A chromosomal translocation t(12;16)(q13;p11) that leads to a gene fusion encoding the TLS:CHOP (or FUS-CHOP) fusion protein is associated with myxoid round cell liposarcoma. These transgenic mice express the fusion protein TLS:CHOP under the direction of the rat Prrx1, paired related homeobox 1, promoter, in the appendicular skeleton. Mice hemizygous for the transgenic insert are viable, fertile and do not form tumors. The Donating Investigator has not attempted to make the strain homozygous.

When crossed to mice carrying a null allele for Trp53
(see Stock No. <a href="https://www.jax.org/strain/002101">002101</a>), the double mutant mice develop sarcomas predominantly located in the appendicular skeleton and are a model for myxoid round cell liposarcoma.

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Prx1-TLS:CHOP transgenic mice (pTC transgenic mice) express the fusion protein TLS:CHOP in the appendicular skeleton, and may have applications related to the therapeutic treatment of myxoid round cell liposarcoma.

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B6;CBA-Tg(Prrx1-FUS/DDIT3)1Mete/J Frozen Embryo