Mice that are hemizygous for the clock fluorescent reporter transgene are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The mPeriod1-Venus transgene has widespread expression in multiple brain regions (high expression in: suprachiasmatic nuclei (SCN), Purkinje cells, cerebellum, cerebral cortex and hippocampus) and parallels Per1 expression. In addition, the transgene recapitulates Per1 rhythmic and light-inducible expression in the SCN. This mutant mouse strain may be useful for in vivo imaging to monitor circadian clock timing.

These clock fluorescent reporter (mPeriod1-Venus) mutant mice have widespread expression in multiple brain regions paralleling Per1 expression and recapitulating Per1 rhythmic and light-inducible expression in the SCN. This mutant mouse strain may be useful for in vivo imaging to monitor circadian clock timing.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.