Genetic Background | Generation |
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000664 C57BL/6J |
|
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Tyr | tyrosinase |
Himalayan, an allele at the tryosonase locus, arose spontaneously in the offspring of a cross between a DBA/2J male and an AKR/J female at The Jackson Laboratory in 1958. An affected male was backcrosses to an AKR/J female and the Tyrc-h/Tyrc carriers were mated to a C57BL/10Gn. Pairs were mated to produce the Tyrc-h/Tyrc-h mouse. The mutation was backcrossed onto strain C57BL/6J and was cryopreserved in 1987 by mating B6.Cg-Tyrc-h homozygous males at N36F1 to C57BL/6J females.
Allele Name | himalayan |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Tyr, tyrosinase |
Gene Synonym(s) | |
Strain of Origin | (DBA/2 x AKR/J)F1 |
Chromosome | 7 |
General Note | Melanin granules of the retina are indistinguishable from those of chinchilla or of wild-type homozygotes (J:5001). Pigment synthesis in himalayan mice is temperature-sensitive; pigment develops in growing hairs of mice housed at 15oC but not in those housed at 30oC (J:6275). In explanation of this effect, it has been shown that tyrosinase in these mice is heat-labile (J:12173), being maximally active at well below body temperature. Tyrosinase of Tyrch homozygotes is strongly bound by an inhibitor at 37oC but not at lower temperatures (J:6508). |
Molecular Note | The mutation in the himalayan allele was found to be an A-to-G point mutation at coding nucleotide 1259 that results in an amino acid change at position 420 from histidine to arginine (p.H420R). |
When using the B6.Cg-Tyrc-h/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000104 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Tyr<c-h> |
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