WLHR/LeJ

Stock No:: 000147

Cryo Recovery

Overview

Genetic overview

Genetic Background	Generation

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Research Applications

Neurobiology Research
Sensorineural Research
Cancer Research
Cardiovascular Research
Dermatology Research
Immunology, Inflammation and Autoimmunity Research
Research Tools
Metabolism Research

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Base Price

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$2,595.00 Domestic price Cryo Recovery

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Details

Important Note

This strain is homozygous for Esd^c and segregating for Hr^hr and wl, which are held in repulsion.

Detailed Description

WLHR/Le is a balanced stock with wabbler-lethal (wl) and hairless (hr) spontaneous mutations maintained in repulsion on Chromosome 14. Homozygous wabbler-lethal mutant mice are first recognizable at 12 days of age and usually die at about four weeks. They have an abnormal wobbly gait and a pronounced tremor when walking. In an extensive study of behavioral development of this mutant, homozygous wabbler-lethal mice were shown to be deficient in nearly all behaviors tested. Histological examination showed myelin degeneration widely distributed throughout the CNS, particularly in the vestibulocerebellar and spinocerebellar systems. Electron microscopy showed widespread axonal (Wallerian) degeneration in the medulla with secondary myelin dissolution. Similar abnormalities were present to a lesser extent in the basal ganglia, spinal cord, and cerebellum and in the optic nerve. Homozygous hairless mutant mice have a higher incidence and earlier onset of leukemia, reducible by virus-specific antibody. A deficiency of splenic T helper cells (Ly1⁺) may account for low cellular immune response of homozygous mutant mice. The coat is normal on hairless mice up to 10 days but then hair is lost from the follicle. Waves of hair growth with few thin fuzzy hairs ocur at monthly intervals for some time but homozygotes eventually become continuously hairless. Vibrissae are repeatedly regrown and shed, becoming more abnormal with age. Toenails are long and curved. There is hyperkeratosis of statified epithelium and the upper part of hair canals beginning at 14 days. Hair club formation is abnormal. Cysts form from the hyperkeratotic upper part of hair canals and sheaths of abnormal follicles stranded in dermis. Some cysts also form from sebaceous glands. All cysts undergo sebaceous transformation and later keratinization.

Development

The first wabbler lethal (wl) mouse appeared in descendents of a non-inbred pirouette (pi/pi) mouse carrying brown (Typr1^b) and nonagouti (a) that was returned to the Jackson Laboratory from Dr. R. A. Fisher in 1948 after the fire. The pirouette male was mated to a C57BL/6J female and several lines were made. An outcross was also made to strain HD/Hu of Dr. Katrina Hummel. Strain HD/Hu was homozygous for hairless (Hr^hr) and dilute (Myo5a^d). The stock was bred using tested but non-sibling matings until 1958 when inbreeding was started as a balanced stock with wl and hr in repulsion phase because they were closely linked on chromosome 14. The stock was also selected to be homozygous brown and nonagouti. It was cryopreserved in 1989 by mating known doubly heterozygous males to either known heterozygous or untested females at generations F115-120.

Genetics

Hr^hr

Allele Symbol: Hr^hr

Allele Name	hairless
Allele Type	Spontaneous
Allele Synonym(s)	SKH-1; hr
Gene Symbol and Name	Hr, lysine demethylase and nuclear receptor corepressor
Gene Synonym(s)	AU; rh-bmh; baldy; bldy; hairless; ba; MUHH; MUHH1; N; HSA277165; HYPT4; rh-bmh; rh; bldy; ALUNC; rhino-bald Mill Hill; hr
Strain of Origin	Not Specified
Chromosome	14
Molecular Note	The hr allele is the result of a retroviral integration. Insertion of murine leukemia proviral sequences into intron 6 results in aberrant splicing of the gene.

Atp8a2^wl

Allele Symbol: Atp8a2^wl

Allele Name	wabbler lethal
Allele Type	Spontaneous
Allele Synonym(s)	Wl
Gene Symbol and Name	Atp8a2, ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Gene Synonym(s)	ATPIB; wl; ATP; ML-1; AI415030; IB; vmd; expressed sequence AI415030; wabbler-lethal; wl; vestibulomotor degeneration; CAMRQ4; agitans-like; agil; agil; Ib
Strain of Origin	STOCK Grxcr1
Chromosome	14
Molecular Note	Spontaneous deletion of 21 bp in exon 22 results in elimination of seven highly conserved amino acids (TAIEDRL) from the nucleotide-binding domain (N-domain).

Esd

Marker Symbol: Esd

Marker Synonym(s)
Chromosome(s)	14

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Atp8a2^wl related

Neurobiology Research
- Ataxia (Movement) Defects
- Myelination Defects
- Tremor Defects
- Vestibular Defects
Sensorineural Research
- Vestibular Defects

Genotype: Hr^hr related

Cancer Research
- Increased Tumor Incidence
  - Leukemia
  - Leukemia: lymphocytic
  - Lymphomas
  - Lymphomas: thymic
  - Skin Cancers
  - Skin Cancers: Induced
- Toxicology
Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Relatively Resistant
Dermatology Research
- Skin and Hair Texture Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Research Tools
- Toxicology Research
  - drug/compound testing

Metabolism Research

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Atp8a2^wl/Atp8a2⁺
Not Specified

behavior/neurological phenotype

abnormal motor coordination/balance
- all heterozygotes are not symptomatic
- symptoms are subtle and obvious only to experienced observers

ataxia
- Background Sensitivity - heterozygous mice are distinguishable from normal mice only in exceptional cases
- mild ataxia is characterized by the hind feet going out to the side more than normal and the body being closer to the ground

nervous system phenotype

demyelination
- at 2 weeks of age a small amount of myelin degeneration is found in the vestibulo-spinal tract and at 2.5 weeks myelin degeneration is still confined to the vestibulo-spinal pathway with the cerebellar systems unaffected
- moderate demyelination restricted to the vestibulospinal tract

Genotype: Atp8a2^wl/Atp8a2^wl
involves: C57BL/6

nervous system phenotype

cochlear ganglion degeneration
- at 2 months

decreased retinal photoreceptor cell number
- at P30 and P60

short photoreceptor outer segment
- at P30 and P60

vision/eye phenotype

decreased retinal photoreceptor cell number
- at P30 and P60

short photoreceptor outer segment
- at P30 and P60

vision/eye phenotype
- outer segment photoreceptors exhibit normal morphology

hearing/vestibular/ear phenotype

hearing/vestibular/ear phenotype
- outer and inner hair cells appear normal

increased or absent threshold for auditory brainstem response
- at 2 months

behavior/neurological phenotype

decreased startle reflex

Genotype: Atp8a2^wl/Atp8a2^wl
Not Specified

mortality/aging

lethality at weaning, complete penetrance
- most homozygotes die by wean age, with males dying at approximately 3 weeks of age and females dying approximately a week later

nervous system phenotype

demyelination
- at one week of age a small amount of myelin degeneration can be found in the ventral funiculus of the spinal cord; at two weeks of age myelin degeneration is marked in the vestibulo-spinal tracts and beginning in the spino-cerebellar tracts; and by 2.5 weeks of age very severe demyelination is found throughout the archi- and paleocerebellar systems, with heavy degeneration permeating the vestibulo-spinal tract, dorsal spinocerebellar tract, brachium conjunctivum, magnocellular red nucleus, rubrospinal tract, vestibular nerve and nuclei, juxtarestiform body, trapezoid body and the superior olivary nucleus, and moderate degeneration in the medial lemnicus, medial longitudinal fasiculus and tecto-spinal tractseks of age very severe demyelination is found throughout the archi- and paleocerebellar systems, with heavy degeneration permeating the vestibulo-spinal tract, dorsal spinocerebellar tract, brachium conjunctivum, magnocellular red nucleus, rubrospinal tract, vestibular nerve and nuclei, juxtarestiform body, trapezoid body and the superior olivary nucleus, and moderate degeneration in the medial lemnicus, medial longitudinal fasiculus and tecto-spinal tracts
- in the vestibulosponal tract from the lateral vestibular nucleus to the spinal cord, and in the entering fibers of the eighth cranial nerve, the juxtaresiform body, the medullary center of the cerebellum, the medial longitudinal fasciculus, the trapezoid body, the lateral lemniscus, brachium conjunctivum, red nucleus, and the rubrospinal and tectospinal tractsbody, the lateral lemniscus, brachium conjunctivum, red nucleus, and the rubrospinal and tectospinal tracts

nervous system phenotype
- demyelination is not found in the telencephalon at 2.5 weeks of age
- there is no myelin degeneration detected in the thalamus

behavior/neurological phenotype

abnormal gait

abnormal motor coordination/balance
- swaying of the body, dragging of the hind limbs and progressive incoordination of the limbs when walking

abnormal reflex
- no reaction to pinching of the tail

ataxia
- homozygotes have difficulty in walking and when trying to walk seem to pull the hind feet along rather than pushing off with them

behavior/neurological phenotype
- can orient in water and swim

impaired limb coordination

limb grasping
- when homozyogtes are lifted by the tail, the hind feet lock together in a spasm

tremors

hearing/vestibular/ear phenotype

hearing/vestibular/ear phenotype
- normal hearing and auditory reflexes

homeostasis/metabolism phenotype

abnormal circulating amino acid level
- plasma phenylalanine concentration rises after 18 days of age to abnormally high levels and phenylalanine loading experiments show that at 22 days of age homozygotes can not normally metabolize exogenous phenylalanine, although they can at 14 days of age

abnormal enzyme/coenzyme level
- liver homogenates have decreased phenylalanine hydroxylase activity, decreased phenylalanine-sodium pyruvate transaminase activity, and increased phenylalanine-alpha-ketoglutarate transaminase activity, increased tyrosine-alpha-ketoglutarate transaminase activity, increased tryptophan-alpha-ketoglutarate activity, and increased tryptophan pyrrolase activityactivity, increased tryptophan-alpha-ketoglutarate activity, and increased tryptophan pyrrolase activity

hypoglycemia
- mice are hypoglycemic from 20 days until death

increased circulating tyrosine level
- plasma tyrosine concentration is higher than normal at 14 days of age then rapidly drops to abnormally low levels (at 26 days of age 13.36 ug/ml vs 23.12 ug/ml in heterozygotes) and plasma tryptophan levels are lower than normal at 14 days of age and become progressively lower to 26 days of age (14.13 ug/ml vs 22.18 ug/ml in heterozygotes), although loading experiments show that homozygotes handle added tyrosine and tryptophan in a manner comparable to that of heterozygous littermatesme progressively lower to 26 days of age (14.13 ug/ml vs 22.18 ug/ml in heterozygotes), although loading experiments show that homozygotes handle added tyrosine and tryptophan in a manner comparable to that of heterozygous littermates

Genotype: Atp8a2^wl/Atp8a2^wl
involves: C57BL/6J

nervous system phenotype

optic nerve degeneration
- at 28 days of age there is primary axonal degeneration of the optic nerve, but significant dysmyelination or hypomyelination are not found in the optic nerves at this timepoint

vision/eye phenotype

optic nerve degeneration
- at 28 days of age there is primary axonal degeneration of the optic nerve, but significant dysmyelination or hypomyelination are not found in the optic nerves at this timepoint

growth/size/body region phenotype

decreased body weight
- at 28 days of age the average weight of males, 6.3g, is less than half that of normal controls, 14.2g

Genotype: Hr^hr/Hr^hr
Not Specified

endocrine/exocrine gland phenotype

abnormal mammary gland morphology
- nipple at bottom of cup-shaped depression in skin
- no ducts
- small

sebaceous gland atrophy

behavior/neurological phenotype

abnormal nursing
- failure

integument phenotype

abnormal dermis reticular layer morphology
- cystic

abnormal mammary gland morphology
- nipple at bottom of cup-shaped depression in skin
- no ducts
- small

abnormal skin morphology
- thickened cutis

deformed nails
- curved

dermal cysts

epidermal hyperplasia

hairless
- beginning ~15 days of age and progressing from nose back

hyperkeratosis

sebaceous gland atrophy

Genotype: Hr^hr/Hr^hr
HRS/J

cellular phenotype

decreased T cell proliferation
- to alloantigens by T helper cells

hearing/vestibular/ear phenotype

absent linear vestibular evoked potential
- VESPs are absent at the maximum stimulus intensity used

neoplasm

increased leukemia incidence
- at 8 to 10 months of age 45% of homozygotes have lymphoid leukemia, compared with only 1% in heterozygotes, and approximately 72% of these homozygotes develop myeloid leukemia later in life up to 18 months of age
- increased incidence

hematopoietic system phenotype

decreased T cell number
- of CD5+ T cells

decreased T cell proliferation
- to alloantigens by T helper cells

increased macrophage cell number
- although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes

immune system phenotype

decreased T cell number
- of CD5+ T cells

decreased T cell proliferation
- to alloantigens by T helper cells

increased macrophage cell number
- although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes

References

Additional References

Reske-Kunz AB; Scheid MP; Boyse EA. 1979. Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. (1): 228-33. PubMed: 310859 MGI: 6076
Morrissey PJ; Parkinson DR; Schwartz RS; Waksal SD. 1980. Immunologic abnormalities in HRS/J mice. I. Specific deficit in T lymphocyte helper function in a mutant mouse. (4): 1558-62. PubMed: 6447727 MGI: 6364
Cachon-Gonzalez MB; Fenner S; Coffin JM; Moran C; Best S; Stoye JP. 1994. Structure and expression of the hairless gene of mice. (16): 7717-21. PubMed: 8052649 MGI: 19785

Additional - Atp8a2^wl

Lane PW; Dickie MM. 1961. Linkage of wabbler-lethal and hairless in the mouse 159-60. MGI: 270
Carroll EW; Curtis RL; Sullivan DA; Melvin JL. 1992. Wallerian degeneration in the optic nerve of the wabbler-lethal (wl/wl) mouse. (3-4): 411-8. PubMed: 1382814 MGI: 2856
Luse SA; Chenard C; Finke EH. 1967. The wabbler-lethal mouse. An electron microscopic study of the nervous system. (2): 153-61. PubMed: 6028244 MGI: 5017
Siegel SJ; Rauch H. 1969. Aromatic amino acid metabolism in the wabbler-lethal mouse. (4): 311-8. PubMed: 4388883 MGI: 5097
Dickie MM; Schneider J; Harman PJ. 1952. A juvenile wabbler-lethal in the house mouse. 283-286. MGI: 13021
Thiessen DD. 1965. The wabbler-lethal mouse: a study in development 87-100. MGI: 14778
Harman PJ. 1954. Genetically controlled demyelination in the mammalian central nervous system 546-50. MGI: 15073
Murad S; Kishimoto Y. 1975. Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. (15): 5841-6. PubMed: 1150661 MGI: 108034
Zhu X; Libby RT; de Vries WN; Smith RS; Wright DL; Bronson RT; Seburn KL; John SW. 2012. Mutations in a P-type ATPase gene cause axonal degeneration. (8): e1002853. PubMed: 22912588 MGI: 189223
Coleman JA; Zhu X; Djajadi HR; Molday LL; Smith RS; Libby RT; John SW; Molday RS. 2014. Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. (Pt 5): 1138-49. PubMed: 24413176 MGI: 212415
Fairfield H; Srivastava A; Ananda G; Liu R; Kircher M; Lakshminarayana A; Harris BS; Karst SY; Dionne LA; Kane CC; Curtain M; Berry ML; Ward-Bailey PF; Greenstein I; Byers C; Czechanski A; Sharp J; Palmer K; Gudis P; Martin W; Tadenev A; Bogdanik L; Pratt CH; Chang B; Schroeder DG; Cox GA; Cliften P; Milbrandt J; Murray S; Burgess R; Bergstrom DE; Donahue LR; Hamamy H; Masri A; Santoni FA; Makrythanasis P; Antonarakis SE; Shendure J; Reinholdt LG. 2015. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. (7): 948-57. PubMed: 25917818 MGI: 223405

Additional - Hr^hr

Pauling L. 1991. Effect of ascorbic acid on incidence of spontaneous mammary tumors and UV-light-induced skin tumors in mice. (6 Suppl): 1252S-1255S. PubMed: 1962578 MGI: 634
Brooke HC. 1926. Hairless mice 173-74. MGI: 2405
Crew FAE; Mirskaia L. 1931. The character of "hairless" in the mouse 17-24. MGI: 2409
Dunn TB; Deringer MK. 1968. Reticulum cell neoplasm, type B, or the Hodgkin's-like lesion of the mouse. (4): 771-821. PubMed: 4869134 MGI: 2417
Mann SJ. 1971. Hair loss and cyst formation in hairless and rhino mutant mice. (4): 485-99. PubMed: 5118596 MGI: 5228
Heiniger HJ; Huebner RJ; Meier H. 1976. Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis. (5): 1073-4. PubMed: 186616 MGI: 5715
Hiai H; Morrissey P; Khiroya R; Schwartz RS. 1977. Selective expression of xenotropic virus in congenic HRS/J (hairless) mice. (5634): 247-9. PubMed: 201855 MGI: 5897
Pottathil R; Meier H; Huebner RJ. 1978. Suppression of leukemogenesis in hairless mice by anti-type C viral immune gamma globulins. (8): 443-4. PubMed: 213736 MGI: 6048
Reske-Kunz AB; Scheid MP; Boyse EA. 1979. Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. (1): 228-33. PubMed: 310859 MGI: 6076
Morrissey PJ; Parkinson DR; Schwartz RS; Waksal SD. 1980. Immunologic abnormalities in HRS/J mice. I. Specific deficit in T lymphocyte helper function in a mutant mouse. (4): 1558-62. PubMed: 6447727 MGI: 6364
Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. (5-6): 601-13. PubMed: 6971254 MGI: 6474
Johnson DA; Meier H. 1981. Immune responsiveness of HRS/J mice to syngeneic lymphoma cells. (2): 461-4. PubMed: 6265551 MGI: 6524
Stelzner KF. 1983. Four dominant autosomal mutations affecting skin and hair development in the mouse. (3): 193-6. PubMed: 6863894 MGI: 7091
Stoye JP; Fenner S; Greenoak GE; Moran C; Coffin JM. 1988. Role of endogenous retroviruses as mutagens: the hairless mutation of mice. (3): 383-91. PubMed: 2840205 MGI: 9240
MONTAGNA W; CHASE HB; MELARAGNO HP. 1952. The skin of hairless mice. I. The formation of cysts and the distribution of lipids. (1): 83-94. PubMed: 14946445 MGI: 14815
Fraser FC. 1946. The expression and interaction of hereditary factors producing hypotrichosis in the mouse: histology and experimental results. 10-25. MGI: 14861
Cachon-Gonzalez MB; Fenner S; Coffin JM; Moran C; Best S; Stoye JP. 1994. Structure and expression of the hairless gene of mice. (16): 7717-21. PubMed: 8052649 MGI: 19785
Kinley JS; Moan J; Dall'Aqua F; Young AR. 1994. Quantitative assessment of epidermal melanogenesis in C3H/Tif hr/hr mice treated with topical furocoumarins and UVA radiation. (1): 97-103. PubMed: 8027588 MGI: 19469
Mucenski ML; Bedigian HG; Shull MM; Copeland NG; Jenkins NA. 1988. Comparative molecular genetic analysis of lymphomas from six inbred mouse strains. (3): 839-46. PubMed: 2828679 MGI: 25554
DERINGER MK. 1956. The effect of subcutaneous inoculation of 4-o-tolylazo-o-toluidine in strain HR mice. (4): 533-9. PubMed: 13367821 MGI: 24780
Meier H; Myers DD; Huebner RJ. 1969. Genetic control by the hr-locus of susceptibility and resistance to leukemia. (3): 759-66. PubMed: 4310515 MGI: 24867
Bailey DE; Bunker HP. 1973. Spontaneous mutation to hr 31. MGI: 27463
Starcher B; O'Neal P; Granstein RD; Beissert S. 1996. Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice. (2): 159-63. PubMed: 8757756 MGI: 34584
Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. (1): 19-32. PubMed: 9328433 MGI: 44135
Kondo T; Shiomoto Y; Kondo T; and Kubo S. 1997. The "NOA" MOUSE; A NEW HAIR-DEFICIENT MUTANT (A POSSIBLE ANIMAL MODEL OF ALLERGIC DERMATITIS) (3): 698-700. MGI: 43528
Panteleyev AA; van der Veen C; Rosenbach T; Muller-Rover S; Sokolov VE ; Paus R. 1998. Towards defining the pathogenesis of the hairless phenotype. (6): 902-7. PubMed: 9620297 MGI: 48064
Staats J. 1985. Standardized Nomenclature for Inbred Strains of Mice: eighth listing. (3): 945-77. PubMed: 3971387 MGI: 51750
Panteleyev AA; Botchkareva NV; Sundberg JP; Christiano AM; Paus R. 1999. The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation. (1): 159-71. PubMed: 10393848 MGI: 56885
Cachon-Gonzalez MB; San-Jose I; Cano A; Vega JA; Garcia N; Freeman T; Schimmang T; Stoye JP. 1999. The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype. (2): 113-26. PubMed: 10536052 MGI: 58833
Jensen JM; Schutze S; Forl M; Kronke M; Proksch E. 1999. Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. (12): 1761-70. PubMed: 10606630 MGI: 59997
Ahmad W; Panteleyev AA; Christiano AM. 1999. The molecular basis of congenital atrichia in humans and mice: mutations in the hairless gene. (3): 240-3. PubMed: 10674375 MGI: 60880
Vollmar B; Morgenthaler M; Amon M; Menger MD. 2000. Skin microvascular adaptations during maturation and aging of hairless mice (4): H1591-9. PubMed: 11009445 MGI: 66172
The Jackson Laboratory Office of Genetic Resources. 1993. Registry of Remutations at The Jackson Laboratory . MGI: 79342
Balansky RM; Izzotti A; D'Agostini F; Camoirano A; Bagnasco M; Lubet RA; De Flora S. 2003. Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice. (9): 1525-32. PubMed: 12844483 MGI: 86485
Wilgus TA; Koki AT; Zweifel BS; Rubal PA; Oberyszyn TM. 2003. Chemotherapeutic efficacy of topical celecoxib in a murine model of ultraviolet light B-induced skin cancer. (1): 33-9. PubMed: 12949841 MGI: 86657
Zarach JM; Beaudoin GM 3rd; Coulombe PA; Thompson CC. 2004. The co-repressor hairless has a role in epithelial cell differentiation in the skin. (17): 4189-200. PubMed: 15280217 MGI: 93042
Wang XP; Schunck M; Kallen KJ; Neumann C; Trautwein C; Rose-John S; Proksch E. 2004. The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. (1): 124-31. PubMed: 15191552 MGI: 91494
Egberts F; Heinrich M; Jensen JM; Winoto-Morbach S; Pfeiffer S; Wickel M; Schunck M; Steude J; Saftig P; Proksch E; Schutze S. 2004. Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. (Pt 11): 2295-307. PubMed: 15126630 MGI: 90732
van Schanke A; Jongsma MJ; Bisschop R; van Venrooij GM; Rebel H; de Gruijl FR. 2005. Single UVB Overexposure Stimulates Melanocyte Proliferation in Murine Skin, in Contrast to Fractionated or UVA-1 Exposure. (1): 241-7. PubMed: 15654980 MGI: 97274
Wulff BC; Kusewitt DF; VanBuskirk AM; Thomas-Ahner JM; Duncan FJ; Oberyszyn TM. 2008. Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A. (10): 2467-73. PubMed: 18463679 MGI: 141011
Zhang W; Hanks AN; Boucher K; Florell SR; Allen SM; Alexander A; Brash DE; Grossman D. 2005. UVB-induced apoptosis drives clonal expansion during skin tumor development. (1): 249-57. PubMed: 15498793 MGI: 96003
Kajiya K; Hirakawa S; Detmar M. 2006. Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. (4): 1496-503. PubMed: 17003502 MGI: 114467
Kato M; Takeda K; Kawamoto Y; Tsuzuki T; Kato Y; Ohno T; Hossain K; Iftakhar-E-Khuda I; Ohgami N; Isobe K; Takahashi M; Nakashima I. 2006. Novel Hairless RET-Transgenic Mouse Line with Melanocytic Nevi and Anagen Hair Follicles. (11): 2547-50. PubMed: 16778787 MGI: 114485
Dwivedi C; Valluri HB; Guan X; Agarwal R. 2006. Chemopreventive effects of alpha-santalol on ultraviolet B radiation-induced skin tumor development in SKH-1 hairless mice. (9): 1917-22. PubMed: 16679309 MGI: 114439
Michna L; Wagner GC; Lou YR; Xie JG; Peng QY; Lin Y; Carlson K; Shih WJ; Conney AH; Lu YP. 2006. Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice. (10): 2108-15. PubMed: 16699173 MGI: 114440
Doig J; Anderson C; Lawrence NJ; Selfridge J; Brownstein DG; Melton DW. 2006. Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression. (47): 6229-38. PubMed: 16682947 MGI: 116936
Brouxhon S; Konger RL; VanBuskirk J; Sheu TJ; Ryan J; Erdle B; Almudevar A; Breyer RM; Scott G; Pentland AP. 2007. Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness. (2): 439-46. PubMed: 16977324 MGI: 118670
Tober KL; Thomas-Ahner JM; Kusewitt DF; Oberyszyn TM. 2007. Effects of UVB on E prostanoid receptor expression in murine skin. (1): 214-21. PubMed: 16917495 MGI: 118063
Jones SM; Johnson KR; Yu H; Erway LC; Alagramam KN; Pollak N; Jones TA. 2005. A quantitative survey of gravity receptor function in mutant mouse strains. (4): 297-310. PubMed: 16235133 MGI: 118003
Sato J; Yanai M; Hirao T; Denda M. 2000. Water content and thickness of the stratum corneum contribute to skin surface morphology. (8): 412-7. PubMed: 10994776 MGI: 118044
Kato M; Ohgami N; Kawamoto Y; Tsuzuki T; Hossain K; Yanagishita T; Ohshima Y; Tsuboi H; Yamanoshita O; Matsumoto Y; Takahashi M; Nakashima I. 2007. Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development. (5): 1244-9. PubMed: 17159911 MGI: 122182
Pirinen E; Kuulasmaa T; Pietila M; Heikkinen S; Tusa M; Itkonen P; Boman S; Skommer J; Virkamaki A; Hohtola E; Kettunen M; Fatrai S; Kansanen E; Koota S; Niiranen K; Parkkinen J; Levonen AL; Yla-Herttuala S; Hiltunen JK; Alhonen L; Smith U; Janne J; Laakso M. 2007. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism. (13): 4953-67. PubMed: 17485446 MGI: 123851
Fischer SM; Pavone A; Mikulec C; Langenbach R; Rundhaug JE. 2007. Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. (5): 363-71. PubMed: 17219415 MGI: 122726
Gates AH; Arundell FD; Karasek MA. 1969. Hereditary defect of the pilosebaceous unit in a new double mutant mouse. (2): 115-8. PubMed: 5774889 MGI: 127681
Astner S; Wu A; Chen J; Philips N; Rius-Diaz F; Parrado C; Mihm MC; Goukassian DA; Pathak MA; Gonzalez S. 2007. Dietary lutein/zeaxanthin partially reduces photoaging and photocarcinogenesis in chronically UVB-irradiated Skh-1 hairless mice. (6): 283-91. PubMed: 17717424 MGI: 129839
Gallagher CH; Canfield PJ; Greenoak GE; Reeve VE. 1984. Characterization and histogenesis of tumors in the hairless mouse produced by low-dosage incremental ultraviolet radiation. (3): 169-74. PubMed: 6470519 MGI: 128296
Tsukahara K; Kakuo S; Moriwaki S; Hotta M; Ohuchi A; Kitahara T; Harada N. 2008. The characteristics of aromatase deficient hairless mice indicate important roles of extragonadal estrogen in the skin. (1-2): 82-90. PubMed: 17951050 MGI: 131608
Hachem JP; Houben E; Crumrine D; Man MQ; Schurer N; Roelandt T; Choi EH; Uchida Y; Brown BE; Feingold KR; Elias PM. 2006. Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis. (9): 2074-2086. PubMed: 16691196 MGI: 112818
Kaya G; Tran C; Sorg O; Hotz R; Grand D; Carraux P; Didierjean L; Stamenkovic I; Saurat JH. 2006. Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. (12): e493. PubMed: 17177600 MGI: 135259
Aberg KM; Man MQ; Gallo RL; Ganz T; Crumrine D; Brown BE; Choi EH; Kim DK; Schroder JM; Feingold KR; Elias PM. 2008. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. (4): 917-25. PubMed: 17943185 MGI: 136599
Halin C; Fahrngruber H; Meingassner JG; Bold G; Littlewood-Evans A; Stuetz A; Detmar M. 2008. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. (1): 265-77. PubMed: 18535184 MGI: 138473
Elias PM; Arbiser J; Brown BE; Rossiter H; Man MQ; Cerimele F; Crumrine D; Gunathilake R; Choi EH; Uchida Y; Tschachler E; Feingold KR. 2008. Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis. (3): 689-99. PubMed: 18688025 MGI: 140681
Sitaru C; Chiriac MT; Mihai S; Buning J; Gebert A; Ishiko A; Zillikens D. 2006. Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. (5): 3461-8. PubMed: 16920988 MGI: 140614
Jeong SK; Kim HJ; Youm JK; Ahn SK; Choi EH; Sohn MH; Kim KE; Hong JH; Shin DM; Lee SH. 2008. Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery. (8): 1930-9. PubMed: 18305573 MGI: 142711
Suzu S; Tanaka-Douzono M; Nomaguchi K; Yamada M; Hayasawa H; Kimura F; Motoyoshi K. 2000. p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction. (19): 5114-22. PubMed: 11013214 MGI: 151495
Heiniger HJ; Meier H; Kaliss N; Cherry M; Chen HW; Stoner RD. 1974. Hereditary immunodeficiency and leukemogenesis in HRS-J mice. (1): 201-11. PubMed: 4588546 MGI: 24697
Roelandt T; Giddelo C; Heughebaert C; Denecker G; Hupe M; Crumrine D; Kusuma A; Haftek M; Roseeuw D; Declercq W; Feingold KR; Elias PM; Hachem JP. 2009. The 'caveolae brake hypothesis' and the epidermal barrier. (4): 927-36. PubMed: 19005485 MGI: 151320
Keeler CE. 1931. The Independence of Dominant Spotting and Recessive Spotting ('Piebald') in the House Mouse. (2): 101-2. PubMed: 16587618 MGI: 154445
Man MQ; Lin TK; Santiago JL; Celli A; Zhong L; Huang ZM; Roelandt T; Hupe M; Sundberg JP; Silva KA; Crumrine D; Martin-Ezquerra G; Trullas C; Sun R; Wakefield JS; Wei ML; Feingold KR; Mauro TM; Elias PM. 2014. Basis for enhanced barrier function of pigmented skin. (9): 2399-407. PubMed: 24732399 MGI: 213933
Yoshino M; Nakatsu Y; Riele H; Hirota S; Kitamura Y; Tanaka K. 2002. Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice. (11): 935-40. PubMed: 12531021 MGI: 80695
Kimura Y; Sumiyoshi M. 2009. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. (11): 2079-86. PubMed: 19776181 MGI: 154825
Lu YP; Lou YR; Yen P; Mitchell D; Huang MT; Conney AH. 1999. Time course for early adaptive responses to ultraviolet B light in the epidermis of SKH-1 mice. (18): 4591-602. PubMed: 10493513 MGI: 58486
Sand JM; Aziz MH; Dreckschmidt NE; Havighurst TC; Kim K; Oberley TD; Verma AK. 2010. PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. (1): 270-7. PubMed: 19626035 MGI: 160680
Jung SK; Lee KW; Byun S; Lee EJ; Kim JE; Bode AM; Dong Z; Lee HJ. 2010. Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo. (5): 911-7. PubMed: 20008033 MGI: 160856
Xia X; Park E; Liu B; Willette-Brown J; Gong W; Wang J; Mitchell D; Fischer SM; Hu Y. 2010. Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. (5): 2500-8. PubMed: 20304950 MGI: 161871
Gilliver SC; Emmerson E; Campbell L; Chambon P; Hardman MJ; Ashcroft GS. 2010. 17Beta-estradiol inhibits wound healing in male mice via estrogen receptor-alpha. (6): 2707-21. PubMed: 20448060 MGI: 162417
Zhu F; Dolle ME; Berton TR; Kuiper RV; Capps C; Espejo A; McArthur MJ; Bedford MT; van Steeg H; de Vries A; Johnson DG. 2010. Mouse models for the p53 R72P polymorphism mimic human phenotypes. (14): 5851-9. PubMed: 20587514 MGI: 163562
Jiang YJ; Lu B; Tarling EJ; Kim P; Man MQ; Crumrine D; Edwards PA; Elias PM; Feingold KR. 2010. Regulation of ABCG1 expression in human keratinocytes and murine epidermis. (11): 3185-95. PubMed: 20675829 MGI: 166700
Lou YR; Peng QY; Li T; Medvecky CM; Lin Y; Shih WJ; Conney AH; Shapses S; Wagner GC; Lu YP. 2011. Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice. (7): 1078-84. PubMed: 21525235 MGI: 174739
Siebert N; Xu W; Grambow E; Zechner D; Vollmar B. 2011. Erythropoietin improves skin wound healing and activates the TGF-beta signaling pathway. (12): 1753-65. PubMed: 21894148 MGI: 181133
Chang YC; Wang JD; Hahn RA; Gordon MK; Joseph LB; Heck DE; Heindel ND; Young SC; Sinko PJ; Casillas RP; Laskin JD; Laskin DL; Gerecke DR. 2014. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. (2): 236-244. PubMed: 25127551 MGI: 215926
Hansmann B; Ahrens K; Wu Z; Proksch E; Meyer-Hoffert U; Schroder JM. 2012. Murine filaggrin-2 is involved in epithelial barrier function and down-regulated in metabolically induced skin barrier dysfunction. (4): 271-6. PubMed: 22417302 MGI: 183151
Rodriguez-Martin M; Martin-Ezquerra G; Man MQ; Hupe M; Youm JK; Mackenzie DS; Cho S; Trullas C; Holleran WM; Radek KA; Elias PM. 2011. Expression of epidermal CAMP changes in parallel with permeability barrier status. (11): 2263-70. PubMed: 21796152 MGI: 183276
Hirayama T; Van de Bittner GC; Gray LW; Lutsenko S; Chang CJ. 2012. Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model. (7): 2228-33. PubMed: 22308360 MGI: 183722
Voskamp P; Bodmann CA; Rebel HG; Koehl GE; Tensen CP; Bouwes Bavinck JN; El Ghalbzouri A; Van Kranen HJ; Willemze R; Geissler EK; De Gruijl FR. 2012. Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset. (6): 1267-76. PubMed: 22161643 MGI: 187210
Sahu RP; Dasilva SC; Rashid B; Martel KC; Jernigan D; Mehta SR; Mohamed DR; Rezania S; Bradish JR; Armstrong AB; Warren S; Konger RL. 2012. Mice lacking epidermal PPARgamma exhibit a marked augmentation in photocarcinogenesis associated with increased UVB-induced apoptosis, inflammation and barrier dysfunction. (7): E1055-66. PubMed: 22467332 MGI: 187177
Batal M; Boudry I; Mouret S; Clery-Barraud C; Wartelle J; Berard I; Douki T. 2014. DNA damage in internal organs after cutaneous exposure to sulphur mustard. (1): 39-44. PubMed: 24732442 MGI: 213423
Kim H; Casta A; Tang X; Luke CT; Kim AL; Bickers DR; Athar M; Christiano AM. 2012. Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling. (6): e39691. PubMed: 22761871 MGI: 189013
Matsuda M; Hoshino T; Yamakawa N; Tahara K; Adachi H; Sobue G; Maji D; Ihn H; Mizushima T. 2013. Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice. (4): 919-28. PubMed: 23096703 MGI: 197619
Yin Y; Li W; Son YO; Sun L; Lu J; Kim D; Wang X; Yao H; Wang L; Pratheeshkumar P; Hitron AJ; Luo J; Gao N; Shi X; Zhang Z. 2013. Quercitrin protects skin from UVB-induced oxidative damage. (2): 89-99. PubMed: 23545178 MGI: 198342
Cooper KL; King BS; Sandoval MM; Liu KJ; Hudson LG. 2013. Reduction of arsenite-enhanced ultraviolet radiation-induced DNA damage by supplemental zinc. (2): 81-8. PubMed: 23523584 MGI: 198349
Wu CL; Qiang L; Han W; Ming M; Viollet B; He YY. 2013. Role of AMPK in UVB-induced DNA damage repair and growth control. (21): 2682-9. PubMed: 22751115 MGI: 199120
Yamada T; Hasegawa S; Inoue Y; Date Y; Yamamoto N; Mizutani H; Nakata S; Matsunaga K; Akamatsu H. 2013. Wnt/beta-Catenin and Kit Signaling Sequentially Regulate Melanocyte Stem Cell Differentiation in UVB-Induced Epidermal Pigmentation. (12): 2753-62. PubMed: 23702581 MGI: 203969
Batal M; Boudry I; Mouret S; Wartelle J; Emorine S; Bertoni M; Berard I; Clery-Barraud C; Douki T. 2013. Temporal and spatial features of the formation of DNA adducts in sulfur mustard-exposed skin. (3): 644-50. PubMed: 24141030 MGI: 206306
Cusumano ZT; Watson ME Jr; Caparon MG. 2014. Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity. (1): 233-42. PubMed: 24144727 MGI: 207295
Xu J; Weng Z; Arumugam A; Tang X; Chaudhary SC; Li C; Christiano AM; Elmets CA; Bickers DR; Athar M. 2014. Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch(+/-) Mice. (5): 1529-40. PubMed: 24631180 MGI: 209226
D'Agostini F; Balansky RM; Bennicelli C; Lubet RA; Kelloff GJ; De Flora S. 2001. Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice. (3): 607-15. PubMed: 11179494 MGI: 68438
Lichtenberger BM; Gerber PA; Holcmann M; Buhren BA; Amberg N; Smolle V; Schrumpf H; Boelke E; Ansari P; Mackenzie C; Wollenberg A; Kislat A; Fischer JW; Rock K; Harder J; Schroder JM; Homey B; Sibilia M. 2013. Epidermal EGFR controls cutaneous host defense and prevents inflammation. (199): 199ra111. PubMed: 23966300 MGI: 214559
Pratheeshkumar P; Son YO; Wang X; Divya SP; Joseph B; Hitron JA; Wang L; Kim D; Yin Y; Roy RV; Lu J; Zhang Z; Wang Y; Shi X. 2014. Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-kappaB signaling pathways in SKH-1 hairless mice skin. (1): 127-37. PubMed: 25062774 MGI: 215708
Jain AK; Tewari-Singh N; Inturi S; Kumar D; Orlicky DJ; Agarwal C; White CW; Agarwal R. 2015. Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. (1): 71-8. PubMed: 25791923 MGI: 223968
Arumugam A; Weng Z; Chaudhary SC; Afaq F; Elmets CA; Athar M. 2014. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch. (3): 394-401. PubMed: 25094045 MGI: 221212
Xiao Y; Thoresen DT; Williams JS; Wang C; Perna J; Petrova R; Brownell I. 2015. Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium. (23): 7195-200. PubMed: 26015562 MGI: 224498
Turner MJ; DaSilva-Arnold S; Luo N; Hu X; West CC; Sun L; Hall C; Bradish J; Kaplan MH; Travers JB; Sun Y. 2014. STAT6-mediated keratitis and blepharitis: a novel murine model of ocular atopic dermatitis. (6): 3803-8. PubMed: 24845637 MGI: 231113
Li C; Srivastava RK; Weng Z; Croutch CR; Agarwal A; Elmets CA; Afaq F; Athar M. 2016. Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes. (10): 2637-49. PubMed: 27528504 MGI: 236690
Konger RL; Derr-Yellin E; Hojati D; Lutz C; Sundberg JP. 2016. Comparison of the acute ultraviolet photoresponse in congenic albino hairless C57BL/6J mice relative to outbred SKH1 hairless mice. (9): 688-93. PubMed: 27095432 MGI: 272161
Tharmarajah G; Faas L; Reiss K; Saftig P; Young A; Van Raamsdonk CD. 2012. Adam10 haploinsufficiency causes freckle-like macules in Hairless mice. (5): 555-65. PubMed: 22834956 MGI: 289104
Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. MGI: 30414
Murphy ED. 1966. Characteristic Tumors. In: Biology of the Laboratory Mouse. McGraw-Hill, New York. MGI: 24911
Heston WE. 1963. Genetics of Neoplasia. In: Methodology in Mammalian Genetics. Holden-Day, San Francisco. MGI: 23511

Technical Support

Contact Technical Support

Genotyping Protocols
- SEPARATED MELT: Hr^hr
- Genotyping resources and troubleshooting
Mating System
- Progeny Tested
- TJL Breeding Scheme: progeny test
- for hr: heterozygote x heterozygote in repulsion with wl
- for wl: heterozygote x heterozygote in repulsion with hr
- for Es10^c: homozygote x homozygote
  TJL Breeding Summary: hr + Es10^c/+ wl Es10^c X hr + Es10^c/+ wl Es10^c. This yields progeny of three genotypes that can be identified phenotypically before weaning
- see Strain Description above.
Appearance
- brown, haired, normal gait
  Related Genotype: a/a Tyrp1^b/Tyrp1^b wl + Esd^c/+ Hr^hr Esd^c or a/a Tyrp1^b/Tyrp1^b ? + Esd^c/+ ? Esd^c
  
  brown, haired, wobbly gait
  Related Genotype: a/a Tyrp1^b/Tyrp1^b + wl Esd^c/? wl Esd^c
  
  pigmented, hairless, normal gait
  Related Genotype: a/a Tyrp1^b/Tyrp1^b Hr^hr + Esd^c/Hr^hr ? Esd^c

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Please inquire

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Genetic overview

Research Applications

Base Price

Important Note

Detailed Description

Development

Hrhr

Allele Symbol: Hrhr

Atp8a2wl

Allele Symbol: Atp8a2wl

Esd

Marker Symbol: Esd

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Atp8a2wl related

Genotype: Hrhr related

Mammalian Phenotype Terms by Genotype

Genotype: Atp8a2wl/Atp8a2+Not Specified

behavior/neurological phenotype

nervous system phenotype

Genotype: Atp8a2wl/Atp8a2wlinvolves: C57BL/6

nervous system phenotype

vision/eye phenotype

hearing/vestibular/ear phenotype

behavior/neurological phenotype

Genotype: Atp8a2wl/Atp8a2wlNot Specified

mortality/aging

nervous system phenotype

behavior/neurological phenotype

hearing/vestibular/ear phenotype

homeostasis/metabolism phenotype

Genotype: Atp8a2wl/Atp8a2wlinvolves: C57BL/6J

nervous system phenotype

vision/eye phenotype

growth/size/body region phenotype

Genotype: Hrhr/HrhrNot Specified

endocrine/exocrine gland phenotype

behavior/neurological phenotype

integument phenotype

Genotype: Hrhr/HrhrHRS/J

cellular phenotype

hearing/vestibular/ear phenotype

neoplasm

hematopoietic system phenotype

immune system phenotype

References

Additional References

Additional - Atp8a2wl

Additional - Hrhr

Genotyping Protocols

Mating System

Appearance

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Hr^hr

Allele Symbol: Hr^hr

Atp8a2^wl

Allele Symbol: Atp8a2^wl

Genotype: Atp8a2^wl related

Genotype: Hr^hr related

Genotype: Atp8a2^wl/Atp8a2⁺
Not Specified

Genotype: Atp8a2^wl/Atp8a2^wl
involves: C57BL/6

Genotype: Atp8a2^wl/Atp8a2^wl
Not Specified

Genotype: Atp8a2^wl/Atp8a2^wl
involves: C57BL/6J

Genotype: Hr^hr/Hr^hr
Not Specified

Genotype: Hr^hr/Hr^hr
HRS/J

Additional - Atp8a2^wl

Additional - Hr^hr