This mutation was identified in an ENU screen for recessive cardiovascular development phenotypes in Dr. Cecilia Lo's laboratory, NHLBI Cardiovascular Development Consortium (CvDC). It was recovered from G1 sperm and associated with the phenotype described here. Because G1 sperm were cryopreserved, additional incidental mutations are also segregating in this strain. 
<p>
Homozygotes demonstrate congenital heart diseases associated with heterotaxy including dextrocardia/mesocardia, transposition of great artery (TGA) with tricuspid atresia, Taussig-Bing type double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), muscular VSD, right sided aortic arch (RAA), aortic arch anomalies, and duplicated inferior vena cava (IVC). Thymus hypoplasia, right pulmonary isomerism, and midline liver are also seen.




This mutation was identified in a screen of ENU-induced mutations and may be useful in studies of congenital heart disease and heterotaxy.<p><b>The Jackson Laboratory cannot guarantee that cryorecovery of G1 sperm from the Bench to Bassinet (B2B) collection will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.</b>

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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C57BL/6J-Wdr62<b2b1508Clo>/J Frozen Embryo