The fused mutation is dominant and generally more severe in homozygotes, but has highly varying penetrance in both the heterozygote and homozygote, to the extent that some homozygotes do not have an abnormal phenotype. Phenotypic traits of mice carrying the Axin1Fu allele include shortened, bifurcated, or absent tails, kinked tails with fused vertebrae, other asymmetrical fusions of vertebrae, axial duplications, and ribs fused at the proximal ends. Imperforate anus, anemia at birth, waltzing movement, deafness, and missing or abnormal kidneys have also been reported. Both heterozygotes and homozygotes are generally fertile although female carriers transmit with a lower penetrance than males do. (Reed, 1936; Dunn and Gluecksohn-Waelsch, 1954; Theiler and Gluecksohn-Waelsch, 1956.)
Genetic Background | Generation |
---|---|
001198 129P4/RrRkJ |
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Axin1 | axin 1 |
The fused mutation is dominant and generally more severe in homozygotes, but has highly varying penetrance in both the heterozygote and homozygote, to the extent that some homozygotes do not have an abnormal phenotype. Phenotypic traits of mice carrying the Axin1Fu allele include shortened, bifurcated, or absent tails, kinked tails with fused vertebrae, other asymmetrical fusions of vertebrae, axial duplications, and ribs fused at the proximal ends. Imperforate anus, anemia at birth, waltzing movement, deafness, and missing or abnormal kidneys have also been reported. Both heterozygotes and homozygotes are generally fertile although female carriers transmit with a lower penetrance than males do. (Reed, 1936; Dunn and Gluecksohn-Waelsch, 1954; Theiler and Gluecksohn-Waelsch, 1956.)
Fused (Axin1Fu) arose in stocks at the Bussy Institute at Harvard prior to 1931. It was first maintained at The Jackson Laboratory by Dr. Leroy Stevens in 1958 on a 129 background. It was then taken by Dr. Meredith Runner and maintained on the 129RrDg background to N31 in 1967. During this time it was bred by backcrossing a fused heterozygous male to a 129RrDg female. In 1967 the stock was maintained by Dr. Margaret Green, and was inbred by mating a heterozygous affected male to a normal non-fused female sibling. It was cryopreserved in 1985 by mating heterozygous expressing males to +/+ females or vice versa at N31F55.
Allele Name | fused |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | Fu; Tf |
Gene Symbol and Name | Axin1, axin 1 |
Gene Synonym(s) | |
Strain of Origin | Bussey Institution stock |
Chromosome | 17 |
General Note | Gametic imprinting has been detected for Axin1Fu (J:11139), and the locus may be affected by inherited inactivation (J:6577). Penetrance is affected by the genetic background, although expressivity is not. A suppressor gene in C57BL/6 decreases the penetrance of Axin1Fu in hybrids (J:11139). The suppressor gene did not affect penetrance of Axin1Fu in mice chimeric between C57BL/6 and a stock carrying Axin1Fu (J:19657). |
Molecular Note | The mutation is an IAP retrotransposon insertion within the sixth intron that results in the production of wild-type transcripts as well as mutant transcripts that initiate at both the authentic promoter and the 3'-most long terminal repeat of the insertion. |
When using the 129P4.Cg-Axin1Fu/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000212 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous and Wild-type for Axin1<Fu> 1 pair minimum |
Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.