behavior/neurological phenotype

• increased chemically-elicited antinociception
  • Normal - however, a recombinant line with the mutant allele and the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine
  (MGI Ref ID J:159561)
  • mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
  (MGI Ref ID J:159561)
  • om C57BL/6
  (MGI Ref ID J:159561)

• abnormal behavioral response to addictive substance
  • mice the Oprm1 allele from C57BL/6
  (MGI Ref ID J:159561)
  • following naloxone-precipitated morphine withdrawal, female mice on the original line with the Oprm1 allele from 129S6/SvEvTac exhibit less jumping than males unlike wild-type or recombinant mice the Oprm1 allele from C57BL/6
  (MGI Ref ID J:159561)

• abnormal conditioned place preference behavior
  (MGI Ref ID J:159561)
  • Normal - however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
  (MGI Ref ID J:159561)
  • recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
  (MGI Ref ID J:159561)

• enhanced behavioral response to morphine
  • Normal - however, a recombinant line with the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine
  (MGI Ref ID J:159561)
  • Normal - however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
  (MGI Ref ID J:159561)
  • om C57BL/6
  (MGI Ref ID J:159561)
  • recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
  (MGI Ref ID J:159561)
  • mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
  (MGI Ref ID J:159561)
  • in a hot plate assay, recombinant mice with an Oprm1 allele from C57BL/6 exhibit faster development of morphine tolerance compared with wild-type mice
  (MGI Ref ID J:159561)

mammalian phenotype

• behavior/neurological phenotype
  • Normal - mice exhibit normal general learning and motor function
  (MGI Ref ID J:159561)

mortality/aging

• prenatal lethality, incomplete penetrance
  • fewer than expected mice are born
  (MGI Ref ID J:159561)

immune system phenotype

• increased susceptibility to Coronaviridae infection
  • mice infected with the mouse-adapted SARS-CoV MA15 exhibit more weight loss than wild-type mice and a moderate, but insignificant, increase in viral titers
  (MGI Ref ID J:288523)

behavior/neurological phenotype

• enhanced behavioral response to morphine
  • Normal - however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
  (MGI Ref ID J:159561)
  • omozygous mice
  (MGI Ref ID J:159561)
  • recombinant mice with the Oprm1 allele from C57BL/6 exhibit an intermediate rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type and homozygous mice
  (MGI Ref ID J:159561)

• abnormal conditioned place preference behavior
  • Normal - however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
  (MGI Ref ID J:159561)
  • omozygous mice
  (MGI Ref ID J:159561)
  • recombinant mice with the Oprm1 allele from C57BL/6 exhibit an intermediate rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type and homozygous mice
  (MGI Ref ID J:159561)