The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia. The BXH set is derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Irf8 | interferon regulatory factor 8 |
The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia.
A SNP data set is available through the Mouse Phenome Database for the BXH strains.
Another BXH genotype data set consists of 472 MIT CA-repeat dinucleotide microsatellite markers that were typed at UTHSC from 1998 through 2000. The file is taken directly from Williams and colleagues (2001) without any significant modification in genotypes. This order of markers has been updated to conform to the March 2005 assembly of the mouse genome (Build 34 or UCSC mm6). The data set may be downloaded from the University of Tennessee Gene Network site . A data set from Mouse Genome Informatics
Contributed Data Sets is also available.
Tools for using the RI set are presented through the Mouse Phenome Database
Specialized Strain Panel Query Form, and
Gene Network.
.
BXH2 is susceptible to M. bovis (tuberculosis) and malaria infections despite Nramp1 resistance due to an Icsbp1 (Irf8) mutation. (P Gros and colleagues).
The first 12 BXH recombinant inbred (RI) lines were generated and maintained at The Jackson Laboratory by Dr. Benjamin Taylor (labcode Ty) in 1969. Dr. Linda Siracusa at the Kimmell Cancer Center (labcode Kcc) generated a second set of 8 strains in 1995 by selecting for tyrosinase-negative albinos; a gene on the central part of chromosome (Chr) 7. BXH strains are derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains. Several of the original strains are extinct. The Jackson Laboratory currently distributes 10 of the original Ty strains and 2 of the Kcc strains.
Allele Name | myeloproliferative syndrome |
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Allele Type | Spontaneous |
Allele Synonym(s) | Icsbp1C294; Irf8BXH2; IRF-8C294; Irf8m; Irf8R294C |
Gene Symbol and Name | Irf8, interferon regulatory factor 8 |
Gene Synonym(s) | |
Strain of Origin | BXH2/TyJ |
Chromosome | 8 |
Molecular Note | Sequencing revealed a C-to-T transition at coding nucleotide 880, creating an arginine to cysteine substitution at codon 294 (p.R294C) within the putative IAD domain. |
When using the BXH2/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000034 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Inbred, 1 pair minimum |
Frozen Mouse Embryo | BXH2/TyJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | BXH2/TyJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | BXH2/TyJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | BXH2/TyJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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