Overview

Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (Mitf^Mi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes white mutant mice show slight microphthalmia but normal skeleton. Mice heterozygous for the microphthalmia (Mitf^Mi) mutation have less iris pigment than wildtype and often have white spotting on the belly, head, and tail. Homozygous mutant mice have small eyes and are devoid of pigment in the eyes, inner ear, and skin. Homozygotes are deaf at an early age. There is a decrease of mast cells in the spleen and gut. Most homozygotes die around weaning but some may live for several months. There is a deficiency of secondary bone resorption (osteopetrosis) and the incisors fail to erupt. Immunological defects include decreased macrophage chemotac...

Genetic overview

Genetic Background	Generation
000664 C57BL/6J

Mitf^Mi

Allele Type	Gene Symbol	Gene Name
Other	Mitf	melanogenesis associated transcription factor

Mitf^Mi-wh

Allele Type	Gene Symbol	Gene Name
Spontaneous	Mitf	melanogenesis associated transcription factor

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Research Applications

Dermatology Research
Developmental Biology Research
Endocrine Deficiency Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Sensorineural Research
Mouse/Human Gene Homologs
Hematological Research

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Details

Detailed Description

Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (Mitf^Mi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes white mutant mice show slight microphthalmia but normal skeleton. Mice heterozygous for the microphthalmia (Mitf^Mi) mutation have less iris pigment than wildtype and often have white spotting on the belly, head, and tail. Homozygous mutant mice have small eyes and are devoid of pigment in the eyes, inner ear, and skin. Homozygotes are deaf at an early age. There is a decrease of mast cells in the spleen and gut. Most homozygotes die around weaning but some may live for several months. There is a deficiency of secondary bone resorption (osteopetrosis) and the incisors fail to erupt. Immunological defects include decreased macrophage chemotactic responses, impaired proliferative responses to B cell and T cell mitogens, diminished responses in vitro to T-dependent and T-independent antigens and reduced NK cell activity. Compound heterozygotes (Mitf^Mi-wh/Mitf^Mi) closely resemble white homozygotes (Mitf^Mi-wh/Mitf^Mi-wh) but their eyes are slightly more pigmented and not as small.

Development

The white spontaneous mutation (Mitf^Mi-wh) was found among offspring of a cross between the DBA and C57BL strains. The microphthalmia (Mitf^Mi) was found among descendants of an irradiated male.

Genetics

Mitf^Mi

Allele Symbol: Mitf^Mi

Allele Name	microphthalmia
Allele Type	Other
Allele Synonym(s)	Mitf^Mi; microphthalmia
Gene Symbol and Name	Mitf, melanogenesis associated transcription factor
Gene Synonym(s)	bHLHe32; BCC2; black eyed white; bw; Gsfbcc2; CMM8; Gsfbcc2; WS2; WS2A; MI; gsf bright coat colour 2; microphthalmia; mi; vit; wh; vitiligo; mi; COMMAD
Strain of Origin	Not Specified
Chromosome	6
General Note	This mutation produces an osteopetrosis that resembles human osteopetrosis more than that produced by Ctsf^op. Mitf^Mi mutant mice have normal levels of M-CSF and its receptor. Osteoplasts are produced, but are unable to function normally in bone resorption (J:22788). Combination heterozygotes of Mitf^Mi-wh/Mitf^Mi show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967). Mitf^Mi-Or/Mitf^Mi mice resemble homozygous Mitf^Mi-Or (J:15060).
Molecular Note	This mutation was identified during an irradiation experiment, but it is not known whether it was induced in the treated male or spontaneously arose in an untreated mate. RT-PCR analysis identified a 3 nucleotide deletion in the transcript that results in a loss of one of four conserved arginine residues in the basic domain of the encoded protein. This mutation is predicted to affect the ability of the protein to bind DNA.

Mitf^Mi-wh

Allele Symbol: Mitf^Mi-wh

Allele Name	white
Allele Type	Spontaneous
Allele Synonym(s)	white; Mitf^Mi-wh
Gene Symbol and Name	Mitf, melanogenesis associated transcription factor
Gene Synonym(s)	bHLHe32; BCC2; black eyed white; bw; Gsfbcc2; CMM8; Gsfbcc2; WS2; WS2A; MI; gsf bright coat colour 2; microphthalmia; mi; vit; wh; vitiligo; mi; COMMAD
Strain of Origin	(C57BL x DBA)F1
Chromosome	6
General Note	Combination heterozygotes of Mitf^Mi-wh/Mitf^Mi, Mitf^Mi-wh/Mitf^Mi-b, and Mitf^Mi-wh/Mitf^Mi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). Mitf^Mi-b/Mitf^Mi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).
Molecular Note	T to A transversion at bp 764, which leads to an isoleucine to asparagine substitution at the corresponding amino acid (212) in the encoded protein. This mutation is in the basic region of the protein.

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Mitf^Mi related

Dermatology Research
- Color and White Spotting Defects
Developmental Biology Research
- Neural Crest Defects
- Skeletal Defects
  - osteopetrosis
Endocrine Deficiency Research
- Bone/Bone Marrow Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Neurobiology Research
- Hearing Defects
Sensorineural Research
- Eye Defects
- Hearing Defects
Mouse/Human Gene Homologs
- Waardenburg syndrome, type IIA
Hematological Research
- Mast Cell Deficiency
  - osteopetrosis

Genotype: Mitf^Mi-wh related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Neurobiology Research
- Hearing Defects
Sensorineural Research
- Eye Defects
- Hearing Defects
Mouse/Human Gene Homologs
- Waardenburg syndrome, type IIA
Dermatology Research
- Color and White Spotting Defects
Endocrine Deficiency Research
- Bone/Bone Marrow Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * DBA

growth/size/body region phenotype

decreased body size
- reduced body size compared to f Tyr^c homozygotes

reproductive system phenotype

decreased litter size
- litter size is reduced in homozygous female to homozygous male crosses

reduced fertility

vision/eye phenotype

decreased eye pigmentation
- little or no pigment in the iris

microphthalmia
- eye size appears reduced compared to f Tyr^c homozygotes
- the eyes are only mildly reduced in size

ocular albinism
- eyes are pink and pigmentless

hearing/vestibular/ear phenotype

abnormal cochlea morphology
- no section of the cochlear duct was ever found to be normal

abnormal cochlear hair cell morphology

abnormal stria vascularis morphology
- abnormal in its entirety

abnormal vestibular saccule morphology
- the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

integument phenotype

absent coat pigmentation
- coat color is indistinguishable from that of Tyr^c homozygotes
- the coat is entirely lacking pigment

nervous system phenotype

abnormal cochlear hair cell morphology

pigmentation phenotype

absent coat pigmentation
- coat color is indistinguishable from that of Tyr^c homozygotes
- the coat is entirely lacking pigment

decreased eye pigmentation
- little or no pigment in the iris

ocular albinism
- eyes are pink and pigmentless

Genotype: Mitf^Mi-wh/Mitf⁺
involves: C57BL * DBA

integument phenotype

abnormal foot pigmentation
- reduced foot pigmentation

decreased tail pigmentation
- reduced tail pigmentation

diluted coat color
- coat color darkens slightly with age
- coat color is gray and somewhat lighter than that of Myo5a^d homozygotes

white spotting
- small spots may occur on the back, but spotting is not found on the head

vision/eye phenotype

abnormal iris pigmentation
- moderate dilution of the iris pigmentation

decreased eye pigmentation
- eyes are a very dark ruby color

limbs/digits/tail phenotype

decreased tail pigmentation
- reduced tail pigmentation

pigmentation phenotype

abnormal foot pigmentation
- reduced foot pigmentation

abnormal iris pigmentation
- moderate dilution of the iris pigmentation

decreased eye pigmentation
- eyes are a very dark ruby color

decreased tail pigmentation
- reduced tail pigmentation

diluted coat color
- coat color darkens slightly with age
- coat color is gray and somewhat lighter than that of Myo5a^d homozygotes

white spotting
- small spots may occur on the back, but spotting is not found on the head

Genotype: Mitf^Mi/Mitf^Mi
Not Specified

craniofacial phenotype

failure of tooth eruption
- incisors fail to erupt

immune system phenotype

abnormal osteoclast morphology
- cells are smaller, rounder, and contain fewer nuclei than in heterozygous controls
- cells contain greater amounts of cytoplasmic basophilia and cytoplasmic RNA compared to heterozygous controls
- the ratio of regular to irregular nuclei is significantly greater in homozygotes compared to heterozygous controls

decreased mast cell number
- deficiency in gut and liver

increased osteoclast cell number
- increase in the number of osteoclasts on the parietal bones of most homozygotes at P0, P3, P7.5 and P10 compared to heterozygous controls

integument phenotype

absent coat pigmentation
- homozygotes are white

growth/size/body region phenotype

failure of tooth eruption
- incisors fail to erupt

mortality/aging

decreased survivor rate
- viability is very low

postnatal lethality
- most die at weaning but infrequently some live several months

nervous system phenotype

abnormal cochlear hair cell morphology

absent optic nerve
- at P0, the optic canal is open and nerve fibers pass toward the brain along the optic stalk; however, no defined optic nerve is present

pigmentation phenotype

abnormal retinal pigment epithelium morphology
- at all stages the mitotic values in the pigment layer is increased compared to controls
- at E10.5 the pigment layer is thicker than in control littermates and this is more prominent dorsally where the layer is irregular
- at E11.5 layer thickness is increased and dorsal regions are particularly thickened and wavy
- at E11.5, this layer is a thickened monolayer ventrally and an irregular multilayered structure dorsally
- at P0 folds are present
- at P0, the ventral and ventral lateral portions of the layer are mainly a cuboidal monolayer while the dorsal and dorsal-lateral areas are composed of columnar cells in irregular multiple layers

abnormal retinal pigmentation
- complete absence of pigment granules at E11.5 and at P0

absent coat pigmentation
- homozygotes are white

decreased eye pigmentation

hearing/vestibular/ear phenotype

abnormal cochlea morphology
- no section of the cochlear duct was ever found to be normal

abnormal cochlear hair cell morphology

abnormal scala media morphology

abnormal stria vascularis morphology
- abnormal in its entirety

abnormal vestibular saccule morphology
- the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

skeleton phenotype

abnormal osteoclast morphology
- cells are smaller, rounder, and contain fewer nuclei than in heterozygous controls
- cells contain greater amounts of cytoplasmic basophilia and cytoplasmic RNA compared to heterozygous controls
- the ratio of regular to irregular nuclei is significantly greater in homozygotes compared to heterozygous controls

abnormal skeleton morphology

failure of tooth eruption
- incisors fail to erupt

increased osteoclast cell number
- increase in the number of osteoclasts on the parietal bones of most homozygotes at P0, P3, P7.5 and P10 compared to heterozygous controls

osteopetrosis
- cells show defects in function and hormone response and fusion disability
- probable defect is in progenitor osteoclasts and can be transmitted via transplanted spleen and bone marrow cells

vision/eye phenotype

abnormal ciliary body morphology
- thicker and less folded than in control littermates at P0

abnormal eye development
- at all stages the mitotic values in the pigment layer is increased compared to controls
- at E10.5 - E12 the average number of mitoses in the nervous layer of the retina is increased1.2 to 1.4 times compared to controls; however unlike in controls the number of mitoses does not increase from E14 - E16

abnormal optic choroid morphology
- remains open at E12 and in areas along the edges inversion of the pigment epithelium is seen

abnormal optic cup morphology
- abnormal morphology persists through E11.5
- arching of the cup is reduced and the medial-lateral diameter is increased at E10.5
- at P0 the cup is poorly arched around the lens

abnormal optic stalk morphology
- abnormal morphology persists through E11.5
- increased diameter of the stalk at E10.5
- optic stalk is still present at E14, E16, and P0 when in control littermates it is nearly or completely absent

abnormal posterior eye segment morphology
- the lens fills the space normally occupied by the vitreous body

abnormal retinal neuronal layer morphology
- at E10.5 - E12 the average number of mitoses in the nervous layer of the retina is increased1.2 to 1.4 times compared to controls; however unlike in controls the number of mitoses does not increase from E14 - E16
- the nervous layer is irregular in thickness, folded and the strata are less clearly defined

abnormal retinal pigment epithelium morphology
- at all stages the mitotic values in the pigment layer is increased compared to controls
- at E10.5 the pigment layer is thicker than in control littermates and this is more prominent dorsally where the layer is irregular
- at E11.5 layer thickness is increased and dorsal regions are particularly thickened and wavy
- at E11.5, this layer is a thickened monolayer ventrally and an irregular multilayered structure dorsally
- at P0 folds are present
- at P0, the ventral and ventral lateral portions of the layer are mainly a cuboidal monolayer while the dorsal and dorsal-lateral areas are composed of columnar cells in irregular multiple layers

abnormal retinal pigmentation
- complete absence of pigment granules at E11.5 and at P0

absent optic nerve
- at P0, the optic canal is open and nerve fibers pass toward the brain along the optic stalk; however, no defined optic nerve is present

coloboma
- at E16, the optic canal is open to the brain and this coloboma extends along the entire ventral surface of the optic cup and optic stalk
- at P0, the coloboma is wider at its anterior edge with overlapping edges in the posterior region and inversion of the pigmented layer is seen along one or both edges
- in anterior regions the edges of the coloboma do not meet while in ventral regions the edges overlap

decreased eye pigmentation

eyelids fail to open

microphthalmia
- first detectable at E14, becoming more obvious with age
- the eyes are severely reduced in size

hematopoietic system phenotype

abnormal osteoclast morphology
- cells are smaller, rounder, and contain fewer nuclei than in heterozygous controls
- cells contain greater amounts of cytoplasmic basophilia and cytoplasmic RNA compared to heterozygous controls
- the ratio of regular to irregular nuclei is significantly greater in homozygotes compared to heterozygous controls

decreased mast cell number
- deficiency in gut and liver

increased osteoclast cell number
- increase in the number of osteoclasts on the parietal bones of most homozygotes at P0, P3, P7.5 and P10 compared to heterozygous controls

Genotype: Mitf^Mi/Mitf⁺
Not Specified

hearing/vestibular/ear phenotype

abnormal cochlea morphology
- no section of the cochlear duct was ever found to be normal

abnormal cochlear hair cell morphology

abnormal stria vascularis morphology
- abnormal in its entirety

abnormal vestibular saccule morphology
- the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

nervous system phenotype

abnormal cochlear hair cell morphology

pigmentation phenotype

abnormal coat/hair pigmentation
- slight dilution of the fur in the young returns to normal in the adult

abnormal iris stromal pigmentation
- less iris pigment than normal

belly spot

decreased eye pigmentation
- iris pigmentation is reduced

head spot

white spotting
- some, but not all, heterozygotes have a small spot on the head between the eyes and ears or spots on the belly or tail
- white regions on tail

vision/eye phenotype

abnormal iris stromal pigmentation
- less iris pigment than normal

decreased eye pigmentation
- iris pigmentation is reduced

integument phenotype

abnormal coat/hair pigmentation
- slight dilution of the fur in the young returns to normal in the adult

belly spot

head spot

white spotting
- some, but not all, heterozygotes have a small spot on the head between the eyes and ears or spots on the belly or tail
- white regions on tail

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
B6.Cg-Mitf

homeostasis/metabolism phenotype

decreased bleeding time
- bleed time of only 1 minute after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls

vision/eye phenotype

abnormal optic choroid morphology
- at birth the choroid fissure is irregularly closed in the anterior eye and open from the posterior part of the lens to the rear of the optic cup
- in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure

abnormal optic cup morphology
- irregularly formed surrounding less than half of the spherical lens
- slightly reduced in size from E13 onwards

abnormal optic fissure closure
- at E12 the choroid fissure is mostly closed but the joining of the retinal nervous layer is not smooth and a large retinal eversion is present at the rear of the optic cup where the fissure fails to close
- in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure

abnormal optic stalk morphology
- shorter and somewhat greater in diameter at E11.5 and E12
- slight increase in diameter at E11

abnormal posterior eye segment morphology
- the lens fills the space normally occupied by the vitreous body

abnormal retinal neuronal layer morphology
- at birth, the layers are less clearly defined

abnormal retinal pigment epithelium morphology
- after E12 in some area the cells are columnar rather than cuboidal
- at all stages the number of mitoses is increased compared to control pigment layers
- at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
- pigment granules are absent at E11

abnormal retinal pigmentation
- after E12, a few pigment granules may be found in the front edge of the pigment layer
- at birth a few pigment granules are present near the iris
- pigment granules are absent from the pigment layer at E11

microphthalmia
- slightly smaller at birth

mammalian phenotype

skeleton phenotype
- unlike Mitf^Mi homozygotes no skeletal abnormalities are seen

pigmentation phenotype

abnormal retinal pigment epithelium morphology
- after E12 in some area the cells are columnar rather than cuboidal
- at all stages the number of mitoses is increased compared to control pigment layers
- at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
- pigment granules are absent at E11

abnormal retinal pigmentation
- after E12, a few pigment granules may be found in the front edge of the pigment layer
- at birth a few pigment granules are present near the iris
- pigment granules are absent from the pigment layer at E11

Genotype: Mitf^Mi/Mitf^Mi
involves: C57BL/6J

craniofacial phenotype

failure of tooth eruption
- incisors fail to erupt

vision/eye phenotype

microphthalmia

growth/size/body region phenotype

decreased body size
- mice are half the normal size

failure of tooth eruption
- incisors fail to erupt

hematopoietic system phenotype

abnormal osteoclast morphology
- small osteoclasts

immune system phenotype

abnormal osteoclast morphology
- small osteoclasts

integument phenotype

absent coat pigmentation
- white coat

mortality/aging

postnatal lethality
- mice do not live past 3 weeks of age

pigmentation phenotype

absent coat pigmentation
- white coat

skeleton phenotype

abnormal osteoclast morphology
- small osteoclasts

failure of tooth eruption
- incisors fail to erupt

osteopetrosis
- severe osteopetrosis, with extensive accumulation of unresorbed endochondral bone and no bone marrow cavity

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * C57BL/6J * DBA

integument phenotype

absent coat pigmentation
- white coat

mammalian phenotype

skeleton phenotype
- Normal - normal bone development and mice do not develop osteopetrosis

pigmentation phenotype

absent coat pigmentation
- white coat

decreased eye pigmentation
- eyes are slightly pigmented

vision/eye phenotype

decreased eye pigmentation
- eyes are slightly pigmented

microphthalmia

References

Additional References

Hodgkinson CA; Moore KJ; Nakayama A; Steingrimsson E; Copeland NG; Jenkins NA; Arnheiter H. 1993. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74(2):395-404PubMed: 8343963 MGI: J:13562
Tachibana M; Perez-Jurado LA; Nakayama A; Hodgkinson CA; Li X; Schneider M; Miki T; Fex J; Francke U; Arnheiter H. 1994. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3. Hum Mol Genet 3(4):553-7PubMed: 8069297 MGI: J:17853
Steingrimsson E; Moore KJ; Lamoreux ML; Ferre-D'Amare AR; Burley SK; Zimring DC; Skow LC; Hodgkinson CA; Arnheiter H; Copeland NG; Jenkins NA. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments] Nat Genet 8(3):256-63PubMed: 7874168 MGI: J:21366
Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20PubMed: 7852195 MGI: J:21682
Deol MS. 1967. The neural crest and the acoustic ganglion. J Embryol Exp Morphol 17(3):533-41PubMed: 6049665 MGI: J:5048
Raisz LG; Simmons HA; Gworek SC; Eilon G. 1977. Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators. J Exp Med 145(4):857-65PubMed: 870607 MGI: J:5804
Ogihara H; Morii E; Kim DK; Oboki K; Kitamura Y. 2001. Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene. Blood 97(3):645-51PubMed: 11157480 MGI: J:67218
Ito A; Kataoka TR; Kim DK; Koma Y; Lee YM; Kitamura Y. 2001. Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice. Blood 97(7):2075-83PubMed: 11264174 MGI: J:68425
Morii E; Ogihara H; Kim DK; Ito A; Oboki K; Lee YM; Jippo T; Nomura S; Maeyama K; Lamoreux ML; Kitamura Y. 2001. Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain. Blood 97(7):2038-44PubMed: 11264169 MGI: J:68426

Additional - Mitf^Mi related

Additional - Mitf^Mi-wh related

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When using the B6.Cg-Mitf^Mi-wh/Mitf^Mi/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000158 in your Materials and Methods section.

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	Heterozygous for Mitf<Mi-wh> or Mitf<Mi>

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Genetic overview

Research Applications

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Detailed Description

Development

MitfMi

Allele Symbol: MitfMi

MitfMi-wh

Allele Symbol: MitfMi-wh

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: MitfMi related

Genotype: MitfMi-wh related

Mammalian Phenotype Terms by Genotype

Genotype: MitfMi-wh/MitfMi-whinvolves: C57BL * DBA

growth/size/body region phenotype

reproductive system phenotype

vision/eye phenotype

hearing/vestibular/ear phenotype

integument phenotype

nervous system phenotype

pigmentation phenotype

Genotype: MitfMi-wh/Mitf+involves: C57BL * DBA

integument phenotype

vision/eye phenotype

limbs/digits/tail phenotype

pigmentation phenotype

Genotype: MitfMi/MitfMiNot Specified

craniofacial phenotype

immune system phenotype

integument phenotype

growth/size/body region phenotype

mortality/aging

nervous system phenotype

pigmentation phenotype

hearing/vestibular/ear phenotype

skeleton phenotype

vision/eye phenotype

hematopoietic system phenotype

Genotype: MitfMi/Mitf+Not Specified

hearing/vestibular/ear phenotype

nervous system phenotype

pigmentation phenotype

vision/eye phenotype

integument phenotype

Genotype: MitfMi-wh/MitfMi-whB6.Cg-Mitf

homeostasis/metabolism phenotype

vision/eye phenotype

mammalian phenotype

pigmentation phenotype

Genotype: MitfMi/MitfMiinvolves: C57BL/6J

craniofacial phenotype

vision/eye phenotype

growth/size/body region phenotype

hematopoietic system phenotype

immune system phenotype

integument phenotype

mortality/aging

pigmentation phenotype

skeleton phenotype

Genotype: MitfMi-wh/MitfMi-whinvolves: C57BL * C57BL/6J * DBA

integument phenotype

mammalian phenotype

pigmentation phenotype

vision/eye phenotype

References

Additional References

Additional - MitfMi related

Additional - MitfMi-wh related

Genotyping Protocols

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Mitf^Mi

Allele Symbol: Mitf^Mi

Mitf^Mi-wh

Allele Symbol: Mitf^Mi-wh

Genotype: Mitf^Mi related

Genotype: Mitf^Mi-wh related

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * DBA

Genotype: Mitf^Mi-wh/Mitf⁺
involves: C57BL * DBA

Genotype: Mitf^Mi/Mitf^Mi
Not Specified

Genotype: Mitf^Mi/Mitf⁺
Not Specified

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
B6.Cg-Mitf

Genotype: Mitf^Mi/Mitf^Mi
involves: C57BL/6J

Genotype: Mitf^Mi-wh/Mitf^Mi-wh
involves: C57BL * C57BL/6J * DBA

Additional - Mitf^Mi related

Additional - Mitf^Mi-wh related