycle
- females reach estrus every 14 days compared with a normal approximately 5 day cycle
- subcutaneous adninistration of CSF-1 from birth restores a normal estrous cycle

reduced female fertility

integument phenotype

abnormal branching of the mammary ductal tree
- precocious development of the lobulo-alveolar system

abnormal lactation
- milk proteins are expressed but parturition does not initiate lactation

abnormal mammary gland development

abnormal mammary gland growth during lactation
- incomplete mammary gland ductal growth occurs during pregnancy

abnormal mammary gland lobule morphology

cellular phenotype

abnormal osteoclast differentiation
- exogenous M-CSF enables normal osteoclast differentiation

behavior/neurological phenotype

abnormal eating behavior
- pups drink less of the mother's milk possibly due to being unable to compete with normal littermates

abnormal mating frequency
- only 64.4% of superovulated mutant females successfully mated as evidenced by a vaginal plug compared with 88.9% of mated superovulated heterozygous females

reduced male mating frequency
- normal mating behavior is restored following treatment with circulating testosterone or CSF-1 throughout the postnatal period

cardiovascular system phenotype

decreased susceptibility to atherosclerosis
- lesions are also less frequent and when present, less advanced with no lesions containing fibrous caps observed
- mice on a high fat diet for 15 weeks develop smaller atherosclerosis lesions than do the C57BL/6J controls

growth/size/body region phenotype

absent teeth
- at weaning mice need to be provided with soft food in order to thrive
- noticeably absent at 10 days of age

decreased body weight
- mice have decreased body weight until weaning when they will normalize their weight if fed a liquid diet

hematopoietic system phenotype

abnormal osteoclast cell number

abnormal osteoclast differentiation
- exogenous M-CSF enables normal osteoclast differentiation

decreased osteoclast cell number
- at birth the osteoclast population appears normal but quickly decreases to negligible numbers by the time the mouse is 3-4 days of age

immune system phenotype

abnormal osteoclast cell number

abnormal osteoclast differentiation
- exogenous M-CSF enables normal osteoclast differentiation

decreased osteoclast cell number
- at birth the osteoclast population appears normal but quickly decreases to negligible numbers by the time the mouse is 3-4 days of age

skeleton phenotype

abnormal bone marrow cavity morphology
- the excessive accumulations of bone lack marrow cavities

abnormal bone remodeling
- although bone remodeling is reduced, overall decline in rate of bone formation removes excess bone resulting in nearly normal bone
- compared with normal littermates, bone matrix formation is significantly elevated before 40 days of age and significantly reduced between 81 days and 10 months of age

abnormal osteoclast cell number

abnormal osteoclast differentiation
- exogenous M-CSF enables normal osteoclast differentiation

absent teeth
- at weaning mice need to be provided with soft food in order to thrive
- noticeably absent at 10 days of age

decreased osteoclast cell number
- at birth the osteoclast population appears normal but quickly decreases to negligible numbers by the time the mouse is 3-4 days of age

domed cranium
- mutants are recognized at 10 days of age by a characteristic domed head

craniofacial phenotype

absent teeth
- at weaning mice need to be provided with soft food in order to thrive
- noticeably absent at 10 days of age

domed cranium
- mutants are recognized at 10 days of age by a characteristic domed head

endocrine/exocrine gland phenotype

abnormal branching of the mammary ductal tree
- precocious development of the lobulo-alveolar system

abnormal lactation
- milk proteins are expressed but parturition does not initiate lactation

abnormal mammary gland development

abnormal mammary gland growth during lactation
- incomplete mammary gland ductal growth occurs during pregnancy

abnormal mammary gland lobule morphology

abnormal ovary morphology
- very few macrophages present in ovaries at all stages of cycle and follicular development

abnormal testis physiology
- testosterone level in the tesis is lower than normal

abnormal thyroid parafollicular C-cell morphology
- this cell population is increased in this mutation

decreased corpora lutea number

Genotype: Csf1^op/Csf1^op
B6;C3Fe a/a-Csf1^op/J

immune system phenotype

abnormal microglial cell morphology
- decrease in numbers of microglia in the white matter of the brain and spinal cord compared to wild-type mice

decreased macrophage cell number
- in the bronchoalveolar lavage of bleomycin-treated mice compared with similarly treated wild-type mice
- numbers are significantly decreased in atral follicles
- numbers were enhanced by treatment with macrophage colony-stimulating factor

impaired macrophage chemotaxis
- to the bronchoalveolar lavage of bleomycin-treated mice compared with similarly treated wild-type mice

growth/size/body region phenotype

abnormal postnatal growth
- growth of mutants is slower than wild-type mice

cellular phenotype

impaired granulosa cell differentiation
- the numbers of cells in the atral follicles are significantly reduced but differentiation increases after treatment with macrophage colony-stimulating factor

impaired macrophage chemotaxis
- to the bronchoalveolar lavage of bleomycin-treated mice compared with similarly treated wild-type mice

homeostasis/metabolism phenotype

decreased physiological sensitivity to xenobiotic
- mice are protected from bleomycin-induced lung fibrosis with fewer recruited alveolar macrophages in the bronchoalveolar lavage compared with similarly treated wild-type mice

hematopoietic system phenotype

abnormal microglial cell morphology
- decrease in numbers of microglia in the white matter of the brain and spinal cord compared to wild-type mice

decreased macrophage cell number
- in the bronchoalveolar lavage of bleomycin-treated mice compared with similarly treated wild-type mice
- numbers are significantly decreased in atral follicles
- numbers were enhanced by treatment with macrophage colony-stimulating factor

impaired macrophage chemotaxis
- to the bronchoalveolar lavage of bleomycin-treated mice compared with similarly treated wild-type mice

nervous system phenotype

abnormal microglial cell morphology
- decrease in numbers of microglia in the white matter of the brain and spinal cord compared to wild-type mice

abnormal neurite morphology
- neurons explanted from embryonic day 17 cortex and cultured for 1 to 2 days have fewer processes and at 4 and 8 days of culture have decreased complexity of neurites compared with controls

hearing/vestibular/ear phenotype

abnormal auditory brainstem response waveform shape
- latencies are prolonged and amplitudes reduced with an absolute delay in the wave I latency, prolongation of the wave I-V interval, and loss of amlitude and integrity of the later components; subcutaneous administration of CSF1 daily for 10 weeks beginning at 2 days of age ameliorates this phenotype toward normal valuesg at 2 days of age ameliorates this phenotype toward normal values

vision/eye phenotype

abnormal visual evoked potential
- administration of the GABA A antagonist bicuculline results not only in changes in neural firing in the supragranular laminae, as is the case in wild-type controls, but also results in diffusely elevated unit firing in several laminae in homozygotes indicating abnormal intracortical circuitryating abnormal intracortical circuitry
- intracortical visual evoked potential readings show total intracortical current to be significantly reduced, both in the initial excitation and subsequent inhibition, with deficits found in both transmembrane current flow and multiple unit activity, although the onset latencies of current flow are normal; subcutaneous administration of CSF1 daily for 10 weeks beginning at 2 days of age ameliorates this phenotype toward normal valuesugh the onset latencies of current flow are normal; subcutaneous administration of CSF1 daily for 10 weeks beginning at 2 days of age ameliorates this phenotype toward normal values
- supragranular laminae and thalamorecipient layers both show abnormal processing
- surface visual evoked potentials are dramatically reduced or absent

endocrine/exocrine gland phenotype

abnormal ovarian follicle number
- there are fewer atral and mature follicles in the proestrus ovary compared with controls

abnormal ovarian folliculogenesis

decreased mature ovarian follicle number

decreased secondary ovarian follicle number
- fewer follicles develop compared with normal

impaired granulosa cell differentiation
- the numbers of cells in the atral follicles are significantly reduced but differentiation increases after treatment with macrophage colony-stimulating factor

reproductive system phenotype

abnormal ovarian follicle number
- there are fewer atral and mature follicles in the proestrus ovary compared with controls

abnormal ovarian folliculogenesis

abnormal ovulation
- the number of eggs ovulated at each cycle varies significantly
- total number of oocytes ovulated is less than expected

decreased mature ovarian follicle number

decreased secondary ovarian follicle number
- fewer follicles develop compared with normal

impaired granulosa cell differentiation
- the numbers of cells in the atral follicles are significantly reduced but differentiation increases after treatment with macrophage colony-stimulating factor

behavior/neurological phenotype

behavior/neurological phenotype
- mutants do not exhibit any neurological signs

Genotype: Csf1^op/Csf1^op
B6C3Fe a/a-Csf1^op/J

mortality/aging

postnatal lethality, incomplete penetrance
- reduced numbers of homozygotes survive to weaning

endocrine/exocrine gland phenotype

abnormal branching of the mammary ductal tree
- ductal structures are poorly developed with incomplete arborization

abnormal lactation
- only 10% of females can lactate, however, lactation in this subset is inefficient

abnormal mammary gland alveolus morphology
- alveolar cells are cuboidal, contain large lipid vesicles and the lumen is small or unformed

abnormal mammary gland development
- alveolar cells are cuboidal, contain large lipid vesicles and the lumen is small or unformed
- postpartum females exhibit incompletely differentiated mammary gland tissue with a nonsecretory phenotype

abnormal mammary gland growth during pregnancy
- lobulo-alveolar development is premature and occupies 56% of mammary gland by day 18 of pregnancy

increased testis weight
- as a percentage of body weight, testicular tissue is increased over controls

thymus cortex hypoplasia
- consists mostly of thymic epithelial cells

thymus medulla atrophy
- atrophic with numerous macrophages

homeostasis/metabolism phenotype

amyloid beta deposits
- 100 to 200 fibrillar plaques observed in cerebral cortex
- 20 to 60 plaques observed in amygdala and hypothalamus
- small number of plaques observed in hippocampus

decreased circulating testosterone level

hearing/vestibular/ear phenotype

abnormal auditory brainstem response
- delayed and diminished response to brainstem auditory evoked potential (BAEP)

abnormal vestibular system physiology
- poorly formed or absent response to surface visual evoked potential (VEP)

cardiovascular system phenotype

abnormal Kupffer cell morphology
- 30% fewer Kupffer cells than normal littermates
- Kupffer cells possess phagocytized blood cells, poorly developed organelles and microvilli projections
- irregular distribution of Kupffer cells in liver lobules

abnormal perivascular macrophage morphology
- reduced numbers of perivascular macrophages (as identified by F4/80 staining) are found in parietal cortex

craniofacial phenotype

abnormal parietal bone morphology
- parietal bone grows only through the trabecular bone formation with no subperiosteal bone lamellae forming as in normal mice

domed cranium
- flat bone grows without resorption while keeping the normal primary curvature resulting in a more globular skull

muscle phenotype

abnormal masseter muscle morphology
- severely atrophied white and intermediate muscle fibers are observed in the superficial region of the masseter muscle
- the decrease in diameter of muscle fibers was larger than found in mice fed a granulated diet
- the decrease in sensory input due to underdevelopment of periodontal ligaments in the absence of teeth likely results in atrophy of the masseter muscle
- the progression and extent of atrophy differed among regions of the muscle

vision/eye phenotype

abnormal visual evoked potential
- altered neural firing as demonstrated by multiple unit activity (MUA) measurement
- total intracortical transmembrane current significantly reduced as measured by intracortical VEP

integument phenotype

abnormal branching of the mammary ductal tree
- ductal structures are poorly developed with incomplete arborization

abnormal lactation
- only 10% of females can lactate, however, lactation in this subset is inefficient

abnormal mammary gland alveolus morphology
- alveolar cells are cuboidal, contain large lipid vesicles and the lumen is small or unformed

abnormal mammary gland development
- alveolar cells are cuboidal, contain large lipid vesicles and the lumen is small or unformed
- postpartum females exhibit incompletely differentiated mammary gland tissue with a nonsecretory phenotype

abnormal mammary gland growth during pregnancy
- lobulo-alveolar development is premature and occupies 56% of mammary gland by day 18 of pregnancy

cellular phenotype

abnormal osteoclast differentiation
- daily injection of exogenous M-CSF recruits functional osteoclasts
- linked to impaired remodeling of bone and no marrow cavity formation in long bones
- minimally a single injection of 5 micrograms rhM-CSF is needed for transient recruitment of osteoclasts

necrospermia
- percentage of dead sperm is two times higher than controls

oligozoospermia
- epididymal sperm count 60% lower than control

growth/size/body region phenotype

decreased body weight
- low body weight

postnatal growth retardation
- slower growth rate

immune system phenotype

abnormal Kupffer cell morphology
- 30% fewer Kupffer cells than normal littermates
- Kupffer cells possess phagocytized blood cells, poorly developed organelles and microvilli projections
- irregular distribution of Kupffer cells in liver lobules

abnormal Langerhans cell morphology
- bone chimera experiments suggest hematopoietic precursors to Langerhans cells have reduced capability to differentiate into Langerhan cells when skin is inflammed

abnormal Langerhans cell physiology
- Langerhan cell numbers are slow to recover after UV irradiation
- two weeks after UV irradiation, numbers are 25% compared to unirradiated mutant mice while at the same timepoint irradiated wild-type LC numbers are close to 100% of control

abnormal microglial cell morphology
- microglial cells in frontal cortex have smaller cell bodies and shorter cytoplasmic processes
- reduced numbers of microglial cells in frontal cortex, parietal cortex and corpus callosum

abnormal osteoclast differentiation
- daily injection of exogenous M-CSF recruits functional osteoclasts
- linked to impaired remodeling of bone and no marrow cavity formation in long bones
- minimally a single injection of 5 micrograms rhM-CSF is needed for transient recruitment of osteoclasts

abnormal osteoclast morphology
- reduced size and number of multinuclear osteoclasts

abnormal perivascular macrophage morphology
- reduced numbers of perivascular macrophages (as identified by F4/80 staining) are found in parietal cortex

abnormal spleen red pulp morphology
- extensive extramedullary hematopoiesis

abnormal splenic cell ratio
- increased concentration of CFU-S cells, however , size and differentiation pattern of spleen colonies is normal
- reduced number of macrophages
- spleen mostly composed of fibroblastoid cells

abnormal splenocyte physiology
- mutants have prolonged hemopoiesis

absent Langerhans cell
- absence of Langerhans cells in newborns but numbers recover in adults

decreased leukocyte cell number

decreased macrophage cell number
- decreased numbers in spleen and marrow
- decreased numbers of macrophages in liver, spleen, bone marrow, kidney, subcutaneous tissue, uterus and ovary
- macrophage organelles and microvillous projections are poorly developed
- macrophages exhibit intracytoplasmic organelles in splenic, thymic and bone marrow

decreased monocyte cell number
- almost complete absence of monocytes in peripheral blood

decreased osteoclast cell number
- TRAP+ cells (osteoclasts) were present in low numbers in the bony trabecula regions compared to controls

thymus cortex hypoplasia
- consists mostly of thymic epithelial cells

thymus medulla atrophy
- atrophic with numerous macrophages

skeleton phenotype

abnormal bone marrow cavity morphology
- apparent at postnatal Day 2 and by Day 7 femoral marrow cellularity and progenitor cell content was significantly reduced
- none in long bones where no bone remodeling occurs
- reduced numbers of hematopoietic cells

abnormal bone marrow morphology
- femoral bone marrow cellularity is reduced early but recovers to control levels by 8 months of age

abnormal bone remodeling
- in long bones, therefore no marrow cavity formation

abnormal femur morphology
- distal end is wide, diaphysis does not have a well defined cortex

abnormal long bone hypertrophic chondrocyte zone

abnormal osteoclast differentiation
- daily injection of exogenous M-CSF recruits functional osteoclasts
- linked to impaired remodeling of bone and no marrow cavity formation in long bones
- minimally a single injection of 5 micrograms rhM-CSF is needed for transient recruitment of osteoclasts

abnormal osteoclast morphology
- reduced size and number of multinuclear osteoclasts

abnormal parietal bone morphology
- parietal bone grows only through the trabecular bone formation with no subperiosteal bone lamellae forming as in normal mice

abnormal tibia morphology
- proximal end is wide, diaphysis does not have a well defined cortex

decreased osteoclast cell number
- TRAP+ cells (osteoclasts) were present in low numbers in the bony trabecula regions compared to controls

domed cranium
- flat bone grows without resorption while keeping the normal primary curvature resulting in a more globular skull

increased bone trabecula number
- excessive amount of bone trabeculae
- higher amounts of bony trabeculae

reproductive system phenotype

abnormal mammary gland growth during pregnancy
- lobulo-alveolar development is premature and occupies 56% of mammary gland by day 18 of pregnancy

abnormal uterus development
- poor development of glandular epithelia

endometrium hypoplasia
- endometrium is hypoplastic

increased testis weight
- as a percentage of body weight, testicular tissue is increased over controls

myometrium hypoplasia
- myometrium is hypoplastic

necrospermia
- percentage of dead sperm is two times higher than controls

oligozoospermia
- epididymal sperm count 60% lower than control

reduced male fertility
- males mate on the first night, but not on subsequent nights in timed mating experiments
- males take 5 times longer to mate than controls

nervous system phenotype

abnormal microglial cell morphology
- microglial cells in frontal cortex have smaller cell bodies and shorter cytoplasmic processes
- reduced numbers of microglial cells in frontal cortex, parietal cortex and corpus callosum

amyloid beta deposits
- 100 to 200 fibrillar plaques observed in cerebral cortex
- 20 to 60 plaques observed in amygdala and hypothalamus
- small number of plaques observed in hippocampus

decreased hippocampus pyramidal cell number
- hippocampal neuron loss in CA1 and CA3 regions

hematopoietic system phenotype

abnormal Kupffer cell morphology
- 30% fewer Kupffer cells than normal littermates
- Kupffer cells possess phagocytized blood cells, poorly developed organelles and microvilli projections
- irregular distribution of Kupffer cells in liver lobules

abnormal Langerhans cell morphology
- bone chimera experiments suggest hematopoietic precursors to Langerhans cells have reduced capability to differentiate into Langerhan cells when skin is inflammed

abnormal bone marrow cell morphology/development

abnormal hematopoietic stem cell morphology

abnormal microglial cell morphology
- microglial cells in frontal cortex have smaller cell bodies and shorter cytoplasmic processes
- reduced numbers of microglial cells in frontal cortex, parietal cortex and corpus callosum

abnormal osteoclast differentiation
- daily injection of exogenous M-CSF recruits functional osteoclasts
- linked to impaired remodeling of bone and no marrow cavity formation in long bones
- minimally a single injection of 5 micrograms rhM-CSF is needed for transient recruitment of osteoclasts

abnormal osteoclast morphology
- reduced size and number of multinuclear osteoclasts

abnormal perivascular macrophage morphology
- reduced numbers of perivascular macrophages (as identified by F4/80 staining) are found in parietal cortex

abnormal spleen red pulp morphology
- extensive extramedullary hematopoiesis

abnormal splenic cell ratio
- increased concentration of CFU-S cells, however , size and differentiation pattern of spleen colonies is normal
- reduced number of macrophages
- spleen mostly composed of fibroblastoid cells

abnormal splenocyte physiology
- mutants have prolonged hemopoiesis

absent Langerhans cell
- absence of Langerhans cells in newborns but numbers recover in adults

decreased bone marrow cell number
- marrow mostly composed of fibroblastoid cells
- number of cells 10 fold less than controls
- reduced numbers of CFU-S cells

decreased leukocyte cell number

decreased macrophage cell number
- decreased numbers in spleen and marrow
- decreased numbers of macrophages in liver, spleen, bone marrow, kidney, subcutaneous tissue, uterus and ovary
- macrophage organelles and microvillous projections are poorly developed
- macrophages exhibit intracytoplasmic organelles in splenic, thymic and bone marrow

decreased monocyte cell number
- almost complete absence of monocytes in peripheral blood

decreased osteoclast cell number
- TRAP+ cells (osteoclasts) were present in low numbers in the bony trabecula regions compared to controls

extramedullary hematopoiesis
- observed in splenic red pulp

thymus cortex hypoplasia
- consists mostly of thymic epithelial cells

thymus medulla atrophy
- atrophic with numerous macrophages

liver/biliary system phenotype

abnormal Kupffer cell morphology
- 30% fewer Kupffer cells than normal littermates
- Kupffer cells possess phagocytized blood cells, poorly developed organelles and microvilli projections
- irregular distribution of Kupffer cells in liver lobules

limbs/digits/tail phenotype

abnormal femur morphology
- distal end is wide, diaphysis does not have a well defined cortex

abnormal tibia morphology
- proximal end is wide, diaphysis does not have a well defined cortex

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Csf1^op/Csf1^op
C57BL/6J-Csf1^op

mortality/aging

premature death
- 40% of mice that survive weaning die by 12 months
- hydrocephalus is observed in mice that die at an early age

homeostasis/metabolism phenotype

decreased circulating phosphate level
- serum phosphate levels average 30% below control

skeleton phenotype

abnormal bone marrow cavity morphology
- abnormally high numbers of megakaryocytes
- delayed development of bone marrow cavity

abnormal bone structure
- large lipoid masses in vascular and extravascular areas of bone

abnormal osteoblast physiology
- decreased bone matrix formation after day 81
- increased bone matrix formation to postnatal day 40

abnormal osteoclast morphology
- abnormal distribution of acid phosphatase activity
- osteoclasts small and few in number

abnormal skeleton morphology
- overall skeleton is smaller than in wild-type

abnormal trabecular bone morphology
- long bones filled with primary spongiosa

absent incisors
- absence of incisors is observed by 10 days

absent teeth
- homozygous mice are toothless

decreased osteoclast cell number

domed cranium
- observed by 10 days

osteopetrosis

osteoporosis
- mice exhibit osteoporosis

immune system phenotype

abnormal osteoclast morphology
- abnormal distribution of acid phosphatase activity
- osteoclasts small and few in number

abnormal spleen red pulp morphology
- sinusoids less developed

decreased macrophage cell number
- cells expressing F4/80+ (a marker for macrophages) are almost entirely absent

decreased osteoclast cell number

hematopoietic system phenotype

abnormal osteoclast morphology
- abnormal distribution of acid phosphatase activity
- osteoclasts small and few in number

abnormal spleen red pulp morphology
- sinusoids less developed

decreased macrophage cell number
- cells expressing F4/80+ (a marker for macrophages) are almost entirely absent

decreased osteoclast cell number

reproductive system phenotype

reduced fertility

craniofacial phenotype

abnormal snout morphology
- snouts are rounded

absent incisors
- absence of incisors is observed by 10 days

absent teeth
- homozygous mice are toothless

domed cranium
- observed by 10 days

limbs/digits/tail phenotype

abnormal autopod morphology
- all hind foot digits curve progressively laterally or medially
- change in shape of hind feet during growth, first digit of hindfoot often becomes parallel to the second digit

short limbs

short tail
- frequent development of s-type curves

growth/size/body region phenotype

abnormal snout morphology
- snouts are rounded

absent incisors
- absence of incisors is observed by 10 days

absent teeth
- homozygous mice are toothless

slow postnatal weight gain
- from day 10 weight gain does not match control

endocrine/exocrine gland phenotype

abnormal thyroid parafollicular C-cell morphology
- parafollicular cell density in thyroid is significantly increased during first three months

References

Additional References

Bruhns P; Samuelsson A; Pollard JW; Ravetch JV. 2003. Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity 18(4):573-81. PubMed: 12705859 MGI: J:83013
Ida-Yonemochi H; Noda T; Shimokawa H; Saku T. 2002. Disturbed tooth eruption in osteopetrotic (op/op) mice: histopathogenesis of tooth malformation and odontomas. J Oral Pathol Med 31(6):361-73. PubMed: 12201247 MGI: J:78487
Kaku M; Tsutsui K; Motokawa M; Kawata T; Fujita T; Kohno S; Tohma Y; Ohtani J; Tenjoh K; Tanne K. 2003. Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice. Brain Res Brain Res Protoc 12(2):104-8. PubMed: 14613812 MGI: J:87261
Lenda DM; Kikawada E; Stanley ER; Kelley VR. 2003. Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. J Immunol 170(6):3254-62. PubMed: 12626584 MGI: J:82301
Lenda DM; Stanley ER; Kelley VR. 2004. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. J Immunol 173(7):4744-54. PubMed: 15383612 MGI: J:93714
Naito M; Hayashi S; Yoshida H; Nishikawa S; Shultz LD; Takahashi K. 1991. Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol 139(3):657-67. PubMed: 1887865 MGI: J:26978
Sasaki A; Yokoo H; Naito M; Kaizu C; Shultz LD; Nakazato Y. 2000. Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor. Neuropathology 20(2):134-42. PubMed: 10935450 MGI: J:82594
Tagaya H; Kunisada T; Yamazaki H; Yamane T; Tokuhisa T; Wagner EF; Sudo T; Shultz LD; Hayashi SI. 2000. Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood 95(11):3363-70. PubMed: 10828017 MGI: J:82593
Yoshida H; Hayashi S; Kunisada T; Ogawa M; Nishikawa S; Okamura H; Sudo T; Shultz LD; Nishikawa S. 1990. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345(6274):442-4. PubMed: 2188141 MGI: J:10519

Additional - a related

Baba K; Sakakibara S; Setsu T; Terashima T. 2007. The superficial layers of the superior colliculus are cytoarchitectually and myeloarchitectually disorganized in the reelin-deficient mouse, reeler. Brain Res 1140:205-15. PubMed: 17173877 MGI: J:120267
Batchelor AL; Phillips RJ; Searle AG. 1966. A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res 3(3):218-29. PubMed: 5962396 MGI: J:5021
Bjorbaek C; Elmquist JK; Frantz JD; Shoelson SE; Flier JS. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1(4):619-25. PubMed: 9660946 MGI: J:119803
Bultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. PubMed: 8125260 MGI: J:16984
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. PubMed: 1473152 MGI: J:3523
Bultman SJ; Russell LB; Gutierrez-Espeleta GA; Woychik RP. 1991. Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse. Proc Natl Acad Sci U S A 88(18):8062-6. PubMed: 1896452 MGI: J:16567
Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)] Z Versuchstierkd 31(6):249-54. PubMed: 3227730 MGI: J:16568
Butler AE; Janson J; Soeller WC; Butler PC. 2003. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52(9):2304-14. PubMed: 12941770 MGI: J:132530
Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. PubMed: 13877379 MGI: J:160128
Cook S; Johnson K. 1994. Remutation to slaty Mouse Genome 92:672. MGI: J:27515
Cropley JE; Suter CM; Beckman KB; Martin DI. 2006. Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A 103(46):17308-12. PubMed: 17101998 MGI: J:117156
De Souza J; Butler AA; Cone RD. 2000. Disproportionate inhibition of feeding in A(y) mice by certain stressors: a cautionary note. Neuroendocrinology 72(2):126-32. PubMed: 10971147 MGI: J:102986
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. PubMed: 5798139 MGI: J:30922
Duchesnes CE; Naggert JK; Tatnell MA; Beckman N; Marnane RN; Rodrigues JA; Halim A; Pontre B; Stewart AW; Wolff GL; Elliott R; Mountjoy KG. 2009. New Zealand Ginger Mouse: Novel model that associates the tyrp1b pigmentation gene locus with regulation of lean body mass. Physiol Genomics 37(3):164-74. PubMed: 19293329 MGI: J:146052
Dunn LC. 1945. A New Eye Color Mutant in the Mouse with Asymmetrical Expression. Proc Natl Acad Sci U S A 31(11):343-6. PubMed: 16578176 MGI: J:13122
Dunn LC. 1928. A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A 14(10):816-9. PubMed: 16587414 MGI: J:15011
Dunn LC; Macdowell EC; Lebedeff GA. 1937. Studies on Spotting Patterns III. Interaction between Genes Affecting White Spotting and Those Affecting Color in the House Mouse. Genetics 22(2):307-18. PubMed: 17246842 MGI: J:12954
Enshell-Seijffers D; Lindon C; Morgan BA. 2008. The serine protease Corin is a novel modifier of the Agouti pathway. Development 135(2):217-25. PubMed: 18057101 MGI: J:130426
Feuerer M; Herrero L; Cipolletta D; Naaz A; Wong J; Nayer A; Lee J; Goldfine AB; Benoist C; Shoelson S; Mathis D. 2009. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15(8):930-9. PubMed: 19633656 MGI: J:152186
Franz T. 1994. Extra-toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain. Acta Anat (Basel) 150(1):38-44. PubMed: 7976186 MGI: J:19818
Fujimoto W; Shiuchi T; Miki T; Minokoshi Y; Takahashi Y; Takeuchi A; Kimura K; Saito M; Iwanaga T; Seino S. 2007. Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A 104(39):15514-9. PubMed: 17873059 MGI: J:125193
Gajewska M; Krysiak E; Wirth-Dziecialowska E. 2010. New coat color mutation mapped in distal part MMU10 MGI Direct Data Submission :. MGI: J:162146
Galbraith DB; Arceci RJ. 1974. Melanocyte populations of yellow and black hair bulbs in the mouse. J Hered 65(6):381-2. PubMed: 4448905 MGI: J:5512
Galbraith DB; Patrignani AM. 1976. Sulfhydryl compounds in melanocytes of yellow (Ay/a), nonagouti (a/a), and agouti (A/A) mice. Genetics 84(3):587-91. PubMed: 1001879 MGI: J:5737
Galbraith DB; Wolff GL; Brewer NL. 1980. Hair pigment patterns in different integumental environments of the mouse. Influence of the agouti suppressor (A<sup>s</sup>) mutation on expression of agouti locus alleles. J Hered 71:229-234. MGI: J:12033
Galbraith DB; Wolff GL; Brewer NL. 1979. Tissue microenvironment and the genetic control of hair pigment patterns in mice Dev Genet 1(2):167-179. MGI: J:156092
Geschwind II; Huseby RA; Nishioka R. 1972. The effect of melanocyte-stimulating hormone on coat color in the mouse. Recent Prog Horm Res 28:91-130. PubMed: 4631622 MGI: J:5324
Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. PubMed: 8648194 MGI: J:32132
Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague. MGI: J:30758
Heaney JD; Michelson MV; Youngren KK; Lam MY; Nadeau JH. 2009. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet 18(8):1395-404. PubMed: 19168544 MGI: J:146879
Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. PubMed: 4634048 MGI: J:5346
Horike N; Kumagai A; Shimono Y; Onishi T; Itoh Y; Sasaki T; Kitagawa K; Hatano O; Takagi H; Susumu T; Teraoka H; Kusano K; Nagaoka Y; Kawahara H; Takemori H. 2010. Downregulation of SIK2 expression promotes the melanogenic program in mice. Pigment Cell Melanoma Res 23(6):809-19. PubMed: 20819186 MGI: J:215877
Hustad CM; Perry WL; Siracusa LD; Rasberry C; Cobb L; Cattanach BM; Kovatch R; Copeland NG; Jenkins NA. 1995. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1):255-65. PubMed: 7635290 MGI: J:24934
Iwatsuka H; Shino A; Suzuoki Z. 1970. General survey of diabetic features of yellow KK mice. Endocrinol Jpn 17(1):23-35. PubMed: 5468422 MGI: J:26460
Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. PubMed: 17652101 MGI: J:129904
Kaelin CB; Xu X; Hong LZ; David VA; McGowan KA; Schmidt-Kuntzel A; Roelke ME; Pino J; Pontius J; Cooper GM; Manuel H; Swanson WF; Marker L; Harper CK; van Dyk A; Yue B; Mullikin JC; Warren WC; Eizirik E; Kos L; O'Brien SJ; Barsh GS; Menotti-Raymond M. 2012. Specifying and sustaining pigmentation patterns in domestic and wild cats. Science 337(6101):1536-41. PubMed: 22997338 MGI: J:188277
Kaminen-Ahola N; Ahola A; Maga M; Mallitt KA; Fahey P; Cox TC; Whitelaw E; Chong S. 2010. Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genet 6(1):e1000811. PubMed: 20084100 MGI: J:156866
Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. PubMed: 1409442 MGI: J:1295
Knisely AS; Gasser DL; Silvers WK. 1975. Expression in organ culture of agouti locus genes of the mouse. Genetics 79(3):471-5. PubMed: 1126628 MGI: J:5533
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. PubMed: 11277491 MGI: J:103803
Lane PW. 1989. Mottled agouti-J (am-J) Mouse News Lett 84:89. MGI: J:16570
Leamy LJ; Hrubant HE. 1971. Effects of alleles at the agouti locus on odontometric traits in the C57BL-6 strain of house mice. Genetics 67(1):87-96. PubMed: 5556294 MGI: J:16571
Loosli R. 1963. Tanoid--a new agouti mutant in the mouse. J Hered 54:26-29. MGI: J:13082
Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. PubMed: 17247639 MGI: J:12970
Martin NM; Houston PA; Patterson M; Sajedi A; Carmignac DF; Ghatei MA; Bloom SR; Small CJ. 2006. Abnormalities of the somatotrophic axis in the obese agouti mouse. Int J Obes (Lond) 30(3):430-8. PubMed: 16172617 MGI: J:151302
Martinez HG; Quinones MP; Jimenez F; Estrada CA; Clark K; Muscogiuri G; Sorice G; Musi N; Reddick RL; Ahuja SS. 2011. Critical role of chemokine (C-C motif) receptor 2 (CCR2) in the KKAy + Apoe -/- mouse model of the metabolic syndrome. Diabetologia 54(10):2660-8. PubMed: 21779871 MGI: J:177084
Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. PubMed: 4558326 MGI: J:5288
Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. PubMed: 8449404 MGI: J:4186
Miyazaki M; Sampath H; Liu X; Flowers MT; Chu K; Dobrzyn A; Ntambi JM. 2009. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun 380(4):818-22. PubMed: 19338759 MGI: J:147343
Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. PubMed: 9877102 MGI: J:52183
Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. PubMed: 2379821 MGI: J:29467
Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. PubMed: 5902512 MGI: J:5001
Mutant Mouse Regional Resource Centers. 2004. Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) Unpublished :. MGI: J:94077
Novak EK; Gautam R; Reddington M; Collinson LM; Copeland NG; Jenkins NA; McGarry MP; Swank RT. 2002. The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background. Blood 100(1):128-35. PubMed: 12070017 MGI: J:77395
Novak EK; Wieland F; Jahreis GP; Swank RT. 1980. Altered secretion of kidney lysosomal enzymes in the mouse pigment mutants ruby-eye, ruby-eye-2-J, and maroon. Biochem Genet 18(5-6):549-61. PubMed: 6776948 MGI: J:6422
Nuotio-Antar AM; Hachey DL; Hasty AH. 2007. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 293(6):E1517-28. PubMed: 17878220 MGI: J:145108
Papacleovoulou G; Abu-Hayyeh S; Nikolopoulou E; Briz O; Owen BM; Nikolova V; Ovadia C; Huang X; Vaarasmaki M; Baumann M; Jansen E; Albrecht C; Jarvelin MR; Marin JJ; Knisely AS; Williamson C. 2013. Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clin Invest 123(7):3172-81. PubMed: 23934127 MGI: J:201610
Pettitt SJ; Liang Q; Rairdan XY; Moran JL; Prosser HM; Beier DR; Lloyd KC; Bradley A; Skarnes WC. 2009. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods :1-3. PubMed: 19525957 MGI: J:149352
Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. PubMed: 1090472 MGI: J:5519
Poole TW. 1982. The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. J Exp Zool 220(1):57-64. PubMed: 7077265 MGI: J:6763
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345. MGI: J:13094
Quevedo WC Jr; Holstein TJ. 1992. The shift from physiological genetics to molecular genetics in the study of mouse tyrosinase. Pigment Cell Res Suppl 2:57-60. PubMed: 1409439 MGI: J:3852
RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. PubMed: 18117146 MGI: J:148461
Rakyan VK; Chong S; Champ ME; Cuthbert PC; Morgan HD; Luu KV; Whitelaw E. 2003. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100(5):2538-43. PubMed: 12601169 MGI: J:82396
Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. PubMed: 23251662 MGI: J:195664
Rosenfeld CS; Sieli PT; Warzak DA; Ellersieck MR; Pennington KA; Roberts RM. 2013. Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice. Proc Natl Acad Sci U S A 110(2):537-42. PubMed: 23267115 MGI: J:193279
Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. PubMed: 17247308 MGI: J:12958
Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. PubMed: 17247280 MGI: J:148462
Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. PubMed: 17247200 MGI: J:148463
Russell LB. 1964. Genetic and Functional Mosaicism in the Mouse. In: The Role of the Chromosomes in Development. Academic Press, New York. MGI: J:29504
Russell LB; Cupp McDaniel MN; Woodiel FN,. 1963. Crossing over within the a "locus" of the mouse Genetics 48:907 Abstr. MGI: J:174047
SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. PubMed: 13563791 MGI: J:13013
Sakurai T; Ochiai H; Takeuchi T. 1975. Ultrastructural change of melanosomes associated with agouti pattern formation in mouse hair. Dev Biol 47(2):466-71. PubMed: 1204945 MGI: J:5606
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. MGI: J:78801
Soeller WC; Janson J; Hart SE; Parker JC; Carty MD; Stevenson RW; Kreutter DK; Butler PC. 1998. Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide. Diabetes 47(5):743-50. PubMed: 9588445 MGI: J:133694
Staats J. 1985. Standardized Nomenclature for Inbred Strains of Mice: eighth listing. Cancer Res 45(3):945-77. PubMed: 3971387 MGI: J:50296
Suto J. 2008. Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice. Med Sci Monit 14(2):CR65-74. PubMed: 18227763 MGI: J:131439
Suto J. 2009. Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome 20(1):1-13. PubMed: 19067046 MGI: J:143893
Suto J; Matsuura S; Imamura K; Yamanaka H; Sekikawa K. 1998. Genetics of obesity in KK mouse and effects of A(y) allele on quantitative regulation. Mamm Genome 9(7):506-10. PubMed: 9657845 MGI: J:48704
Suwa A; Yoshino M; Yamazaki C; Naitou M; Fujikawa R; Matsumoto S; Kurama T; Shimokawa T; Aramori I. 2010. RMI1 deficiency in mice protects from diet and genetic-induced obesity. FEBS J 277(3):677-86. PubMed: 20050919 MGI: J:168271
Sweet SE; Quevedo WC Jr. 1968. Role of melanocyte morphology in pigmentation of mouse hair. Anat Rec 162(2):243-54. PubMed: 5726144 MGI: J:5095
Tamate HB; Takeuchi T. 1981. Induction of the shift in melanin synthesis in lethal yellow (A<y>/a) mice in vitro. Dev Genet 2:349-356. MGI: J:11956
Tanaka S; Kuwahara S; Nishijima K; Ohno T; Matsuzawa A. 2006. Genetic association of mutation at agouti locus with adrenal x zone morphology in BALB/c mice. Exp Anim 55(4):343-7. PubMed: 16880681 MGI: J:111619
Tanaka S; Nishimura M; Matsuzawa A. 1994. Genetic association between agouti locus and adrenal X zone morphology in SM/J mice. Acta Anat (Basel) 149(3):170-3. PubMed: 7976166 MGI: J:19308
The Jackson Laboratory Office of Genetic Resources. 1979. Registry of Remutations at The Jackson Laboratory, 1979-1980 MGI Direct Data Submission :. MGI: J:78474
The Jackson Laboratory Office of Genetic Resources. 1983. Registry of Remutation at The Jackson Laboratory, 1983-1984 MGI Direct Data Submission :. MGI: J:79402
The Mammalian Genetics Unit at Harwell. 2004. Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK Unpublished :. MGI: J:90559
Tsuruta Y; Yoshimatsu H; Hidaka S; Kondou S; Okamoto K; Sakata T. 2002. Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression. Am J Physiol Endocrinol Metab 282(4):E967-73. PubMed: 11882520 MGI: J:75872
Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. PubMed: 8202545 MGI: J:18750
Wolff GL. 1978. Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics 88(3):529-39. PubMed: 640377 MGI: J:5964
Woychik RP; Generoso WM; Russell LB; Cain KT; Cacheiro NL; Bultman SJ; Selby PB; Dickinson ME; Hogan BL; Rutledge JC. 1990. Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. Proc Natl Acad Sci U S A 87(7):2588-92. PubMed: 2320577 MGI: J:10399
Wu Q; Howell MP; Cowley MA; Palmiter RD. 2008. Starvation after AgRP neuron ablation is independent of melanocortin signaling. Proc Natl Acad Sci U S A 105(7):2687-92. PubMed: 18272480 MGI: J:132184
Zevnik B; Uyttersprot NC; Perez AV; Bothe GW; Kern H; Kauselmann G. 2014. C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. PLoS One 9(3):e90570. PubMed: 24599260 MGI: J:213411
Zheng B; Sage M; Cai WW; Thompson DM; Tavsanli BC; Cheah YC; Bradley A. 1999. Engineering a mouse balancer chromosome. Nat Genet 22(4):375-8. PubMed: 10431243 MGI: J:56548

Additional - Csf1^op related

Abboud SL; Woodruff K; Liu C; Shen V; Ghosh-Choudhury N. 2002. Rescue of the osteopetrotic defect in op/op mice by osteoblast-specific targeting of soluble colony-stimulating factor-1. Endocrinology 143(5):1942-9. PubMed: 11956177 MGI: J:76327
Alnaeeli M; Penninger JM; Teng YT. 2006. Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol 177(5):3314-26. PubMed: 16920972 MGI: J:139526
Araki M; Fukumatsu Y; Katabuchi H; Shultz LD; Takahashi K; Okamura H. 1996. Follicular development and ovulation in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. Biol Reprod 54(2):478-84. PubMed: 8788202 MGI: J:30863
Banaei-Bouchareb L; Gouon-Evans V; Samara-Boustani D; Castellotti MC; Czernichow P; Pollard JW; Polak M. 2004. Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. J Leukoc Biol 76(2):359-67. PubMed: 15178709 MGI: J:91463
Baran CP; Opalek JM; McMaken S; Newland CA; O'Brien JM Jr; Hunter MG; Bringardner BD; Monick MM; Brigstock DR; Stromberg PC; Hunninghake GW; Marsh CB. 2007. Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med 176(1):78-89. PubMed: 17431224 MGI: J:147697
Batchelor PE; Porritt MJ; Nilsson SK; Bertoncello I; Donnan GA; Howells DW. 2002. Periwound dopaminergic sprouting is dependent on numbers of wound macrophages. Eur J Neurosci 15(5):826-32. PubMed: 11906524 MGI: J:107999
Begg SK; Radley JM; Pollard JW; Chisholm OT; Stanley ER; Bertoncello I. 1993. Delayed hematopoietic development in osteopetrotic (op/op) mice. J Exp Med 177(1):237-42. PubMed: 8418205 MGI: J:3480
Berezovskaya O; Maysinger D; Fedoroff S. 1995. The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int J Dev Neurosci 13(3-4):285-99. PubMed: 7572282 MGI: J:30212
Bergmann CE; Hoefer IE; Meder B; Roth H; van Royen N; Breit SM; Jost MM; Aharinejad S; Hartmann S; Buschmann IR. 2006. Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J Leukoc Biol 80(1):59-65. PubMed: 16684892 MGI: J:110465
Blevins G; Fedoroff S. 1995. Microglia in colony-stimulating factor 1-deficient op/op mice. J Neurosci Res 40(4):535-44. PubMed: 7616613 MGI: J:23600
Brown NJ; Hutcheson J; Bickel E; Scatizzi JC; Albee LD; Haines GK 3rd; Eslick J; Bradley K; Taricone E; Perlman H. 2004. Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo. J Immunol 173(12):7584-93. PubMed: 15585886 MGI: J:94851
Bruhns P; Samuelsson A; Pollard JW; Ravetch JV. 2003. Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity 18(4):573-81. PubMed: 12705859 MGI: J:83013
Buchholz BM; Chanthaphavong RS; Bauer AJ. 2009. Nonhemopoietic cell TLR4 signaling is critical in causing early lipopolysaccharide-induced ileus. J Immunol 183(10):6744-53. PubMed: 19846874 MGI: J:157181
Carenini S; Maurer M; Werner A; Blazyca H; Toyka KV; Schmid CD; Raivich G; Martini R. 2001. The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in p0. J Cell Biol 152(2):301-8. PubMed: 11266447 MGI: J:67581
Cecchini MG; Dominguez MG; Mocci S; Wetterwald A; Felix R; Fleisch H; Chisholm O; Hofstetter W; Pollard JW; Stanley ER. 1994. Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development 120(6):1357-72. PubMed: 8050349 MGI: J:18915
Chang MD; Stanley ER; Khalili H; Chisholm O; Pollard JW. 1995. Osteopetrotic (op/op) mice deficient in macrophages have the ability to mount a normal T-cell-dependent immune response. Cell Immunol 162(1):146-52. PubMed: 7704903 MGI: J:24207
Chang Y; Albright S; Lee F. 1994. Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. J Neuroimmunol 52(1):9-17. PubMed: 8207122 MGI: J:19249
Choi JH; Cheong C; Dandamudi DB; Park CG; Rodriguez A; Mehandru S; Velinzon K; Jung IH; Yoo JY; Oh GT; Steinman RM. 2011. Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis. Immunity 35(5):819-31. PubMed: 22078798 MGI: J:178831
Clohisy DR; Ramnaraine ML. 1997. Osteoclast formation during tumor osteolysis does not require proliferating osteoclast precursor cells. J Orthop Res 15(2):301-6. PubMed: 9167635 MGI: J:41527
Clynes R; Ravetch JV. 1995. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity 3(1):21-6. PubMed: 7621075 MGI: J:78887
Cohen PE; Chisholm O; Arceci RJ; Stanley ER; Pollard JW. 1996. Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biol Reprod 55(2):310-7. PubMed: 8828834 MGI: J:34371
Cohen PE; Hardy MP; Pollard JW. 1997. Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice. Mol Endocrinol 11(11):1636-50. PubMed: 9328346 MGI: J:43181
Cohen PE; Zhu L; Pollard JW. 1997. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biol Reprod 56(1):110-8. PubMed: 9002639 MGI: J:38039
D'Errico JA; MacNeil RL; Strayhorn CL; Piotrowski BT; Somerman MJ. 1995. Models for the study of cementogenesis. Connect Tissue Res 33(1-3):9-17. PubMed: 7554968 MGI: J:30202
Dai XM; Ryan GR; Hapel AJ; Dominguez MG; Russell RG; Kapp S; Sylvestre V; Stanley ER. 2002. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99(1):111-20. PubMed: 11756160 MGI: J:73663
Dai XM; Zong XH; Sylvestre V; Stanley ER. 2004. Incomplete restoration of colony-stimulating factor 1 (CSF-1) function in CSF-1-deficient Csf1op/Csf1op mice by transgenic expression of cell surface CSF-1. Blood 103(3):1114-23. PubMed: 14525772 MGI: J:87641
De Ciuceis C; Amiri F; Brassard P; Endemann DH; Touyz RM; Schiffrin EL. 2005. Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury. Arterioscler Thromb Vasc Biol 25(10):2106-13. PubMed: 16100037 MGI: J:114425
De I; Steffen MD; Clark PA; Patros CJ; Sokn E; Bishop SM; Litscher S; Maklakova VI; Kuo JS; Rodriguez FJ; Collier LS. 2016. CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages. Cancer Res 76(9):2552-60. PubMed: 27013192 MGI: J:231828
Deckers MM; Van Beek ER; Van Der Pluijm G; Wetterwald A; Van Der Wee-Pals L; Cecchini MG; Papapoulos SE; Lowik CW. 2002. Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice. J Bone Miner Res 17(6):998-1007. PubMed: 12054176 MGI: J:112373
Dhawan J; Rando TA; Elson SE; Lee F; Stanley ER; Blau HM. 1996. Myoblast-mediated expression of colony stimulating factor-1 (CSF-1) in the cytokine-deficient op/op mouse. Somat Cell Mol Genet 22(5):363-81. PubMed: 9039846 MGI: J:38812
Erblich B; Zhu L; Etgen AM; Dobrenis K; Pollard JW. 2011. Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS One 6(10):e26317. PubMed: 22046273 MGI: J:178079
Fantin A; Vieira JM; Gestri G; Denti L; Schwarz Q; Prykhozhij S; Peri F; Wilson SW; Ruhrberg C. 2010. Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 116(5):829-40. PubMed: 20404134 MGI: J:163512
Felix R; Cecchini MG; Fleisch H. 1990. Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse. Endocrinology 127(5):2592-4. PubMed: 2146111 MGI: J:10799
Felix R; Hofstetter W; Wetterwald A; Cecchini MG; Fleisch H. 1994. Role of colony-stimulating factor-1 in bone metabolism. J Cell Biochem 55(3):340-9. PubMed: 7962166 MGI: J:19367
Feltis BA; Jechorek RP; Erlandsen SL; Wells CL. 1994. Bacterial translocation and lipopolysaccharide-induced mortality in genetically macrophage-deficient op/op mice. Shock 2(1):29-33. PubMed: 7735981 MGI: J:20379
Galeazzi F; Lovato P; Blennerhassett PA; Haapala EM; Vallance BA; Collins SM. 2001. Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages. Am J Physiol Gastrointest Liver Physiol 281(1):G151-8. PubMed: 11408267 MGI: J:107859
Ghia JE; Blennerhassett P; El-Sharkawy RT; Collins SM. 2007. The protective effect of the vagus nerve in a murine model of chronic relapsing colitis. Am J Physiol Gastrointest Liver Physiol 293(4):G711-8. PubMed: 17673544 MGI: J:126720
Ghia JE; Galeazzi F; Ford DC; Hogaboam CM; Vallance BA; Collins S. 2008. Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol 294(3):G770-7. PubMed: 18202111 MGI: J:132596
Gillum MP; Kotas ME; Erion DM; Kursawe R; Chatterjee P; Nead KT; Muise ES; Hsiao JJ; Frederick DW; Yonemitsu S; Banks AS; Qiang L; Bhanot S; Olefsky JM; Sears DD; Caprio S; Shulman GI. 2011. SirT1 regulates adipose tissue inflammation. Diabetes 60(12):3235-45. PubMed: 22110092 MGI: J:191377
Ginhoux F; Tacke F; Angeli V; Bogunovic M; Loubeau M; Dai XM; Stanley ER; Randolph GJ; Merad M. 2006. Langerhans cells arise from monocytes in vivo. Nat Immunol 7(3):265-73. PubMed: 16444257 MGI: J:112594
Gouon-Evans V; Rothenberg ME; Pollard JW. 2000. Postnatal mammary gland development requires macrophages and eosinophils. Development 127(11):2269-82. PubMed: 10804170 MGI: J:110688
Groh J; Basu R; Stanley ER; Martini R. 2016. Cell-Surface and Secreted Isoforms of CSF-1 Exert Opposing Roles in Macrophage-Mediated Neural Damage in Cx32-Deficient Mice. J Neurosci 36(6):1890-901. PubMed: 26865613 MGI: J:231622
Groh J; Klein I; Hollmann C; Wettmarshausen J; Klein D; Martini R. 2015. CSF-1-activated macrophages are target-directed and essential mediators of schwann cell dedifferentiation and dysfunction in Cx32-deficient mice. Glia 63(6):977-86. PubMed: 25628221 MGI: J:220861
Guleria I; Pollard JW. 2000. The trophoblast is a component of the innate immune system during pregnancy. Nat Med 6(5):589-93. PubMed: 10802718 MGI: J:119170
Guleria I; Pollard JW. 2001. Aberrant macrophage and neutrophil population dynamics and impaired Th1 response to Listeria monocytogenes in colony-stimulating factor 1-deficient mice. Infect Immun 69(3):1795-807. PubMed: 11179357 MGI: J:67608
Hoeffel G; Wang Y; Greter M; See P; Teo P; Malleret B; Leboeuf M; Low D; Oller G; Almeida F; Choy SH; Grisotto M; Renia L; Conway SJ; Stanley ER; Chan JK; Ng LG; Samokhvalov IM; Merad M; Ginhoux F. 2012. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med 209(6):1167-81. PubMed: 22565823 MGI: J:189052
Hulsmans M; Clauss S; Xiao L; Aguirre AD; King KR; Hanley A; Hucker WJ; Wulfers EM; Seemann G; Courties G; Iwamoto Y; Sun Y; Savol AJ; Sager HB; Lavine KJ; Fishbein GA; Capen DE; Da Silva N; Miquerol L; Wakimoto H; Seidman CE; Seidman JG; Sadreyev RI; Naxerova K; Mitchell RN; Brown D; Libby P; Weissleder R; Swirski FK; Kohl P; Vinegoni C; Milan DJ; Ellinor PT; Nahrendorf M. 2017. Macrophages Facilitate Electrical Conduction in the Heart. Cell 169(3):510-522.e20. PubMed: 28431249 MGI: J:241503
Hume DA; Favot P. 1995. Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor? J Interferon Cytokine Res 15(4):279-84. PubMed: 7627801 MGI: J:25708
Hunt JS; Chen HL; Hu XL; Pollard JW. 1993. Normal distribution of tumor necrosis factor-alpha messenger ribonucleic acid and protein in the uteri, placentas, and embryos of osteopetrotic (op/op) mice lacking colony-stimulating factor-1. Biol Reprod 49(3):441-52. PubMed: 8399834 MGI: J:14542
Huynh D; Akcora D; Malaterre J; Chan CK; Dai XM; Bertoncello I; Stanley ER; Ramsay RG. 2013. CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. PLoS One 8(2):e56951. PubMed: 23451116 MGI: J:197186
Ida-Yonemochi H; Noda T; Shimokawa H; Saku T. 2002. Disturbed tooth eruption in osteopetrotic (op/op) mice: histopathogenesis of tooth malformation and odontomas. J Oral Pathol Med 31(6):361-73. PubMed: 12201247 MGI: J:78487
Ingman WV; Wyckoff J; Gouon-Evans V; Condeelis J; Pollard JW. 2006. Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev Dyn 235(12):3222-9. PubMed: 17029292 MGI: J:116644
Iwata Y; Bostrom EA; Menke J; Rabacal WA; Morel L; Wada T; Kelley VR. 2012. Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice. J Immunol 188(9):4568-80. PubMed: 22467656 MGI: J:188447
Jang MH; Herber DM; Jiang X; Nandi S; Dai XM; Zeller G; Stanley ER; Kelley VR. 2006. Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. J Immunol 177(6):4055-63. PubMed: 16951369 MGI: J:138044
Kaku M; Kawata T; Kawasoko S; Fujita T; Tokimasa C; Niida S; Tanne K. 1998. Osteoclast appearance in developmental stages of different bones after a single injection of macrophage colony- stimulating factor in op/op mice. Biomed Res 19(1):77-81. MGI: J:47075
Kaku M; Kawata T; Kawasoko S; Fujita T; Tokimasa C; Tanne K. 1999. Remodeling of the sagittal suture in osteopetrotic (op/op) mice associated with cranial flat bone growth. J Craniofac Genet Dev Biol 19(2):109-12. PubMed: 10416154 MGI: J:58056
Kaku M; Tsutsui K; Motokawa M; Kawata T; Fujita T; Kohno S; Tohma Y; Ohtani J; Tenjoh K; Tanne K. 2003. Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice. Brain Res Brain Res Protoc 12(2):104-8. PubMed: 14613812 MGI: J:87261
Kalla R; Liu Z; Xu S; Koppius A; Imai Y; Kloss CU; Kohsaka S; Gschwendtner A; Moller JC; Werner A; Raivich G. 2001. Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice. J Comp Neurol 436(2):182-201. PubMed: 11438923 MGI: J:70370
Kanzaki S; Takada Y; Niida S; Takeda Y; Udagawa N; Ogawa K; Nango N; Momose A; Matsuo K. 2011. Impaired vibration of auditory ossicles in osteopetrotic mice. Am J Pathol 178(3):1270-8. PubMed: 21356377 MGI: J:169684
Karlsson MC; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV. 2003. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med 198(2):333-40. PubMed: 12874264 MGI: J:119256
Kawata T; Fujita T; Tokimasa C; Sugiyama H; Ozawa S; Tanne K. 2001. Analysis of histochemically and morphometrically in the anterior belly digastric muscle of osteopetrotic (op/op) mice. Exp Anim 50(2):133-8. PubMed: 11381616 MGI: J:69954
Kawata T; Kawasoko S; Kaku M; Fujita T; Tokimasa C; Niida S ; Tanne K. 1999. Recruitment of osteoclasts in the mandibular condyle of growing osteopetrotic (op/op) mice after a single injection of macrophage colony-stimulating factor. Arch Oral Biol 44(1):81-8. PubMed: 10075153 MGI: J:53698
Kawata T; Tokimasa C; Fujita T; Kaku M; Kawasoko S; Sugiyama H ; Ozawa S ; Tanne K. 1999. Morphological change of the nasopremaxillary suture in growing toothless osteopetrotic (op/op) mice. J Craniofac Genet Dev Biol 19(1):48-55. PubMed: 10378148 MGI: J:55462
Kawata T; Tokimasa C; Fujita T; Kawasoko S; Kaku M; Sugiyama H; Tanne K. 1998. Midpalatal suture of osteopetrotic (op/op) mice exhibits immature fusion. Exp Anim 47(4):277-81. PubMed: 10067173 MGI: J:51854
Kawata T; Tokimasa C; Fujita T; Ozawa S; Sugiyama H; Tanne K. 1999. Facial skeletal growth in growing 'toothless' osteopetrotic (op/op) mice: radiographic findings J Craniofac Genet Dev Biol 19(4):221-5. PubMed: 10731091 MGI: J:61237
Kawata T; Tokimasa C; Nowroozi N; Fujita T; Kaku M; Kawasoko S ; Sugiyama H ; Ozawa S ; Zernik JH ; Tanne K. 1999. Lack of the bone remodeling in osteopetrotic (op/op) mice associated with microdontia. J Craniofac Genet Dev Biol 19(2):113-7. PubMed: 10416155 MGI: J:56255
Kawata T; Zernik JH; Fujita T; Tokimasa C; Tanne K. 1999. Mechanism in inhibitory effects of vitamin K2 on osteoclastic bone resorption: in vivo study in osteopetrotic (op/op) mice. J Nutr Sci Vitaminol (Tokyo) 45(4):501-7. PubMed: 10575640 MGI: J:59641
Kim EY; Battaile JT; Patel AC; You Y; Agapov E; Grayson MH; Benoit LA; Byers DE; Alevy Y; Tucker J; Swanson S; Tidwell R; Tyner JW; Morton JD; Castro M; Polineni D; Patterson GA; Schwendener RA; Allard JD; Peltz G; Holtzman MJ. 2008. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med 14(6):633-40. PubMed: 18488036 MGI: J:136947
Kim HJ; Alonzo ES; Dorothee G; Pollard JW; Sant'Angelo DB. 2010. Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus. PLoS One 5(7):e11439. PubMed: 20625428 MGI: J:163125
Kim IS; Baek SH. 2010. Mouse models for breast cancer metastasis. Biochem Biophys Res Commun 394(3):443-7. PubMed: 20230796 MGI: J:159230
Kiso Y; Pollard JW; Croy BA. 1992. A study of granulated metrial gland cell differentiation in pregnant, macrophage-deficient, osteopetrotic (op/op) mice. Experientia 48(10):973-5. PubMed: 1426147 MGI: J:3619
Ko EA; Amiri F; Pandey NR; Javeshghani D; Leibovitz E; Touyz RM; Schiffrin EL. 2007. Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. Am J Physiol Heart Circ Physiol 292(4):H1789-95. PubMed: 17142347 MGI: J:125825
Kobayashi M; Masuda Y; Kishino M; Ishida T; Maeda N; Morimoto T. 2002. Characteristics of mastication in the anodontic mouse. J Dent Res 81(9):594-7. PubMed: 12202638 MGI: J:105926
Kodama H; Yamasaki A; Abe M; Niida S; Hakeda Y; Kawashima H. 1993. Transient recruitment of osteoclasts and expression of their function in osteopetrotic (op/op) mice by a single injection of macrophage colony-stimulating factor. J Bone Miner Res 8(1):45-50. PubMed: 8427048 MGI: J:4732
Kodama I; Niida S; Sanada M; Yoshiko Y; Tsuda M; Maeda N; Ohama K. 2004. Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice. J Bone Miner Res 19(2):200-6. PubMed: 14969389 MGI: J:111232
Kondo Y; Adams JM; Vanier MT; Duncan ID. 2011. Macrophages counteract demyelination in a mouse model of globoid cell leukodystrophy. J Neurosci 31(10):3610-24. PubMed: 21389217 MGI: J:170081
Kondo Y; Lemere CA; Seabrook TJ. 2007. Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. J Neuroinflammation 4:31. PubMed: 18093340 MGI: J:132962
Kondo Y; Ramaker JM; Radcliff AB; Baldassari S; Mayer JA; Ver Hoeve JN; Zhang CL; Chiu SY; Colello RJ; Duncan ID. 2013. Spontaneous Optic Nerve Compression in the Osteopetrotic (op/op) Mouse: A Novel Model of Myelination Failure. J Neurosci 33(8):3514-25. PubMed: 23426679 MGI: J:194253
Kubota Y; Takubo K; Shimizu T; Ohno H; Kishi K; Shibuya M; Saya H; Suda T. 2009. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 206(5):1089-102. PubMed: 19398755 MGI: J:148497
Kurotaki D; Kon S; Bae K; Ito K; Matsui Y; Nakayama Y; Kanayama M; Kimura C; Narita Y; Nishimura T; Iwabuchi K; Mack M; van Rooijen N; Sakaguchi S; Uede T; Morimoto J. 2011. CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J Immunol 186(4):2229-37. PubMed: 21239712 MGI: J:169161
Lagasse E; Weissman IL. 1997. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 89(7):1021-31. PubMed: 9215625 MGI: J:41240
Lai JF; Zindl CL; Duffy LB; Atkinson TP; Jung YW; van Rooijen N; Waites KB; Krause DC; Chaplin DD. 2010. Critical role of macrophages and their activation via MyD88-NFkappaB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS One 5(12):e14417. PubMed: 21203444 MGI: J:168336
Lane PW. 1973. Osteopetrosis (op) Mouse News Lett 48:35. MGI: J:35678
Lenda DM; Kikawada E; Stanley ER; Kelley VR. 2003. Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. J Immunol 170(6):3254-62. PubMed: 12626584 MGI: J:82301
Lenda DM; Stanley ER; Kelley VR. 2004. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. J Immunol 173(7):4744-54. PubMed: 15383612 MGI: J:93714
Li J; Chen K; Zhu L; Pollard JW. 2006. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis 44(7):328-35. PubMed: 16823860 MGI: J:110981
Lieschke GJ; Stanley E; Grail D; Hodgson G; Sinickas V; Gall JA; Sinclair RA; Dunn AR. 1994. Mice lacking both macrophage- and granulocyte-macrophage colony-stimulating factor have macrophages and coexistent osteopetrosis and severe lung disease. Blood 84(1):27-35. PubMed: 8018921 MGI: J:19089
Lin EY; Li JF; Bricard G; Wang W; Deng Y; Sellers R; Porcelli SA; Pollard JW. 2007. VEGF Restores Delayed Tumor Progression in Tumors Depleted of Macrophages. Mol Oncol 1(3):288-302. PubMed: 18509509 MGI: J:138643
Lin EY; Li JF; Gnatovskiy L; Deng Y; Zhu L; Grzesik DA; Qian H; Xue XN; Pollard JW. 2006. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66(23):11238-46. PubMed: 17114237 MGI: J:116132
Lin EY; Nguyen AV; Russell RG; Pollard JW. 2001. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193(6):727-40. PubMed: 11257139 MGI: J:68146
Lin EY; Pollard JW. 2004. Macrophages: modulators of breast cancer progression. Novartis Found Symp 256:158-68; discussion 168-72, 259. PubMed: 15027489 MGI: J:90229
Lin RS; Jimenez-Movilla M; Dean J. 2014. Figla-Cre transgenic mice expressing myristoylated EGFP in germ cells provide a model for investigating perinatal oocyte dynamics. PLoS One 9(1):e84477. PubMed: 24400092 MGI: J:209947
Lomas-Neira J; Chung CS; Perl M; Gregory S; Biffl W; Ayala A. 2006. Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge. Am J Physiol Lung Cell Mol Physiol 290(1):L51-8. PubMed: 16157517 MGI: J:104798
Loureiro RM; Monaco KA; Kearney JB; Blickarz-Durand CE; Kirby SL; Inamdar MS; Bautch VL. 2008. csf1 is required for early embryonic macrophage development: characterization of the csf1(op)/csf1(op) mutation in ES cell-derived macrophages. Br J Haematol 141(5):739-42. PubMed: 18422785 MGI: J:141708
Lu L; Osmond DG. 2001. Regulation of cell survival during B lymphopoiesis in mouse bone marrow: enhanced pre-B-cell apoptosis in CSF-1-deficient op/op mutant mice. Exp Hematol 29(5):596-601. PubMed: 11376872 MGI: J:69425
Luo J; Elwood F; Britschgi M; Villeda S; Zhang H; Ding Z; Zhu L; Alabsi H; Getachew R; Narasimhan R; Wabl R; Fainberg N; James ML; Wong G; Relton J; Gambhir SS; Pollard JW; Wyss-Coray T. 2013. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med 210(1):157-72. PubMed: 23296467 MGI: J:194761
Mackler AM; Barber EM; Takikawa O; Pollard JW. 2003. Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. J Immunol 170(2):823-30. PubMed: 12517946 MGI: J:127135
Maeda N; Kawata T; Yoshiko Y; Hosoi M; Suemune S; Okada N; Tanne K. 1994. Postnatal changes in the masseter muscle of the toothless (op/op) mouse with less-developed periodontal ligaments. Biomed Res 15(4):255-261. MGI: J:20589
Marks SC Jr; Iizuka T; MacKay CA; Mason-Savas A; Cielinski MJ. 1997. The effects of colony-stimulating factor-1 on the number and ultrastructure of osteoclasts in toothless (tl) rats and osteopetrotic (op) mice. Tissue Cell 29(5):589-95. PubMed: 9364807 MGI: J:44590
Marks SC Jr; Lane PW. 1976. Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse. J Hered 67(1):11-18. PubMed: 1262696 MGI: J:5634
McCary LC; DeLuca HF. 1996. Osteopetrotic (op/op) mice are unable to maintain serum calcium levels despite hyperabsorption of calcium. Endocrinology 137(3):1049-56. PubMed: 8603573 MGI: J:31874
McCary LC; Smith CM; DeLuca HF. 1997. Hypophosphatemia and the development of rickets in osteopetrotic (op/op) mice. J Bone Miner Res 12(11):1944-51. PubMed: 9383699 MGI: J:44543
McCary LC; Staun M; DeLuca HF. 1999. A characterization of vitamin D-independent intestinal calcium absorption in the osteopetrotic (op/op) mouse. Arch Biochem Biophys 368(2):249-56. PubMed: 10441375 MGI: J:56835
Menke J; Hsu MY; Byrne KT; Lucas JA; Rabacal WA; Croker BP; Zong XH; Stanley ER; Kelley VR. 2008. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. J Immunol 181(10):7367-79. PubMed: 18981160 MGI: J:141073
Michaelson MD; Bieri PL; Mehler MF; Xu H; Arezzo JC; Pollard JW; Kessler JA. 1996. CSF-1 deficiency in mice results in abnormal brain development. Development 122(9):2661-72. PubMed: 8787741 MGI: J:35818
Mikkelsen HB; Thuneberg L. 1999. Op/op mice defective in production of functional colony-stimulating factor-1 lack macrophages in muscularis externa of the small intestine. Cell Tissue Res 295(3):485-93. PubMed: 10022968 MGI: J:53792
Misharin AV; Cuda CM; Saber R; Turner JD; Gierut AK; Haines GK 3rd; Berdnikovs S; Filer A; Clark AR; Buckley CD; Mutlu GM; Budinger GR; Perlman H. 2014. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep 9(2):591-604. PubMed: 25373902 MGI: J:218528
Miyamoto K; Yoshida S; Kawasumi M; Hashimoto K; Kimura T; Sato Y; Kobayashi T; Miyauchi Y; Hoshi H; Iwasaki R; Miyamoto H; Hao W; Morioka H; Chiba K; Kobayashi T; Yasuda H; Penninger JM; Toyama Y; Suda T; Miyamoto T. 2011. Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med 208(11):2175-81. PubMed: 22006978 MGI: J:178762
Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. PubMed: 15271901 MGI: J:91775
Mueller CG; Cremer I; Paulet PE; Niida S; Maeda N; Lebeque S; Fridman WH; Sautes-Fridman C. 2001. Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle. J Immunol 167(9):5052-60. PubMed: 11673514 MGI: J:67032
Mullaly SC; Kubes P. 2006. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol 177(11):8154-63. PubMed: 17114491 MGI: J:140680
Muller M; Berghoff M; Kobsar I; Kiefer R; Martini R. 2007. Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0. Exp Neurol 203(1):55-62. PubMed: 16962581 MGI: J:141511
Muller PA; Koscso B; Rajani GM; Stevanovic K; Berres ML; Hashimoto D; Mortha A; Leboeuf M; Li XM; Mucida D; Stanley ER; Dahan S; Margolis KG; Gershon MD; Merad M; Bogunovic M. 2014. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell 158(2):300-13. PubMed: 25036630 MGI: J:214621
Murase S; Hayashi Y. 1998. Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells. J Neurosci 18(24):10481-92. PubMed: 9852586 MGI: J:52174
Myint YY; Miyakawa K; Naito M; Shultz LD; Oike Y; Yamamura K; Takahashi K. 1999. Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation. Am J Pathol 154(2):553-66. PubMed: 10027413 MGI: J:52817
Nagahama SI; Cunningham ML; Lee MY; Byers MR. 1998. Normal development of dental innervation and nerve/tissue interactions in the colony-stimulating factor-1 deficient osteopetrotic mouse. Dev Dyn 211(1):52-9. PubMed: 9438423 MGI: J:45196
Naito M; Hayashi S; Yoshida H; Nishikawa S; Shultz LD; Takahashi K. 1991. Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol 139(3):657-67. PubMed: 1887865 MGI: J:26978
Naito M; Umeda S; Takahashi K; Shultz LD. 1997. Macrophage differentiation and granulomatous inflammation in osteopetrotic mice (op/op) defective in the production of CSF-1. Mol Reprod Dev 46(1):85-91. PubMed: 8981368 MGI: J:37427
Nakamichi Y; Mizoguchi T; Arai A; Kobayashi Y; Sato M; Penninger JM; Yasuda H; Kato S; Deluca HF; Suda T; Udagawa N; Takahashi N. 2012. Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice. Proc Natl Acad Sci U S A 109(25):10006-11. PubMed: 22670054 MGI: J:185502
Nandi S; Akhter MP; Seifert MF; Dai XM; Stanley ER. 2006. Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain. Blood 107(2):786-95. PubMed: 16210339 MGI: J:126635
Nandi S; Gokhan S; Dai XM; Wei S; Enikolopov G; Lin H; Mehler MF; Stanley ER. 2012. The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Dev Biol 367(2):100-13. PubMed: 22542597 MGI: J:185808
Neugarten J; Feith GW; Assmann KJ; Shan Z; Stanley ER; Schlondorff D. 1995. Role of macrophages and colony-stimulating factor-1 in murine antiglomerular basement membrane glomerulonephritis. J Am Soc Nephrol 5(11):1903-9. PubMed: 7542490 MGI: J:26586
Ngo VN; Korner H; Gunn MD; Schmidt KN; Riminton DS; Cooper MD; Browning JL; Sedgwick JD; Cyster JG. 1999. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 189(2):403-12. PubMed: 9892622 MGI: J:52941
Niida S; Abe M; Suemune S; Yoshiko Y; Maeda N; Yamasaki A. 1997. Restoration of disturbed tooth eruption in osteopetrotic (op/op) mice by injection of macrophage colony-stimulating factor. Exp Anim 46(2):95-101. PubMed: 9145288 MGI: J:40564
Niida S; Kondo T; Hiratsuka S; Hayashi S; Amizuka N; Noda T; Ikeda K; Shibuya M. 2005. VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice. Proc Natl Acad Sci U S A 102(39):14016-21. PubMed: 16172397 MGI: J:101408
Niida S; Wakisaka H; Kanno E; Yamasaki A. 1994. Cranial flat bone formation in the osteopetrotic (Op/Op) mouse Biomed Res 15(1):37-44. MGI: J:18356
Nilsson SK; Bertoncello I. 1994. The development and establishment of hemopoiesis in fetal and newborn osteopetrotic (op/op) mice. Dev Biol 164(2):456-62. PubMed: 8045348 MGI: J:19549
Nilsson SK; Bertoncello I. 1994. Age-related changes in extramedullary hematopoiesis in the spleen of normal and perturbed osteopetrotic (op/op) mice [published erratum appears in Exp Hematol 1994 Jun;22(6):527-8] Exp Hematol 22(4):377-83. PubMed: 8150037 MGI: J:17699
Nilsson SK; Lieschke GJ; Garcia-Wijnen CC; Williams B; Tzelepis D; Hodgson G; Grail D; Dunn AR; Bertoncello I. 1995. Granulocyte-macrophage colony-stimulating factor is not responsible for the correction of hematopoietic deficiencies in the maturing op/op mouse. Blood 86(1):66-72. PubMed: 7795257 MGI: J:26516
Nishino I; Amizuka N; Ozawa H. 2001. Histochemical examination of osteoblastic activity in op/op mice with or without injection of recombinant M-CSF. J Bone Miner Metab 19(5):267-76. PubMed: 11498728 MGI: J:117405
Nishioji K; Okanoue T; Mori T; Sakamoto S; Itoh Y. 1999. Experimental liver injury induced by Propionibacterium acnes and lipopolysaccharide in macrophage colony stimulating factor-deficient osteopetrotic (op/op) mice. Dig Dis Sci 44(10):1975-84. PubMed: 10548345 MGI: J:59689
Nowicki A; Szenajch J; Ostrowska G; Wojtowicz A; Wojtowicz K; Kruszewski AA; Maruszynski M; Aukerman SL; Wiktor-Jedrzejczak W. 1996. Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma. Int J Cancer 65(1):112-9. PubMed: 8543387 MGI: J:31373
Oguma K; Oshima H; Aoki M; Uchio R; Naka K; Nakamura S; Hirao A; Saya H; Taketo MM; Oshima M. 2008. Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells. EMBO J 27(12):1671-81. PubMed: 18511911 MGI: J:137013
Ohira T; Wang XD; Ito T; Kawano F; Goto K; Izawa T; Ohno H; Kizaki T; Ohira Y. 2015. Macrophage deficiency in osteopetrotic (op/op) mice inhibits activation of satellite cells and prevents hypertrophy in single soleus fibers. Am J Physiol Cell Physiol 308(10):C848-55. PubMed: 25788575 MGI: J:224228
Okuno Y; Nakamura-Ishizu A; Kishi K; Suda T; Kubota Y. 2011. Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. Blood 117(19):5264-72. PubMed: 21411758 MGI: J:173270
Ortega N; Wang K; Ferrara N; Werb Z; Vu TH. 2010. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech 3(3-4):224-35. PubMed: 20142327 MGI: J:160852
Ovadia S; Insogna K; Yao GQ. 2006. The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice. Biol Reprod 74(2):331-6. PubMed: 16237150 MGI: J:105388
Owens GC; Bunge RP. 1991. Schwann cells infected with a recombinant retrovirus expressing myelin-associated glycoprotein antisense RNA do not form myelin. Neuron 7(4):565-75. PubMed: 1718333 MGI: J:26987
Pasparakis M; Kousteni S; Peschon J; Kollias G. 2000. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell Immunol 201(1):33-41. PubMed: 10805971 MGI: J:62236
Philippart C; Tzehoval E; Moricard Y; Bringuier AF; Seebold C; Lemoine FM; Arys A; Dourov N; Labat ML. 1993. Immune cell defects affect bone remodelling in osteopetrotic op/op mice. Bone Miner 23(3):317-32. PubMed: 8148672 MGI: J:18531
Pollard JW; Dominguez MG; Mocci S; Cohen PE; Stanley ER. 1997. Effect of the colony-stimulating factor-1 null mutation, osteopetrotic (csfm(op)), on the distribution of macrophages in the male mouse reproductive tract. Biol Reprod 56(5):1290-300. PubMed: 9160730 MGI: J:40266
Pollard JW; Hennighausen L. 1994. Colony stimulating factor 1 is required for mammary gland development during pregnancy. Proc Natl Acad Sci U S A 91(20):9312-6. PubMed: 7937762 MGI: J:20519
Pollard JW; Hunt JS; Wiktor-Jedrzejczak W; Stanley ER. 1991. A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol 148(1):273-83. PubMed: 1834496 MGI: J:70400
Popi AF; Osugui L; Perez KR; Longo-Maugeri IM; Mariano M. 2012. Could a B-1 cell derived phagocyte "be one" of the peritoneal macrophages during LPS-driven inflammation? PLoS One 7(3):e34570. PubMed: 22479646 MGI: J:187119
Pull SL; Doherty JM; Mills JC; Gordon JI; Stappenbeck TS. 2005. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A 102(1):99-104. PubMed: 15615857 MGI: J:95824
Pyonteck SM; Gadea BB; Wang HW; Gocheva V; Hunter KE; Tang LH; Joyce JA. 2012. Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development. Oncogene 31(11):1459-67. PubMed: 21822305 MGI: J:186151
Qian B; Deng Y; Im JH; Muschel RJ; Zou Y; Li J; Lang RA; Pollard JW. 2009. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 4(8):e6562. PubMed: 19668347 MGI: J:152473
Qiao JH; Tripathi J; Mishra NK; Cai Y; Tripathi S; Wang XP; Imes S ; Fishbein MC ; Clinton SK ; Libby P ; Lusis AJ ; Rajavashisth TB. 1997. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol 150(5):1687-99. PubMed: 9137093 MGI: J:40136
Qiu X; Zhu L; Pollard JW. 2009. Colony-stimulating factor-1-dependent macrophage functions regulate the maternal decidua immune responses against Listeria monocytogenes infections during early gestation in mice. Infect Immun 77(1):85-97. PubMed: 18852237 MGI: J:144590
Radi ZA; Koza-Taylor PH; Bell RR; Obert LA; Runnels HA; Beebe JS; Lawton MP; Sadis S. 2011. Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury. Am J Pathol 179(1):240-7. PubMed: 21703406 MGI: J:174004
Raivich G; Moreno-Flores MT; Moller JC; Kreutzberg GW. 1994. Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse. Eur J Neurosci 6(10):1615-8. PubMed: 7850025 MGI: J:128182
Rajavashisth T; Qiao JH; Tripathi S; Tripathi J; Mishra N; Hua M ; Wang XP ; Loussararian A ; Clinton S ; Libby P ; Lusis A. 1998. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. J Clin Invest 101(12):2702-10. PubMed: 9637704 MGI: J:48300
Ryan GR; Dai XM; Dominguez MG; Tong W; Chuan F; Chisholm O; Russell RG; Pollard JW; Stanley ER. 2001. Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis. Blood 98(1):74-84. PubMed: 11418465 MGI: J:70188
Ryder M; Gild M; Hohl TM; Pamer E; Knauf J; Ghossein R; Joyce JA; Fagin JA. 2013. Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PLoS One 8(1):e54302. PubMed: 23372702 MGI: J:195921
Sasaki A; Yokoo H; Naito M; Kaizu C; Shultz LD; Nakazato Y. 2000. Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor. Neuropathology 20(2):134-42. PubMed: 10935450 MGI: J:82594
Sauter KA; Pridans C; Sehgal A; Tsai YT; Bradford BM; Raza S; Moffat L; Gow DJ; Beard PM; Mabbott NA; Smith LB; Hume DA. 2014. Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. J Leukoc Biol 96(2):265-74. PubMed: 24652541 MGI: J:218573
Schonlau F; Schlesiger C; Ehrchen J; Grabbe S; Sorg C; Sunderkotter C. 2003. Monocyte and macrophage functions in M-CSF-deficient op/op mice during experimental leishmaniasis. J Leukoc Biol 73(5):564-73. PubMed: 12714570 MGI: J:120654
Shaposhnik Z; Wang X; Lusis AJ. 2010. Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis. J Lipid Res 51(7):1962-70. PubMed: 20194110 MGI: J:162834
Shibata Y; Zsengeller Z; Otake K; Palaniyar N; Trapnell BC. 2001. Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema. Blood 98(9):2845-52. PubMed: 11675359 MGI: J:72385
Sielska M; Przanowski P; Wylot B; Gabrusiewicz K; Maleszewska M; Kijewska M; Zawadzka M; Kucharska J; Vinnakota K; Kettenmann H; Kotulska K; Grajkowska W; Kaminska B. 2013. Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response. J Pathol 230(3):310-21. PubMed: 23520016 MGI: J:198377
Smith JD; Trogan E; Ginsberg M; Grigaux C; Tian J; Miyata M. 1995. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A 92(18):8264-8. PubMed: 7667279 MGI: J:29024
Stanley ER; Berg KL; Einstein DB; Lee PS; Pixley FJ; Wang Y; Yeung YG. 1997. Biology and action of colony--stimulating factor-1. Mol Reprod Dev 46(1):4-10. PubMed: 8981357 MGI: J:37433
Stanley ER; Berg KL; Einstein DB; Lee PS; Yeung YG. 1994. The biology and action of colony stimulating factor-1. Stem Cells (Dayt) 12 Suppl 1:15-24. PubMed: 7696959 MGI: J:25733
Suda T; Tanaka S; Takahashi N. 1993. Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors. Osteoporos Int 3 Suppl 1:111-3. PubMed: 8461535 MGI: J:12210
Sundquist KT; Cecchini MG; Marks SC. 1995. Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice. Bone 16(1):39-46. PubMed: 7742081 MGI: J:26261
Tagaya H; Kunisada T; Yamazaki H; Yamane T; Tokuhisa T; Wagner EF; Sudo T; Shultz LD; Hayashi SI. 2000. Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood 95(11):3363-70. PubMed: 10828017 MGI: J:82593
Tajima T; Murata T; Aritake K; Urade Y; Michishita M; Matsuoka T; Narumiya S; Ozaki H; Hori M. 2012. EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Am J Physiol Gastrointest Liver Physiol 302(5):G524-34. PubMed: 22159280 MGI: J:183452
Takahashi K; Naito M; Morioka Y; Schultz LD. 1993. Immunophenotypic and ultrastructural differentiation and maturation of nonlymphoid dendritic cells in osteopetrotic (op) mice with the total absence of macrophage colony stimulating factor activity. Adv Exp Med Biol 329:293-7. PubMed: 8379385 MGI: J:28547
Takahashi K; Naito M; Shultz LD. 1992. Differentiation of epidermal Langerhans cells in macrophage colony-stimulating-factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Invest Dermatol 99(5):46S-47S. PubMed: 1431208 MGI: J:3186
Takahashi K; Naito M; Shultz LD; Hayashi S; Nishikawa S. 1993. Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Leukoc Biol 53(1):19-28. PubMed: 8426088 MGI: J:4355
Takahashi K; Naito M; Umeda S; Shultz LD. 1994. The role of macrophage colony-stimulating factor in hepatic glucan-induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony-stimulating factor. Am J Pathol 144(6):1381-92. PubMed: 8203474 MGI: J:18577
Takahashi K; Umeda S; Shultz LD; Hayashi S; Nishikawa S. 1994. Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activty. J Leukoc Biol 55(5):581-8. PubMed: 8182336 MGI: J:18058
Takatsuka H; Umezu H; Hasegawa G; Usuda H; Ebe Y; Naito M; Shultz LD. 1998. Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor. J Submicrosc Cytol Pathol 30(2):239-47. PubMed: 9648288 MGI: J:113247
Tammela T; Zarkada G; Nurmi H; Jakobsson L; Heinolainen K; Tvorogov D; Zheng W; Franco CA; Murtomaki A; Aranda E; Miura N; Yla-Herttuala S; Fruttiger M; Makinen T; Eichmann A; Pollard JW; Gerhardt H; Alitalo K. 2011. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol :. PubMed: 21909098 MGI: J:175965
Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. PubMed: 16172157 MGI: J:106721
Tiffee JC; Xing L; Nilsson S; Boyce BF. 1999. Dental abnormalities associated with failure of tooth eruption in src knockout and op/op mice. Calcif Tissue Int 65(1):53-8. PubMed: 10369734 MGI: J:56180
Ueki Y; Lin CY; Senoo M; Ebihara T; Agata N; Onji M; Saheki Y; Kawai T; Mukherjee PM; Reichenberger E; Olsen BR. 2007. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell 128(1):71-83. PubMed: 17218256 MGI: J:117880
Umeda S; Beamer WG; Takagi K; Naito M; Hayashi S; Yonemitsu H; Yi T; Shultz LD. 1999. Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol 155(1):223-33. PubMed: 10393854 MGI: J:108187
Umeda S; Takahashi K; Naito M; Shultz LD; Takagi K. 1996. Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation. J Submicrosc Cytol Pathol 28(1):13-26. PubMed: 8929623 MGI: J:33189
Usuda H; Naito M; Umeda S; Takahashi K; Shultz LD. 1994. Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity. J Submicrosc Cytol Pathol 26(1):111-9. PubMed: 8149328 MGI: J:18828
Van Nguyen A; Pollard JW. 2002. Colony stimulating factor-1 is required to recruit macrophages into the mammary gland to facilitate mammary ductal outgrowth. Dev Biol 247(1):11-25. PubMed: 12074549 MGI: J:129047
Voehringer D; van Rooijen N; Locksley RM. 2007. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol 81(6):1434-44. PubMed: 17339609 MGI: J:122340
Vyazunova I; Maklakova VI; Berman S; De I; Steffen MD; Hong W; Lincoln H; Morrissy AS; Taylor MD; Akagi K; Brennan CW; Rodriguez FJ; Collier LS. 2014. Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis. PLoS One 9(11):e113489. PubMed: 25423036 MGI: J:223532
Wegiel J; Wisniewski HM; Dziewiatkowski J; Tarnawski M; Kozielski R ; Trenkner E ; Wiktor-Jedrzejczak W. 1998. Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice. Brain Res 804(1):135-9. PubMed: 9729335 MGI: J:49613
Wei S; Nandi S; Chitu V; Yeung YG; Yu W; Huang M; Williams LT; Lin H; Stanley ER. 2010. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol 88(3):495-505. PubMed: 20504948 MGI: J:164923
Werner SA; Gluhak-Heinrich J; Woodruff K; Wittrant Y; Cardenas L; Roudier M; MacDougall M. 2007. Targeted expression of csCSF-1 in op/op mice ameliorates tooth defects. Arch Oral Biol 52(5):432-43. PubMed: 17126805 MGI: J:146705
Wiktor-Jedrzejczak W; Ansari AA; Szperl M; Urbanowska E. 1992. Distinct in vivo functions of two macrophage subpopulations as evidenced by studies using macrophage-deficient op/op mouse. Eur J Immunol 22(7):1951-4. PubMed: 1378025 MGI: J:1517
Wiktor-Jedrzejczak W; Bartocci A; Ferrante AW Jr; Ahmed-Ansari A; Sell KW; Pollard JW; Stanley ER. 1990. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse [published erratum appears in Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5937] Proc Natl Acad Sci U S A 87(12):4828-32. PubMed: 2191302 MGI: J:33975
Wiktor-Jedrzejczak W; Gordon S. 1996. Cytokine regulation of the macrophage (M phi) system studied using the colony stimulating factor-1-deficient op/op mouse. Physiol Rev 76(4):927-47. PubMed: 8874489 MGI: J:36652
Wiktor-Jedrzejczak W; Ratajczak MZ; Ptasznik A; Sell KW; Ahmed-Ansari A; Ostertag W. 1992. CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages. Exp Hematol 20(8):1004-10. PubMed: 1505635 MGI: J:2131
Wiktor-Jedrzejczak W; Urbanowska E; Szperl M. 1994. Granulocyte-macrophage colony-stimulating factor corrects macrophage deficiencies, but not osteopetrosis, in the colony-stimulating factor-1-deficient op/op mouse. Endocrinology 134(4):1932-5. PubMed: 8137761 MGI: J:17593
Wiktor-Jedrzejczak WW; Ahmed A; Szczylik C; Skelly RR. 1982. Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation J Exp Med 156(5):1516-27. PubMed: 7130905 MGI: J:104139
Witmer-Pack MD; Hughes DA; Schuler G; Lawson L; McWilliam A; Inaba K; Steinman RM; Gordon S. 1993. Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse. J Cell Sci 104(Pt 4):1021-9. PubMed: 8314887 MGI: J:4764
Wood GW; Hausmann E; Choudhuri R. 1997. Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancy. Mol Reprod Dev 46(1):62-9; discussion 69-70. PubMed: 8981365 MGI: J:37428
Wu K; Byers DE; Jin X; Agapov E; Alexander-Brett J; Patel AC; Cella M; Gilfilan S; Colonna M; Kober DL; Brett TJ; Holtzman MJ. 2015. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med 212(5):681-97. PubMed: 25897174 MGI: J:222695
Wyckoff JB; Wang Y; Lin EY; Li JF; Goswami S; Stanley ER; Segall JE; Pollard JW; Condeelis J. 2007. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67(6):2649-56. PubMed: 17363585 MGI: J:120318
Yamada G; Nakamura S; Haraguchi R; Sakai M; Suzuki K; Miyado K; Hasuwa H; Ogino Y; Minami T; Tohno Y; Blum M; Shultz LD. 1998. Aberrant regulation of bone trace elements in motheaten and osteopetrosis mutant mice. Cell Mol Biol (Noisy-Le-Grand) 44(2):315-9. PubMed: 9593582 MGI: J:47798
Yamamoto N; Naraparaju VR. 1996. A defect in beta-galactosidase of B lymphocytes in the osteopetrotic (op/op) mouse. Immunol Lett 50(1-2):35-40. PubMed: 8793557 MGI: J:34280
Yao GQ; Wu JJ; Ovadia S; Troiano N; Sun BH; Insogna K. 2009. Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice. Am J Physiol Endocrinol Metab 296(4):E714-20. PubMed: 19141689 MGI: J:148134
Yao GQ; Wu JJ; Sun BH; Troiano N; Mitnick MA; Insogna K. 2003. The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo. Endocrinology 144(8):3677-82. PubMed: 12865350 MGI: J:84815
Yoshida H; Hayashi S; Kunisada T; Ogawa M; Nishikawa S; Okamura H; Sudo T; Shultz LD; Nishikawa S. 1990. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345(6274):442-4. PubMed: 2188141 MGI: J:10519
Zarebski A; Velu CS; Baktula AM; Bourdeau T; Horman SR; Basu S; Bertolone SJ; Horwitz M; Hildeman DA; Trent JO; Grimes HL. 2008. Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. Immunity 28(3):370-80. PubMed: 18328744 MGI: J:132941
Zhang HH; Basu S; Wu F; Begley CG; Saris CJ; Dunn AR; Burgess AW; Walker F. 2007. Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF. J Leukoc Biol 82(4):915-25. PubMed: 17652450 MGI: J:125155
Zhou H; Lapointe BM; Clark SR; Zbytnuik L; Kubes P. 2006. A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol 177(11):8103-10. PubMed: 17114485 MGI: J:140683
de Villiers WJ; Smith JD; Miyata M; Dansky HM; Darley E; Gordon S. 1998. Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E. Arterioscler Thromb Vasc Biol 18(4):631-40. PubMed: 9555870 MGI: J:47535

Also Known As: osteopetrosis

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Csf1op

Allele Symbol: Csf1op

a

Allele Symbol: a

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Csf1op related

Mammalian Phenotype Terms by Genotype

Genotype: Csf1op/Csf1opinvolves: C3HeB/FeJ * C57BL/6J

homeostasis/metabolism phenotype

reproductive system phenotype

integument phenotype

cellular phenotype

behavior/neurological phenotype

cardiovascular system phenotype

growth/size/body region phenotype

hematopoietic system phenotype

immune system phenotype

skeleton phenotype

craniofacial phenotype

endocrine/exocrine gland phenotype

Genotype: Csf1op/Csf1opB6;C3Fe a/a-Csf1op/J

immune system phenotype

growth/size/body region phenotype

cellular phenotype

homeostasis/metabolism phenotype

hematopoietic system phenotype

nervous system phenotype

hearing/vestibular/ear phenotype

vision/eye phenotype

endocrine/exocrine gland phenotype

reproductive system phenotype

behavior/neurological phenotype

Genotype: Csf1op/Csf1opB6C3Fe a/a-Csf1op/J

mortality/aging

endocrine/exocrine gland phenotype

homeostasis/metabolism phenotype

hearing/vestibular/ear phenotype

cardiovascular system phenotype

craniofacial phenotype

muscle phenotype

vision/eye phenotype

integument phenotype

cellular phenotype

growth/size/body region phenotype

immune system phenotype

skeleton phenotype

reproductive system phenotype

nervous system phenotype

hematopoietic system phenotype

liver/biliary system phenotype

limbs/digits/tail phenotype

Genotype: Csf1op/Csf1opC57BL/6J-Csf1op

mortality/aging

homeostasis/metabolism phenotype

skeleton phenotype

immune system phenotype

hematopoietic system phenotype

reproductive system phenotype

craniofacial phenotype

limbs/digits/tail phenotype

growth/size/body region phenotype

endocrine/exocrine gland phenotype

References

Additional References

Additional - a related

Additional - Csf1op related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Csf1^op

Allele Symbol: Csf1^op

Genotype: Csf1^op related

Genotype: Csf1^op/Csf1^op
involves: C3HeB/FeJ * C57BL/6J

Genotype: Csf1^op/Csf1^op
B6;C3Fe a/a-Csf1^op/J

Genotype: Csf1^op/Csf1^op
B6C3Fe a/a-Csf1^op/J

Genotype: Csf1^op/Csf1^op
C57BL/6J-Csf1^op

Additional - Csf1^op related