Regulators of G protein signaling (RGS) are GTPase-activating proteins for Gi and Gq &alpha;-subunits that control the intensity and duration of G protein-coupled receptor (GPCR) signaling. The associated pathways control glucose and fatty acid metabolism and the onset of obesity and diabetes. 

This targeted mutation strain carries a knockout of Rgs16 (regulator of G-protein signaling 16) gene as confirmed by Western blot analysis. Mice on a mixed C57BL6 and SJL genetic background show a mild increase in fatty acid oxidation rates and plasma &beta;-ketone levels after a 12-hour fast at the end of Zeitgeber time 12 (ZT12) light phase. These mice have been backcrossed to C57BL/6 for at least 10 generations, and the phenotype has not been confirmed.

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This targeted mutation strain carries a knockout of Rgs16 (regulator of G-protein signaling 16). Mice on a mixed C57BL6 and SJL genetic background show a mild increase in fatty acid oxidation rates and plasma &beta;-ketone levels after a 12-hour fast. This C57BL/6 background has not been assayed, as yet.

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