A-Kinase Anchoring Protein 220 (AKAP220) protein, encoded by the Akap11 (A kinase (PRKA) anchor protein 11) gene, is a ubiquitously-expressed vesicular- and membrane-associated anchoring protein. It has been implicated in the modulation of cytoskeletal signaling events, and is integral to water reabsorption processes in the kidney.

Exons 6 and 7 of the mouse Akap11 gene have been excised in this knockout allele. Protein is reported to be undetectable in all tested tissues from homozygous animals. Mice homozygous for the null allele have reduced body size throughout life (both males and females). They also display reduced locomotion and elevated anxiety behavior in open field test. Phenotypic analysis of the kidney collecting duct reveals mislocalization of aquaporin-2 (AQP2) water channels and disrupted apical actin in knockout mice, leading to changes in water homeostasis.

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Exons 6 and 7 of the mouse Akap11 gene have been deleted to create a knockout allele. Homozygous knockout mice exhibit reduced body size, reduced locomotion, elevated anxiety, and changes in water homeostasis.

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