The fused mutation is dominant and generally more severe in homozygotes, but has highly varying penetrance in both the heterozygote and homozygote, to the extent that some homozygotes do not have an abnormal phenotype. Phenotypic traits of mice carrying the Axin1Fu allele include shortened, bifurcated, or absent tails, kinked tails with fused vertebrae, other asymmetrical fusions of vertebrae, axial duplications, and ribs fused at the proximal ends. Imperforate anus, anemia at birth, waltzing movement, deafness, and missing or abnormal kidneys have also been reported. Both heterozygotes and homozygotes are generally fertile although female carriers transmit with a lower penetrance than males do. (Reed, 1936; Dunn and Gluecksohn-Waelsch, 1954; Theiler and Gluecksohn-Waelsch, 1956.)
| Genetic Background | Generation |
|---|---|
|
001198 129P4/RrRkJ |
|
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Axin1 | axin 1 |
| Service/Product | Description | Price |
|---|---|---|
| Heterozygous and Wild-type for Axin1<Fu> 1 pair minimum |
| Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $2595.00 |
| Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $2595.00 |
| Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $3373.50 |
| Frozen Mouse Embryo | 129P4.Cg-Axin1<Fu>/J Frozen Embryos | $3373.50 |
