The BXD set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes. The BXD strains are derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671) progenitor strains.Read More +
The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.
The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network.
The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains."
Currently there are no related genes or alleles for this strain.
Mice of this strain are prone to seizures beginning at about 6 weeks of age. The mice recover from initial seizures, but seizures are sometimes fatal in mice older than 10 weeks. It is recommended that these mice be housed in a quiet area, away from traffic, noise and activity. Cages should be changed only as frequently as necessary, preferably by the same technician, and mice should be handled slowly and gently. Changes in diet, e.g., increasing/decreasing fat content, have not been found to eliminate seizures. The strain is currently maintained on NIH-31, 6% fat.
When using the BXD13/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000040 in your Materials and Methods section.