The mouse coat color mutant, mahogunin, ring finger 1; mahoganoid (Mgrn1md), darkens coat color and decreases the obesity of Ay mice .
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Mgrn1 | mahogunin, ring finger 1 |
The mouse coat color mutant, mahogunin, ring finger 1; mahoganoid (Mgrn1md), darkens coat color and decreases the obesity of Ay mice that ectopically overexpress agouti-signaling protein (ASP). This mutations and others in the Mgrn1 mahoganoid allelic series are due to large retroviral insertions. Overexpression of ASP inhibits the rise in cAMP levels in response to alpha-melanocyte-stimulating hormone, an MC4R agonist, by blocking ligand binding and by directing MC4R trafficking to the lysosome.
Allele Name | mahoganoid |
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Allele Type | Spontaneous |
Allele Synonym(s) | md |
Gene Symbol and Name | Mgrn1, mahogunin, ring finger 1 |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 16 |
General Note | The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791). |
Molecular Note | The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. |
When using the mahoganoid mouse strain in a publication, please cite the originating article(s) and include JAX stock #000001 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Mgrn1<md> |
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