JAX
Mouse Strain Datasheet - 000058
B6(Cg)-Tyrc-2J/J
Also Known As: B6 albino, albino B6
B6(Cg)-Tyrc-2J/J, or B6-albino mice, are C57BL/6J mice that carry a mutation in the tyrosinase gene. Pigment is completely absent from skin, hair and eyes in mice homozygous for Tyrc-2J. This unique characteristic makes these mice ideal for creation of novel strains with targeted mutations (gene knockouts). B6-albino mice are used to generate blastocysts that can be used for microinjection of genetically modified C57BL/6J embryonic stem cells. Following implantation and gestation, resulting offspring that are chimeric for the donor embryonic stem cells and the recipient blastocyst are easily identified by coat color. This allows an easy method to create knockout mice on the C57BL/6J genetic background.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
F48+51N3F4pN3F16
(05-AUG-14) |
Tyrc-2J
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Tyr | tyrosinase |
Research Applications
- Research Tools
- Dermatology Research
- Sensorineural Research
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Genetics Research
- Mutagenesis and Transgenesis: Production of Transgenic Mice
- Genetics Research
Genotype: Tyrc-2J related
- Dermatology Research
- Color and White Spotting Defects
- Sensorineural Research
- Retinal Degeneration
Mammalian Phenotype Terms by Genotype
Genotype: Tyrc-2J/Tyrc-2J
B6(Cg)-Tyrc-2J/J
pigmentation phenotype
- abnormal melanosome morphology
- absence of pigment in melanosomes (MGI Ref ID J:178454)
- absent coat pigmentation
- absent hair follicle melanin granules
- forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants (MGI Ref ID J:6611)
- absent skin pigmentation
- (MGI Ref ID J:36008)
vision/eye phenotype
- abnormal aqueous drainage system morphology
- had mild focal angle developmental defects, whereas pigmented mice had no observed defects (MGI Ref ID J:82280)
- abnormal eye physiology
- resistant to light damage as compared to albino BALB/cByJ (MGI Ref ID J:99553)
- abnormal intraocular pressure
- increased pressure as compared to pigmented C57BL/6J (MGI Ref ID J:82879)
- abnormal retina morphology
- abnormal retinal ganglion layer morphology
- beginning at E11 through E16, cells exhibit smaller size and abnormal packing and organization (MGI Ref ID J:77026)
- abnormal retinal photoreceptor morphology
- abnormal vision
- dark-adapted threshold s are elevated (decreased sensitivity) in comparison to C57BL/6J (MGI Ref ID J:99554)
- decreased a wave amplitude
- reduction in a-wave and b-wave amplitude in young adults as demonstrated by electroretinogram (MGI Ref ID J:92276)
- decreased b wave amplitude
- reduction in a-wave and b-wave amplitude in young adults as demonstrated by electroretinogram (MGI Ref ID J:92276)
- decreased retinal photoreceptor cell number
- increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels (MGI Ref ID J:92276)
- retinal degeneration
- (MGI Ref ID J:92276)
nervous system phenotype
- abnormal retinal photoreceptor morphology
- decreased retinal photoreceptor cell number
- increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels (MGI Ref ID J:92276)
cellular phenotype
- abnormal keratinocyte apoptosis
- (MGI Ref ID J:112959)
- increased cellular sensitivity to ionizing radiation
- mice show dose-dependent DNA lesion formation (cyclobutane dimers) from UV-B exposure, but wild-type or forskolin-treated Mc1re mutants show little damage (MGI Ref ID J:112959)
integument phenotype
- abnormal keratinocyte apoptosis
- (MGI Ref ID J:112959)
- absent coat pigmentation
- absent hair follicle melanin granules
- forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants (MGI Ref ID J:6611)
- absent skin pigmentation
- (MGI Ref ID J:36008)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tyrc-2J/Tyrc-2J
involves: C57BL/6
pigmentation phenotype
- absent skin pigmentation
integument phenotype
Phenotype Information
References
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Additional References
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Additional - Tyrc-2J related
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