The Txnip (thioredoxin interacting protein) gene produces a redox-sensitive signaling protein that participates in a variety of biological functions that are still being characterized.
This strain was created by breeding animals carrying a floxed exon 1 allele (see Stock No. 016847) with Sox2-cre mice to excise the targeted exon.
A similar knockout allele in which the same floxed exon was removed via crosses with a Prm-cre strain (Txniptm1.1Rlee) was published in Circulation Research, 2007 (PMID 17916779). Fasting blood glucose levels in their homozygous mice indicated hypoglycemia without hyperinsulinemia. When placed on a high-fat diet for 4 weeks, their homozygous mice showed significant increases in adipogenesis and insulin sensitivity as compared to wildtype controls. Their homozygotes were viable and fertile.
Although generated in a similar fashion, the offered Txniptm1.1Rlee allele has not been fully characterized.
