This spontaneous mutation maps to a region that includes Clcn1 and the phenotype is consistent with that of Clcn1 mutants. By three weeks of age myol homozygotes have difficulty righting themselves and exhibit a stiffening and stretching of their legs when touched or moved.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | H2 | histocompatibility-2, MHC |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Specified) | myol | myotonia-like |
This spontaneous mutation maps to a region that includes Clcn1 and the phenotype is consistent with that of Clcn1 mutants. By three weeks of age myol homozygotes have difficulty righting themselves and exhibit a stiffening and stretching of their legs when touched or moved. This continues throughout their lifespan. The average litter size in 57 litters from heterozygous intercrosses was 4.58 pups per litter and 18% affected mice were seen in this colony. If the born dead, found dead, and missing at wean age pups were all homozygotes, this would be the expected 25% affected offspring produced. Thus, although identified mutants generally live to adulthood there may be significant perinatal death. No outward phenotype was detected in heterozygotes. Because the strain of origin may have had the H2p haplotype, the cryorecovered bankstock may be segregating at the H2 locus.
The myotonia-like mutation arose spontaneously in the C3.Cg-H2p hael/GrsrJ strain at The Jackson Laboratory and was maintained by sibling intercrossing for a few generations before sperm was cryopreserved from heterozygous males. Successful cryorecovery has been done using C3H/HeJ oocytes. The hael phenotype was not seen in this mutant subline, but this recessive mutation may be segregating in this sperm bankstock.
Allele Name | p variant |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | |
Gene Symbol and Name | H2, histocompatibility-2, MHC |
Gene Synonym(s) | |
Strain of Origin | various |
Chromosome | 17 |
Molecular Note | The p haplotype of the H2 complex is known to be present in the inbred strains F/St, NB, and P/J. |
Allele Name | myotonia-like |
---|---|
Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | myol, myotonia-like |
Gene Synonym(s) | |
Strain of Origin | C3.Cg-H2p hael/GrsrJ |
Chromosome | 6 |
Molecular Note | This heritable phenotypic marker arose spontaneously at The Jackson Laboratory and was mapped to Chromosome 6 between rs3702975 at 12,199,651 bp and rs3023069 at 52,243,142 bp, an interval that includes the candidate gene Clcn1. |
When using the myotonia-like mouse strain in a publication, please cite the originating article(s) and include JAX stock #024060 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
Frozen Mouse Embryo | C3.Cg-myol/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C3.Cg-myol/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C3.Cg-myol/GrsrJ | $3373.50 |
Frozen Mouse Embryo | C3.Cg-myol/GrsrJ | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.