B6.C3 A/a Mgrn1^md/J

Stock number: 000001
Product name: mahoganoid
Research areas: Dermatology Research

Description

The mouse coat color mutant, mahogunin, ring finger 1; mahoganoid (Mgrn1^md), darkens coat color and decreases the obesity of A^y mice .

Detailed description

The mouse coat color mutant, mahogunin, ring finger 1; mahoganoid (Mgrn1^md), darkens coat color and decreases the obesity of A^y mice that ectopically overexpress agouti-signaling protein (ASP). This mutations and others in the Mgrn1 mahoganoid allelic series are due to large retroviral insertions. Overexpression of ASP inhibits the rise in cAMP levels in response to alpha-melanocyte-stimulating hormone, an MC4R agonist, by blocking ligand binding and by directing MC4R trafficking to the lysosome.

Allele

Symbol: Mgrn1^md
Name: mahoganoid
MGI accession ID: MGI:1856070
Generation method: Spontaneous
Synonyms: md
Marker symbol: Mgrn1
Marker name: mahogunin, ring finger 1
Marker synonyms: 2610042J20Rik; mKIAA0544; nc; RGD1311862; RNF156
Chromosome: 16
Strain of origin: C3H/HeJ
Molecular note: The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice.
General note: The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrn^mg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791).