In this strain, exons 5-10 of the glucosidase beta 2 (<i>Gba2</i>) gene were removed, abolishing gene expression. GBA2 is an enzyme expressed at high levels in teh testis and brain, and at lower levels in other tissues. GBA2 catalyzes the cleavage and formation of bile acid-glucose conjugates and the cleavage of glucosylceramides. Homozygotes are viable and normal in size.  Homozygous males have impaired fertility due to globozoospermia, abnormal acrosomes, and highluy defective sperm mobility, while heterozygous males are fertile.  Glucosylceramides accumulate in the testes to high levels. 

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In this strain the <i>Gba2</i> gene is disrupted thereby abolishing expression. Homozygous males have impaired fertility, reduced bile acid glucosidase and glucosyltransferase activity.

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