Overview

Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (Mitf^Mi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes white mutant mice show slight microphthalmia but normal skeleton. Mice heterozygous for the microphthalmia (Mitf^Mi) mutation have less iris pigment than wildtype and often have white spotting on the belly, head, and tail. Homozygous mutant mice have small eyes and are devoid of pigment in the eyes, inner ear, and skin. Homozygotes are deaf at an early age. There is a decrease of mast cells in the spleen and gut. Most homozygotes die around weaning but some may live for several months. There is a deficiency of secondary bone resorption (osteopetrosis) and the incisors fail to erupt. Immunological defects include decreased macrophage chemotac...

Genetic overview

Genetic Background	Generation
000664 C57BL/6J

Mitf^Mi

Allele Type	Gene Symbol	Gene Name
Other	Mitf	melanogenesis associated transcription factor

Mitf^Mi-wh

Allele Type	Gene Symbol	Gene Name
Spontaneous	Mitf	melanogenesis associated transcription factor

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Research Applications

Dermatology Research
Developmental Biology Research
Endocrine Deficiency Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Sensorineural Research
Mouse/Human Gene Homologs
Hematological Research

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Details

Detailed Description

Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (Mitf^Mi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes white mutant mice show slight microphthalmia but normal skeleton. Mice heterozygous for the microphthalmia (Mitf^Mi) mutation have less iris pigment than wildtype and often have white spotting on the belly, head, and tail. Homozygous mutant mice have small eyes and are devoid of pigment in the eyes, inner ear, and skin. Homozygotes are deaf at an early age. There is a decrease of mast cells in the spleen and gut. Most homozygotes die around weaning but some may live for several months. There is a deficiency of secondary bone resorption (osteopetrosis) and the incisors fail to erupt. Immunological defects include decreased macrophage chemotactic responses, impaired proliferative responses to B cell and T cell mitogens, diminished responses in vitro to T-dependent and T-independent antigens and reduced NK cell activity. Compound heterozygotes (Mitf^Mi-wh/Mitf^Mi) closely resemble white homozygotes (Mitf^Mi-wh/Mitf^Mi-wh) but their eyes are slightly more pigmented and not as small.

Development

The white spontaneous mutation (Mitf^Mi-wh) was found among offspring of a cross between the DBA and C57BL strains. The microphthalmia (Mitf^Mi) was found among descendants of an irradiated male.

Genetics

Mitf^Mi

Allele Symbol: Mitf^Mi

Allele Name	microphthalmia
Allele Type	Other
Allele Synonym(s)	m; mi
Gene Symbol and Name	Mitf, melanogenesis associated transcription factor
Gene Synonym(s)
Strain of Origin	Not Specified
Chromosome	6
General Note	This mutation produces an osteopetrosis that resembles human osteopetrosis more than that produced by Ctsf^op. Mitf^Mi mutant mice have normal levels of M-CSF and its receptor. Osteoplasts are produced, but are unable to function normally in bone resorption (J:22788). Combination heterozygotes of Mitf^Mi-wh/Mitf^Mi show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967). Mitf^Mi-Or/Mitf^Mi mice resemble homozygous Mitf^Mi-Or (J:15060).
Molecular Note	This mutation was identified during an irradiation experiment, but it is not known whether it was induced in the treated male or spontaneously arose in an untreated mate. RT-PCR analysis identified a 3 nucleotide deletion in the transcript that results in a loss of one of four conserved arginine residues in the basic domain of the encoded protein. This mutation is predicted to affect the ability of the protein to bind DNA.

Mitf^Mi-wh

Allele Symbol: Mitf^Mi-wh

Allele Name	white
Allele Type	Spontaneous
Allele Synonym(s)	Mi^wh; mitf^wh
Gene Symbol and Name	Mitf, melanogenesis associated transcription factor
Gene Synonym(s)
Strain of Origin	(C57BL x DBA)F1
Chromosome	6
General Note	Combination heterozygotes of Mitf^Mi-wh/Mitf^Mi, Mitf^Mi-wh/Mitf^Mi-b, and Mitf^Mi-wh/Mitf^Mi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). Mitf^Mi-b/Mitf^Mi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).
Molecular Note	T-to-A transversion at bp 764, which leads to an isoleucine to asparagine substitution at amino acid 212 in the encoded protein (p.I212N). This mutation is in the basic region of the protein.

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Mitf^Mi related

Dermatology Research
- Color and White Spotting Defects
Developmental Biology Research
- Neural Crest Defects
- Skeletal Defects
  - osteopetrosis
Endocrine Deficiency Research
- Bone/Bone Marrow Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Neurobiology Research
- Hearing Defects
Sensorineural Research
- Eye Defects
- Hearing Defects
Mouse/Human Gene Homologs
- Waardenburg syndrome, type IIA
Hematological Research
- Mast Cell Deficiency
  - osteopetrosis

Genotype: Mitf^Mi-wh related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Neurobiology Research
- Hearing Defects
Sensorineural Research
- Eye Defects
- Hearing Defects
Mouse/Human Gene Homologs
- Waardenburg syndrome, type IIA
Dermatology Research
- Color and White Spotting Defects
Endocrine Deficiency Research
- Bone/Bone Marrow Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * DBA

growth/size/body region phenotype

decreased body size
- reduced body size compared to f Tyr^c homozygotes

pigmentation phenotype

decreased eye pigmentation
- little or no pigment in the iris

absent coat pigmentation
- the coat is entirely lacking pigment
- coat color is indistinguishable from that of Tyr^c homozygotes

ocular albinism
- eyes are pink and pigmentless

reproductive system phenotype

reduced fertility

decreased litter size
- litter size is reduced in homozygous female to homozygous male crosses

vision/eye phenotype

ocular albinism
- eyes are pink and pigmentless

microphthalmia
- the eyes are only mildly reduced in size
- eye size appears reduced compared to f Tyr^c homozygotes

decreased eye pigmentation
- little or no pigment in the iris

hearing/vestibular/ear phenotype

abnormal cochlear hair cell morphology

abnormal vestibular saccule morphology
- the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

abnormal stria vascularis morphology
- abnormal in its entirety

abnormal cochlea morphology
- no section of the cochlear duct was ever found to be normal

integument phenotype

absent coat pigmentation
- the coat is entirely lacking pigment
- coat color is indistinguishable from that of Tyr^c homozygotes

nervous system phenotype

abnormal cochlear hair cell morphology

Genotype: Mitf^Mi-wh/Mitf⁺
involves: C57BL * DBA

pigmentation phenotype

decreased tail pigmentation
- reduced tail pigmentation

diluted coat color
- coat color is gray and somewhat lighter than that of Myo5a^d homozygotes
- coat color darkens slightly with age

abnormal foot pigmentation
- reduced foot pigmentation

decreased eye pigmentation
- eyes are a very dark ruby color

abnormal iris pigmentation
- moderate dilution of the iris pigmentation

white spotting
- small spots may occur on the back, but spotting is not found on the head

vision/eye phenotype

abnormal iris pigmentation
- moderate dilution of the iris pigmentation

decreased eye pigmentation
- eyes are a very dark ruby color

integument phenotype

diluted coat color
- coat color is gray and somewhat lighter than that of Myo5a^d homozygotes
- coat color darkens slightly with age

white spotting
- small spots may occur on the back, but spotting is not found on the head

abnormal foot pigmentation
- reduced foot pigmentation

decreased tail pigmentation
- reduced tail pigmentation

limbs/digits/tail phenotype

decreased tail pigmentation
- reduced tail pigmentation

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
B6.Cg-Mitf

homeostasis/metabolism phenotype

decreased bleeding time
- bleed time of only 1 minute after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls

vision/eye phenotype

abnormal optic cup morphology
- irregularly formed surrounding less than half of the spherical lens
- slightly reduced in size from E13 onwards

microphthalmia
- slightly smaller at birth

abnormal retinal pigmentation
- at birth a few pigment granules are present near the iris
- after E12, a few pigment granules may be found in the front edge of the pigment layer
- pigment granules are absent from the pigment layer at E11

abnormal posterior eye segment morphology
- the lens fills the space normally occupied by the vitreous body

abnormal optic fissure closure
- in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
- at E12 the choroid fissure is mostly closed but the joining of the retinal nervous layer is not smooth and a large retinal eversion is present at the rear of the optic cup where the fissure fails to close

abnormal optic choroid morphology
- in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
- at birth the choroid fissure is irregularly closed in the anterior eye and open from the posterior part of the lens to the rear of the optic cup

abnormal retinal pigment epithelium morphology
- at all stages the number of mitoses is increased compared to control pigment layers
- pigment granules are absent at E11
- after E12 in some area the cells are columnar rather than cuboidal
- at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region

abnormal retinal neuronal layer morphology
- at birth, the layers are less clearly defined

abnormal optic stalk morphology
- shorter and somewhat greater in diameter at E11.5 and E12
- slight increase in diameter at E11

mammalian phenotype

skeleton phenotype
- unlike Mitf^Mi homozygotes no skeletal abnormalities are seen

pigmentation phenotype

abnormal retinal pigmentation
- at birth a few pigment granules are present near the iris
- pigment granules are absent from the pigment layer at E11
- after E12, a few pigment granules may be found in the front edge of the pigment layer

abnormal retinal pigment epithelium morphology
- pigment granules are absent at E11
- at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
- at all stages the number of mitoses is increased compared to control pigment layers
- after E12 in some area the cells are columnar rather than cuboidal

Genotype: Mitf^Mi/Mitf⁺
Not Specified

integument phenotype

white spotting
- white regions on tail
- some, but not all, heterozygotes have a small spot on the head between the eyes and ears or spots on the belly or tail

head spot

abnormal coat/hair pigmentation
- slight dilution of the fur in the young returns to normal in the adult

belly spot

nervous system phenotype

abnormal cochlear hair cell morphology

pigmentation phenotype

belly spot

decreased eye pigmentation
- iris pigmentation is reduced

white spotting
- white regions on tail
- some, but not all, heterozygotes have a small spot on the head between the eyes and ears or spots on the belly or tail

abnormal coat/hair pigmentation
- slight dilution of the fur in the young returns to normal in the adult

head spot

abnormal iris stromal pigmentation
- less iris pigment than normal

hearing/vestibular/ear phenotype

abnormal cochlear hair cell morphology

abnormal cochlea morphology
- no section of the cochlear duct was ever found to be normal

abnormal vestibular saccule morphology
- the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

abnormal stria vascularis morphology
- abnormal in its entirety

vision/eye phenotype

abnormal iris stromal pigmentation
- less iris pigment than normal

decreased eye pigmentation
- iris pigmentation is reduced

Genotype: Mitf^Mi/Mitf^Mi
Not Specified

craniofacial phenotype

failure of tooth eruption
- incisors fail to erupt

immune system phenotype

increased osteoclast cell number
- increase in the number of osteoclasts on the parietal bones of most homozygotes at P0, P3, P7.5 and P10 compared to heterozygous controls

abnormal osteoclast morphology
- cells contain greater amounts of cytoplasmic basophilia and cytoplasmic RNA compared to heterozygous controls
- the ratio of regular to irregular nuclei is significantly greater in homozygotes compared to heterozygous controls
- cells are smaller, rounder, and contain fewer nuclei than in heterozygous controls

decreased mast cell number
- deficiency in gut and liver

integument phenotype

absent coat pigmentation
- homozygotes are white

growth/size/body region phenotype

failure of tooth eruption
- incisors fail to erupt

mortality/aging

postnatal lethality
- most die at weaning but infrequently some live several months

decreased survivor rate
- viability is very low

nervous system phenotype

abnormal cochlear hair cell morphology

absent optic nerve
- at P0, the optic canal is open and nerve fibers pass toward the brain along the optic stalk; however, no defined optic nerve is present

pigmentation phenotype

abnormal retinal pigment epithelium morphology
- at all stages the mitotic values in the pigment layer is increased compared to controls
- at E11.5, this layer is a thickened monolayer ventrally and an irregular multilayered structure dorsally
- at P0 folds are present
- at E11.5 layer thickness is increased and dorsal regions are particularly thickened and wavy
- at P0, the ventral and ventral lateral portions of the layer are mainly a cuboidal monolayer while the dorsal and dorsal-lateral areas are composed of columnar cells in irregular multiple layers
- at E10.5 the pigment layer is thicker than in control littermates and this is more prominent dorsally where the layer is irregular

absent coat pigmentation
- homozygotes are white

abnormal retinal pigmentation
- complete absence of pigment granules at E11.5 and at P0

decreased eye pigmentation

hearing/vestibular/ear phenotype

abnormal cochlea morphology
- no section of the cochlear duct was ever found to be normal

abnormal scala media morphology

abnormal vestibular saccule morphology
- the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

abnormal stria vascularis morphology
- abnormal in its entirety

abnormal cochlear hair cell morphology

skeleton phenotype

osteopetrosis
- cells show defects in function and hormone response and fusion disability
- probable defect is in progenitor osteoclasts and can be transmitted via transplanted spleen and bone marrow cells

abnormal skeleton morphology

abnormal osteoclast morphology
- the ratio of regular to irregular nuclei is significantly greater in homozygotes compared to heterozygous controls
- cells are smaller, rounder, and contain fewer nuclei than in heterozygous controls
- cells contain greater amounts of cytoplasmic basophilia and cytoplasmic RNA compared to heterozygous controls

failure of tooth eruption
- incisors fail to erupt

increased osteoclast cell number
- increase in the number of osteoclasts on the parietal bones of most homozygotes at P0, P3, P7.5 and P10 compared to heterozygous controls

vision/eye phenotype

abnormal retinal pigment epithelium morphology
- at E10.5 the pigment layer is thicker than in control littermates and this is more prominent dorsally where the layer is irregular
- at P0 folds are present
- at E11.5 layer thickness is increased and dorsal regions are particularly thickened and wavy
- at P0, the ventral and ventral lateral portions of the layer are mainly a cuboidal monolayer while the dorsal and dorsal-lateral areas are composed of columnar cells in irregular multiple layers
- at E11.5, this layer is a thickened monolayer ventrally and an irregular multilayered structure dorsally
- at all stages the mitotic values in the pigment layer is increased compared to controls

abnormal retinal pigmentation
- complete absence of pigment granules at E11.5 and at P0

coloboma
- in anterior regions the edges of the coloboma do not meet while in ventral regions the edges overlap
- at P0, the coloboma is wider at its anterior edge with overlapping edges in the posterior region and inversion of the pigmented layer is seen along one or both edges
- at E16, the optic canal is open to the brain and this coloboma extends along the entire ventral surface of the optic cup and optic stalk

microphthalmia
- the eyes are severely reduced in size
- first detectable at E14, becoming more obvious with age

abnormal optic cup morphology
- at P0 the cup is poorly arched around the lens
- abnormal morphology persists through E11.5
- arching of the cup is reduced and the medial-lateral diameter is increased at E10.5

abnormal eye development
- at all stages the mitotic values in the pigment layer is increased compared to controls
- at E10.5 - E12 the average number of mitoses in the nervous layer of the retina is increased1.2 to 1.4 times compared to controls; however unlike in controls the number of mitoses does not increase from E14 - E16

absent optic nerve
- at P0, the optic canal is open and nerve fibers pass toward the brain along the optic stalk; however, no defined optic nerve is present

abnormal optic stalk morphology
- optic stalk is still present at E14, E16, and P0 when in control littermates it is nearly or completely absent
- abnormal morphology persists through E11.5
- increased diameter of the stalk at E10.5

eyelids fail to open

abnormal posterior eye segment morphology
- the lens fills the space normally occupied by the vitreous body

abnormal optic choroid morphology
- remains open at E12 and in areas along the edges inversion of the pigment epithelium is seen

decreased eye pigmentation

abnormal retinal neuronal layer morphology
- at E10.5 - E12 the average number of mitoses in the nervous layer of the retina is increased1.2 to 1.4 times compared to controls; however unlike in controls the number of mitoses does not increase from E14 - E16
- the nervous layer is irregular in thickness, folded and the strata are less clearly defined

abnormal ciliary body morphology
- thicker and less folded than in control littermates at P0

hematopoietic system phenotype

abnormal osteoclast morphology
- cells are smaller, rounder, and contain fewer nuclei than in heterozygous controls
- the ratio of regular to irregular nuclei is significantly greater in homozygotes compared to heterozygous controls
- cells contain greater amounts of cytoplasmic basophilia and cytoplasmic RNA compared to heterozygous controls

decreased mast cell number
- deficiency in gut and liver

increased osteoclast cell number
- increase in the number of osteoclasts on the parietal bones of most homozygotes at P0, P3, P7.5 and P10 compared to heterozygous controls

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * C57BL/6J * DBA

integument phenotype

absent coat pigmentation
- white coat

mammalian phenotype

skeleton phenotype
- Normal - normal bone development and mice do not develop osteopetrosis

pigmentation phenotype

absent coat pigmentation
- white coat

decreased eye pigmentation
- eyes are slightly pigmented

vision/eye phenotype

decreased eye pigmentation
- eyes are slightly pigmented

microphthalmia

Genotype: Mitf^Mi/Mitf^Mi
involves: C57BL/6J

craniofacial phenotype

failure of tooth eruption
- incisors fail to erupt

skeleton phenotype

failure of tooth eruption
- incisors fail to erupt

abnormal osteoclast morphology
- small osteoclasts

osteopetrosis
- severe osteopetrosis, with extensive accumulation of unresorbed endochondral bone and no bone marrow cavity

vision/eye phenotype

microphthalmia

growth/size/body region phenotype

decreased body size
- mice are half the normal size

failure of tooth eruption
- incisors fail to erupt

hematopoietic system phenotype

abnormal osteoclast morphology
- small osteoclasts

immune system phenotype

abnormal osteoclast morphology
- small osteoclasts

integument phenotype

absent coat pigmentation
- white coat

mortality/aging

postnatal lethality
- mice do not live past 3 weeks of age

pigmentation phenotype

absent coat pigmentation
- white coat

References

Additional References

Deol MS. 1967. The neural crest and the acoustic ganglion. J Embryol Exp Morphol 17(3):533-41PubMed: 6049665 MGI: J:5048
Hodgkinson CA; Moore KJ; Nakayama A; Steingrimsson E; Copeland NG; Jenkins NA; Arnheiter H. 1993. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74(2):395-404PubMed: 8343963 MGI: J:13562
Ito A; Kataoka TR; Kim DK; Koma Y; Lee YM; Kitamura Y. 2001. Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice. Blood 97(7):2075-83PubMed: 11264174 MGI: J:68425
Morii E; Ogihara H; Kim DK; Ito A; Oboki K; Lee YM; Jippo T; Nomura S; Maeyama K; Lamoreux ML; Kitamura Y. 2001. Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain. Blood 97(7):2038-44PubMed: 11264169 MGI: J:68426
Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20PubMed: 7852195 MGI: J:21682
Ogihara H; Morii E; Kim DK; Oboki K; Kitamura Y. 2001. Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene. Blood 97(3):645-51PubMed: 11157480 MGI: J:67218
Raisz LG; Simmons HA; Gworek SC; Eilon G. 1977. Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators. J Exp Med 145(4):857-65PubMed: 870607 MGI: J:5804
Steingrimsson E; Moore KJ; Lamoreux ML; Ferre-D'Amare AR; Burley SK; Zimring DC; Skow LC; Hodgkinson CA; Arnheiter H; Copeland NG; Jenkins NA. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments] Nat Genet 8(3):256-63PubMed: 7874168 MGI: J:21366
Tachibana M; Perez-Jurado LA; Nakayama A; Hodgkinson CA; Li X; Schneider M; Miki T; Fex J; Francke U; Arnheiter H. 1994. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3. Hum Mol Genet 3(4):553-7PubMed: 8069297 MGI: J:17853

Additional - Mitf^Mi related

Additional - Mitf^Mi-wh related

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When using the B6.Cg-Mitf^Mi-wh/Mitf^Mi/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000158 in your Materials and Methods section.

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Genetic overview

Research Applications

Base Price

Detailed Description

Development

MitfMi

Allele Symbol: MitfMi

MitfMi-wh

Allele Symbol: MitfMi-wh

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: MitfMi related

Genotype: MitfMi-wh related

Mammalian Phenotype Terms by Genotype

Genotype: MitfMi-wh/MitfMi-whinvolves: C57BL * DBA

growth/size/body region phenotype

pigmentation phenotype

reproductive system phenotype

vision/eye phenotype

hearing/vestibular/ear phenotype

integument phenotype

nervous system phenotype

Genotype: MitfMi-wh/Mitf+involves: C57BL * DBA

pigmentation phenotype

vision/eye phenotype

integument phenotype

limbs/digits/tail phenotype

Genotype: MitfMi-wh/MitfMi-whB6.Cg-Mitf

homeostasis/metabolism phenotype

vision/eye phenotype

mammalian phenotype

pigmentation phenotype

Genotype: MitfMi/Mitf+Not Specified

integument phenotype

nervous system phenotype

pigmentation phenotype

hearing/vestibular/ear phenotype

vision/eye phenotype

Genotype: MitfMi/MitfMiNot Specified

craniofacial phenotype

immune system phenotype

integument phenotype

growth/size/body region phenotype

mortality/aging

nervous system phenotype

pigmentation phenotype

hearing/vestibular/ear phenotype

skeleton phenotype

vision/eye phenotype

hematopoietic system phenotype

Genotype: MitfMi-wh/MitfMi-whinvolves: C57BL * C57BL/6J * DBA

integument phenotype

mammalian phenotype

pigmentation phenotype

vision/eye phenotype

Genotype: MitfMi/MitfMiinvolves: C57BL/6J

craniofacial phenotype

skeleton phenotype

vision/eye phenotype

growth/size/body region phenotype

hematopoietic system phenotype

immune system phenotype

integument phenotype

mortality/aging

pigmentation phenotype

References

Additional References

Additional - MitfMi related

Additional - MitfMi-wh related

Genotyping Protocols

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Mitf^Mi

Allele Symbol: Mitf^Mi

Mitf^Mi-wh

Allele Symbol: Mitf^Mi-wh

Genotype: Mitf^Mi related

Genotype: Mitf^Mi-wh related

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * DBA

Genotype: Mitf^Mi-wh/Mitf⁺
involves: C57BL * DBA

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
B6.Cg-Mitf

Genotype: Mitf^Mi/Mitf⁺
Not Specified

Genotype: Mitf^Mi/Mitf^Mi
Not Specified

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * C57BL/6J * DBA

Genotype: Mitf^Mi/Mitf^Mi
involves: C57BL/6J

Additional - Mitf^Mi related

Additional - Mitf^Mi-wh related