By three weeks of age sule homozygotes lean in a subtle sideways tilt and are slightly smaller than their unaffected littermates. Homozygotes have slightly reduced fecundity and fewer homozygotes are identified than Mendelian inheritance would predict, indicative of either prenatal death or incomplete penetrance.
The sule mutation arose spontaneously in the strain B6;C3Fe-Wnt7apx-2J/GrsrJ at The Jackson Laboratory. This mutant subline was maintained by sibling intercrossing sule heterozygotes and homozygotes and the Wnt7apx-2J phenotype was not seen in any generation. Sperm was cryopreserved from homozygous males at generation F15 and standard recovery uses C57BL/6J ooctyes.
|Allele Name||subtle leaner|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||sule, subtle leaner|
|Strain of Origin||B6;C3Fe-Wnt7apx-2J/GrsrJ|
|Molecular Note||This heritable phenotypic mutant arose spontaneously at The Jackson Laboratory.|