BXH2/TyJ

Stock number: 000034
Research areas: Research Tools

Description

The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia. The BXH set is derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains.

Detailed description

The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia. A SNP data set is available through the Mouse Phenome Database for the BXH strains. Another BXH genotype data set consists of 472 MIT CA-repeat dinucleotide microsatellite markers that were typed at UTHSC from 1998 through 2000. The file is taken directly from Williams and colleagues (2001) without any significant modification in genotypes. This order of markers has been updated to conform to the March 2005 assembly of the mouse genome (Build 34 or UCSC mm6). The data set may be downloaded from the University of Tennessee Gene Network site . A data set from Mouse Genome Informatics Contributed Data Sets is also available.

Tools for using the RI set are presented through the Mouse Phenome Database

Specialized Strain Panel Query Form, and

Gene Network. .

BXH2 is susceptible to M. bovis (tuberculosis) and malaria infections despite Nramp1 resistance due to an Icsbp1 (Irf8) mutation. (P Gros and colleagues).

Development

The first 12 BXH recombinant inbred (RI) lines were generated and maintained at The Jackson Laboratory by Dr. Benjamin Taylor (labcode Ty) in 1969. Dr. Linda Siracusa at the Kimmell Cancer Center (labcode Kcc) generated a second set of 8 strains in 1995 by selecting for tyrosinase-negative albinos; a gene on the central part of chromosome (Chr) 7. BXH strains are derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains. Several of the original strains are extinct. The Jackson Laboratory currently distributes 10 of the original Ty strains and 2 of the Kcc strains.

Allele

Symbol: Irf8^myls
Name: myeloproliferative syndrome
MGI accession ID: MGI:3578920
Generation method: Spontaneous
Marker symbol: Irf8
Marker name: interferon regulatory factor 8
Chromosome: 8
Strain of origin: BXH2/TyJ
Molecular note: Sequencing revealed a C-to-T transition at coding nucleotide 880, creating an arginine to cysteine substitution at codon 294 (p.R294C) within the putative IAD domain.