These mice possess loxP sites on either side of exon 4 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 4 deleted in the cre-expressing tissues.
When bred to a strain with Cre recombinase expression in liver (see Stock No. 003574 for example), this mutant mouse strain may be useful in studies of hepatocyte proliferation and liver regeneration.
When bred to a strain with Cre recombinase expression in myeloid cell lineages (see Stock No. 004781 for example), this mutant mouse strain may be useful in studies of glomerulonephritis, autoimmunity and systemic lupus erythematosus (SLE).
