JAX
Mouse Strain Datasheet - 000058
B6(Cg)-Tyrc-2J/J
Also Known As: B6 albino, albino B6
B6(Cg)-Tyrc-2J/J, or B6-albino mice, are C57BL/6J mice that carry a mutation in the tyrosinase gene. Pigment is completely absent from skin, hair and eyes in mice homozygous for Tyrc-2J. This unique characteristic makes these mice ideal for creation of novel strains with targeted mutations (gene knockouts). B6-albino mice are used to generate blastocysts that can be used for microinjection of genetically modified C57BL/6J embryonic stem cells. Following implantation and gestation, resulting offspring that are chimeric for the donor embryonic stem cells and the recipient blastocyst are easily identified by coat color. This allows an easy method to create knockout mice on the C57BL/6J genetic background.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
F48+51N3F4pN3F16
|
Tyrc-2J
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Tyr | tyrosinase |
Research Applications
- Research Tools
- Dermatology Research
- Sensorineural Research
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Genetics Research
- Mutagenesis and Transgenesis: Production of Transgenic Mice
- Genetics Research
Genotype: Tyrc-2J related
- Dermatology Research
- Color and White Spotting Defects
- Sensorineural Research
- Retinal Degeneration
Mammalian Phenotype Terms by Genotype
Genotype: Tyrc-2J/Tyrc-2J
B6(Cg)-Tyrc-2J/J
pigmentation phenotype
- abnormal melanosome morphology
- absence of pigment in melanosomes (MGI Ref ID J:178454)
- absent coat pigmentation
- absent hair follicle melanin granules
- forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants (MGI Ref ID J:6611)
- absent skin pigmentation
- (MGI Ref ID J:36008)
vision/eye phenotype
- abnormal aqueous drainage system morphology
- had mild focal angle developmental defects, whereas pigmented mice had no observed defects (MGI Ref ID J:82280)
- abnormal eye physiology
- resistant to light damage as compared to albino BALB/cByJ (MGI Ref ID J:99553)
- abnormal intraocular pressure
- increased pressure as compared to pigmented C57BL/6J (MGI Ref ID J:82879)
- abnormal retina morphology
- abnormal retinal ganglion layer morphology
- beginning at E11 through E16, cells exhibit smaller size and abnormal packing and organization (MGI Ref ID J:77026)
- abnormal retinal photoreceptor morphology
- abnormal vision
- dark-adapted threshold s are elevated (decreased sensitivity) in comparison to C57BL/6J (MGI Ref ID J:99554)
- decreased a wave amplitude
- reduction in a-wave and b-wave amplitude in young adults as demonstrated by electroretinogram (MGI Ref ID J:92276)
- decreased b wave amplitude
- reduction in a-wave and b-wave amplitude in young adults as demonstrated by electroretinogram (MGI Ref ID J:92276)
- decreased retinal photoreceptor cell number
- increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels (MGI Ref ID J:92276)
- retinal degeneration
- (MGI Ref ID J:92276)
nervous system phenotype
- abnormal retinal photoreceptor morphology
- decreased retinal photoreceptor cell number
- increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels (MGI Ref ID J:92276)
cellular phenotype
- abnormal keratinocyte apoptosis
- (MGI Ref ID J:112959)
- increased cellular sensitivity to ionizing radiation
- mice show dose-dependent DNA lesion formation (cyclobutane dimers) from UV-B exposure, but wild-type or forskolin-treated Mc1re mutants show little damage (MGI Ref ID J:112959)
integument phenotype
- abnormal keratinocyte apoptosis
- (MGI Ref ID J:112959)
- absent coat pigmentation
- absent hair follicle melanin granules
- forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants (MGI Ref ID J:6611)
- absent skin pigmentation
- (MGI Ref ID J:36008)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tyrc-2J/Tyrc-2J
involves: C57BL/6
pigmentation phenotype
- absent skin pigmentation
integument phenotype
Phenotype Information
References
- Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. PubMed: 6793688MGI: J:6611
Additional References
- Bravo-Nuevo A; Walsh N; Stone J. 2004. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Invest Ophthalmol Vis Sci 45(6):2005-12. PubMed: 15161869MGI: J:92276
- Hofele K; Sedelis M; Auburger GW; Morgan S; Huston JP; Schwarting RK. 2001. Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility. Exp Neurol 168(1):116-22. PubMed: 11170726MGI: J:67792
- Kwon BS; Haq AK; Wakulchik M; Kestler D; Barton DE; Francke U; Lamoreux ML; Whitney JB 3rd; Halaban R. 1989. Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene. J Invest Dermatol 93(5):589-94. PubMed: 2507645MGI: J:10058
- Kwon BS; Wakulchik M; Haq AK; Halaban R; Kestler D. 1988. Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression. Biochem Biophys Res Commun 153(3):1301-9. PubMed: 3134020MGI: J:9242
- Le Fur N; Kelsall SR; Mintz B. 1996. Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics 37(2):245-8. PubMed: 8921397MGI: J:36008
- Nusinowitz S; Nguyen L; Radu R; Kashani Z; Farber D; Danciger M. 2003. Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65. Exp Eye Res 77(5):627-38. PubMed: 14550405MGI: J:86186
- Porter S; Mintz B. 1991. Multiple alternatively spliced transcripts of the mouse tyrosinase-encoding gene. Gene 97(2):277-82. PubMed: 1900251MGI: J:11014
- Rikke BA; Simpson VJ; Montoliu L; Johnson TE. 2001. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics. Alcohol Clin Exp Res 25(2):171-6. PubMed: 11236829MGI: J:68230
- Ruppert S; Muller G; Kwon B; Schutz G. 1988. Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO J 7(9):2715-22. PubMed: 2846281MGI: J:9439
- Schuster-Gossler K; Lee AW; Lerner CP; Parker HJ; Dyer VW; Scott VE; Gossler A; Conover JC. 2001. Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines. Biotechniques 31(5):1022-4, 1026. PubMed: 11730008MGI: J:144015
- Zurita E; Chagoyen M; Cantero M; Alonso R; Gonzalez-Neira A; Lopez-Jimenez A; Lopez-Moreno JA; Landel CP; Benitez J; Pazos F; Montoliu L. 2010. Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res :. PubMed: 20506040MGI: J:160203
Additional - Tyrc-2J related
- Adams EJ; Chen XW; O'Shea KS; Ginsburg D. 2014. Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem 289(30):20858-70. PubMed: 24876386MGI: J:232065
- Adini I; Ghosh K; Adini A; Chi ZL; Yoshimura T; Benny O; Connor KM; Rogers MS; Bazinet L; Birsner AE; Bielenberg DR; D'Amato RJ. 2014. Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest 124(1):425-36. PubMed: 24355922MGI: J:208014
- Alur RP; Cox TA; Crawford MA; Gong X; Brooks BP. 2008. Optic nerve axon number in mouse is regulated by PAX2. J AAPOS 12(2):117-21. PubMed: 18083586MGI: J:172973
- Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. PubMed: 18715234MGI: J:141035
- Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. PubMed: 16827931MGI: J:128215
- Balkema GW; Cusick K; Nguyen TH. 2001. Diurnal variation in synaptic ribbon length and visual threshold. Vis Neurosci 18(5):789-97. PubMed: 11925014MGI: J:99554
- Bhansali P; Rayport I; Rebsam A; Mason C. 2014. Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice. Neural Dev 9:11. PubMed: 24885435MGI: J:211641
- Bravo-Nuevo A; Walsh N; Stone J. 2004. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Invest Ophthalmol Vis Sci 45(6):2005-12. PubMed: 15161869MGI: J:92276
- Chopra M; Biehl M; Steinfatt T; Brandl A; Kums J; Amich J; Vaeth M; Kuen J; Holtappels R; Podlech J; Mottok A; Kraus S; Jordan-Garrote AL; Bauerlein CA; Brede C; Ribechini E; Fick A; Seher A; Polz J; Ottmuller KJ; Baker J; Nishikii H; Ritz M; Mattenheimer K; Schwinn S; Winter T; Schafer V; Krappmann S; Einsele H; Muller TD; Reddehase MJ; Lutz MB; Mannel DN; Berberich-Siebelt F; Wajant H; Beilhack A. 2016. Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion. J Exp Med 213(9):1881-900. PubMed: 27526711MGI: J:236727
- Cohen-Solal KA; Crespo-Carbone SM; Namkoong J; Mackason KR; Roberts KG; Reuhl KR; Chen S. 2002. Progressive appearance of pigmentation in amelanotic melanoma lesions. Pigment Cell Res 15(4):282-9. PubMed: 12100494MGI: J:77989
- Cortese K; Giordano F; Surace EM; Venturi C; Ballabio A; Tacchetti C; Marigo V. 2005. The ocular albinism type 1 (OA1) gene controls melanosome maturation and size. Invest Ophthalmol Vis Sci 46(12):4358-64. PubMed: 16303920MGI: J:103788
- D'Orazio JA; Nobuhisa T; Cui R; Arya M; Spry M; Wakamatsu K; Igras V; Kunisada T; Granter SR; Nishimura EK; Ito S; Fisher DE. 2006. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 443(7109):340-4. PubMed: 16988713MGI: J:112959
- Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. PubMed: 18344445MGI: J:136923
- Dentin R; Liu Y; Koo SH; Hedrick S; Vargas T; Heredia J; Yates J rd; Montminy M. 2007. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449(7160):366-9. PubMed: 17805301MGI: J:126351
- Eisenhofer G; Tian H; Holmes C; Matsunaga J; Roffler-Tarlov S; Hearing VJ. 2003. Tyrosinase: a developmentally specific major determinant of peripheral dopamine. FASEB J 17(10):1248-55. PubMed: 12832289MGI: J:119178
- Fetoni AR; Picciotti PM; Paludetti G; Troiani D. 2011. Pathogenesis of presbycusis in animal models: a review. Exp Gerontol 46(6):413-25. PubMed: 21211561MGI: J:186964
- Gibbs D; Cideciyan AV; Jacobson SG; Williams DS. 2009. Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence. Invest Ophthalmol Vis Sci 50(9):4386-93. PubMed: 19324852MGI: J:154563
- Green EL. 1973. Albino-2J (c<2J>) Mouse News Lett 49:31. MGI: J:27522
- Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T. 2015. Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes. Nat Commun 6:7139. PubMed: 25972253MGI: J:224874
- Hickman HD; Reynoso GV; Ngudiankama BF; Cush SS; Gibbs J; Bennink JR; Yewdell JW. 2015. CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells. Immunity 42(3):524-37. PubMed: 25769612MGI: J:223820
- Higuchi H; Macke EL; Lee WH; Miller SA; Xu JC; Ikeda S; Ikeda A. 2014. Genetic basis of age-dependent synaptic abnormalities in the retina. Mamm Genome :. PubMed: 25273269MGI: J:216971
- Honda T; Egen JG; Lammermann T; Kastenmuller W; Torabi-Parizi P; Germain RN. 2014. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity 40(2):235-47. PubMed: 24440150MGI: J:209370
- Iacovelli J; Zhao C; Wolkow N; Veldman P; Gollomp K; Ojha P; Lukinova N; King A; Feiner L; Esumi N; Zack DJ; Pierce EA; Vollrath D; Dunaief JL. 2011. Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression. Invest Ophthalmol Vis Sci 52(3):1378-83. PubMed: 21212186MGI: J:170522
- Imanishi Y; Sun W; Maeda T; Maeda A; Palczewski K. 2008. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem 283(36):25091-102. PubMed: 18606814MGI: J:142021
- Iwai-Takekoshi L; Ramos A; Schaler A; Weinreb S; Blazeski R; Mason C. 2016. Retinal pigment epithelial integrity is compromised in the developing albino mouse retina. J Comp Neurol 524(18):3696-3716. PubMed: 27097562MGI: J:237402
- Jarrett SG; Horrell EM; Christian PA; Vanover JC; Boulanger MC; Zou Y; D'Orazio JA. 2014. PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. Mol Cell 54(6):999-1011. PubMed: 24950377MGI: J:215489
- Jhunjhunwala S; Chen LC; Nichols EE; Thomson AW; Raimondi G; Little SR. 2013. All-trans retinoic acid and rapamycin synergize with transforming growth factor-beta1 to induce regulatory T cells but confer different migratory capacities. J Leukoc Biol 94(5):981-9. PubMed: 23898044MGI: J:209554
- Johnson BA; Cole BS; Geisert EE; Ikeda S; Ikeda A. 2010. Tyrosinase is the modifier of retinoschisis in mice. Genetics 186(4):1337-44. PubMed: 20876567MGI: J:166949
- Katz ML; Wendt KD; Sanders DN. 2005. RPE65 gene mutation prevents development of autofluorescence in retinal pigment epithelial phagosomes. Mech Ageing Dev 126(4):513-21. PubMed: 15722110MGI: J:98275
- Kitamoto J; Libby RT; Gibbs D; Steel KP; Williams DS. 2005. Myosin VI is required for normal retinal function. Exp Eye Res 81(1):116-20. PubMed: 15978262MGI: J:134368
- Kiyama T; Li H; Gupta M; Lin YP; Chuang AZ; Otteson DC; Wang SW. 2012. Distinct neurogenic potential in the retinal margin and the pars plana of Mammalian eye. J Neurosci 32(37):12797-807. PubMed: 22973003MGI: J:187665
- LaVail MM; Gorrin GM; Repaci MA; Thomas LA; Ginsberg HM. 1987. Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci 28(7):1043-8. PubMed: 3596986MGI: J:99553
- Lammermann T; Afonso PV; Angermann BR; Wang JM; Kastenmuller W; Parent CA; Germain RN. 2013. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498(7454):371-5. PubMed: 23708969MGI: J:198733
- Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. PubMed: 11277491MGI: J:103803
- Le Fur N; Kelsall SR; Mintz B. 1996. Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics 37(2):245-8. PubMed: 8921397MGI: J:36008
- Lehman AL; Silvers WK; Puri N; Wakamatsu K; Ito S; Brilliant MH. 2000. The underwhite (uw) locus acts autonomously and reduces the production of melanin J Invest Dermatol 115(4):601-6. PubMed: 10998130MGI: J:64978
- Libby RT; Smith RS; Savinova OV; Zabaleta A; Martin JE; Gonzalez FJ; John SW. 2003. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Science 299(5612):1578-81. PubMed: 12624268MGI: J:82280
- Liu X; Alli R; Steeves M; Nguyen P; Vogel P; Geiger TL. 2012. The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity. J Immunol 189(2):669-78. PubMed: 22711892MGI: J:189797
- Mitra D; Luo X; Morgan A; Wang J; Hoang MP; Lo J; Guerrero CR; Lennerz JK; Mihm MC; Wargo JA; Robinson KC; Devi SP; Vanover JC; D'Orazio JA; McMahon M; Bosenberg MW; Haigis KM; Haber DA; Wang Y; Fisher DE. 2012. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 491(7424):449-53. PubMed: 23123854MGI: J:189208
- Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20. PubMed: 7852195MGI: J:21682
- Nishimura EK; Granter SR; Fisher DE. 2005. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307(5710):720-4. PubMed: 15618488MGI: J:96016
- Ohlemiller KK; Rice ME; Lett JM; Gagnon PM. 2009. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Hear Res 249(1-2):1-14. PubMed: 19141317MGI: J:145863
- Onojafe IF; Adams DR; Simeonov DR; Zhang J; Chan CC; Bernardini IM; Sergeev YV; Dolinska MB; Alur RP; Brilliant MH; Gahl WA; Brooks BP. 2011. Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. J Clin Invest 121(10):3914-23. PubMed: 21968110MGI: J:178454
- Peuhu E; Kaukonen R; Lerche M; Saari M; Guzman C; Rantakari P; De Franceschi N; Warri A; Georgiadou M; Jacquemet G; Mattila E; Virtakoivu R; Liu Y; Attieh Y; Silva KA; Betz T; Sundberg JP; Salmi M; Deugnier MA; Eliceiri KW; Ivaska J. 2017. SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. EMBO J 36(2):165-182. PubMed: 27974362MGI: J:240189
- Potter CS; Pruett ND; Kern MJ; Baybo MA; Godwin AR; Potter KA; Peterson RL; Sundberg JP; Awgulewitsch A. 2011. The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. J Invest Dermatol 131(4):828-37. PubMed: 21191399MGI: J:182085
- Rachel RA; Dolen G; Hayes NL; Lu A; Erskine L; Nowakowski RS; Mason CA. 2002. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. J Neurosci 22(11):4249-63. PubMed: 12040030MGI: J:77026
- Raven MA; Reese BE. 2002. Horizontal cell density and mosaic regularity in pigmented and albino mouse retina. J Comp Neurol 454(2):168-76. PubMed: 12412141MGI: J:126185
- Rikke BA; Simpson VJ; Montoliu L; Johnson TE. 2001. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics. Alcohol Clin Exp Res 25(2):171-6. PubMed: 11236829MGI: J:68230
- Rizvi TA; Huang Y; Sidani A; Atit R; Largaespada DA; Boissy RE; Ratner N. 2002. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. J Neurosci 22(22):9831-40. PubMed: 12427839MGI: J:109211
- Robison WG Jr; Kuwabara T. 1976. Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice. Exp Eye Res 22(5):549-57. PubMed: 1278263MGI: J:5656
- Roffler-Tarlov S; Liu JH; Naumova EN; Bernal-Ayala MM; Mason CA. 2013. L-Dopa and the albino riddle: content of L-Dopa in the developing retina of pigmented and albino mice. PLoS One 8(3):e57184. PubMed: 23526936MGI: J:200184
- Rosenzweig HL; Kawaguchi T; Martin TM; Planck SR; Davey MP; Rosenbaum JT. 2009. Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. Invest Ophthalmol Vis Sci 50(4):1739-45. PubMed: 19098321MGI: J:146921
- Rosenzweig HL; Martin TM; Jann MM; Planck SR; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci 49(4):1518-24. PubMed: 18385071MGI: J:136140
- Savinova OV; Sugiyama F; Martin JE; Tomarev SI; Paigen BJ; Smith RS; John SW. 2001. Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet 2(1):12. PubMed: 11532192MGI: J:82879
- Schuster-Gossler K; Lee AW; Lerner CP; Parker HJ; Dyer VW; Scott VE; Gossler A; Conover JC. 2001. Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines. Biotechniques 31(5):1022-4, 1026. PubMed: 11730008MGI: J:144015
- Schwesinger C; Yee C; Rohan RM; Joussen AM; Fernandez A; Meyer TN; Poulaki V; Ma JJ; Redmond TM; Liu S; Adamis AP; D'Amato RJ. 2001. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol 158(3):1161-72. PubMed: 11238064MGI: J:133002
- Sierra A; Martin-Suarez S; Valcarcel-Martin R; Pascual-Brazo J; Aelvoet SA; Abiega O; Deudero JJ; Brewster AL; Bernales I; Anderson AE; Baekelandt V; Maletic-Savatic M; Encinas JM. 2015. Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis. Cell Stem Cell 16(5):488-503. PubMed: 25957904MGI: J:224680
- Solodova E; Jablonska J; Weiss S; Lienenklaus S. 2011. Production of IFN-beta during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage. PLoS One 6(4):e18543. PubMed: 21494554MGI: J:172226
- Svensson RU; Haverkamp JM; Thedens DR; Cohen MB; Ratliff TL; Henry MD. 2011. Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer. Am J Pathol 179(1):502-12. PubMed: 21703427MGI: J:173997
- Taft RA; Low BE; Byers SL; Murray SA; Kutny P; Wiles MV. 2013. The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells. PLoS One 8(7):e67826. PubMed: 23844102MGI: J:204306
- Takeuchi S; Zhang W; Wakamatsu K; Ito S; Hearing VJ; Kraemer KH; Brash DE. 2004. Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A 101(42):15076-81. PubMed: 15477596MGI: J:93542
- Thiels E; Hoffman EK; Gorin MB. 2008. A reliable behavioral assay for the assessment of sustained photophobia in mice. Curr Eye Res 33(5):483-91. PubMed: 18568886MGI: J:139747
- Tinkum KL; Marpegan L; White LS; Sun J; Herzog ED; Piwnica-Worms D; Piwnica-Worms H. 2011. Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells. Mol Cell Biol 31(18):3759-72. PubMed: 21791610MGI: J:175772
- Tong PL; Roediger B; Kolesnikoff N; Biro M; Tay SS; Jain R; Shaw LE; Grimbaldeston MA; Weninger W. 2015. The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy. J Invest Dermatol 135(1):84-93. PubMed: 25007044MGI: J:216200
- Uehara S; Izumi Y; Kubo Y; Wang CC; Mineta K; Ikeo K; Gojobori T; Tachibana M; Kikuchi T; Kobayashi T; Shibahara S; Taya C; Yonekawa H; Shiroishi T; Yamamoto H. 2009. Specific expression of Gsta4 in mouse cochlear melanocytes: a novel role for hearing and melanocyte differentiation. Pigment Cell Melanoma Res 22(1):111-9. PubMed: 18983533MGI: J:221706
- Waisberg M; Vickers BK; Yager SB; Lin CK; Pierce SK. 2012. Testing in mice the hypothesis that melanin is protective in malaria infections. PLoS One 7(1):e29493. PubMed: 22242171MGI: J:184147
- Whitney IE; Raven MA; Ciobanu DC; Williams RW; Reese BE. 2009. Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Invest Ophthalmol Vis Sci 50(5):1996-2003. PubMed: 19168892MGI: J:149703
- Xie T; Nguyen T; Hupe M; Wei ML. 2009. Multidrug resistance decreases with mutations of melanosomal regulatory genes. Cancer Res 69(3):992-9. PubMed: 19155314MGI: J:144973
- Young A; Powelson EB; Whitney IE; Raven MA; Nusinowitz S; Jiang M; Birnbaumer L; Reese BE; Farber DB. 2008. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci 49(7):3245-52. PubMed: 18378571MGI: J:136897
