These MIC (TetO-Pyv mT-IRES-Cre) transgenic mice express activated PyVT (Polyomavirus middle T antigen) and IRES-Cre recombinase under the control of a tetO (tetracycline-responsive) promoter element. When these transgenic mice are bred with other transgenic mice expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), tissue-specific transgene expression can be regulated with the tetracycline analog, doxycycline. Mice homozygous for the MIC are viable and fertile.
<p>When crossed to a MMTV-rtTA strain,  doxycycline induction results in development of multifocal mammary tumors
within 16 days.
</p>

 These MIC transgenic mice express activated PyVT (Polyomavirus middle T antigen) and Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and are an effective tool for generating inducible, tissue-specific, targeted mutants to study polyomavirus middle T antigen (PyV mT)-mediated mammary tumorigenesis.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.