These H-2 KbDb knock-out mice carry knock-out alleles of the MHC class I genes (Kb null and Db null) and lack CD8+ TCRalpha/beta T-cells, but have more CD4-positive, alpha beta T cells, and fewer single positive CD8 peripheral T-cells. Mice homozygous for both alleles exhibit diminished innate immune response, have decreased susceptibility to Lymphocytic Choriomeningitis Virus infection, and have an increased cytoxic T cell response to Listeria monocytogenes infection.
These mutant mice exhibit enhanced motor learning, with lowered threshold for induction of long-term depression at parallel fiber- Purkinje cell synapses.



 In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

These double H2KbDb KO mice carry knockout alleles of the MHC class I genes and exhibit decreased susceptibility to viral infection, as well as enhanced motor learning. They are suitable for use in applications related to the study of adaptive immunity, cytoxic T cell response and cerebellar synaptic plasticity.

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B6.129P2-H2-K1<b-tm1Bpe> H2-D1<b-tm1Bpe>/DcrJ Frozen Embryo