Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a) is located in the Down syndrome critical region and may be involved in cognitive development. This Dyrk1am1 gene trap allele has a 
beta-geo cassette inserted into intron 4 of the Dyrk1a gene. The mutation is homozygous lethal. Heterozygous mice are viable and fertile with no obvious abnormalities.
When heterozygotes are combined with mice carrying Dp(16Lipi-Zbtb21)1Yey (or Dp(16)1), double mutant mice exhibit an improved performance in T maze and fear conditioning test as compared to Dp(16)1/+ mice alone, but performance does not reach wild-type levels. This strain may be useful for studying Down syndrome.

This gene trap mutation of the Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a) gene is located in the Down syndrome critical region. The mutation results in homozygous lethality.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.