These MIC (TetO-Pyv mT-IRES-Cre) transgenic mice express activated PyVT (Polyomavirus middle T antigen) and IRES-Cre recombinase under the control of a tetO (tetracycline-responsive) promoter element. When these transgenic mice are bred with other transgenic mice expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), tissue-specific transgene expression can be regulated with the tetracycline analog, doxycycline. Mice homozygous for the MIC are viable and fertile.
<p>When crossed to a MMTV-rtTA strain,  doxycycline induction results in development of multifocal mammary tumors
within 16 days.
</p>

Use of MICE only available to non-profit entities.

 These MIC transgenic mice express activated PyVT (Polyomavirus middle T antigen) and Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and are an effective tool for generating inducible, tissue-specific, targeted mutants to study polyomavirus middle T antigen (PyV mT)-mediated mammary tumorigenesis.

A minimum of two mice must be ordered. Additional mice will be charged on a per-mouse basis. Click the “Details” button to learn more.

Our minimum guarantee for cryorecovery orders is 2 carriers. To ensure that your colony can be rapidly expanded upon arrival, additional carriers may be added to your order.