Bmi1 (Bmi1 polycomb ring finger oncogene) is a key transcriptional regulator in several organ stem cells and in cancer. Expression is upregulated in a progressive manner in a wide variety of human tumors, including colorectal cancer.

Exons 4-8 of the mouse Bmi1 gene are flanked by loxP sites in this targeted allele. Cre-mediated excision of the floxed region results in a null allele. 

In a study of intestinal tumorigenesis, a conditional knockout of the Apc gene (Apc;Vil-cre) was combined with a germline knockout of Bmi1. In contrast to wild-type controls, compound mutant mice showed no increase in median tumor size, and a dramatic decrease in tumor number, between 3 and 4 months of age. As such, it is believed that the gene is required for both progression and maintenance of small intestinal adenomas.

Bmi1 is upregulated in a progressive manner in a wide variety of human tumors. Exons 4-8 of the mouse Bmi1 gene are flanked by loxP sites in this targeted allele. Cre-mediated excision of the floxed region results in a null allele.

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