These Grn floxed mutant mice possess a single loxP site upstream of the promoter region of the granulin (Grn) gene, and a second loxP site fused to a FRT-flanked neomycin/kanamycin (neo/kan) resistance cassette downstream of exon 4. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 1- 4 deleted in cre-expressing tissues. When bred with mice expressing Cre-recombinase driven by the chicken actin gene promoter (CAG-cre), granulin deficiency is widespread (see Stock No. <a href="https://www.jax.org/strain/013175">013175</a>). These mice exhibit neurodegeneration as seen in human frontotemporal dementia and have an exaggerated inflammation response when exposed to microbial agents. This floxed strain may be used to generate whole mouse or tissue-specific mutants that are useful for studying inflammation, infectious disease, frontotemporal dementia and other neurodegenerative diseases.

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These Grn floxed mutant mice possess a single loxP site upstream of the promoter region of the granulin (Grn) gene, and a second loxP site fused to a FRT-flanked neomycin/kanamycin (neo/kan) resistance cassette downstream of exon 4. This floxed strain may be used to generate whole mouse or tissue-specific mutants that are useful for studying inflammation, infectious disease, frontotemporal dementia and other neurodegenerative diseases.

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