The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density. The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network. This subline of BXD29/Ty is homozygous for the mutation defective lipopolysaccharide response 2 Jackson, which arose spontaneously in the parental strain. The non-mutant parental strain is available as stock number 010981.
In 2011, a spontaneous mutation, telencephalon midline malformation (tmm), was observed in the BXD29-Tlr4lps-2J/J strain (Rosen G et al, Cereb Cortex 2012 March 27). The mutation is 100% penetrant on this genetic background and is characterized by large nodular bilateral subcortical heterotopias with partial callosal agenesis. Mice perform similar to wild-type in tests for motor coordination (rotarod) and learning/memory (water maze), but exhibit a defect in rapid auditory processing.
