Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Tyr | tyrosinase |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Dnd1 | DND microRNA-mediated repression inhibitor 1 |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | Oca2 | oculocutaneous albinism II |
This strain was derived from a 129 line (referred to as 129/Sv-WCP) congenic for dominant spotting (KitW) and chinchilla (Tyrc-ch). The congenic was developed from an F1 male (WC x C57BL/6) backcrossed to a 129/Sv female. At the 8th backcross generation, 20% of the males produced by a heterozygous female developed testicular teratomas. Subsequently, sibling matings were selected for the ability to produce males with a high teratoma incidence and the dominant spotting allele was bred out (Stevens LC, 1973, J Natl Cancer Inst). Teratoma incidence in this strain is now attributed to a combination of the spontaneous mutation Dnd1Ter and the 129 strain background. By 1972, the colony had reached 20 generations of inbreeding. This strain was obtained from LC Stevens at The Jackson Laboratory and was cryopreserved in 1989.
Allele Name | chinchilla |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | cch; cr |
Gene Symbol and Name | Tyr, tyrosinase |
Gene Synonym(s) | |
Strain of Origin | fancier's stock |
Chromosome | 7 |
Molecular Note | The mutation in the chinchilla allele was found to be a G-to-A point mutation that results in an amino acid change at position 482 or 464 from alanine to threonine (p.A482T for pre-protein, p.A464T for mature protein). |
Allele Name | teratoma |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | Ter |
Gene Symbol and Name | Dnd1, DND microRNA-mediated repression inhibitor 1 |
Gene Synonym(s) | |
Strain of Origin | 129P3 |
Chromosome | 18 |
Molecular Note | A single C to T base change created a stop codon at arginine residue 178 (p.R178*) or 190 (p.R190*) depending on the isoform. |
When using the 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000091 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Homozygous or Wild-type for Dnd1<Ter>, Wild-type for Oca2 , Homozygous for Tyr<c-ch>, 1 pair minimum |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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