Overview

Also Known As:A.By-H2^b/SnJ, A.By/SnJ

Dr. George Snell, of The Jackson Laboratory, created this H2-congenic strain by crossing of mice of a non-inbred stock carrying the brachyury mutation (and therefore called BY) to mice of the A/Lilly inbred strain, then repeatedly backcrossing to the latter strain mice that proved resistant to A-derived tumors. A/Lilly was a subline of strain A that Snell obtained from the Lilly Company after the 1947 fire at The Jackson Laboratory; when it was learned that this strain was contaminated, Snell performed a single additional backcross to the A/WySn subline, taking it to generation N11 (Rodgers 2004; Klein 1989). The BY stock apparently was obtained from Dr. Dobrovolskaia-Zavadskaia, who described a short-tailed mouse sired by a gonadally-irradiated male; she believed the brachyury mutation not to have been caused by the radiation, but to have been a pre-existing spontaneous mutation (Dobrovoskaya-Zajadkaya 1927; Rodgers 2004). In a subsequent article, she described short tailed (...

Genetic overview

Genetic Background	Generation

H2^bc

Allele Type	Gene Symbol	Gene Name
Spontaneous	H2	histocompatibility-2, MHC

Apobec3^Rfv3-s

Allele Type	Gene Symbol	Gene Name
Spontaneous	Apobec3	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

H2-T18^f

Allele Type	Gene Symbol	Gene Name
Not Applicable	H2-T18	histocompatibility 2, T region locus 18

Marker(s)

	Marker Symbol	Marker Name
	H2	histocompatibility-2, MHC

View Genetics

Research Applications

Immunology, Inflammation and Autoimmunity Research

View All Research Applications

Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

Dr. George Snell, of The Jackson Laboratory, created this H2-congenic strain by crossing of mice of a non-inbred stock carrying the brachyury mutation (and therefore called BY) to mice of the A/Lilly inbred strain, then repeatedly backcrossing to the latter strain mice that proved resistant to A-derived tumors. A/Lilly was a subline of strain A that Snell obtained from the Lilly Company after the 1947 fire at The Jackson Laboratory; when it was learned that this strain was contaminated, Snell performed a single additional backcross to the A/WySn subline, taking it to generation N11 (Rodgers 2004; Klein 1989). The BY stock apparently was obtained from Dr. Dobrovolskaia-Zavadskaia, who described a short-tailed mouse sired by a gonadally-irradiated male; she believed the brachyury mutation not to have been caused by the radiation, but to have been a pre-existing spontaneous mutation (Dobrovoskaya-Zajadkaya 1927; Rodgers 2004). In a subsequent article, she described short tailed (brachyure) and tailless (anoure) mice - the latter presumaby T/t - from the same litters, but these may have come from a different investigator (Rodgers 2004).

The H2-T18 locus, which previously was called Tla and whose encoded proteins have been referred to as TL antigens, was discovered by Dr. Lloyd Old and colleagues when antisera produced by C57BL/6 mice following immunization with leukemia cells from A strain mice were found to react with thymocytes from a subset of mouse strains, as well as with cells of particular leukemias. Interestingly, some leukemias expressed the reactive antigen despite being from mice of strains whose thymocytes were negative for the antigen. Different antigens and combinations of antigens were identified in thymocytes of various mouse strains using a series of antisera. By such serological analysis, thymocytes from mice of all H2^b strains were negative for any TL antigen. (For a review of the Tla genes and their encoded antigens and additional references, see Chorney et al. 1982.)

This strain, like C57L, LP/J and 129 substrains, was classified in early articles dealing with H2-T18/Tla/TL as having the null, H2-T18^b haplotype of other H2^b strains. Shen et al. (1982), using a panel of monoclonal antibodies, identified a new Tla specificity, which they assigned the f haplotype, shared by this subset of otherwise H2^b strains. Snell realized earlier from results of transplantation studies that A.BY differed from other H2^b strains and that the difference mapped to the region of Tla; he therefore proposed to call the H2 haplotype of A.BY bc, as this was the next H2^b variant in the series. We therefore have renamed this strain accordingly.

Control Suggestions

000647 A/WySnJ

Additional Information

Considerations for Choosing Controls

Selected References

Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62PubMed: 9148789 MGI: J:41130
SNELL GD; JACKSON RB. 1958. Histocompatibility genes of the mouse. II. Production and analysis of isogenic resistant lines. J Natl Cancer Inst 21(5):843-77PubMed: 13599016 MGI: J:117

View All References

Genetics

H2^bc

Allele Symbol: H2^bc

Allele Name	histocompatibility-2, MHC; bc variant
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	H2, histocompatibility-2, MHC
Gene Synonym(s)
Strain of Origin	Not Specified
Chromosome	17

Apobec3^Rfv3-s

Allele Symbol: Apobec3^Rfv3-s

Allele Name	recovery from Friend virus 3, susceptible
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Apobec3, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This recessive allele is found in BALB/c, and A.BY strains and is associated with high FV titers after inoculation. This allele produces an alternative mRNA transcript that excludes exon 2 and produces a protein that is 3- to 5- fold less potent in anti-viral activity as the protein encoded by the Apobec3^Rfv3-s allele.

H2-T18^f

Allele Symbol: H2-T18^f

Allele Name	f variant
Allele Type	Not Applicable
Allele Synonym(s)	Tla^f
Gene Symbol and Name	H2-T18, histocompatibility 2, T region locus 18
Gene Synonym(s)
Strain of Origin	Not Applicable
Chromosome	17
Molecular Note	The allele H2-T18^f determines presence of specificity TL.2.

H2

Marker Symbol: H2

Marker Synonym(s)
Chromosome(s)	17

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers

Mammalian Phenotype Terms by Genotype

References

Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62PubMed: 9148789 MGI: J:41130
SNELL GD; JACKSON RB. 1958. Histocompatibility genes of the mouse. II. Production and analysis of isogenic resistant lines. J Natl Cancer Inst 21(5):843-77PubMed: 13599016 MGI: J:117

Additional References

Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8PubMed: 7106865 MGI: J:6828

Additional - Apobec3^Rfv3-s related

Additional - H2 related

Additional - H2^bc related

Additional - H2-T18^f related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Appearance
- albino
  Related Genotype: a/a Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c
Citation
When using the A.BY-H2^bc H2-T18^f/SnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000140 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Homozygous, 1 pair minimum

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As:A.By-H2b/SnJ, A.By/SnJ

Genetic overview

Marker(s)

Research Applications

Base Price

Detailed Description

Control Suggestions

Additional Information

Selected References

H2bc

Allele Symbol: H2bc

Apobec3Rfv3-s

Allele Symbol: Apobec3Rfv3-s

H2-T18f

Allele Symbol: H2-T18f

H2

Marker Symbol: H2

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

References

Additional References

Additional - Apobec3Rfv3-s related

Additional - H2 related

Additional - H2bc related

Additional - H2-T18f related

Genotyping Protocols

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Also Known As:A.By-H2^b/SnJ, A.By/SnJ

H2^bc

Allele Symbol: H2^bc

Apobec3^Rfv3-s

Allele Symbol: Apobec3^Rfv3-s

H2-T18^f

Allele Symbol: H2-T18^f

Additional - Apobec3^Rfv3-s related

Additional - H2^bc related

Additional - H2-T18^f related