Flexed tail homozygotes can be identified hematologically as earlyas embryonic day 13 and are detectably paler than normal by embryonic day 16, with most paler than normal by embryonic day 15. Homozygotes are small at birth and have a transitory siderocytic hypochromic anemia due to defective heme synthesis in fetal but not adult reticulocytes. Fetal erythrocytes have more alpha hemoglobin synthesis than beta hemoglobin synthesis. Very high numbers of siderocytes are found at birth and this decreases during the first few weeks of life and stabilizes at approximately 3 weeks of age with 3% siderocytes, significantly higher than in wildtype adults. Most homozygotes have a belly spot and 1 to 5 flexures in the tail due to vertebral fusions. Vertebral fusions are also found elsewhere in the vertebral column. Fewer than expected homozygotes are generated indicating prenatal death and the postnatal death rate is approximately 4 times normal. A small minority of homozygotes have been ...
This strain is homozygous for f.
Flexed tail homozygotes can be identified hematologically as earlyas embryonic day 13 and are detectably paler than normal by embryonic day 16, with most paler than normal by embryonic day 15. Homozygotes are small at birth and have a transitory siderocytic hypochromic anemia due to defective heme synthesis in fetal but not adult reticulocytes. Fetal erythrocytes have more alpha hemoglobin synthesis than beta hemoglobin synthesis. Very high numbers of siderocytes are found at birth and this decreases during the first few weeks of life and stabilizes at approximately 3 weeks of age with 3% siderocytes, significantly higher than in wildtype adults. Most homozygotes have a belly spot and 1 to 5 flexures in the tail due to vertebral fusions. Vertebral fusions are also found elsewhere in the vertebral column. Fewer than expected homozygotes are generated indicating prenatal death and the postnatal death rate is approximately 4 times normal. A small minority of homozygotes have been found to have embryonic neural tube defects or a dorsal enlargement of the head.
The FL/1Re inbred strain, homozygous for f and wildtype for Kit, was made from a female WB/Re heterozygous for KitW bred to a male heterozygous for f from a partially inbred stock derived from crosses between C3H/J and Snell?s WA linkage-testing stock. The integrated FL/1Re congenic strain, segregating for both KitW and f, was derived by repeated backcross-intercross to the developing FL/Re inbred. To generate this FL/1Re segregating congenic a female from the F1 generation of FL/Re heterozygous for KitW and homozygous for f was backcrossed to a WC/Re inbred wildtype for both Kit and f and a Kit wildtype f heterozygous offspring was bred to the F2 generation of the incipient FL/1Re inbred (Russell and McFarland, 1966). This strategy of maintenance, backcrossing KitW carriers to f/f of the FL/1Re homozygous inbred, was maintained for several decades, with this strain reaching generation N58 in 1974, and in 1980 embryos were generated for cryopreservation from +/+ f/f FL/1Re inbred females at generation F79 and KitW/+ f/+ and KitW/+ +/+ congenic males at generation N81.
|Allele Name||dominant spotting|
|Gene Symbol and Name||Kit, kit oncogene|
|Gene Synonym(s)||Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco1; Gsfsco5; Gsfsco5; Gsfsow3; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; belly-spot; c-KIT; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male|
|Strain of Origin||old mutant of the mouse fancy|
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided,
their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of
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